8,498 results match your criteria california dental

Mobile-based oral cancer classification for point-of-care screening.

J Biomed Opt 2021 Jun;26(6)

Wyant College of Optical Sciences, The Univ. of Arizona, United States.

Significance: Oral cancer is among the most common cancers globally, especially in low- and middle-income countries. Early detection is the most effective way to reduce the mortality rate. Deep learning-based cancer image classification models usually need to be hosted on a computing server. Read More

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Correction to: Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons.

Cell Mol Life Sci 2021 Jun 22. Epub 2021 Jun 22.

Institute for Pediatric Regenerative Medicine of Shriners Hospitals for Children, University of California at Davis, School of Medicine, 2425 Stockton Blvd., Sacramento, CA, 95817, USA.

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Using Baseplating and a Miniscope Preanchored with an Objective Lens for Calcium Transient Research in Mice.

J Vis Exp 2021 Jun 5(172). Epub 2021 Jun 5.

Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University.

Neuroscientists use miniature microscopes (miniscopes) to observe neuronal activity in freely behaving animals. The University of California, Los Angeles (UCLA) Miniscope team provides open resources for researchers to build miniscopes themselves. The V3 UCLA Miniscope is one of the most popular open-source miniscopes currently in use. Read More

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Three-Dimensional Culture of Ameloblast-Originated HAT-7 Cells for Functional Modeling of Defective Tooth Enamel Formation.

Front Pharmacol 2021 2;12:682654. Epub 2021 Jun 2.

Department of Oral Biology, Semmelweis University, Budapest, Hungary.

Amelogenesis, the formation of dental enamel, is well understood at the histomorphological level but the underlying molecular mechanisms are poorly characterized. Ameloblasts secrete enamel matrix proteins and Ca, and also regulate extracellular pH as the formation of hydroxyapatite crystals generates large quantities of protons. Genetic or environmental impairment of transport and regulatory processes (e. Read More

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Training dental hygienists to place interim therapeutic restorations in a school-based teledentistry program: Oregon's virtual dental home.

J Public Health Dent 2021 Jun 17. Epub 2021 Jun 17.

Department of Community Dentistry, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA.

Objectives: The objectives of this study on Oregon's virtual dental home were to: 1) demonstrate the feasibility of pilot project training of existing Expanded Practice Dental Hygienists (EPDHs) to perform interim therapeutic restorations (ITRs) in the community settings after diagnosis by the supervising dentist via teledentistry and 2) evaluate satisfaction of parents/guardians of children participating in a pilot program that provides school-based/on-site preventive dental care services utilizing expanded scope EPDHs to conduct dental screenings and place ITRs.

Methods: This demonstration project was a 4-years longitudinal cohort study (2016-2019) in the school/community-based settings focusing on children in kindergarten to 3rd grade. EPDHs and dentists from a Dental Care Organization were trained to utilize teledentistry and EPDHs were trained to place ITRs, the latter provided onsite dental care. Read More

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Bite force estimates in juvenile based on simulated puncture marks.

PeerJ 2021 2;9:e11450. Epub 2021 Jun 2.

Department of Geological Sciences, East Carolina University, Greenville, North Carolina, United States of America.

Background: Bite marks attributed to adult have been subject to numerous studies. However, few bite marks attributed to have been traced to juveniles, leaving considerable gaps in understanding ontogenetic changes in bite mechanics and force, and the paleoecological role of juvenile tyrannosaurs in the late Cretaceous.

Methods: Here we present bite force estimates for a juvenile based on mechanical tests designed to replicate bite marks previously attributed to a of approximately 13 years old. Read More

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Sentinel acute pancreatitis event (SAPE) increases severity of subsequent episodes in mice.

Gastroenterology 2021 Jun 14. Epub 2021 Jun 14.

Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA 02118;; Department of Surgery, University of California Los Angeles, Los Angeles, California 90095.

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Reduction of headache intensity and frequency with maxillary stabilization splint therapy in patients with temporomandibular disorders-headache comorbidity: a systematic review and meta-analysis.

J Dent Anesth Pain Med 2021 Jun 1;21(3):183-205. Epub 2021 Jun 1.

Division of Dental Public Health and Pediatric Dentistry, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California, USA.

This systematic review and meta-analysis aimed to analyze the effectiveness of maxillary stabilization splint (SS) therapy to reduce headache (HA) intensity and HA frequency in patients with temporomandibular disorders (TMD)-HA comorbidity. Randomized controlled trials (RCTs) using full-arch coverage, hard resin, and maxillary SS therapy were included. Electronic databases, including Cochrane Library, MEDLINE through PubMed, Web of Science, and EMBASE, were searched. Read More

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Transcriptomics of type 2 diabetic and healthy human neutrophils.

