655 results match your criteria caffeine withdrawal


Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men.

J Biol Rhythms 2021 May 23:7487304211013995. Epub 2021 May 23.

Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland.

Acute caffeine intake can attenuate homeostatic sleep pressure and worsen sleep quality. Caffeine intake-particularly in high doses and close to bedtime-may also affect circadian-regulated rapid eye movement (REM) sleep promotion, an important determinant of subjective sleep quality. However, it is not known whether such changes persist under chronic caffeine consumption during daytime. Read More

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Caffeine supplementation in the hospital: Potential role for the treatment of caffeine withdrawal.

Food Chem Toxicol 2021 Apr 28;153:112228. Epub 2021 Apr 28.

Cardiovascular Division, Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA. Electronic address:

Caffeine use in the population is widespread. Caffeine withdrawal in the hospital setting is an underappreciated syndrome with symptoms including drowsiness, difficulty concentrating, mood disturbances, low motivation, flu-like symptoms, and headache. Withdrawal may occur upon abstinence from chronic daily exposure at doses as low as 100 mg/day and following only 3-7 days of consumption at higher doses. Read More

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Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review.

BMC Anesthesiol 2021 Mar 31;21(1):100. Epub 2021 Mar 31.

Department of Intensive Care Services, Royal Brisbane and Women's Hospital and Faculty of Health, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.

Background: Caffeine is the most utilised psychoactive drug worldwide. However, caffeine withdrawal and the therapeutic use of caffeine in intensive care and in the perioperative period have not been well summarised. Our objective was to conduct a scoping review of caffeine withdrawal and use in the intensive care unit (ICU) and postoperative patients. Read More

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Effects of Caffeinated and Decaffeinated Coffee on Hemodialysis-Related Headache (CoffeeHD): A Randomized Multicenter Clinical Trial.

J Ren Nutr 2021 Mar 12. Epub 2021 Mar 12.

Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon; Department of Nephrology, Hôtel-Dieu de France Hospital, Beirut, Lebanon.

Objectives: Historically, headache was reported in up to 76% of hemodialysis patients. Some authors suggested that headache resulted from caffeine withdrawal. This study aims to compare the incidence of headache and hypotension between patients drinking regular or decaffeinated coffee during dialysis. Read More

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The impact of daily caffeine intake on nighttime sleep in young adult men.

Sci Rep 2021 Feb 25;11(1):4668. Epub 2021 Feb 25.

Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland.

Acute caffeine intake can delay sleep initiation and reduce sleep intensity, particularly when consumed in the evening. However, it is not clear whether these sleep disturbances disappear when caffeine is continuously consumed during daytime, which is common for most coffee drinkers. To address this question, we investigated the sleep of twenty male young habitual caffeine consumers during a double-blind, randomized, crossover study including three 10-day conditions: caffeine (3 × 150 mg caffeine daily), withdrawal (3 × 150 mg caffeine for 8 days, then switch to placebo), and placebo (3 × placebo daily). Read More

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February 2021

Relation between coffee consumption and risk of seizure-related respiratory dysfunction in patients with drug-resistant focal epilepsy.

Epilepsia 2021 Mar 14;62(3):765-777. Epub 2021 Feb 14.

Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and University of Lyon, Lyon, France.

Objective: Caffeine is an antagonist of the adenosine pathway, which is involved in regulation of breathing. Extracellular concentrations of adenosine are increased in the immediate aftermath of a seizure. Seizure-related overstimulation of adenosine receptors might promote peri-ictal apnea. Read More

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Caffeine supplementation as part of enhanced recovery after surgery pathways: a narrative review of the evidence and knowledge gaps.

Can J Anaesth 2021 06 9;68(6):876-879. Epub 2021 Feb 9.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Caffeine is used daily by 85% of United States adults and caffeine withdrawal is a major cause of perioperative headache. Studies have shown that caffeine supplementation in chronic caffeinators reduces the incidence of perioperative headache. This narrative review discusses the perioperative implications of caffeine withdrawal and outlines the benefits of and strategies of caffeine supplementation in the perioperative period. Read More

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Nutraceuticals for Sleep Disorders.

Comb Chem High Throughput Screen 2021 Jan 20. Epub 2021 Jan 20.

Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, Delhi. India.

