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Glenohumeral osteoarthritis with intact rotator cuff treated with reverse shoulder arthroplasty: a systematic review.

J Shoulder Elbow Surg 2021 Jul 19. Epub 2021 Jul 19.

Division of Upper Extremity Surgery, Department of Orthopaedic Surgery, Director of Upper Extremity Surgery Research, Emory University 59 Executive Park South, Atlanta, GA 30329, USA.

Background: While reverse shoulder arthroplasty has shown satisfactory outcomes in rotator cuff deficient shoulders, its performance in shoulders with an intact rotator cuff has not been fully elucidated. Shoulder osteoarthritis can present with alterations in glenoid morphology which have contributed to inconsistent outcomes in anatomic shoulder replacement. A predominance of these arthroplasty complications is due to the glenoid component. Read More

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Effects of Mindfulness-Based Interventions on Mental Health in Nurses: A Meta-Analysis of Randomized Controlled Trials.

Issues Ment Health Nurs 2021 Jul 22:1-9. Epub 2021 Jul 22.

Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.

Mindfulness as a positive mental health intervention approach has been increasingly applied to nurses. This meta-analysis evaluated the psychological effects of mindfulness-based interventions (MBIs) on mental health in nurses. We searched PubMed, EMBASE, Cochrane, and CINAHL up to February 2020. Read More

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Comparison of Hepatotoxicity Associated With New BCR-ABL Tyrosine Kinase Inhibitors vs Imatinib Among Patients With Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 Jul 1;4(7):e2120165. Epub 2021 Jul 1.

School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China.

Importance: Although BCR-ABL fusion oncoprotein tyrosine kinase inhibitors (BCR-ABL TKIs) can substantially improve the survival rate of chronic myeloid leukemia (CML), they are clinically accompanied by severe hepatotoxicity.

Objective: To compare the relative risk (RR) of hepatotoxicity of new-generation BCR-ABL TKIs with that of imatinib, and to provide an overall assessment of the clinical benefit.

Data Sources: PubMed, Embase, Cochrane library databases, and ClinicalTrials. Read More

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Development and validation of an immune gene set-based prognostic signature in cutaneous melanoma.

Future Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

We aimed to fully understand the landscape of the skin cutaneous melanoma (SKCM) microenvironment and develop an immune prognostic signature that can predict the prognosis for SKCM patients. RNA sequencing data and clinical information were downloaded from the Cancer Genome Atlas and Gene Expression Omnibus databases. The immune-prognostic signature was constructed by LASSO Cox regression analysis. Read More

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Real-world data-based adverse drug reactions detection from the Korea Adverse Event Reporting System databases with electronic health records-based detection algorithm.

Health Informatics J 2021 Jul-Sep;27(3):14604582211033014

Konyang University Hospital, Republic of Korea; Konyang University College of Medicine, Republic of Korea.

Pharmacovigilance involves monitoring of drugs and their adverse drug reactions (ADRs) and is essential for their safety post-marketing. Because of the different types and structures of medical databases, several previous surveillance studies have analyzed only one database. In the present study, we extracted potential drug-ADR pairs from electronic health record (EHR) data using the MetaNurse algorithm and analyzed them using the Korean Adverse Event Reporting System (KAERS) database for systematic validation. Read More

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Contrast-enhanced ultrasound Liver Imaging Reporting and Data System category M: a systematic review and meta-analysis.

Ultrasonography 2021 May 19. Epub 2021 May 19.

Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: A meta-analysis was conducted to determine the proportion of contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System category M (LR-M) in hepatocellular carcinomas (HCCs) and non-HCC malignancies and to investigate the frequency of individual CEUS LR-M imaging features.

Methods: The MEDLINE and Embase databases were searched from inception to July 23, 2020 for studies reporting the proportion of CEUS LR-M in HCC and non-HCC malignancies. The meta-analytic pooled proportions of HCC and non-HCC malignancies in the CEUS LR-M category were calculated. Read More

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Effects of resistance bands exercise for frail older adults: A systematic review and meta-analysis of randomised controlled studies.

