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Pulmonary-to-systemic venous collateral in obstructed supracardiac totally anomalous pulmonary venous connection: Blood finds a way!

J Card Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

We describe a rare variant of obstructed supracardiac totally anomalous venous connection in a 7-day-old boy where the vertical vein was occluded and the entire pulmonary venous return was draining through a large tortuous pulmonary-systemic venous collateral. The case highlights the importance of computed tomography angiography in demonstrating such complex anatomies in congenital heart diseases. Read More

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Response to: Surgical approach for totally implantable venous access port: a full strategy to avoid the percutaneous approach complications.

Langenbecks Arch Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.

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A salt resistant biosurfactant produced by moderately halotolerant Pseudomonas aeruginosa (AHV-KH10) and its application for bioremediation of diesel-contaminated sediment in saline environment.

Biodegradation 2021 Apr 15. Epub 2021 Apr 15.

Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

A halotolerant bacterial strain was isolated from oily-contaminated sites of Persian Gulf, which characterized as Pseudomonas aeruginosa (AHV-KH10) by 16S rRNA gene sequencing. This strain was used for bioremediation of diesel-contaminated sediments. Biosurfactant production was initially screened by using oil displacement test and drop-collapse method, followed by measurement of surface tension (ST) of growth medium. Read More

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Combinations of by-products from biodiesel production included in the supplement for finishing heifers on deferred pastures.

Trop Anim Health Prod 2021 Apr 15;53(2):262. Epub 2021 Apr 15.

College of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Av. Senador Filinto Muller, 2443, Vila Ipirang, Campo Grande, Mato Grosso do Sul, 79074-460, Brazil.

We hypothesized that by-products from biodiesel production like crambe meal (Crambe abyssinica) totally replace soybean meal (Glycine max) and crude glycerin could partially replace corn (Zea mays). Our aim was to evaluate different supplements with combinations of crambe meal and crude glycerin replacing soybean meal or corn on performance and carcass traits of finishing heifers. Sixty Nellore heifers 18 months old were used, and 298. Read More

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Dose escalation study of targeted alpha therapy with [Ac]Ac-DOTA-substance P in recurrence glioblastoma - safety and efficacy.

Eur J Nucl Med Mol Imaging 2021 Apr 15. Epub 2021 Apr 15.

European Commission, Joint Research Centre, Directorate for Nuclear Safety and Security, Karlsruhe, Germany.

Glioblastoma is the most common and malignant primary brain tumour, with a poor prognosis. Introduction of new treatment options is critically important. The study aimed to assess the appropriateness of escalation doses and toxicity of [Ac]Ac-DOTA-SP therapy. Read More

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Halo Nevi Are Not Trivial: About 2 Young Patients of Regressed Primary Melanoma That Simulates Halo Nevi.

Case Rep Dermatol Med 2021 22;2021:6672528. Epub 2021 Mar 22.

Dermatology Department, CHU UCL Namur, Site Sainte Elisabeth, Place Louise Godin 15, 5000 Namur, Belgium.

Background: Halo nevi are often considered benign, and the possibility of malignancy is not always clear to practitioners. We present two case reports suggesting that a halo nevus appearance can be seen in melanoma, even in young adults. A literature search for halo nevi revealing melanoma shows that this is a very rare condition. Read More

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Influence of Ethylene Signaling in the Crosstalk Between Fe, S, and P Deficiency Responses in .

Front Plant Sci 2021 30;12:643585. Epub 2021 Mar 30.

Department of Agronomy (DAUCO-María de Maeztu Unit of Excellence), Edificio Celestino Mutis, Campus de Rabanales CeiA3, Universidad de Córdoba, Córdoba, Spain.

To cope with P, S, or Fe deficiency, dicot plants, like , develop several responses (mainly in their roots) aimed to facilitate the mobilization and uptake of the deficient nutrient. Within these responses are the modification of root morphology, an increased number of transporters, augmented synthesis-release of nutrient solubilizing compounds and the enhancement of some enzymatic activities, like ferric reductase activity (FRA) or phosphatase activity (PA). Once a nutrient has been acquired in enough quantity, these responses should be switched off to minimize energy costs and toxicity. Read More

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Oral Resveratrol supplementation attenuates exercise-induced Interleukin-6 but not Oxidative Stress after a high intensity cycling challenge in adults.

