17,301 results match your criteria calcium phosphate


Bonding a titanium plate and soft tissue interface by using an adhesive bone paste composed of α-tricalcium phosphate and α-cyclodextrin/nonanyl group-modified poly(vinyl alcohol) inclusion complex.

Colloids Surf B Biointerfaces 2021 Apr 9;203:111757. Epub 2021 Apr 9.

Polymers and Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan. Electronic address:

Adhesive bone pastes for dental implants and soft tissue interfaces were developed using α-tricalcium phosphate (α-TCP) and α-cyclodextrin (α-CD)/nonanyl group-modified poly(vinyl alcohol) (C9-PVA) inclusion complex solution (ICS). The thixotropic solution of α-CD/C9-PVA ICS was prepared by mixing α-CD and C9-PVA in deionized water. The α-CD/C9-PVA bone paste led to the highest bonding and shear adhesion between commercial pure titanium plates and soft tissue like collagen casing. Read More

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Design, Synthesis, Pharmacokinetics, and Biodistribution of a Series of Bone-Targeting EP4 Receptor Agonist Prodrugs for Treatment of Osteoporosis and Other Bone Conditions.

ACS Pharmacol Transl Sci 2021 Apr 10;4(2):908-925. Epub 2021 Mar 10.

Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5Z 4B4, Canada.

A series of bone-targeting EP4 receptor agonist conjugate prodrugs were prepared wherein a potent EP4 receptor agonist was bound to a biologically inactive, bisphosphonate-based bone-targeting moiety. Singly and doubly radiolabeled conjugates were synthesized and were shown to be stable in blood, to be rapidly eliminated from the bloodstream, and to be effectively taken up into bone in vivo after intravenous dosing. From these preliminary studies a preferred conjugate (also known as and Mes-1007) was selected for follow up biodistribution and elimination studies. Read More

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Monetite-based composite cranial implants demonstrate long-term clinical volumetric balance by concomitant bone formation and degradation.

Acta Biomater 2021 Apr 12. Epub 2021 Apr 12.

Department of Materials Science and Engineering, Uppsala University, Uppsala, Sweden.

The use of calcium phosphates (CaPs) as synthetic bone substitutes should ideally result in a volumetric balance with concomitant bone formation and degradation. Clinical data on such properties is nevertheless lacking, especially for monetite-based CaPs. However, a monetite-based composite implant has recently shown promising cranial reconstructions, with both CaP degradation and bone formation. Read More

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Microbiome analysis of feline odontoclastic resorptive lesion (FORL) and feline oral health.

J Med Microbiol 2021 Apr;70(4)

School of Medicine Dentistry and Nursing, University of Glasgow, Glasgow, UK.

Feline odontoclastic resorptive lesion (FORL) is one of the most common and painful oral diseases of the cat. It is characterised by tooth resorption due to destructive activity of odontoclasts. FORL can result in tooth loss. Read More

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Restoring Facial Contour and Harmony Using Biphasic Calcium Phosphate Bioceramics.

Plast Reconstr Surg Glob Open 2021 Apr 8;9(4):e3516. Epub 2021 Apr 8.

EINCO Biomaterial Ltda., Belo Horizonte, Minas Gerais, Brazil.

Background: The restoration of facial contour is one of the pillars for the treatment of facial disharmonies and deformities. Fat transplantation and fillers have been widely used to improve the positioning of soft tissues, which are, however, directly related to the conditions and positioning of the underlying bone tissue. Recontouring of the latter has been performed using osteotomies and several types of bone grafts or biomaterials, as inlay or onlay grafts/implants. Read More

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In vitro biodegradation behavior of biodegradable hydroxyapatite coated AZ31 alloy treated at various pH values.

J Appl Biomater Funct Mater 2021 Jan-Dec;19:22808000211010037

Institute of Traumatology and Orthopaedics, 108 Military Central Hospital, Hanoi, Vietnam.

Objectives: The aim of this study is to evaluate the effect of pH treatment on the formation of hydroxyapatite (HA) coating layer and the biodegradation rate of hydroxyapatite coated AZ31 alloy for applications in biodegradable implants.

Methods: HA was grown on the surface of AZ31 substrate at three different pH solutions of 7.5, 9. Read More

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An Ammonia-Induced Calcium Phosphate Nanostructure: A Potential Assay for Studying Osteoporosis and Bone Metastasis.

ACS Appl Mater Interfaces 2021 Apr 12. Epub 2021 Apr 12.