J Clin Nurs 2021 Jul 21. Epub 2021 Jul 21.

School of Nursing, Kaohsiung Medical University, Kaohsiung City, Taiwan.

Aims And Objectives: Research examining the effectiveness of resistance band exercises for improving physical and psychological dimensions among frail older adults has been inconsistent. We aimed to examine the effects of resistance band exercises for improving outcomes in frail older adults.

Background: To provide robust evidence regarding the effectiveness of resistance band exercises and explore other potential outcomes in frail older adults, a systematic review of RCTs remains necessary. Read More

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Ejaculation Disorders in Male Patients With Cancer: A Systematic Review and Meta-Analysis of Prevalence.

J Urol 2021 Jul 21:101097JU0000000000002136. Epub 2021 Jul 21.

The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK.

Purpose: Ejaculatory dysfunction (EjD) and erectile dysfunction after cancer treatment are clinically important complications, but their exact prevalence by various kinds of cancer site and type of treatment is unknown. The aim of this systematic review and meta-analysis was to examine the available evidence and provide pooled estimates for prevalence of EjD and erectile dysfunction in relation to all cancer sites and identify characteristics associated with EjD in cancer patients.

Materials And Methods: We performed a systematic review and meta-analysis of cross-sectional and case-control studies. Read More

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Prognostic significance of the systemic immune-inflammation index in pancreatic carcinoma patients: A meta-analysis.

Biosci Rep 2021 Jul 21. Epub 2021 Jul 21.

The First Affiliated Hospital of Hunan University of Medicine, Huaihua, China.

Background: Systemic immune-inflammation index (SII) is a prognostic indicator for several malignancies, including pancreatic carcinoma, however, there is no consensus on its significance. In the current study, a systematic meta-analysis was used to explore the correlation between SII and prognosis in pancreatic carcinoma patients.

Methods: PubMed, Embase and Cochrane Library databases were screened from inception to May 2020. Read More

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Effectiveness of Semi-Occluded Vocal Tract Exercises (SOVTEs) in Patients with Dysphonia: A Systematic Review and Meta-Analysis.

J Voice 2021 Jul 17. Epub 2021 Jul 17.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Research Department, SOMA- Osteopathic Institute Milan, Milan, Italy.

Background: Dysphonia is a disorder characterized by an alteration in the overall quality of the voice which reduces quality of life. Therefore, we assessed the effectiveness of SOVTEs in the management of dysfunctional and organic dysphonia for acoustic, perceptual-auditive, aerodynamic parameters and self-perception of the disease.

Methods: a systematic review and meta-analysis were conducted. Read More

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Safety of exercise training in multiple sclerosis: a protocol for an updated systematic review and meta-analysis.

Syst Rev 2021 Jul 20;10(1):208. Epub 2021 Jul 20.

Discipline of Libraries, Archives, Records & Information Science, School of Media, Creative Arts & Social Inquiry, Faculty of Humanities, Curtin University, Perth, WA, Australia.

Background: There has been an exponential growth in the number of clinical research studies regarding exercise training in multiple sclerosis, and literature reviews and meta-analyses have documented the many benefits of exercise training. This research further requires careful review for documenting the safety of exercise training in multiple sclerosis, as clarity on safety represents a major hurdle in the clinical prescription of exercise behaviour.

Objectives: To enhance understanding of the feasibility of exercise in multiple sclerosis, we (1) provide a protocol of a systematic review and meta-analysis that summarises rates and risks of clinical relapse, adverse events (i. Read More

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The causal influence of responsive parenting behaviour on academic readiness: a protocol for a systematic review and meta-analysis of randomized controlled trials.

Syst Rev 2021 Jul 20;10(1):207. Epub 2021 Jul 20.

