87,594 results match your criteria calcification


Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients.

Cancer Med 2021 Nov 27. Epub 2021 Nov 27.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.

Background: Xanthogranulomatous cholecystitis (XGC) is an extremely rare entity. Due to XGC's clinical and radiological resemblance to gallbladder carcinoma (GBC), intraoperative frozen section during cholecystectomy is often performed to exclude the diagnosis of GBC. Our study is aiming to find a noninvasive indicator of XGC. Read More

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November 2021

Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?

Nutrients 2021 Oct 27;13(11). Epub 2021 Oct 27.

International Osteoporosis Foundation, 1260 Nyon, Switzerland.

Vascular Calcification (VC), low bone mass and fragility fractures are frequently observed in ageing subjects. Although this clinical observation could be the mere coincidence of frequent age-dependent disorders, clinical and experimental data suggest that VC and bone loss could share pathophysiological mechanisms. Indeed, VC is an active process of calcium and phosphate precipitation that involves the transition of the vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Read More

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October 2021

Calcification in Three Common Calcified Algae from Phuket, Thailand: Potential Relevance on Seawater Carbonate Chemistry and Link to Photosynthetic Process.

Plants (Basel) 2021 Nov 21;10(11). Epub 2021 Nov 21.

Coastal Oceanography and Climate Change Research Center, Prince of Songkla University, Hat Yai 90110, Songkhla, Thailand.

Calcifying macroalgae contribute significantly to the structure and function of tropical marine ecosystems. Their calcification and photosynthetic processes are not well understood despite their critical role in marine carbon cycles and high vulnerability to environmental changes. This study aims to provide a better understanding of the macroalgal calcification process, focusing on its relevance concerning seawater carbonate chemistry and its relationship to photosynthesis in three dominant calcified macroalgae in Thailand, , and . Read More

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November 2021

Histology and Immunohistochemistry of Radial Arteries Are Suggestive of an Interaction between Calcification and Early Atherosclerotic Lesions in Chronic Kidney Disease.

Medicina (Kaunas) 2021 Oct 24;57(11). Epub 2021 Oct 24.

Department of Nephrology, Hippokration General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.

: recent studies suggest an implication of immune mechanisms in atherosclerotic disease. In this paper, the interaction between inflammation, calcification, and atherosclerosis on the vessel walls of patients with chronic kidney disease (CKD) is described and evaluated. : patients with stage V CKD, either on pre-dialysis (group A) or on hemodialysis (HD) for at least 2 years (group B), in whom a radiocephalic arteriovenous fistula (RCAVF) was created, were included in the study. Read More

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October 2021

Zinc Ameliorates the Osteogenic Effects of High Glucose in Vascular Smooth Muscle Cells.

Cells 2021 Nov 9;10(11). Epub 2021 Nov 9.

Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.

In diabetic patients, medial vascular calcification is common and associated with increased cardiovascular mortality. Excessive glucose concentrations can activate the nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-kB) and trigger pro-calcific effects in vascular smooth muscle cells (VSMCs), which may actively augment vascular calcification. Zinc is able to mitigate phosphate-induced VSMC calcification. Read More

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November 2021

Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease.

Authors:
Asish K Ghosh

Cells 2021 Oct 22;10(11). Epub 2021 Oct 22.

Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Cardiovascular disease is the leading cause of accelerated as well as chronological aging-related human morbidity and mortality worldwide. Genetic, immunologic, unhealthy lifestyles including daily consumption of high-carb/high-fat fast food, lack of exercise, drug addiction, cigarette smoke, alcoholism, and exposure to environmental pollutants like particulate matter (PM)-induced stresses contribute profoundly to accelerated and chronological cardiovascular aging and associated life threatening diseases. All these stressors alter gene expression epigenetically either through activation or repression of gene transcription via alteration of chromatin remodeling enzymes and chromatin landscape by DNA methylation or histone methylation or histone acetylation. Read More

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October 2021

Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis.

Cells 2021 Oct 20;10(11). Epub 2021 Oct 20.

Ocean State Research Institute, Inc., Providence VA Medical Center, Research (151), 830 Chalkstone Avenue, Providence, RI 02908, USA.