Department of Materials Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Osteoclastic resorption of bones plays a central role in both osteoporosis and bone metastasis. A reliable assay that simulates osteoclastic resorption would significantly speed up the process of developing effective therapeutic solutions for those diseases. Here, we reported the development of a novel and robust nanostructured calcium phosphate coating with unique functions on the track-etched porous membrane by using an ammonia-induced mineralization (AiM) technique. Read More

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Injectable bone cement with magnesium-containing microspheres enhances osteogenesis via anti-inflammatory immunoregulation.

Bioact Mater 2021 Oct 19;6(10):3411-3423. Epub 2021 Mar 19.

Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China.

Injectable bone cement is especially useful in minimally invasive surgeries to repair small and irregular bone defects. Amongst different kinds of injectable bone cements, bioactive calcium phosphate bone cement (CPC) has been widely studied due to its biological activity. However, its dense structure and poor biodegradability prevent the ingrowth of living tissue, which leads to undesirable bone regeneration and clinical translation. Read More

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October 2021

Associations of serum sclerostin and Dickkopf-related protein-1 proteins with future cardiovascular events and mortality in haemodialysis patients: a prospective cohort study.

Clin Kidney J 2021 Apr 31;14(4):1165-1172. Epub 2020 Aug 31.

Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Sclerostin and Dickkopf-related protein-1 (Dkk-1) proteins are inhibitors of the canonical Wnt/β-catenin bone pathway. Sclerostin but not Dkk-1 is associated with increased arterial stiffness. This study examined the prognostic significance of sclerostin and Dkk-1 levels for cardiovascular outcomes and mortality in haemodialysis (HD) patients. Read More

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Co-modification of calcium phosphate cement to achieve rapid bone regeneration in osteoporotic femoral condyle defect with lithium and aspirin.

Am J Transl Res 2021 15;13(3):952-966. Epub 2021 Mar 15.

Department of Trauma Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital Wuhu 241001, Anhui, People's Republic of China.

Local application of lithium or aspirin with biological scaffold has been identified as a potent means to improve bone formation. In this study, lithium and aspirin modified calcium phosphate cement (Asp-Li/CPC) was prepared, and the feasibility of this biological scaffold in the treatment of osteoporotic bone defect was observed in vivo and in vitro. In vitro experiments confirmed that Asp-Li/CPC had better ability to promote MC3T3-E1 cells differentiation into osteoblasts, osteoblast mineralization and viability, and promote cell expression of ALP, OP, RUNX-2, OC and COL-1 protein than simple CPC or lithium modified CPC by MTT, Alizarin red staining and Western blot evaluation. Read More

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Synthesis of Beta-tricalcium Phosphate Catalyst from Herring fishbone for the Transesterification of Parsley seed oil.

Environ Technol 2021 Apr 12:1-37. Epub 2021 Apr 12.

Department of Chemical Engineering Science, University of Johannesburg, Johannesburg, Doornfontein and 2006, South Africa.

The transesterification of parsley seed oil using a heterogeneous catalyst prepared from Herring fishbone (HFB) was investigated in this study. The fishbone was calcined at 900 C for 4 h to convert the calcium phosphate in the bone to beta-tricalcium phosphate. The prepared catalyst was then characterized by employing scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD) analysis to determine its morphology and elemental composition. Read More

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Osteogenesis enhancement using poly (l-lactide-co-d, l-lactide)/poly (vinyl alcohol) nanofibrous scaffolds reinforced by phospho-calcified cellulose nanowhiskers.

Int J Biol Macromol 2021 Apr 7;182:168-178. Epub 2021 Apr 7.

BioMatter Unit - École polytechnique de Bruxelles, Université Libre de Bruxelles (ULB), Avenue F.D. Roosevelt, 50, CP 165/61, 1050 Brussels, Belgium. Electronic address:

Electrospun poly (l-lactide-co-d, l-lactide) (PLDLLA)/poly (vinyl alcohol) (PVA) nanofibers were reinforced by various contents (0-1 wt%) of phospho-calcified cellulose nanowhiskers (PCCNWs) as scaffolds in bone applications. The hydrophilicity and rate of hydrolytic degradation of PLDLLA were improved by introducing 10 wt% of PVA. PCCNWs with inherent hydrophilic properties, high aspect ratio, and large elastic modulus enhanced the hydrophilicity, accelerated the rate of degradation, and improved the mechanical properties of the nanofibrous samples. Read More

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PROTEOMIC ANALYSIS IDENTIFIED LBP AND CD14 AS KEY PROTEINS IN BLOOD/BIPHASIC CALCIUM PHOSPHATE MICROPARTICLE INTERACTIONS.

