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Bone Loss and Radiographic Damage Profile in Rheumatoid Arthritis Moroccan Patients.

J Bone Metab 2021 May 31;28(2):151-159. Epub 2021 May 31.

Department of Rheumatology, Mohammed VI University Hospital, Faculty of Medicine, Mohammed I University, Oujda, Morocco.

Background: Rheumatoid arthritis (RA) is a known cause of joint destruction and systemic bone loss. In this study, we aimed to evaluate the bone damage and bone loss profiles of established RA patients.

Methods: We designed a cross-sectional study on a cohort of established RA patients. Read More

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Abnormal functional connectivity within the prefrontal cortex in interstitial cystitis/bladder pain syndrome (IC/BPS): A pilot study using resting state functional near-infrared spectroscopy (rs-fNIRS).

Neurourol Urodyn 2021 Jun 15. Epub 2021 Jun 15.

School of Rehabilitation, Capital Medical University, Beijing, China.

Purpose: To investigate the abnormalities of functional connectivity (FC) within the prefrontal cortex (PFC) of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) based on resting state functional near-infrared spectroscopy (rs-fNIRS) data using FC matrix analysis.

Materials And Methods: Ten patients with IC/BPS (females, 9; mean age, 56.9 ± 12. Read More

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Rotational Thromboelastometry in Neonates Admitted to a Neonatal Intensive Care Unit: A Large Cross-sectional Study.

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Haematology and Blood Bank Unit, "Attikon" Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

The aim of the present study was to assess the coagulation profile in neonatal critical illness using rotational thromboelastometry (ROTEM), and to investigate its association with disease severity and its potential prognostic role in this clinical setting. Over a period of 67 months (July 2014-February 2020) 423 critically ill neonates with confirmed or suspected sepsis, perinatal hypoxia, or respiratory distress syndrome, hospitalized in our neonatal intensive care unit were included in the study. Demographic, clinical, and laboratory data were recorded on admission day and arterial blood was analyzed on ROTEM analyzer using the standard extrinsically activated rotational thromboelastometry assay (EXTEM). Read More

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Incidence and Outcomes of Acute Kidney Injury in COVID-19: A Systematic Review.

Blood Purif 2021 Jun 15:1-14. Epub 2021 Jun 15.

Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky Medical Center, Lexington, Kentucky, USA.

Background And Objectives: The recent worldwide pandemic of COVID-19 has been a serious, multidimensional problem that has left a detrimental worldwide impact on individuals of all ages and several organ systems. The typical manifestation of kidney involvement is acute kidney injury (AKI); however, there is a lack of consensus data regarding AKI epidemiology in COVID-19. This systematic literature review aims to bridge this knowledge gap. Read More

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Overhydration May Be the Missing Link between Peritoneal Protein Clearance and Mortality.

Nephron 2021 Jun 15:1-7. Epub 2021 Jun 15.

Division of Nephrology, Department of Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.

Introduction: Peritoneal protein loss (PPL) has been associated with mortality. Inflammation was assumed a putative cause with malnutrition as a consequence. Hydrostatic convection is a major drive for microvascular protein transport, but most studies in peritoneal dialysis (PD) patients overlooked this mechanism. Read More

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Incorporating oxygenation levels in analytical DNA-damage models - quantifying the oxygen fixation mechanism.

Phys Med Biol 2021 Jun 15. Epub 2021 Jun 15.

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, Oxfordshire, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Purpose: To develop a framework to include oxygenation effects in radiation therapy treatment planning which is valid for all modalities, energy spectra and oxygen levels. The framework is based on predicting the difference in DNA--damage resulting from ionising radiation at variable oxygenation levels.

Methods: Oxygen fixation is treated as a statistical process in a simplified model of complex and simple damage. Read More

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Charge-transfer-induced 2D ferromagnetism and realization of thermo-remnant memory effect in ultrathin β-NiOOH-encapsulated graphene.

