Phys Med Biol 2021 Sep 20. Epub 2021 Sep 20.
Department of Radiology, UC Davis Health System, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USA, Sacramento, California, 95817, UNITED STATES.
Absolute quantification of regional tissue concentration of radioactivity in PET is a critical parameter-of-interest across various clinical and research applications and is affected by a complex interplay of factors including scanner calibration, data corrections, and image reconstruction. The emergence of long AFOV PET systems widens the dynamic range accessible to PET and creates new opportunities in reducing scan time and radiation dose, delayed or low radioactivity imaging, as well as kinetic modeling of the entire human. However, these imaging regimes impose challenging conditions for accurate quantification due to constraints from image reconstruction, low count conditions, as well as large and rapidly changing radioactivity distribution across a large AFOV. Read More