BMC Immunol 2021 Jun 16;22(1):37. Epub 2021 Jun 16.

Genomic Medicine and Infectious Diseases, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA, 92037, USA.

Objectives: Chronic inflammatory diseases, including diabetes and cardiovascular disease, are heterogeneous and often co-morbid, with increasing global prevalence. Uncontrolled type 2 diabetes (T2D) can result in severe inflammatory complications. As neutrophils are essential to normal and aberrant inflammation, we conducted RNA-seq transcriptomic analyses to investigate the association between neutrophil gene expression and T2D phenotype. Read More

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Computer-Controlled CO Laser Ablation System for CBCT and Digital Image Guided Endodontic Access: A Pilot Study.

J Endod 2021 Jun 10. Epub 2021 Jun 10.

Department of Preventive and Restorative Dental Sciences, University of California San Francisco, 707 Parnassus Avenue, San Francisco, California 94142, United States of America.

Introduction: Ideal endodontic access provides unobstructed entry to the pulp chamber and visualization of the canal orifices while preserving the maximum amount of tooth structure. The aim of this study is to implement the use of lasers to accurately and predictably access teeth to follow the principles of minimally invasive endodontics.

Methods: Traditional, conservative, ultra conservative, bridge, truss and orifice directed accesses were performed. Read More

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Invasive Outbreak at a Pediatric Dental Clinic.

Open Forum Infect Dis 2021 Jun 15;8(6):ofab165. Epub 2021 Apr 15.

Disease Control and Epidemiology, Orange County Health Care Agency, Santa Ana, California, USA.

Background: species, specifically and (MABs), are known to contaminate water systems and are uncommon causes of health care-associated infection, but morbidity can be significant and treatment complex.

Methods: Odontogenic MAB infections occurred in patients following pulpotomy procedures at dental clinic A from 1 January to 6 September 2016. We identified confirmed and probable cases using culture data, imaging, pathology results, and surgical findings. Read More

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Therapeutic options for CTLA-4 Insufficiency.

J Allergy Clin Immunol 2021 Jun 7. Epub 2021 Jun 7.

The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Heterozygous germline mutations in cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) impair the immunomodulatory function of regulatory T cells. Affected individuals are prone to life-threatening autoimmune and lymphoproliferative complications. A number of therapeutic options are currently used with variable effectiveness. Read More

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Panoramic imaged carotid atheromas are associated with increased neutrophil count: both validated, independent predictors of near-term myocardial infarction.

Dentomaxillofac Radiol 2021 Jun 16:20210045. Epub 2021 Jun 16.

Maxillofacial Surgery & Medicine, Dental Service, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Objectives: Panoramic images (PXs) demonstrating calcified carotid artery atheromas (CCAAs) are associated with heightened risk of near-term myocardial infarction (MI). Elevated neutrophil counts (NC) within normal range 2,500-6,000 per mm are likewise associated with future MI signaling the role neutrophils play in the chronic inflammation process underlying coronary artery atherogenesis. We determined if CCAAs on PXs are associated with increased NC. Read More

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Complete Genome Sequence of Strain JB001, a Member of Clade G6 (" Nanogingivalaceae").

Jonathon L Baker

Microbiol Resour Announc 2021 Jun 10;10(23):e0051721. Epub 2021 Jun 10.

Genomic Medicine Group, J. Craig Venter Institute, La Jolla, California, USA.

At least 6 highly diverse clades of inhabit the human oral cavity. However, all oral strains with currently available complete genome sequences or cultured isolates belong to clade G1, leaving clades G2 through G6 poorly understood. Here, a complete genome sequence of JB001, a clade G6 (" Nanogingivalaceae") strain, is reported. Read More

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Large-scale open-source three-dimensional growth curves for clinical facial assessment and objective description of facial dysmorphism.

Sci Rep 2021 Jun 9;11(1):12175. Epub 2021 Jun 9.

Department of Human Genetics, KU Leuven, 3000, Leuven, Belgium.

Craniofacial dysmorphism is associated with thousands of genetic and environmental disorders. Delineation of salient facial characteristics can guide clinicians towards a correct clinical diagnosis and understanding the pathogenesis of the disorder. Abnormal facial shape might require craniofacial surgical intervention, with the restoration of normal shape an important surgical outcome. Read More

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Cross-polarization optical coherence tomographic assessment of in situ simulated erosive tooth wear.

J Biophotonics 2021 Jun 9:e202100090. Epub 2021 Jun 9.

Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USA.