Nanotechnology 2021 Jun 15. Epub 2021 Jun 15.

Research Center for Spin Dynamics and Spin-Wave Devices, Seoul National University, Seoul 151-744, South Korea, Seoul, Korea (the Republic of).

For graphene-based 2D materials, charge transfer at the interface between graphene and ferromagnetic metal leads to many intriguing phenomena. However, because of the unidirectional spin orientation in ferromagnetic transition metals, interface interaction plays a detrimental role in diminishing the magnetic parameters on 2D surfaces. To overcome this issue, we have synthesized ultrathin 2D weak antiferromagnetic β-NiOOH layers on a graphene surface. Read More

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Validation of the German Day-to-Day Impact of Vaginal Aging (DIVA) Questionnaire in Peri- and Postmenopausal Women.

Sex Med 2021 Jun 12;9(4):100382. Epub 2021 Jun 12.

Institute of Social Medicine and Health Systems Research, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.

Background: The Day-to-Day Impact of Vaginal Aging (DIVA) questionnaire is a validated patient-reported outcome measure (PROM) capturing the impacts of vaginal symptoms in postmenopausal women.

Aim: We aimed to psychometrically validate the German version of the DIVA questionnaire.

Methods: Data was collected online and by paper-pencil. Read More

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An analysis of the relative and absolute incidence of somatic morbidity in patients with affective disorders-A nationwide cohort study.

J Affect Disord 2021 Jun 7;292:204-211. Epub 2021 Jun 7.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospitals, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark; Section for Epidemiology, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Copenhagen K 1014, Denmark.

Background: Patients with affective disorder seem to experience higher risks of several somatic diseases, but no studies have provided estimates of both absolute and relative risks for these diseases in the same population.

Methods: A prospective cohort of all patients age ≥18 years old with a hospital contact with affective disorder between 1997-2014 (n=246,282) and a random sample from the background population (n=167,562) was followed for hospitalizations with cardiovascular disease, diabetes, cancers, chronic obstructive pulmonary disease (COPD), asthma, inflammatory bowel disease, hip fracture, psoriasis, migraine, or dementia. Adjusted absolute and relative risk estimates were calculated using multivariable adjusted Aalen's additive and Cox proportional hazard regression models. Read More

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Greater adolescent tiredness is related to more emotional arousal during a hyperventilation task: An area under the curve approach.

J Adolesc 2021 Jun 12;90:45-52. Epub 2021 Jun 12.

University of Arkansas, USA. Electronic address:

Introduction: Approximately 36% of adolescents report sleep problems (Crowley et al., 2018). Understanding the relation between sleep and emotional experience is crucial in understanding the high incidence of mental health concerns during adolescence. Read More

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A retrospective evaluation of the value of COVID-19 screening and testing in patients with cancer: Aiming at a moving target.

J Infect Public Health 2021 May 26;14(7):949-953. Epub 2021 May 26.

Department of Oncology, King Abdulaziz Medical City, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia.

Background: Diagnosis of COVID-19 infection in cancer patients is critical to co-manage their underlying disease and infection appropriately. Our study aimed at evaluating the sensitivity and specificity of screening patients with cancer for COVID-19 infection.

Methods: All oncology patients receiving care at Department of Oncology at King Abdulaziz Medical City in Riyadh were screened using the acute respiratory infection (ARI) survey. Read More

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Validity and Test-Retest Reliability of a Thai Stroke Physical Activity Questionnaire.

J Stroke Cerebrovasc Dis 2021 Jun 11;30(8):105907. Epub 2021 Jun 11.

Department of Rehabilitation Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background And Objectives: This study evaluated the validity and reliability of the Stroke Physical Activity Questionnaire (SPAQ), a Thai self-report questionnaire for assessing physical activity (PA) in participants with chronic stroke.