Int J Med Sci 2021 18;18(10):2137-2145. Epub 2021 Mar 18.

Department of Physical Education, National Taichung University of Education, Taichung City, Taiwan.

Previous studies demonstrated that resveratrol (RES) is able to enhance antioxidant, anti-inflammatory and insulin actions in humans. It is unclear whether RES can be used as ergogenic aids to enhance high-intensity cycling exercise performance and attenuate the high-intensity exercise-induced oxidative stress and inflammation. This study investigated the effect of RES supplementation on oxidative stress, inflammation, exercise-induced fatigue, and endurance performance. Read More

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Semantic categorization of Chinese eligibility criteria in clinical trials using machine learning methods.

BMC Med Inform Decis Mak 2021 Apr 15;21(1):128. Epub 2021 Apr 15.

Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.

Background: Semantic categorization analysis of clinical trials eligibility criteria based on natural language processing technology is crucial for the task of optimizing clinical trials design and building automated patient recruitment system. However, most of related researches focused on English eligibility criteria, and to the best of our knowledge, there are no researches studied the Chinese eligibility criteria. Thus in this study, we aimed to explore the semantic categories of Chinese eligibility criteria. Read More

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The mitochondrial genome of () (Diptera: Limoniidae).

Mitochondrial DNA B Resour 2021 Mar 31;6(4):1321-1323. Epub 2021 Mar 31.

Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China.

The crane fly () Mao and Yang, belongs to subfamily Limnophilinae of family Limoniidae. This mitogenome of () was sequenced used next-generation sequencing (NGS), the new representative of the mitogenome of the subfamily. The nearly complete mitogenome is 14,858 bp totally, consisting of 13 protein-coding genes, 2 rRNAs and 22 transfer RNAs. Read More

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The complete chloroplast genome of , an endemic to Europe.

Mitochondrial DNA B Resour 2021 Apr 1;6(4):1300-1302. Epub 2021 Apr 1.

Shandong Institute of Pomology, Shandong Academy of Agricultural Sciences, Taian, PR China.

Sweet chestnut () is an endemic species of genus in Europe, which is widespread in the southern part of continental Europe. The complete genome sequence of chloroplast was determined through Illumina NovaSeq platform. Totally the genome of chloroplast was 160,938 bp in length, GC rich (36. Read More

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Outcome of a Multi-modal CBT-based Treatment Program for Chronic School Refusal.

Glob Pediatr Health 2021 30;8:2333794X211002952. Epub 2021 Mar 30.

Lund University, Lund, Sweden.

School refusal (SR) can have several negative consequences, but effective treatments are available. When chronic, school absence requires comprehensive treatment. This study evaluates an intervention for SR based on a Cognitive Behavioral Therapy (CBT) model, (HSP). Read More

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Synthesis, Inhibitory Activity, and Modeling of Selective COX-1 Inhibitors with a Quinazoline Core.

ACS Med Chem Lett 2021 Apr 12;12(4):610-616. Epub 2021 Mar 12.

Laboratory of Plant Biotechnologies, Czech Academy of Sciences, Institute of Experimental Botany, Rozvojova 263, 165 02 Prague 6 - Lysolaje, Czech Republic.

Selective cyclooxygenase-1 (COX-1) inhibition has got into the spotlight with the discovery of COX-1 upregulation in various cancers and the cardioprotective role of COX-1 in control of thrombocyte aggregation. Yet, COX-1-selective inhibitors are poorly explored. Thus, three series of quinazoline derivatives were prepared and tested for their potential inhibitory activity toward COX-1 and COX-2. Read More

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Effect of GLP-1/GLP-1R on the Polarization of Macrophages in the Occurrence and Development of Atherosclerosis.