Coronary artery disease caused by atherosclerosis is a major cause of morbidity and mortality around the world. Data from preclinical and clinical studies support the belief that atherosclerosis is an inflammatory disease that is mediated by innate and adaptive immune signaling mechanisms. This review sought to highlight the role of Rac-mediated inflammatory signaling in the mechanisms driving atherosclerotic calcification. Read More

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October 2021

Is There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?

J Clin Med 2021 Nov 19;10(22). Epub 2021 Nov 19.

Department of Radiology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-034 Warsaw, Poland.

Molecular profile of breast cancer provides information about its biological activity, prognosis and treatment strategies. The purpose of our study was to investigate the correlation between ultrasound features and molecular subtypes of breast cancer. From June 2019 to December 2019, 86 patients (median age 57 years; range 32-88) with 102 breast cancer tumors were included in the study. Read More

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November 2021

Calcite Nanotuned Chitinous Skeletons of Giant Marine Demosponge.

Int J Mol Sci 2021 Nov 22;22(22). Epub 2021 Nov 22.

Center of Advanced Technology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 10, 61-614 Poznan, Poland.

Marine sponges were among the first multicellular organisms on our planet and have survived to this day thanks to their unique mechanisms of chemical defense and the specific design of their skeletons, which have been optimized over millions of years of evolution to effectively inhabit the aquatic environment. In this work, we carried out studies to elucidate the nature and nanostructural organization of three-dimensional skeletal microfibers of the giant marine demosponge , the body of which is a micro-reticular, durable structure that determines the ideal filtration function of this organism. For the first time, using the battery of analytical tools including three-dimensional micro-X-ray Fluorescence (3D-µXRF), X-ray diffraction (XRD), infra-red (FTIR), Raman and Near Edge X-ray Fine Structure (NEXAFS) spectroscopy, we have shown that biomineral calcite is responsible for nano-tuning the skeletal fibers of this sponge species. Read More

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November 2021

Comparing the Osteogenic Potential and Bone Regeneration Capacities of Dedifferentiated Fat Cells and Adipose-Derived Stem Cells In Vitro and In Vivo: Application of DFAT Cells Isolated by a Mesh Method.

Int J Mol Sci 2021 Nov 17;22(22). Epub 2021 Nov 17.

Department of Oral and Maxillofacial Reconstructive Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan.

Background: We investigated and compared the osteogenic potential and bone regeneration capacities of dedifferentiated fat cells (DFAT cells) and adipose-derived stem cells (ASCs).

Method: We isolated DFAT cells and ASCs from GFP mice. DFAT cells were established by a new culture method using a mesh culture instead of a ceiling culture. Read More

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November 2021

Dextromethorphan Reduces Oxidative Stress and Inhibits Uremic Artery Calcification.

Int J Mol Sci 2021 Nov 13;22(22). Epub 2021 Nov 13.

Institutes of Clinical Medicine, National Yang Ming Chiao Tung University, Hsinchu City 30010, Taiwan.

Medial vascular calcification has emerged as a key factor contributing to cardiovascular mortality in patients with chronic kidney disease (CKD). Vascular smooth muscle cells (VSMCs) with osteogenic transdifferentiation play a role in vascular calcification. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors reduce reactive oxygen species (ROS) production and calcified-medium-induced calcification of VSMCs. Read More

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November 2021

MicroRNAs in Valvular Heart Diseases: Biological Regulators, Prognostic Markers and Therapeutical Targets.

Int J Mol Sci 2021 Nov 9;22(22). Epub 2021 Nov 9.

Cardiovascular Surgery, University Campus Bio-Medico di Roma, 00128 Rome, Italy.

miRNAs have recently attracted investigators' interest as regulators of valvular diseases pathogenesis, diagnostic biomarkers, and therapeutical targets. Evidence from in-vivo and in-vitro studies demonstrated stimulatory or inhibitory roles in mitral valve prolapse development, aortic leaflet fusion, and calcification pathways, specifically osteoblastic differentiation and transcription factors modulation. Tissue expression assessment and comparison between physiological and pathological phenotypes of different disease entities, including mitral valve prolapse and mitral chordae tendineae rupture, emerged as the best strategies to address miRNAs over or under-representation and thus, their impact on pathogeneses. Read More

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November 2021

Bisphosphonates for the Treatment of Calcinosis Cutis-A Retrospective Single-Center Study.

Biomedicines 2021 Nov 16;9(11). Epub 2021 Nov 16.