Methods: The validity of the SPAQ was tested by correlating PA data from the SPAQ with data obtained from a waist worn accelerometer which participants wore for seven days. The participants completed the SPAQ twice, one week apart and test-retest reliability was calculated using intraclass correlation coefficient. Read More

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Performance of the EarlyCDT® Lung test in detection of lung cancer and pulmonary metastases in a high-risk cohort.

Lung Cancer 2021 Jun 10;158:85-90. Epub 2021 Jun 10.

Institute of Regional Health Research, University of Southern Denmark, J.B. Winsløws Vej 19, 3, 5000 Odense C, Denmark; Department of Internal Medicine, Vejle Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100 Vejle, Denmark. Electronic address:

Objectives: Early detection of lung cancer is pivotal for an optimal prognosis. CT screening is currently implemented in USA. To decrease the amount of CT scans, the application of a blood-based biomarker as part of screening criteria is desirable. Read More

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Low dietary quercetin intake by food frequency questionnaire analysis is not associated with hypertension occurrence.

Clin Nutr 2021 May 12;40(6):3748-3753. Epub 2021 May 12.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address:

Background & Aims: Quercetin is one of the most abundant flavonoids in plant kingdom. Because of its strong anti-inflammatory and antioxidant effect, it is of potential in anti-hypertension. The objective of the present study was to explore the relationship between dietary quercetin and hypertension incidence in a Chinese population. Read More

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Children are safe in schools: a review of the Irish experience of reopening schools during the COVID-19 pandemic.

Public Health 2021 Jun 12;195:158-160. Epub 2021 Jun 12.

Office of the Clinical Director for Health Protection, HSE, Ireland; Department of Public Health, HSE Midlands, Tullamore, Ireland.

Objectives: Schools in the Republic of Ireland reopened to students and staff in late August 2020. We sought to determine the test positivity rate of close contacts of cases of coronavirus disease 2019 (COVID-19) in schools during the first half-term of the 2020/2021 academic year.

Methods: National-level data from the schools' testing pathway were interrogated to determine the positivity rate of close contacts of cases of COVID-19 in Irish primary, postprimary and special schools during the first half-term of 2020/2021 academic year. Read More

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Vascularized Carotid Atherosclerotic Plaque Models for the Validation of Novel Methods of Quantifying Intra-Plaque Neovascularization.

J Am Soc Echocardiogr 2021 Jun 12. Epub 2021 Jun 12.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada;; Department of Medicine, Cardiovascular Imaging Network at Queen's (CINQ), Queen's University, Canada. Electronic address:

Background: Intraplaque neovascularization (IPN) in advanced lesions of the carotid artery has been linked to plaque progression and risk of rupture. Quantitative measurement of IPN may provide a more powerful tool for the detection of such "vulnerable" plaque than the current visual scoring grading method. The aim of this study was to develop a phantom platform of a neovascularized atherosclerotic plaque within a carotid artery to assess new methods of quantifying IPN. Read More

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Antibody Responses After mRNA-Based COVID-19 Vaccination in Residential Older Adults: Implications for Reopening.

J Am Med Dir Assoc 2021 Jun 12. Epub 2021 Jun 12.

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Clinical Laboratory, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Objective: COVID-19 disproportionately impacts residents in long-term care facilities. Our objective was to quantify the presence and magnitude of antibody response in vaccinated, older adult residents at assisted living, personal care, and independent living communities.

Design: A cross-sectional quality improvement study was conducted March 15 - April 1, 2021 in the greater Pittsburgh region. Read More

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Evaluation of aging changes in the superficial fat compartments of the midface: a computed tomography study.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Dr. Sadiye Kus Dermatology Clinic, Istanbul.

Background: Previous studies on alterations in superficial fat compartments with age yielded contradictory results; the superficial fat tissue volume or thickness was reported to increase, decrease, or remain unchanged.

Aims: To investigate volumetric and dimensional changes in superficial midfacial fat tissue retrospectively in patients who underwent a repeated computed tomography (CT).