Acta Biomater 2021 Apr 5. Epub 2021 Apr 5.

Université Côte d'Azur, CNRS (UMR 7277), Inserm (U1091), iBV, Nice, France. Electronic address:

Immediately upon implantation, scaffolds for bone repair are exposed to the patient's blood. Blood proteins adhere to the biomaterial surface and the protein layer affects both blood cell functions and biomaterial bioactivity. Previously, we reported that 80-200 µm biphasic calcium phosphate (BCP) microparticles embedded in a blood clot, induce ectopic woven bone formation in mice, when 200-500 µm BCP particles induce mainly fibrous tissue. Read More

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Indications for cement augmentation in fixation of geriatric intertrochanteric femur fractures: a systematic review of evidence.

Arch Orthop Trauma Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Orthopaedic Surgery, Stanford University Medical Center, Stanford, 450 Broadway St., Pavilion C, 4th Floor, Redwood, CA, 94063, USA.

Introduction: Achieving durable mechanical stability in geriatric intertrochanteric proximal femur fractures remains a challenge. Concomitant poor bone quality, unstable fracture patterns, and suboptimal reduction are additional risk factors for early mechanical failure. Cement augmentation of the proximal locking screw or blade is one proposed method to augment implant anchorage. Read More

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Duration of dentin tubule occlusion by the calcium phosphate precipitation method: An in vivo study in beagle dogs.

Dent Mater J 2021 Apr 7. Epub 2021 Apr 7.

Department of Restorative Dentistry and Endodontology, Division of Oral Infections and Disease Control, Osaka University Graduate School of Dentistry.

The aim of the present study was to assess the duration of dentin tubule occlusion by the calcium phosphate precipitation (CPP) method in the vital teeth of beagle dogs. Vital teeth were treated using the CPP method, potassium oxalate, or a bonding agent (Liner bond II) after cavity preparation and acid etching. The dentin tubules of all groups, except for the bonding agent, opened more widely with time in the absence of plaque control. Read More

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Surface Wettability of a Natural Rubber Composite under Stretching: A Model to Predict Cell Survival.

Langmuir 2021 Apr 7. Epub 2021 Apr 7.

Departamento de Física, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina 88040-900, Brazil.

We report the stress-strain effect of a stretchable natural rubber (NR)-calcium phosphate composite on the surface wettability (SW) using an innovative approach coupling a uniaxial tensile micromachine, goniometer, and microscope. In situ contact angle measurements in real time were performed during mechanical tension. Our results show that SW is guided by the stress-strain relationship with two different characteristics, depending on the static or dynamic experiments. Read More

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Association of Nd:YAG laser and calcium-phosphate desensitizing pastes on dentin permeability and tubule occlusion.

J Appl Oral Sci 2021 31;29:e20200736. Epub 2021 Mar 31.

Universidade de São Paulo, Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEM), São Paulo, SP, Brasil.

Objective: To evaluate the efficacy of Nd:YAG laser associated with calcium-phosphate desensitizing pastes on dentin permeability and tubule occlusion after erosive/abrasive challenges.

Methodology: Dentin specimens were exposed to 17% ethylene diamine tetra-acetic acid (EDTA) solution for 5 min and randomly allocated into five groups: G1, control (no treatment); G2, Nd:YAG laser (1 W, 10 Hz, 100 mJ, 85 J/cm2); G3, Laser + TeethmateTM Desensitizer; G4, Laser + Desensibilize Nano P; and G5, Laser+Nupro®. Specimens underwent a 5-day erosion-abrasion cycling. Read More

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Ultrasonic measurement of dentin remineralization effects of dentifrices and silver diamine fluoride.

Acta Odontol Scand 2021 Apr 6:1-8. Epub 2021 Apr 6.

Department of Operative Dentistry, Nihon University School of Dentistry, Tokyo, Japan.

Objective: This study investigated the dentin remineralization effect of the application of a functionalized tri-calcium phosphate (fTCP) dentifrice and a silver diamine fluoride (SDF) solution.

Material And Methods: The materials used were: a fluoride-containing dentifrice with fTCP (fTCP+), a fluoride-containing dentifrice without fTCP (fTCP-) and a 38% SDF solution. Following treatment, the dentin slabs were immersed in a 0. Read More

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Pharmacokinetics of Asfotase Alfa in Adult Patients With Pediatric-Onset Hypophosphatasia.

J Clin Pharmacol 2021 Apr 6. Epub 2021 Apr 6.