Department of Dermatology and Allergy, Technical University of Munich, 80802 Munich, Germany.

(1) Background: Calcinosis cutis is a frequent symptom of autoimmune connective tissue diseases leading to pain, transcutaneous expulsion of calcified material and bacterial superinfection. There is a high need for new therapeutic options as no standardized treatment algorithm is established. While case reports indicate beneficial effects of bisphosphonates, standardized evaluation of treatment effects is missing. Read More

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November 2021

Changes in Plasma Phospholipid Metabolism Are Associated with Clinical Manifestations of Systemic Sclerosis.

Diagnostics (Basel) 2021 Nov 15;11(11). Epub 2021 Nov 15.

Institute for Analytical and General Chemistry, Johannes Kepler University Linz, 4040 Linz, Austria.

Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and/or internal organs, causing a decrease in quality of life and survival. There is no causative therapy, and the pathophysiology of the SSc remains unclear. Studies showed that lipid metabolism was relevant for autoimmune diseases, but little is known about the role of lipids in SSc. Read More

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November 2021

Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis.

Diagnostics (Basel) 2021 Oct 28;11(11). Epub 2021 Oct 28.

Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.

The first case of hyaline vascular type of unicentric Castleman disease (HV-UCD) was reported more than six decades ago. Since patients with HV-UCD are often asymptomatic and this condition is generally discovered incidentally on imaging tests, most of the previous reports were of mediastinal origin detected by chest radiography. In recent years, improved access to imaging modalities has provided new insights in the diagnosis of this condition. Read More

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October 2021

Major Complication Following Kawasaki Disease in an Infant-The Development of Apical Infarction and Aneurysm Formation.

Children (Basel) 2021 Oct 29;8(11). Epub 2021 Oct 29.

Department of Cardiology, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia.

Considerable advances have occurred in the understanding of Kawasaki disease, with a substantial drop in morbidity and mortality following the infusion of gamma globulin during the acute phase. Nevertheless, major complications may still occur. A 27-year-old male presented as an infant of 11 weeks when he was diagnosed as having Kawasaki disease. Read More

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October 2021

The Physiological and Pathological Role of Tissue Nonspecific Alkaline Phosphatase beyond Mineralization.

Biomolecules 2021 Oct 21;11(11). Epub 2021 Oct 21.

Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai 600 077, Tamil Nadu, India.

Tissue-nonspecific alkaline phosphatase (TNAP) is a key enzyme responsible for skeletal tissue mineralization. It is involved in the dephosphorylation of various physiological substrates, and has vital physiological functions, including extra-skeletal functions, such as neuronal development, detoxification of lipopolysaccharide (LPS), an anti-inflammatory role, bile pH regulation, and the maintenance of the blood brain barrier (BBB). TNAP is also implicated in ectopic pathological calcification of soft tissues, especially the vasculature. Read More

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October 2021

Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D-Induced Hypercalcemia.

Biology (Basel) 2021 Oct 29;10(11). Epub 2021 Oct 29.

National Center for Geratrics Gerontology, National Institute for Longevity Sciences, Obu City 474-8511, Japan.

The purpose of this study was to elucidate the effects of static electric field (SEF) treatment on vitamin D (Vit D)-induced hypercalcemia and renal calcification in mice. The mice were assigned to three groups: Vit D-treated mice, mice treated with Vit D and SEF (Vit D + SEF), and untreated mice. After the administration of Vit D, the Vit D + SEF-treated mice were exposed to SEF treatment by a high-voltage alternating current over five days. Read More

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October 2021

SOX9 enthesis cells is associated with spinal ankylosis in ankylosing spondylitis.

Osteoarthritis Cartilage 2021 Nov 23. Epub 2021 Nov 23.

Hanyang University Institute for Rheumatology Research, Hanyang University Hospital for Rheumatic Diseases, Seoul 04763, Republic of Korea; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 04763, Republic of Korea. Electronic address:

Objective: Although cartilage degeneration and invasion of the subchondral bone plate in entheseal lesion has been considered to consequently lead bony ankylosis in ankylosing spondylitis (AS), no evident mechanisms are known.