Sleep is considered as one of the most important aspect for maintaining a healthy life. For a person to function normally at least 6-8 hours of sleep daily is necessary. Sleep not only affects our mood, but also regulates the efficiency of work done. Read More

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January 2021

Caffeine consumption, toxicity, tolerance and withdrawal; shared genetic influences with normative personality and personality disorder traits.

Exp Clin Psychopharmacol 2020 Nov 30. Epub 2020 Nov 30.

Department of Mental Disorders.

Our main aim was to estimate the extent of overlapping etiology between caffeine consumption and response and normative and pathological personality. Linear mixed-effects models were used to identify normative personality domains and personality disorder (PD) traits for inclusion in multivariate twin analyses together with individual caffeine related measures. Data were obtained from Norwegian adult twins in a face-to-face interview conducted in 1999-2004 as part of a population-based study of mental health and through self-report in 2010-2011 and 2015-2017. Read More

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November 2020

Sudden Caffeine Withdrawal Triggers Migraine-A Randomized Controlled Trial.

Front Neurol 2020 10;11:1002. Epub 2020 Sep 10.

Headache Research, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Assessing the effects of caffeine withdrawal on migraine. The effects of caffeine withdrawal on migraineurs are at large unknown. This was a randomized, double-blind, crossover study (NCT03022838), designed to enroll 80 adults with episodic migraine and a daily consumption of 300-800 mg caffeine. Read More

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September 2020

Secondary headache attributed to exposure to or overuse of a substance.

Cephalalgia 2021 Apr 20;41(4):443-452. Epub 2020 Aug 20.

Evangelical Hospital Unna, Unna, Germany.

Background: Secondary headaches attributed to exposure to or the overuse of a substance are classified under chapter eight in the International Classification of Headache Disorders 3rd edition. Three distinct sub-chapters consider: 1. Headache attributed to exposure to a substance, 2. Read More

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The enhancing effect of 200 mg caffeine on mnemonic discrimination is at best small.

Memory 2020 08 17;28(7):858-869. Epub 2020 Aug 17.

Department Psychology, University of Cologne, Cologne, Germany.

Mnemonic discrimination is the ability to discriminate among similar memories, which requires separable representations of similar information. The neurocomputational process that assumedly decorrelates representations during encoding and consolidation is referred to as pattern separation. Deficits in pattern separation contribute to age-related declines in mnemonic functioning, which has motivated the development of targeted interventions. Read More

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Heart Rate Variability Behavior during Exercise and Short-Term Recovery Following Energy Drink Consumption in Men and Women.

Nutrients 2020 Aug 8;12(8). Epub 2020 Aug 8.

Physiology of Work and Exercise Response (POWER) Laboratory, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, 12494 University Blvd., Orlando, FL 32816, USA.

This study examined the cardiac autonomic responses, as measured by heart rate variability (HRV), during cycling exercise and short-term rest after energy drink consumption. Seventeen participants (seven males and 10 females; age: 22.8 ± 3. Read More

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The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment.

Nutrients 2020 Jul 28;12(8). Epub 2020 Jul 28.

Department of Sensory Organs Examination, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.

Migraine is a chronic disorder, and caffeine has been linked with migraine for many years, on the one hand as a trigger, and on the other hand as a cure. As most of the population, including migraineurs, consume a considerable amount of caffeine daily, a question arises as to whether it influences their headaches. Indeed, drinking coffee before a migraine attack may not be a real headache trigger, but a consequence of premonitory symptoms, including yawning, diminished energy levels, and sleepiness that may herald a headache. Read More

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Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in .

Cell Div 2020 29;15:10. Epub 2020 Jun 29.

Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, Gothenburg, SE- 405 30 Sweden.

The evolutionarily conserved Cdc25 phosphatase is an essential protein that removes inhibitory phosphorylation moieties on the mitotic regulator Cdc2. Together with the Wee1 kinase, a negative regulator of Cdc2 activity, Cdc25 is thus a central regulator of cell cycle progression in . The expression and activity of Cdc25 is dependent on the activity of the Target of Rapamycin Complex 1 (TORC1). Read More

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Estimates of Caffeine Use Disorder, Caffeine Withdrawal, Harm and Help-seeking in New Zealand: A cross-sectional survey.

Addict Behav 2020 10 21;109:106470. Epub 2020 May 21.