This clinical study tested cross-polarization optical coherence tomography (CP-OCT) monitoring of erosive tooth wear (ETW). Twenty participants completed a 14-day/arm, 3-arm crossover study simulating different ETW severities. Participants received two enamel specimens (per arm) and were randomized to: severe (s-ETW, lemon juice/pH:2. Read More

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Nonventilator hospital-acquired pneumonia: A call to action.

Infect Control Hosp Epidemiol 2021 Jun 9:1-6. Epub 2021 Jun 9.

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston.

In 2020 a group of U.S. healthcare leaders formed the National Organization to Prevent Hospital-Acquired Pneumonia (NOHAP) to issue a call to action to address non-ventilator-associated hospital-acquired pneumonia (NVHAP). Read More

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Analysis of color and fluorescence of different dentin ceramics and natural human dentin's to enhance shade matching.

J Esthet Restor Dent 2021 Jun 7. Epub 2021 Jun 7.

Division of Restorative Dentistry, School of Dentistry, University of California Los Angeles, Los Angeles, California, USA.

Objectives: This study aimed to compare the color and fluorescence of five dentin ceramic systems with human dentin to enhance shade matching.

Materials And Methods: Five dentin ceramic systems, including Vita, GC, Creation, Noritake, and Ivoclar in 16 shades, and 12 human dentins, were prepared. The fluorescence and color coordinates were measured at 380-780 nm. Read More

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Pathological lesions of the digestive tract in free-ranging mountain gorillas (Gorilla beringei beringei).

Am J Primatol 2021 Jun 7:e23290. Epub 2021 Jun 7.

Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

The finding of parasites and bacterial pathogens in mountain gorilla feces and oral lesions in gorilla skeletal remains has not been linked to pathological evidence of morbidity or mortality. In the current study, we conducted a retrospective study of digestive tracts including oral cavity, salivary glands, esophagus, stomach, intestines (gastrointestinal tract [GI]), liver, and pancreas of 60 free-ranging mountain gorillas from Uganda, Rwanda, and the Democratic Republic of Congo that died between 1985 and 2007. We reviewed clinical histories and gross pathology reports and examined histological sections. Read More

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A role for gut microbiota in early-life stress-induced widespread muscle pain in the adult rat.

Mol Pain 2021 Jan-Dec;17:17448069211022952

Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA.

Adult rats that experienced neonatal limited bedding (NLB), a form of early-life stress, experience persistent muscle mechanical hyperalgesia. Since there is a growing recognition that the gut microbiome regulates pain and nociception, and that early-life stress produces a long-lasting impact on the gut microbiome, we tested the hypothesis that persistent muscle hyperalgesia seen in adult NLB rats could be ameliorated by interventions that modify the gut microbiome. Adult NLB rats received probiotics, either GG (10 billion CFU/150 ml) or De Simone Formulation (DSF) (112. Read More

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Continued Trauma: A Thematic Analysis of the Asylum-Seeking Experience Under the Migrant Protection Protocols.

Health Equity 2021 30;5(1):277-287. Epub 2021 Apr 30.

Department of Emergency Medicine, LAC+USC Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

The Migrant Protection Protocols (MPP) required asylum seekers presenting to the U.S. southern border to wait in Mexico while seeking asylum. Read More

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Clinical Validation of the Champagne Algorithm for Epilepsy Spike Localization.

Front Hum Neurosci 2021 20;15:642819. Epub 2021 May 20.

National Engineering Research Center for E-Learning, Central China Normal University, Wuhan, China.

Magnetoencephalography (MEG) is increasingly used for presurgical planning in people with medically refractory focal epilepsy. Localization of interictal epileptiform activity, a surrogate for the seizure onset zone whose removal may prevent seizures, is challenging and depends on the use of multiple complementary techniques. Accurate and reliable localization of epileptiform activity from spontaneous MEG data has been an elusive goal. Read More

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Heat and Sound Generation During Implant Osteotomy When Using Different Types of Drills in Artificial and Bovine Bone Blocks.

J Oral Implantol 2021 Jun 5. Epub 2021 Jun 5.

Assistance Professor, Dental Education Services.

The purpose of this study was to compare heat and sound generated during implant osteotomy when different types of drill were used in artificial bone and bovine bone blocks. A total of 80 implant osteotomies were formed using 4 implant drilling systems; N1 (OsseoShaper) (Nobel), NobelActive (Nobel), V3 (MIS) and BLX (Straumann) in both artificial bone and bovine bone blocks. Thermocouple probes were used to record temperature change at the depths of 5. Read More

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Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase 2b/3 double-blind, randomised, placebo-controlled trial.

Lancet 2021 Jun 3;397(10292):2372-2384. Epub 2021 Jun 3.