Design: To identify histopathological and physiological changes in enthesitis-related ankylosis in AS, we performed molecular characterization of transcription factors and surface markers, and transcriptome analysis with human tissues. Entheseal tissue containing subchondral bone was obtained from the facet joints of 9 patients with AS and 10 disease controls, and assessed by using differential staining techniques. Read More

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November 2021

Predictability and usefulness of intravascular ultrasound-guided angioplasty in patients with femoropopliteal lesions: a systematic review and meta-analysis.

Int Angiol 2021 Nov 26. Epub 2021 Nov 26.

Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital(Zhuhai hospital affiliated with Jinan University), Zhuhai, Guangdong, China -

Introduction: To assess whether intravascular ultrasound (IVUS)-guided angioplasty in femoropopliteal lesions would improve clinical outcomes and predict restenosis.

Evidence Acquisition: Studies in which IVUS-guided angioplasty was used for femoropopliteal lesions were searched from the MEDLINE, Embase, Web of Science, and Cochrane databases; articles with the full text were included. The primary endpoint of this study was primary patency at 12 months, while the secondary endpoints were primary patency at 24 months, freedom from target lesion revascularization (TLR) at 12 months, and correlation of restenosis with the distal external elastic membrane (EEM) area, post-intervention minimum lumen area, lesion length, dissection, and calcification. Read More

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November 2021

Calcium Score Predicts Mortality After Revascularization in Critical Limb Ischemia.

J Endovasc Ther 2021 Nov 26:15266028211059911. Epub 2021 Nov 26.

Department of Vascular Surgery, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Purpose: The calcium score is a measure of vessel wall calcification and has clinical applications when studied in different vascular beds. The presence of vascular calcification in the arteries of the lower limbs is very common in patients with peripheral arterial disease; however, its relationship with the postoperative outcomes in patients undergoing lower limb revascularization is still poorly studied. The aim of this study is to evaluate association between the calcium score of lower limbs and the postoperative outcomes in patients with peripheral arterial disease undergoing revascularization procedures. Read More

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November 2021

Collagen fibrils and cell nuclei are entrapped within Randall's plaques but not in CaOx matrix overgrowth: A microscopic inquiry into Randall's plaque stone pathogenesis.

Anat Rec (Hoboken) 2021 Nov 25. Epub 2021 Nov 25.

Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN.

Calcium oxalate (CaOx) stones can grow attached to the renal papillary calcification known as Randall's plaque. Although stone growth on Randall's plaque is a common phenomenon, this mechanism of stone formation is still poorly understood. The objective of this study was to investigate the microenvironment of mature Randall's plaque, explore its molecular composition and differentiate plaque from CaOx overgrowth using multimodal imaging on demineralized stone sections. Read More

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November 2021

Medical Image Diagnostic Value of Computed Tomography for Bladder Tumors.

Comput Math Methods Med 2021 16;2021:3781028. Epub 2021 Nov 16.

Department of Urology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, China.

Objective: To study computed tomography (CT) imaging characteristics of bladder tumors, to explore the value of CT in tumor diagnosis, and to identify the relevant factors of CT missed diagnosis so that medical staff can be more accurate in the diagnosis of bladder tumors.

Methods: To retrospectively analyze the CT manifestations of 153 bladder tumor cases confirmed by paraffin pathology in our hospital and to study the difference between the benign and CT imaging features. CT indicators mainly include the number, location, morphology, calcification, bladder wall smoothness, CT value, degree of enhancement, and invasion of surrounding tissues and organs. Read More

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November 2021

Characterization of Venezuelan patients with systemic sclerosis: a study in a tertiary hospital in Caracas.

Reumatol Clin (Engl Ed) 2021 Dec;17(10):601-606

Centro Nacional de Enfermedades Reumáticas, Hospital Universitario de Caracas, Caracas, Venezuela; Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX, United States.

Objective: The aim of the study was to investigate the demographic and clinical characteristics of Venezuelan patients with systemic sclerosis (SSc) seen in a tertiary hospital.

Methods: Consecutive patients 18 years and older who fulfilled the 2013 ACR/EULAR classification criteria for SSc and who were followed up in the outpatient clinic of the Division of Rheumatology at the Hospital Universitario de Caracas were selected for the study. Demographic and clinical variables were registered at the time of inclusion using a standard protocol. Read More

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December 2021

Mitral Annular Calcification in Obstructive Hypertrophic Cardiomyopathy: Prevalence and Outcomes.