School of Population Health, University of Auckland, New Zealand.

Background: Caffeine Use Disorder (CUD) is not yet formally recognized in the DSM-5, but emerging evidence suggests CUD could impact up to one in five people. The primary aim of this study was to estimate levels of caffeine consumption and its associations with CUD and withdrawal, taking socio-demographic characteristics (age, gender, ethnicity, income) into account. Secondary aims were to measure caffeine-related harm and treatment preferences. Read More

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October 2020

A low caffeine dose improves maximal strength, but not relative muscular endurance in either heavier-or lighter-loads, or perceptions of effort or discomfort at task failure in females.

PeerJ 2020 14;8:e9144. Epub 2020 May 14.

School of Sport Health and Social Sciences, Solent University, Southampton, United Kingdom.

Background: The body of literature considering caffeine as an ergogenic aid has primarily considered typically aerobic based exercise, male participants and moderate-to large-caffeine doses. With this in mind the aim of this project was to explore the effects of a low-caffeine dose upon maximal voluntary contraction (MVC) and muscular endurance (time to task failure, TTF) at heavier-and lighter-loads.

Methods: Nineteen physically active, habitual caffeine consuming females randomly performed four testing conditions; two with a low-dose of caffeine (100 mg equating to mean = 1. Read More

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Effects of acute and chronic arecoline in adult zebrafish: Anxiolytic-like activity, elevated brain monoamines and the potential role of microglia.

Prog Neuropsychopharmacol Biol Psychiatry 2021 01 23;104:109977. Epub 2020 May 23.

School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia. Electronic address:

Arecoline is a naturally occurring psychoactive alkaloid with partial agonism at nicotinic and muscarinic acetylcholine receptors. Arecoline consumption is widespread, making it the fourth (after alcohol, nicotine and caffeine) most used substance by humans. However, the mechanisms of acute and chronic action of arecoline in-vivo remain poorly understood. Read More

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January 2021

Mechanisms for the reduction of caffeine consumption: What, how and why.

Drug Alcohol Depend 2020 07 8;212:108024. Epub 2020 May 8.

University of Auckland, New Zealand.

Background: Anecdotal evidence suggests consumers of caffeine self-administer strategies to reduce consumption, but little is known of what these strategies are or how they are implemented. This study aimed to understand the lived experience of reducing caffeine consumption including specific techniques (what) and implementation strategies (how), harm and withdrawal symptoms (why).

Methods: We developed a classification system through an inductive and deductive approach and applied it to a large dataset derived from online sources. Read More

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Caffeine enhances sustained attention among adolescents.

Exp Clin Psychopharmacol 2021 Feb 21;29(1):82-89. Epub 2020 May 21.

Department of Psychology.

Despite the growing interest in caffeine use and its effects among adolescents, and a large literature on caffeine and attention among adults, there is a lack of experimental work examining the impact of caffeine on sustained attention among adolescents. We evaluated the acute effects of caffeine (vs. placebo) during a long (33-min) classic vigilance task among 31 adolescents (aged 12-17; 15 female; median caffeine use = 28 mg/day). Read More

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February 2021

Cannabidiol Prevents the Expression of the Locomotor Sensitization and the Metabolic Changes in the Nucleus Accumbens and Prefrontal Cortex Elicited by the Combined Administration of Cocaine and Caffeine in Rats.

Neurotox Res 2020 Aug 15;38(2):478-486. Epub 2020 May 15.

Departamento de Neurofarmacología Experimental, Instituto de Investigaciones Biológicas Clemente Estable, Avenida Italia 3318, 11600, Montevideo, Uruguay.

In the last years, clinical and preclinical researchers have increased their interest in non-psychotomimetic cannabinoids, like cannabidiol (CBD), as a strategy for treating psychostimulant use disorders. However, there are discrepancies in the pharmacological effects and brain targets of CBD. We evaluated if CBD was able to prevent the locomotor sensitization elicited by cocaine and caffeine co-administration. Read More

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Inconsistency in the Ergogenic Effect of Caffeine in Athletes Who Regularly Consume Caffeine: Is It Due to the Disparity in the Criteria That Defines Habitual Caffeine Intake?

Nutrients 2020 Apr 15;12(4). Epub 2020 Apr 15.