Department of Psychology, Ryerson University, Toronto, Canada.

Background: Children's academic readiness has important implications for subsequent achievement and psychosocial functioning. A growing number of studies are utilizing randomized controlled trials (RCT) to examine whether responsive parenting interventions lead to positive gains in children's academic readiness. A synthesis of the extant literature is warranted to gain a precise estimate of the causal influence of responsive parenting on academic readiness, as well as to examine moderators that may serve to strengthen or weaken this effect. Read More

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Association between autoimmune encephalitis and epilepsy: Systematic review and meta-analysis.

Seizure 2021 Jul 12;91:346-359. Epub 2021 Jul 12.

Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan 650032, PR China. Electronic address:

Background: Diverse neuronal antibodies are related to autoimmune encephalitis (AE) and AE-related epilepsy. However, the epidemiological characteristics of AE, AE-associated antibodies, and AE-related seizures are still unclear.

Aims: This research evaluated the relationship between AE, AE-related seizures, and neuronal antibodies, as well as the morbidity of AE with early incidence. Read More

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Outcomes with CD34-selected stem cell boost for poor graft function after allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis.

Transplant Cell Ther 2021 Jul 17. Epub 2021 Jul 17.

Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS. Electronic address:

Background: Poor graft function (PGF) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) characterized by multilineage cytopenia in the absence of mixed donor chimerism (<95% donor), relapse, or severe graft-vs-host disease (GVHD). We present a systemic review and meta-analysis aimed to assess the outcomes with CD34-selected stem cell boost (SCB) for PGF in adult allo-HSCT patients.

Methods: We screened a total of 1753 records identified from 4 databases (PubMed, Embase, Cochrane, and Clinical trials. Read More

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Prophylactic Intraoperative Uterine Artery Embolization During Cesarean Section or Cesarean Hysterectomy in Patients with Abnormal Placentation: A Systematic Review and Meta-Analysis.

Cardiovasc Intervent Radiol 2021 Jul 19. Epub 2021 Jul 19.

Department of Medical Imaging, Chi Mei Medical Center, NO. 901, Zhonghua Rd., Yongkang Dist., Tainan City, 710, Taiwan.

Purpose: To evaluate the effectiveness and safety of prophylactic intraoperative uterine artery embolization (UAE) performed immediately after fetal delivery during planned cesarean section or cesarean hysterectomy in patients with placenta accreta spectrum disorder or placenta previa.

Methods: A systematic search was conducted on Ovid MEDLINE and Embase, PubMed, Web of Science, and Cochrane databases. Studies were selected using the Population/Intervention/Comparison/Outcomes (PICO) strategy. Read More

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A Novel HCC Prognosis Predictor EEF1E1 Is Related to Immune Infiltration and May Be Involved in EEF1E1/ATM/p53 Signaling.

Front Oncol 2021 2;11:700972. Epub 2021 Jul 2.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: EEF1E1 has been reported to play a role in ovarian cancer, breast cancer, non-small cell lung cancer and other cancers, but its role and mechanism in hepatocellular carcinoma (HCC) are still unknown.

Methods: EEF1E1 expression in human HCC was analyzed the GTEx and TCGA database. Logistic regression analysis was used to analyze the clinicopathological correlation of EEF1E1 expression. Read More

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Clinical efficacy of intravitreal corticoid as an adjunctive therapy to anti-VEGF treatment of neovascular age-related macular degeneration: a Meta-analysis.

Int J Ophthalmol 2021 18;14(7):1092-1099. Epub 2021 Jul 18.

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China.

Aim: To evaluate the efficacy and safety of intravitreal corticoid as an adjunctive therapy to anti-vascular endothelial growth factor (VEGF) treatment of neovascular age-related macular degeneration (nvAMD).