Ann Thorac Surg 2021 Nov 22. Epub 2021 Nov 22.

Department of Cardiovascular Surgery, Mayo Clinic, Rochester.

Background: The prevalence and clinical impact of mitral annular calcification (MAC) in patients with obstructive hypertrophic cardiomyopathy (HCM) are largely unknown.

Methods: We reviewed 2113 HCM patients who underwent septal myectomy from January 2000 to April 2016. Preoperative and intraoperative echocardiograms along with operative notes were reviewed to identify MAC. Read More

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November 2021

Comment to: The utility of ultrasound examination in cubital tunnel syndrome caused by heterotopic ossification.

Med Ultrason 2021 Nov;23(4):496-497

Department of anesthesia & pain medicine, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.

Ultrasound (US) could visualize the pathological anatomy of HO and the enlargement site and compression location of the nerve in the cubital tunnel [1]. We read with great interest the article of Jačisko et al[2]. In addition, we report rare US images of HO in direct contact with the swollen ulnar nerve in the cubital tunnel that was not detected by plain radiography. Read More

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November 2021

De-risking primary prevention: role of imaging.

Ther Adv Cardiovasc Dis 2021 Jan-Dec;15:17539447211051248

Division of Cardiology, Department of Medicine, Los Angeles Biomedical Research Institute, 1124 W Carson Street, Bldg RB-2, Torrance, CA 90502-2064, USA.

Atherosclerotic cardiovascular disease (ASCVD) is a common disease among the general population, and includes four major areas: (1) coronary heart disease (CHD), manifested by stable angina, unstable angina, myocardial infarction (MI), heart failure, and coronary death; (2) cerebrovascular disease, manifested by transient ischemia attack and stroke; (3) peripheral vascular disease, manifested by claudication and critical limb ischemia; and (4) aortic atherosclerosis and aortic aneurysm (thoracic and abdominal). CHD remains the leading cause of death for both men and women in the United States. So, it is imperative to identify people at risk of CHD and provide appropriate medical treatment or intervention to prevent serious complications and outcomes including sudden cardiac death. Read More

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November 2021

Mitochondria and traffic-related air pollution linked coronary artery calcification: exploring the missing link.

Rev Environ Health 2021 Dec 19;36(4):545-563. Epub 2021 Jan 19.

Vascular Biology Lab, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.

The continuing increase in the exposure to Traffic-related air pollution (TRAP) in the general population is predicted to result in a higher incidence of non-communicable diseases like cardiovascular disease. The chronic exposure of air particulate matter from TRAP upon the vascular system leads to the enhancement of deposition of calcium in the vasculature leading to coronary artery calcification (CAC), triggered by inflammatory reactions and endothelial dysfunction. This calcification forms within the intimal and medial layers of vasculature and the underlying mechanism that connects the trigger from TRAP is not well explored. Read More

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December 2021

Biological Equivalence of GGTA-1 Glycosyltransferase Knockout and Standard Porcine Pericardial Tissue Using 90-Day Mitral Valve Implantation in Adolescent Sheep.

Cardiovasc Eng Technol 2021 Nov 24. Epub 2021 Nov 24.

Institute of Cardiovascular Science, University College London, London, UK.

Objective: There is growing interest in the application of genetically engineered reduced antigenicity animal tissue for manufacture of bioprosthetic heart valves (BHVs) to reduce antibody induced tissue calcification and accelerated structural valve degeneration (SVD). This study tested biological equivalence of valves made from Gal-knockout (GalKO) and standard porcine pericardium after 90-day mitral valve implantation in sheep.

Methods: GalKO (n = 5) and standard (n = 5) porcine pericardial BHVs were implanted in a randomized and blind fashion into sheep for 90-days. Read More

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November 2021

Yak Pericardium as an Alternative Biomaterial for Transcatheter Heart Valves.

Front Bioeng Biotechnol 2021 8;9:766991. Epub 2021 Nov 8.

Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

Transcatheter aortic valve implantation (TAVI) has received much attention and development in the past decade due to its lower risk of complication and infections compared to a traditional open thoracotomy. However, the current commercial transcatheter heart valve does not fully meet clinical needs; therefore, new biological materials must be found in order to meet these requirements. We have discovered a new type of biological material, the yak pericardium. Read More

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November 2021