Mediators Inflamm 2021 27;2021:5568159. Epub 2021 Mar 27.

Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, China.

Aims: To investigate the effect of GLP-1/GLP-1R on the polarization of macrophages in the occurrence and development of atherosclerosis.

Methods: Totally, 49 patients with coronary heart disease (CHD) and 52 cases of health control (HC) were recruited, all subjects accept coronary angiography gold standard inspection. One or more major coronary arteries (LM, LAD, LCx, and RCA) stenosis degree in 50% of patients as CHD group; the rest of the stenosis less than 50% or not seen obvious stenosis are assigned to the HC group. Read More

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Epidemiological Characterization of Colistin and Carbapenem Resistant Enterobacteriaceae in a Tertiary: A Hospital from Anhui Province.

Infect Drug Resist 2021 6;14:1325-1333. Epub 2021 Apr 6.

Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, People's Republic of China.

Purpose: Antimicrobial resistance, especially carbapenem resistance Enterobacteriaceae and plasmid mediated mobile colistin resistance, is a serious issue worldwide. This study was designed to determine the epidemiological characteristics of plasmid mediated colistin resistance and carbapenem resistant Enterobacteriaceae from tertiary A hospital located in Hefei, China.

Methods: Totally, 158 carbapenems resistant Enterobacteriaceae (CRE) were screened for antibiotic susceptibility, , extended spectrum β-lactamases (ESBLs), metallo-β-lactamases (MBLs), and fosfomycin resistance genes using PCR and sequencing. Read More

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A meta-analysis indicating extra-short implants (≤ 6 mm) as an alternative to longer implants (≥ 8 mm) with bone augmentation.

Sci Rep 2021 Apr 14;11(1):8152. Epub 2021 Apr 14.

Department of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Ling Yuan Xi Road, Guangzhou, 510006, Guangdong, People's Republic of China.

Extra-short implants, of which clinical outcomes remain controversial, are becoming a potential option rather than long implants with bone augmentation in atrophic partially or totally edentulous jaws. The aim of this study was to compare the clinical outcomes and complications between extra-short implants (≤ 6 mm) and longer implants (≥ 8 mm), with and without bone augmentation procedures. Electronic (via PubMed, Web of Science, EMBASE, Cochrane Library) and manual searches were performed for articles published prior to November 2020. Read More

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Bamboo Nodes of Vocal Fold-A Clinical Study of 14 Cases.

Chin Med Sci J 2021 Mar;36(1):43-49

Department of Rheumatology and Clinical Immunology; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Objective Bamboo node (BN) of vocal folds is a rare disease which is mostly associated with autoimmune diseases and always involves women as reported in literature. The purpose of this study is to investigate the clinical characteristics and the treatments in a series of BN cases. Methods We retrospectively collected and reviewed clinical information of all patients who presented bamboo nodes by fibreoptic laryngoscopy from 2011 to 2020 in our hospital, including the demographic information, clinical symptoms, associated autoimmune diseases, voice abuse, treatments, and outcomes. Read More

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Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors: A Retrospective Study.

Chin Med Sci J 2021 Mar;36(1):27-34

Department of Cancer Prevention, National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.

Objective To characterize Chinese families in which both parents and at least one child are diagnosed with malignant diseases and provide reference for cancer screening or early detection in people whose both parents are diagnosed with cancer. Methods Medical records of all clients to the center of cancer screening and prevention of the National Cancer Center/Cancer Hospital between January 2008 and February 2018 were screened to select families in which both parents and at least one child were diagnosed with malignant diseases. The cancer profiles of fathers, mothers, sons and daughters, their age distribution at diagnosis, and similarity of cancers between two generations were analyzed. Read More

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Thyroid gland metastasis mimicking thyroid carcinoma in a lung cancer patient and dramatic response to crizotinib: A case report.

Tuberk Toraks 2021 Mar;69(1):98-101

Department of Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Metastasis of lung adenocarcinoma to the thyroid is extremely rare. Since treatment for primary thyroid cancer and non thyroid malignancy is totally different, precise diagnosis is clinically important. Read More

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Authors' Reply to: And Justice For All? There Is More To Interoperability of Contact Tracing Apps Than Legal Barriers. Comment on "COVID-19 Contact Tracing Apps: A Technologic Tower of Babel and the Gap for International Pandemic Control".