Methods: Four databases including PubMed, Embase, Cochrane Library, and the clinicaltrials.gov were comprehensively searched for studies comparing intravitreal corticoid plus anti-VEGF (IVC/IVA) anti-VEGF monotherapy (IVA) in patients with nvAMD. Read More

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Effect of kefir beverage consumption on glycemic control: A systematic review and meta-analysis of randomized controlled clinical trials.

Complement Ther Clin Pract 2021 Jul 13;44:101443. Epub 2021 Jul 13.

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Kefir is a fermented beverage obtained as a result of lactic-alcoholic fermentation of milk by using kefir grains or a starter culture. Kefir beverage has numerous health benefits owing to its antimicrobial, anti-inflammatory and anti-diabetic properties, while it could also regulate the gut microbiota. This beverage is recommended as a nutritional approach to glycemic control. Read More

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Effectiveness of Virtual Reality Rehabilitation in Persons with Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Mult Scler Relat Disord 2021 Jul 9;54:103128. Epub 2021 Jul 9.

Assistant professor, University of Brasília, Brazil.

Background: Multiple Sclerosis (MS) is a chronic disease with physical, cognitive, and psychosocial impairments. Virtual Reality (VR) has been used as an innovative tool in neurological rehabilitation. There are promising new studies that have used commercial video games consoles for the rehabilitation of people with MS. Read More

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The comparative effectiveness of 55 interventions in obese patients with polycystic ovary syndrome: A network meta-analysis of 101 randomized trials.

PLoS One 2021 19;16(7):e0254412. Epub 2021 Jul 19.

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Background: Polycystic ovary syndrome (PCOS) affects up to 18% of reproductive-age females. The prevalence of obesity in PCOS patients reaches up to 80%, which is 2-fold higher than the general population.

Objective: The present study aimed to compare the effectiveness of 55 pharmacological interventions across 17 different outcomes in overweight/obese PCOS patients with hyperandrogenism manifestations for both short- and long-term follow-ups. Read More

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Feasibility of sleep extension and its effect on cardiometabolic parameters in free-living settings: a systematic review and meta-analysis of experimental studies.

Eur J Cardiovasc Nurs 2021 Jul 19. Epub 2021 Jul 19.

Department of Biobehavioral Nursing Science, College of Nursing, University of Illinois at Chicago, 845 S Damen Ave., Chicago, 60612, IL, USA.

Aims: Inadequate sleep is a global health issue and has been associated with an increased risk for cardiovascular diseases. As a part of sleep hygiene, intentional lengthening of night-time sleep duration (i.e. Read More

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Comparative efficacy and safety of verapamil and triamcinolone in keloid and hypertrophic scar treatment: a meta-analysis.

J Cosmet Laser Ther 2021 Jul 18:1-9. Epub 2021 Jul 18.

Health Management Centre, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Keloids and hypertrophic scars are harmful to physical and psychological health. The study aims to compare the efficacy and safety of verapamil and triamcinolone in the treatment of keloids and hypertrophic scars. Relevant publications were searched from PubMed, Embase, Cochrane library, CNKI, Weipu, and Wanfang databases. Read More

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Sexual dysfunction among women of reproductive age: A systematic review and meta-analysis.

Int J Reprod Biomed 2021 May 23;19(5):421-432. Epub 2021 Jun 23.

Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Alborz University of Medical Sciences, Karaj, Iran.

Background: Available statistics show a high prevalence of sexual dysfunction (SD) among women worldwide. Various factors affect SD among women of reproductive age.

Objective: To evaluate studies on the prevalence and determinants of SD in different parts of the world. Read More

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An evaluation of the reporting quality in clinical practice guidelines for hepatocellular carcinoma using the RIGHT checklist.

Ann Transl Med 2021 Jun;9(12):1004

Department of Internal Medicine, Henan Cancer Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Clinical practice guidelines (CPGs) on the prevention, surveillance, diagnosis and management of HCC are essential to guide clinical practice. The objective of this study was to evaluate the reporting quality of the most recent CPGs for HCC published worldwide. Read More

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Evaluation of the reporting quality of clinical practice guidelines on gliomas using the RIGHT checklist.