Department of Gastroenterology, University Hospital of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France. Electronic address:

Background: The global prevalence of ulcerative colitis is increasing, and induction and maintenance of remission is a crucial therapeutic goal. We assessed the efficacy and safety of filgotinib, a once-daily, oral Janus kinase 1 preferential inhibitor, for treatment of ulcerative colitis.

Methods: This phase 2b/3, double-blind, randomised, placebo-controlled trial including two induction studies and one maintenance study was done in 341 study centres in 40 countries. Read More

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Monckeberg's Medial Sclerosis as a Cause for Headache and Facial Pain.

Curr Pain Headache Rep 2021 Jun 4;25(8):50. Epub 2021 Jun 4.

Professional Program for International Dentists, University of California Los A ngeles School of Dentistry, Los Angeles, CA, USA.

Purpose Of Review: Mönckeberg's medial sclerosis (MMS) is a chronic, non-inflammatory degenerative condition affecting primarily the tunica media of muscular arteries resulting in their calcification. The purpose of this comprehensive review is to describe MMS as it appears in the literature, in the context of headache and facial pain. Understanding the etiopathology, the associated conditions, and the differential diagnoses is important in managing MMS. Read More

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Multiplexed suppression of TOR complex 1 induces autophagy during starvation.

Autophagy 2021 Jun 14:1-2. Epub 2021 Jun 14.

Division of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan.

Target of rapamycin complex 1 (TORC1) promotes cellular anabolism and suppresses macroautophagy/autophagy. In mammalian cells starved of amino acid, the GATOR1 complex, a negative regulator of TORC1, is released from its inhibitor GATOR2 and inactivates TORC1. We have recently identified the evolutionarily conserved GATOR2 components in fission yeast including Sea3, an ortholog of mammalian WDR59, but, unexpectedly, Sea3 acts as a part of GATOR1 to suppress TORC1. Read More

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Developmental influence on evolutionary rates and the origin of placental mammal tooth complexity.

Proc Natl Acad Sci U S A 2021 Jun;118(23)

Vertebrate Evolution, Development and Ecology, Naturalis Biodiversity Center, Postbus 9517, 2300 RA Leiden, The Netherlands.

Development has often been viewed as a constraining force on morphological adaptation, but its precise influence, especially on evolutionary rates, is poorly understood. Placental mammals provide a classic example of adaptive radiation, but the debate around rate and drivers of early placental evolution remains contentious. A hallmark of early dental evolution in many placental lineages was a transition from a triangular upper molar to a more complex upper molar with a rectangular cusp pattern better specialized for crushing. Read More

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RGD-Modified Alginate-GelMA Hydrogel Sheet Containing Gingival Mesenchymal Stem Cells: A Unique Platform for Wound Healing and Soft Tissue Regeneration.

ACS Biomater Sci Eng 2021 Jun 3. Epub 2021 Jun 3.

Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, California 90095, United States.

Soft tissue reconstruction has remained a major clinical challenge in dentistry and regenerative medicine. Although current methods have shown partial success, there are several disadvantages associated with these approaches. Gingival mesenchymal stem cells (GMSCs) can be simply obtained in the oral cavity for soft tissue augmentation. Read More

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Pain Management for Dental Medicine in 2021: Opioids, Coronavirus and Beyond.

J Pain Res 2021 24;14:1371-1387. Epub 2021 May 24.

Department of Diagnostic Sciences, Craniofacial Pain and Headache Center, Tufts University School of Dental Medicine, Boston, MA, USA.

Over the past year our attention has inevitably been on the coronavirus pandemic, the health and welfare of our families, patients, and office staffs as well as the re-opening of our dental practices. In addition, the opioid crisis continues, is very likely to worsen as a result of the pandemic and continues to be a challenge to Dentistry. National public health issues and healthcare disparities continue and have created a global concern for providing evidence-based, adequate pain management in the dental setting. Read More

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Application of the 10 Keys for Replacement of Multiple Teeth in the Esthetic Zone.

Compend Contin Educ Dent 2021 Jun;42(6):F1-F11

Clinical Associate Professor, University of Melbourne, Melbourne, Australia; Fellow, International Team for Implantology, Private Practice in Dental Implants and Periodontics, Melbourne, Australia.

Ten keys for successful esthetic-zone single immediate implants encapsulate in an evidence-based manner the treatment planning and replacement of single hopeless teeth in the maxillary anterior sextant. These include two treatment-planning, five surgical, and three prosthetic keys, which, collectively, aim to minimize soft- and hard-tissue complications for an optimal esthetic implant restoration. The Straightforward, Advanced, and Complex (SAC) classification is designed to aid clinicians in the treatment planning of dental implant cases. Read More

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