JMIR Mhealth Uhealth 2021 Apr 12. Epub 2021 Apr 12.

Faculty of Law, University of Macau, Faculty of Law University of Macau Avenida da Universidade, Taipa Macau, SAR,China, Macau, CN.

Unstructured: In this letter, we made a response to Crutzen's comment on our recent publication in JMU. Our article was an analysis of the technologic Tower of Babel that analysed the global functioning and interaction of contract tracing apps for COVID-19. In general, we are concerned with both legal and ethical disconformity between different apps, while Cruzten focuses primarily on ethical concerns and the protection of human rights. Read More

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Multi-walled carbon nanotube/hydroxyapatite nanocomposite with leukocyte- and platelet-rich fibrin for bone regeneration in sheep model.

Oral Maxillofac Surg 2021 Apr 14. Epub 2021 Apr 14.

Nanotechnology & Regenerative Medicine Commercialisation Centre (NanoRegMed Ltd), London BioScience Innovation Centre , London, NW1 0NH, UK.

Background: The aim of this study was to evaluate the effects of multi-walled carbon nanotubes/hydroxyapatite (MWCNT/HA) granules with or without leukocyte- and platelet-rich fibrin (L-PRF) on bone regeneration in cancellous bone of sheep model.

Methods: Totally, 32 cylindrical holes were drilled in female sheep (n = 4) in the distal epiphysis and proximal metaphysis of right and left humerus and femur. The defects were randomly filled with (1) MWCNT/HA, (2) MWCNT/HA mixed with L-PRF, (3) L-PRF, and (4) left empty as control. Read More

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Design of 1-Phosphanorbornene Derivatives as Chiral Organocatalysts for Enantioselective (4 + 2) Annulation Reactions of γ-Benzyl Allenoates.

Org Lett 2021 Apr 14. Epub 2021 Apr 14.

College of Chemistry, Green Catalysis Center, International Phosphorus Laboratory, International Joint Research Laboratory for Functional Organophosphorus Materials of Henan Province, Zhengzhou University, Zhengzhou 450001, P. R. China.

Two novel diastereoisomeric P-chirogenic phosphine catalysts, i.e., JiaPhos, which can be easily derived from inexpensive and commercially available starting materials in five chemical operations (totally 4. Read More

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Red-Purple Photochromic Indigos from Green Chemistry: Mono-BOC or Di-BOC -Substituted Indigos Displaying Excited State Proton Transfer or Photoisomerization.

J Phys Chem B 2021 Apr 14. Epub 2021 Apr 14.

University of Coimbra, CQC, Department of Chemistry, Rua Larga, 3004-535 Coimbra, Portugal.

In indigo, excited state proton transfer (ESPT) is known to be associated with the molecular mechanism responsible for highly efficient radiationless deactivation. When this route is blocked (partially or totally), new deactivation routes become available. Using new green chemistry procedures, with favorable green chemistry metrics, monosubstitution and disubstitution of N group(s) in indigo, by -butoxy carbonyl groups, -(-butoxycarbonyl)indigo (NtBOCInd) and -(-butoxycarbonyl)indigo (N,N'tBOCInd), respectively, were synthetically accomplished. Read More

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Complications following secondary voice prosthesis insertion and impact of previous irradiation on their appearance.

Niger J Clin Pract 2021 Apr;24(4):470-475

Faculty of Medicine, University of Novi Sad; Clinical Centre of Vojvodina, Clinic for Otorhinolaryngology and Head and Neck Surgery, Novi Sad, Serbia.

Objective: The aim of this study was to analyze the complications following secondary voice prosthesis insertion and impact of previous irradiation on their appearance.

Methods: This study included 106 totally laryngectomized patients who underwent secondary Provox 2 voice prosthesis insertion. Among them, 79 (74. Read More

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Metabolic responses in neonatal sepsis - a systematic review of human metabolomic studies.