Ann Transl Med 2021 Jun;9(12):1002

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: The reporting quality of clinical practice guidelines (CPGs) for gliomas has not yet been thoroughly assessed. The International Reporting Items for Practice Guidelines in Healthcare (RIGHT) statement developed in 2016 provides a reporting framework to improve the quality of CPGs. We aimed to estimate the reporting quality of glioma guidelines using the RIGHT checklist and investigate how the reporting quality differs by selected characteristics. Read More

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Aspirin Use and Common Cancer Risk: A Meta-Analysis of Cohort Studies and Randomized Controlled Trials.

Front Oncol 2021 18;11:690219. Epub 2021 Jun 18.

School of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Whether aspirin use can decrease or increase cancer risk remains controversial. In this study, a meta-analysis of cohort studies and randomized controlled trials (RCTs) were conducted to evaluate the effect of aspirin use on common cancer risk.

Method: Medline and Embase databases were searched to identify relevant studies. Read More

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Split hand in amyotrophic lateral sclerosis: A systematic review and meta-analysis.

J Clin Neurosci 2021 Aug 21;90:293-301. Epub 2021 Jun 21.

Department of Neurology, Peking Union Medical College Hospital, Beijing 100730, China. Electronic address:

Objective: To investigate the frequency of split hand (SI) and its diagnostic performance in amyotrophic lateral sclerosis (ALS).

Methods: PubMed, EMBASE, OVID and other databases were searched systematically up to March 2021 for relevant reports about the split hand syndrome. Two reviewers screened and selected the titles and abstracts of the studies independently during the database searches and performed full-text reviews and extracted available data. Read More

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Are genetic variations in IL-1β and IL-6 cytokines associated with the risk of pre-eclampsia? Evidence from a systematic review and meta-analysis.

J Matern Fetal Neonatal Med 2021 Jul 18:1-10. Epub 2021 Jul 18.

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: This systematic review and meta-analysis study was performed to assess the potential association between interleukin-1 beta (IL-1β) single nucleotide polymorphisms (SNPs) (rs1143634 and rs16944) and interleukin-6 (IL-6) SNP (rs1800795) and pre-eclampsia (PE).

Methods: A comprehensive literature search was conducted in the international search engines and databases, including MEDLINE (via PubMed), Scopus, and Web of Science (ISI) up to 9 March 2021. After retrieving relevant articles, data extraction was performed by four authors independently. Read More

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Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis.

Lancet Psychiatry 2021 Jul 15. Epub 2021 Jul 15.

University Psychiatric Hospital Campus Duffel, Duffel, Belgium; Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Belgium. Electronic address:

Background: Mental disorders might be a risk factor for severe COVID-19. We aimed to assess the specific risks of COVID-19-related mortality, hospitalisation, and intensive care unit (ICU) admission associated with any pre-existing mental disorder, and specific diagnostic categories of mental disorders, and exposure to psychopharmacological drug classes.

Methods: In this systematic review and meta-analysis, we searched Web of Science, Cochrane, PubMed, and PsycINFO databases between Jan 1, 2020, and March 5, 2021, for original studies reporting data on COVID-19 outcomes in patients with psychiatric disorders compared with controls. Read More

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Study on the potential active components and molecular mechanism of Xiao Huoluo Pills in the treatment of cartilage degeneration of knee osteoarthritis based on bioinformatics analysis and molecular docking technology.

J Orthop Surg Res 2021 Jul 17;16(1):460. Epub 2021 Jul 17.

Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, China.

Background: Knee osteoarthritis is a common joint degenerative disease. Xiao Huoluo Pills (XHLP) has been used to treat degenerative diseases such as osteoarthritis and hyperosteogeny. However, XHLP's specific effective ingredients and mechanism of action against osteoarthritis have not been explored. Read More

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