Centre for Sport Studies, Rey Juan Carlos University, 28942 Fuenlabrada, Spain.

Caffeine is the most popular psychoactive substance in the world, and data suggests that it is widely used by athletes before competition to enhance physical and mental performance. The high number of athletes that regularly use caffeine suggests the need to investigate the effect of acute caffeine ingestion in athletes habituated to caffeine. However, most of the studies supporting this claim have used samples of athletes who do not consume caffeine on a regular basis, and with caffeine intake withdrawal prior to the experiments. Read More

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Effects of Preinjury and Postinjury Exposure to Caffeine in a Rat Model of Traumatic Brain Injury.

J Caffeine Adenosine Res 2020 Mar 4;10(1):12-24. Epub 2020 Mar 4.

Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey.

Lethal apnea is a significant cause of acute mortality following a severe traumatic brain injury (TBI). TBI is associated with a surge of adenosine, which also suppresses respiratory function in the brainstem. This study examined the acute and chronic effects of caffeine, an adenosine receptor antagonist, on acute mortality and morbidity after fluid percussion injury. Read More

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Prevalence and Correlates of Caffeine Use Disorder Symptoms Among a United States Sample.

J Caffeine Adenosine Res 2020 Mar 4;10(1):4-11. Epub 2020 Mar 4.

Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

The recognizes caffeine use disorder as a condition for further study, but there is a need to better understand its prevalence and clinical significance among the general population. A survey was conducted among an online sample of 1006 caffeine-consuming adults using demographic quotas to reflect the U.S. Read More

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Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior.

Pharmacol Biochem Behav 2020 04 24;191:172880. Epub 2020 Feb 24.

Department of Psychiatry, University of California San Diego, School of Medicine, MC 0714, La Jolla, CA 92093, United States of America. Electronic address:

Caffeine is the most widely consumed psychoactive substance in the world. However, there is controversy about whether becoming addicted to caffeine is possible and a lack of well-established animal models to examine caffeine consumption. The present study sought to establish a model of caffeine consumption in Wistar rats, identify different rat populations based on caffeine preference, and determine whether extended voluntary caffeine consumption produces compulsive-like caffeine intake and withdrawal symptoms. Read More

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[Safety and efficacy of caffeine use started at different time in preterm infants: a multicenter study in Jiangsu Province, China].

Zhongguo Dang Dai Er Ke Za Zhi 2020 Feb;22(2):130-135

Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.

Objective: To study the efficacy and safety of caffeine used in the early (≤72 hours after birth) and late (>72 hours after birth) stage in preterm infants with a gestational age of ≤31 weeks.

Methods: A retrospective analysis was performed for 640 preterm infants (with a gestational age of ≤31 weeks) who were admitted to the neonatal intensive care unit of eight hospitals in Jiangsu Province, China. Of the 640 preterm infants, 510 were given caffeine in the early stage (≤72 hours after birth; early use group) and 130 were given caffeine in the late stage (>72 hours after birth; late use group). Read More

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February 2020

Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal.

Sci Rep 2019 12 23;9(1):19644. Epub 2019 Dec 23.

Western University, Exercise and Health Psychology Lab, Department of Kinesiology, Arthur and Sonia Labatt Health Sciences Building, London, Ontario, N6A 5B9, Canada.

Studies show that a single bout of exercise confers cognitive benefits. However, many individuals use psychoactive substances such as caffeine to enhance cognitive performance. The effects of acute exercise in comparison to caffeine on cognition remain unknown. Read More

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December 2019

Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake.

Prog Neuropsychopharmacol Biol Psychiatry 2020 04 19;99:109851. Epub 2019 Dec 19.

Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland.

Background: Circadian and sleep-homeostatic mechanisms regulate timing and quality of wakefulness. To enhance wakefulness, daily consumption of caffeine in the morning and afternoon is highly common. However, the effects of such a regular intake pattern on circadian sleep-wake regulation are unknown. Read More

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Caffeine and Primary (Migraine) Headaches-Friend or Foe?

Front Neurol 2019 3;10:1275. Epub 2019 Dec 3.

Headache Research, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system. Caffeine influences headaches, the migraine syndrome in particular, but how is unclear. This is a narrative review based on selected articles from an extensive literature search. Read More

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December 2019