Acta Paediatr 2021 Apr 13. Epub 2021 Apr 13.

Paediatric Research Group, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.

Aim: To systematically review human metabolomic studies investigating metabolic responses in septic neonates.

Methods: A systematic literature search was performed in the databases MEDLINE, EMBASE and Cochrane library up to the 1st of January 2021. We included studies that assessed neonatal sepsis and the following outcomes; (1) change in the metabolism compared to healthy neonates and/or (2) metabolomics compared to traditional diagnostic tools of neonatal sepsis. Read More

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Total extraperitoneal (TEP) versus laparoscopic transabdominal preperitoneal (TAPP) hernioplasty: systematic review and trial sequential analysis of randomized controlled trials.

Hernia 2021 Apr 13. Epub 2021 Apr 13.

Division of General Surgery, Department of Biomedical Science for Health, Istitituto Clinico Sant'Ambrogio, University of Milan, Milan, Italy.

Purpose: To examine the updated evidence on safety, effectiveness, and outcomes of the totally extraperitoneal (TEP) versus the laparoscopic transabdominal preperitoneal (TAPP) repair and to explore the timely tendency variations favoring one treatment over another.

Methods: Systematic review and trial sequential analysis (TSA) of randomized controlled trials (RCTs). MEDLINE, Scopus, Web of Science, Cochrane Central Library, and ClinicalTrials. Read More

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Identification and validation of a prognostic immune-related lncRNA signature in bladder cancer.

Transl Androl Urol 2021 Mar;10(3):1229-1240

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Recently, researches have implied that immune-related lncRNAs (IR-lncRNAs) have a vital role in tumor occurrence and development. However, the study in bladder cancer (Bca) is still unclear. New biomarkers and reliable prognostic models for Bca are still limited. Read More

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Cytological Evaluation of Palpebral Lesions: An Insight into its Limitations Aided with Histopathological Corroboration.

J Microsc Ultrastruct 2021 Jan-Mar;9(1):12-17. Epub 2020 Nov 9.

Department of Pathology, North Bengal Medical College and Hospital, Siliguri, West Bengal, India.

Context: Eyelids by virtue of its unique histomorphology give rise to multitudes of different pathological conditions. Appropriate preoperative cytological diagnoses of these cases are necessary to determine their optimal therapy.

Aims: The aims of this study were to evaluate the utility of various cytological techniques in diagnosing the definite pathology for palpebral lesions and thereby to highlight the drawbacks associated with cytology in this context. Read More

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November 2020

COVID-19 simulation study-the effect of strict non-pharmaceutical interventions (NPIs) on controlling the spread of COVID-19.

PeerJ 2021 30;9:e11172. Epub 2021 Mar 30.

Department of Health Information Management, University of Pittsburgh, Pittsburgh, PA, USA.

Background: From the beginning of 2020, COVID-19 infection has changed our lives in many aspects and introduced limitations in the way people interact and communicate. In this paper, we are evaluating the effect of non-pharmaceutical interventions (NPI) in limiting the spread of the Severe Acute Respiratory Syndrome Coronavirus 2 pandemic during a wedding ceremony from Irbid, Northern Jordan. Agent-based modeling was used in a real wedding event that occurred at the beginning of the spread of the pandemic in Jordan. Read More

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Evaluation of Radicular Dentin Microcracks Formation after Instrumentation with NiTi Hand and Rotary File System: A Stereomicroscopic Study.

J Contemp Dent Pract 2020 Nov 1;21(11):1233-1237. Epub 2020 Nov 1.

Department of Conservative Dentistry and Endodontics, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Aim And Objective: The present study aimed to assess the formation of microcracks in root dentin post-instrumentation with nickel-titanium (NiTi) hand and rotary file system.

Materials And Methods: Totally, 80 freshly extracted mandibular premolar teeth with single roots were chosen for this study. Access opening was performed and #10 K-file was used to attain patency of canal. Read More

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November 2020