Methods: A total of 262 patients (mean age, 46 years; median elapsed time between two CT imagings, 56 months) were included. Read More

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Alopecia areata severity index (AASI): a reliable scoring system to assess the severity of alopecia areata on face and scalp- a pilot study.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Dermatologist JK Medical Services, Department of Health and Family Welfare, Kashmir.

Background: All scoring systems used in Alopecia Areata (AA) focus mainly on scalp and cannot assess the severity or treatment response when AA involves the beard hair, eyebrows or eyelashes.

Aim: This study describes and assesses the reliability of a new scoring system 'Alopecia Areata Severity Index' (AASI) for measuring the severity of AA of scalp, beard and upper face.

Methods: Scalp hair, beard hair, upper face (eyebrows and eyelashes) were individually assessed and the severity of AA was scored from 0 to 100 (0-50 in case of upper face). Read More

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Multiple in vivo Effects of Cadmium on Photosynthetic Electron Transport in Pea Plants.

Photochem Photobiol 2021 Jun 15. Epub 2021 Jun 15.

Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.

The inhibitory effects of cadmium (CdSO ) on the primary photosynthetic processes were studied in vivo in Pisum sativum by using Multi-function Plant Efficiency Analyser (M-PEA-2). Photosynthetic parameters related to photosystem (PS) II, PS I and intersystem electron carriers were calculated from the light-induced kinetics of prompt chlorophyll a fluorescence (OJIP transient), delayed chlorophyll a fluorescence (DF), and 820 nm modulated reflection (MR). Low-dose exposure to cadmium (20 μM CdSO for 48 h) reduced probability of electron transfer from plastoquinones to the terminal electron acceptors of PSI (δ ) accompanied by a decrease in the rate of P and PC reduction (V ) and the magnitude of the I step on the DF kinetics. Read More

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Thiazolidinediones and Glucagon-like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study.

Hepatology 2021 Jun 15. Epub 2021 Jun 15.

CARIM School for Cardiovascular Disease, Maastricht University, Maastricht, the Netherlands.

Thiazolidinediones (TZDs) and glucagon-like peptide-1 (GLP-1) receptor agonists are potential pharmacological treatment options for patients at risk of nonalcoholic fatty liver disease (NAFLD). Therefore, we examined the association between the risk of NAFLD and the use of thiazolidinediones and GLP-1 receptor agonists compared with the use of sulfonylureas (SUs) and insulins. Additionally, we calculated the incidence of hepatocellular carcinoma (HCC) in users of TZDs and GLP-1 receptor agonists. Read More

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Starting pitchers demonstrate a greater hazard of arm injury compared to relief pitchers.

J Athl Train 2021 Jun 15. Epub 2021 Jun 15.

University of South Carolina Center for Rehabilitation and Reconstruction Sciences, Greenville, South Carolina, USA.

Context: It is currently unclear how different pitching roles affect arm injury risk in professional pitchers.

Objective: 1) Investigate the differences in arm injury hazard between professional baseball starting and relief pitchers; 2) Separately investigate elbow and shoulder injury hazard between professional baseball starting and relief pitchers.

Study Design: Prospective cohort Setting: Minor League Baseball (MiLB) from 2013-2019 Patients or Other Participants: Pitchers Main Outcome Measures: Pitchers were followed for the entire MiLB season and athletic exposures (AE's) and injuries were recorded. Read More

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The Relationship Between Workload and Non-Contact Musculoskeletal Injury in College Swimmers: A Prospective Cohort Study.

J Athl Train 2021 Jun 15. Epub 2021 Jun 15.

Department of Exercise Science, University of South Carolina, Colombia, SC,

Context: Swimmers are known for high training loads and overuse injuries, but few studies have investigated the relationship between the two at the college level.