Orthopedic Department, University of Würzburg, Würzburg, Bavaria, Germany.

Hypophosphatasia is a rare metabolic disease resulting from variant(s) in the gene encoding tissue-nonspecific isozyme of alkaline phosphatase. In this 13-week, Phase 2a, multicenter, randomized, open-label, dose-response study (ClinicalTrials.gov: NCT02797821), the pharmacokinetics of asfotase alfa, an enzyme replacement therapy approved for the treatment of hypophosphatasia, was assessed in adult patients with pediatric-onset hypophosphatasia. Read More

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Programmed BMP-2 release from biphasic calcium phosphates for optimal bone regeneration.

Biomaterials 2021 Mar 29;272:120785. Epub 2021 Mar 29.

Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 03722, Republic of Korea. Electronic address:

This study aimed to fabricate a multi-layered biphasic calcium phosphate (BCP) platform for programmed bone morphogenetic protein-2 (BMP-2) release, which means to block the initial burst release and promote releasing during the differentiation phase of osteogenic cells. And it is to confirm in vivo whether this platform has osteogenic inductivity even when extremely low doses of BMP-2 are loaded compared to the conventional soaking method. Our strategy consisted of preparing a multilayer coating on BCP to minimize the contact between BMP-2 and BCP and allow the loading of BMP-2. Read More

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Synthesis and characterization of silver substituted strontium phosphate silicate apatite using solid-state reaction for osteoregenerative applications.

Bioengineered 2021 Dec;12(1):1111-1125

Department of Orthopaedics, China-Japan Friendship Hospital, Beijing, China.

Strontium phosphosilicate is one of the fastest-growing apatite in bone regeneration application due to the presence of strontium and silica components in the parent materials. However, bacterial infections cause setbacks to the bone regeneration process often leading to surgical revisions, and is a big issue that needs to be addressed. Silver on this front has proven to be a great substituent as seen in the case of calcium phosphate-based ceramics that addresses the bactericidal properties of a biomaterial. Read More

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December 2021

Physicochemical Properties, Degradation, and Biocompatibility of Calcium Phosphate Cement Incorporating Poly(lactic--glycolic acid) Particles with Different Morphologies: A Comparative Study.

ACS Omega 2021 Mar 16;6(12):8322-8331. Epub 2021 Mar 16.

School of Materials Science and Engineering and Key Laboratory of Biomedical Materials of Ministry of Education, South China University of Technology, Guangzhou 510641, China.

Calcium phosphate cement (CPC) is one of the most promising synthetic biomaterials for bone defect repair, but its low degradation rate and the lack of macropores restrict its repair effect. Poly(lactic--glycolic acid) (PLGA) is commonly used as an pore forming agent in CPC, and the morphology of PLGA would affect the properties of CPC. In this study, three kinds of PLGA particles with different morphologies, including dense PLGA microspheres, dense milled PLGA particles with an irregular shape, and porous PLGA microspheres, were respectively incorporated into CPC matrix. Read More

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A Novel Fast-Setting Strontium-Containing Hydroxyapatite Bone Cement With a Simple Binary Powder System.

Front Bioeng Biotechnol 2021 18;9:643557. Epub 2021 Mar 18.

State Key Laboratory for Mechanical Behavior of Materials, School of Material Science and Engineering, Xi'an Jiaotong University, Xi'an, China.

In recent years, strontium-substituted calcium phosphate bone cement (Sr-CPC) has attracted more and more attentions in the field of bone tissue repair due to its comprehensive advantages of both traditional CPC and Sr ions. In this study, a crucial Sr-containing α-Ca Sr (PO) salt has been synthesized using a simplified one-step method at lower synthesis temperature. A novel Sr-CPC has been developed based on the simple binary Sr-containing α-Ca Sr (PO)/Ca(PO)O cement powder. Read More

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Calciphylaxis of the breast, mimicking advanced breast cancer with skin involvement.

Radiol Case Rep 2021 May 20;16(5):1211-1215. Epub 2021 Mar 20.

Department of Radiology, University of Illinois Hospital and Health Sciences, 1740 W Taylor St 2600, Chicago, IL 60642, USA.

Calciphylaxis, also known as calcific uremic arteriolopathy, is a condition most commonly seen in patients with End-stage Renal Disease. The pathophysiology of the condition is related to an elevated calcium-phosphate product. It associated with extensive calcification, especially of the media of arterioles. Read More

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Bioactive small molecules in calcium phosphate scaffold enhanced osteogenic differentiation of human induced pluripotent stem cells.

