Redox Biol 2021 May 20;44:102016. Epub 2021 May 20.
Applied Physiology & Nutrition Research Group, School of Physical Education and Sport, Faculdade de Medicina, Divisão de Reumatologia, Universidade de São Paulo, SP, Brazil; Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil. Electronic address:
Histidine-containing dipeptides (HCDs) are abundantly expressed in striated muscles. Although important properties have been ascribed to HCDs, including H buffering, regulation of Ca transients and protection against oxidative stress, it remains unknown whether they play relevant functions in vivo. To investigate the in vivo roles of HCDs, we developed the first carnosine synthase knockout (CARNS1) rat strain to investigate the impact of an absence of HCDs on skeletal and cardiac muscle function. Read More