Objective: To determine the association between workload and non-contact musculoskeletal injury in college swimmers. We hypothesized (1) higher overall workload (kilometers swum throughout the season) would be associated with increased odds of injury and (2) the ratio of the current week's (acute) workload divided by the current month's (chronic) workload (i. Read More

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Comparison of foot strike sound between rearfoot, midfoot and forefoot strike runners.

J Athl Train 2021 Jun 15. Epub 2021 Jun 15.

Gait & Motion Analysis Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong.

Context: There are three common foot strike techniques in runners. Whether these techniques generate different sounds at the point of impact with the ground may influence lower limb kinetics. No previous studies have determined whether such relationships exist. Read More

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Three-dimensional assessment of the spheno-occipital synchondrosis and clivus after tooth-borne and bone-borne rapid maxillary expansion.

Angle Orthod 2021 Jun 15. Epub 2021 Jun 15.

Objectives: To assess changes in spheno-occipital synchondrosis after rapid maxillary expansion (RME) performed with conventional tooth-borne (TB) and bone-borne (BB) appliances.

Materials And Methods: This study included 40 subjects with transverse maxillary deficiency who received TB RME or BB RME. Cone-beam computed tomography images (CBCT) were taken before treatment (T0), and after a 6-month retention period (T1). Read More

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Long-term Continuity of Antipsychotic Treatment for Schizophrenia: A Nationwide Study.

Schizophr Bull 2021 Jun 15. Epub 2021 Jun 15.

Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland.

Schizophrenia often requires long-term treatment with antipsychotic medication. This study aims to measure the continuity of antipsychotic treatment over the course of illness in schizophrenia, as well as factors involved in the interruption of treatment. For this, we followed up a national cohort of first-episode psychosis patients in Finland for up to 18 years. Read More

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Value of spectral detector computed tomography for the early assessment of technique efficacy after microwave ablation of hepatocellular carcinoma.

PLoS One 2021 15;16(6):e0252678. Epub 2021 Jun 15.

Faculty of Medicine and University Hospital Cologne, Department of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany.

Objectives: To investigate whether virtual monoenergetic images (VMI) and iodine maps derived from spectral detector computed tomography (SDCT) improve early assessment of technique efficacy in patients who underwent microwave ablation (MWA) for hepatocellular carcinoma (HCC) in liver cirrhosis.

Methods: This retrospective study comprised 39 patients with 49 HCC lesions treated with MWA. Biphasic SDCT was performed 7. Read More

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Development and psychometric properties of the Nursing Student Academic Resilience Inventory (NSARI): A mixed-method study.

PLoS One 2021 15;16(6):e0252473. Epub 2021 Jun 15.

Nursing Care Research Center, Semnan University of Medical Sciences, Semnan, Iran.

Introduction: Resilience has been proposed as a suitable solution to better deal with nursing students in cases of challenges but the complex and multidimensional nature of resilience has made its measurement challenging. This study aimed to develop and validate a new inventory theory-driven labeled Nursing Student Academic Resilience Inventory.

Methods: This study was performed with an exploratory sequential mixed-method design. Read More

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Association among pterygium, cataracts, and cumulative ocular ultraviolet exposure: A cross-sectional study in Han people in China and Taiwan.

PLoS One 2021 15;16(6):e0253093. Epub 2021 Jun 15.

Department of Ophthalmology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.

Purpose: Pterygium is an ocular surface disorder mainly caused by ultraviolet (UV) light exposure. This study explored the relationships between six cataract types with pterygium and UV exposure.

Methods: We have previously studied cataracts in residents of three regions in China and Taiwan with different UV intensities. Read More

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Detailed balance limits for inversion in solar-pumped lasers and allied systems.

Opt Lett 2021 Jun;46(12):2916-2919

Solar-pumped lasers and optical amplifiers continue to draw research interest with advances in nanomaterials science and technology. Establishing accurate detailed balance limits for inversion in these systems is essential. In this Letter, we re-examine the threshold limits for inversion in broadband-pumped lasers, with reference to those provided by Roxlo and Yablonvitch [Opt. Read More

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