Dent Mater J 2021 Apr 3. Epub 2021 Apr 3.

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry.

Human induced pluripotent stem cells (hiPSCs) are exciting for regenerative medicine due to their multi-potent differentiation. SB431542 bioactive molecule can activate bone morphogenetic protein-signalling in osteoblasts. The objectives were to: (1) develop a novel injectable calcium phosphate cement (CPC)-SB431542 scaffold for dental/craniofacial bone engineering; and (2) investigate cell proliferation and osteo-differentiation of hiPSC-derived mesenchymal stem cells (hiPSC-MSCs) on CPC-SB431542 scaffold. Read More

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Surface engineering of biomaterials in orthopedic and dental implants: Strategies to improve osteointegration, bacteriostatic and bactericidal activities.

Biotechnol J 2021 Apr 3:e2000116. Epub 2021 Apr 3.

Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore.

Background: The success of biomedical implants in orthopedic and dental applications are usually limited due to insufficient bone-implant integration, and implant-related infections. Biointerfaces are critical in regulating their interactions and the desirable performance of biomaterials in biological environment. Surface engineering has been widely studied to realize better control of the interface interaction to further enhance the desired behavior of biomaterials. Read More

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Tablet Disintegration Performance: Effect of Compression Pressure and Storage Conditions on Surface Liquid Absorption and Swelling Kinetics.

Int J Pharm 2021 Apr 1:120382. Epub 2021 Apr 1.

Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, UK.

The disintegration process of pharmaceutical tablets is a crucial step in the oral delivery of a drug. Tablet disintegration does not only refer to the break up of the interparticle bonds, but also relates to the liquid absorption and swelling behaviour of the tablet. This study demonstrates the use of the sessile drop method coupled with image processing and models to analyse the surface liquid absorption and swelling kinetics of four filler combinations (microcrystalline cellulose (MCC)/mannitol, MCC/lactose, MCC/dibasic calcium phosphate anhydrous (DCPA) and DCPA/lactose) with croscarmellose sodium as a disintegrant. Read More

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Enhancing osteoregenerative potential of biphasic calcium phosphates by using bioinspired ZIF8 coating.

Mater Sci Eng C Mater Biol Appl 2021 Apr 17;123:111972. Epub 2021 Feb 17.

School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia; Institute of Molecular Medicine, Sechenov First Moscow State University, Moscow 119991, Russia. Electronic address:

Biphasic calcium phosphate ceramics (BCPs) have been extensively used as a bone graft in dental clinics to reconstruct lost bone in the jaw and peri-implant hard tissue due to their good bone conduction and similar chemical structure to the teeth and bone. However, BCPs are not inherently osteoinductive and need additional modification and treatment to enhance their osteoinductivity. The present study aims to develop an innovative strategy to improve the osteoinductivity of BCPs using unique features of zeolitic imidazolate framework-8 (ZIF8). Read More

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Monetite, An important Calcium Phosphate Compound - Its Synthesis, Properties and Applications in Orthopedics.

Acta Biomater 2021 Mar 31. Epub 2021 Mar 31.

Department of Mechanical Engineering, Cleveland State University, Cleveland, Ohio, USA. Electronic address:

This review recognizes a unique calcium phosphate (CaP) phase known as monetite or dicalcium phosphate anhydrous (DCPA, CaHPO), and presents an overview of its properties, processing, and applications in orthopedics. The motivation for the present effort is to highlight the state-of-the-art research and development of monetite and propel the research community to explore more of its potentials in orthopedics. After a brief introduction of monetite, we provide a summary of its various synthesis routes like dehydration, solvent-based, energy-assisted processes and also discuss the formation of different crystal structures with respect to the synthesis conditions. Read More

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Scanning Electron Microscopic Evaluation of the Internal Fit Accuracy of 3D-Printed Biphasic Calcium Phosphate Block: An Ex Vivo Pilot Study.

Materials (Basel) 2021 Mar 22;14(6). Epub 2021 Mar 22.

Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03722, Korea.

The aim of this study was to assess the internal fit accuracy of a three-dimensional (3D)-printed biphasic calcium phosphate (BCP) block compared with a 3D-milled poly methyl methacrylate (PMMA) block by scanning electron microscope (SEM) analysis. In a total of 20 porcine rib bones, two different types of defects having two adjacent walls and a floor were produced: a defect with a flat floor (flat defect; = 10) and a defect with a concave floor (curved defect; = 10). Each defect was grafted with either the 3D-printed BCP block or the 3D-milled PMMA block fabricated following the computer aided design. Read More

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