7,129 results match your criteria caffeine administration

Effects of acute ingestion of caffeinated chewing gum on performance in elite judo athletes.

J Int Soc Sports Nutr 2021 Jun 19;18(1):49. Epub 2021 Jun 19.

Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.

Purpose: Previous investigations have found positive effects of acute ingestion of capsules containing 4-to-9 mg of caffeine per kg of body mass on several aspects of judo performance. However, no previous investigation has tested the effectiveness of caffeinated chewing gum as the form of caffeine administration for judoists. The main goal of this study was to assess the effect of acute ingestion of a caffeinated chewing gum on the results of the special judo fitness test (SJFT). Read More

View Article and Full-Text PDF

Pharmacological MRI with Simultaneous Measurement of Cerebral Perfusion and Blood-Cerebrospinal Fluid Barrier Function using Interleaved Echo-Time Arterial Spin Labelling.

Neuroimage 2021 Jun 15;238:118270. Epub 2021 Jun 15.

UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom. Electronic address:

Pharmacological MRI (phMRI) studies seek to capture changes in brain haemodynamics in response to a drug. This provides a methodological platform for the evaluation of novel therapeutics, and when applied to disease states, may provide diagnostic or mechanistic information pertaining to common brain disorders such as dementia. Changes to brain perfusion and blood-cerebrospinal fluid barrier (BCSFB) function can be probed, non-invasively, by arterial spin labelling (ASL) and blood-cerebrospinal fluid barrier arterial spin labelling (BCSFB-ASL) MRI respectively. Read More

View Article and Full-Text PDF

Acute caffeine ingestion improves 3-km run performance, cognitive function, and psychological state of young recreational runners.

Pharmacol Biochem Behav 2021 Jun 15;207:173219. Epub 2021 Jun 15.

Laboratory of Pharmacology, UR12 ES13, Faculty of Medicine, University of Sfax, Tunisia.

The current study aimed to assess the effects of caffeine administration on performance time, cognition, psychomotor state, and blood levels of oxidative stress markers following a 3-km run competition. Thirteen recreational runners performed two test sessions in a double-blind randomized order after placebo or 3 mg/kg of body mass of caffeine. At each session, subjects completed a 3-km running competition around a 400 m outdoor athletics track. Read More

View Article and Full-Text PDF

Short-term effects of caffeine intake on binocular accommodative facility: a quantitative and qualitative analysis.

Clin Exp Optom 2021 Jun 16:1-5. Epub 2021 Jun 16.

CLARO (Clinical and Laboratory Applications of Research in Optometry) Research Group, Department of Optics, Faculty of Sciences, University of Granada, Granada, Spain.

Clinical Relevance: Caffeine intake has been demonstrated to influence several physiological measures, including some related to eye physiology. The ability to focus at different distances is of paramount importance in real-world situations, and thus, the possible impact of caffeine intake on accommodative facility may have important clinical implications.

Background: This placebo-controlled, double-blind, balanced crossover study aimed to assess the acute effects of caffeine ingestion on the frequency and precision of the binocular accommodative facility. Read More

View Article and Full-Text PDF

Adenosine AR/AR Antagonists Enabling Additional HR Antagonism for the Treatment of Parkinson's Disease.

J Med Chem 2021 Jun 9. Epub 2021 Jun 9.

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Universitaets street 1, 40225 Duesseldorf, Germany.

Adenosine A/A receptors (AR/AR) represent targets in nondopaminergic treatment of motor disorders such as Parkinson's disease (PD). As an innovative strategy, multitargeting ligands (MTLs) were developed to achieve comprehensive PD therapies simultaneously addressing comorbid symptoms such as sleep disruption. Recognizing the wake-promoting capacity of histamine H receptor (HR) antagonists in combination with the "caffeine-like effects" of AR/AR antagonists, we designed AR/AR/HR MTLs, where a piperidino-/pyrrolidino(propyloxy)phenyl HR pharmacophore was introduced with overlap into an adenosine antagonist arylindenopyrimidine core. Read More

View Article and Full-Text PDF

Comprehensive Isotope Ratio Metabolomics: Gas chromatography Isotope Ratio Mass Spectrometry of urinary metabolites and exhaled breath.

Anal Chim Acta 2021 Jul 11;1170:338606. Epub 2021 May 11.

Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Spain. Electronic address:

We have developed an analytical procedure to measure the carbon isotopic composition of multiple compounds even when there is a partial overlap in the chromatographic profiles and applied this procedure to measure the carbon isotopic composition of different metabolites in human urine and exhaled breath. Method development and validation was performed with CRM IAEA-600 caffeine after calibration of the reference CO gas using a mixture of certified undecane, pentadecane and eicosane δ(C) standards. The alternative data treatment procedure included the correction of time-lag between Faraday cup amplifiers (44 ms at mass 45 and -160 ms at mass 46), the calculation and correction of chromatographic isotope effects on each peak (isotope shifts) and the calculation of the isotope ratio for each compound using the linear regression slope procedure with data only at the top of the chromatographic peak. Read More

View Article and Full-Text PDF

Prediction of the Area under the Curve Using Limited-Point Blood Sampling in a Cocktail Study to Assess Multiple CYP Activities.

Biol Pharm Bull 2021 ;44(6):762-770

Department of Pharmacy Practice & Science, School of Pharmaceutical Sciences, University of Shizuoka.

A cocktail study is an in vivo evaluation method to assess multiple CYP activities via a single trial and single administration of a cocktail drug that is a combination of multiple CYP substrates. However, multiple blood samples are required to evaluate the pharmacokinetics of a CYP probe drug. A limited-point sampling method is generally beneficial in clinical studies because of the simplified protocol and reduced participant burden. Read More

View Article and Full-Text PDF
January 2021

Quercetin-3--glucuronide in the Ethanol Extract of Lotus Leaf () Enhances Sleep Quantity and Quality in a Rodent Model via a GABAergic Mechanism.

Molecules 2021 May 19;26(10). Epub 2021 May 19.

Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul 02841, Korea.

Current pharmacological treatments for insomnia carry several and long-term side effects. Therefore, natural products without side effects are warranted. In this study, the sleep-promoting activity of the lotus leaf () extract was assessed using ICR mice and Sprague Dawley rats. Read More

View Article and Full-Text PDF

Theacrine, a Potent Antidepressant Purine Alkaloid from a Special Chinese Tea, Promotes Adult Hippocampal Neurogenesis in Stressed Mice.

J Agric Food Chem 2021 Jun 1. Epub 2021 Jun 1.

Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.

Daily intake of tea has been known to relate to a low risk of depression. In this study, we report that a special variety of tea in China, var. (), possesses antidepressant effects but with less adverse effects as compared to traditional tea . Read More

View Article and Full-Text PDF

Acupuncture stimulation at HT7 as a non-pharmacological therapy for sleep disorder caused by caffeine administration in rats.

Acupunct Med 2021 May 30:9645284211011489. Epub 2021 May 30.

KM Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.

Objectives: Insomnia is one of the most common sleep disorders and is difficult to completely treat because of the undesirable side effects of hypnotics. The present study was designed to investigate the hypnotic effect of acupuncture stimulation at HT7 on caffeine-induced sleep disorders and locomotor activity in rats. We also evaluated neuronal activity changes in the arousal region of the basal forebrain. Read More

View Article and Full-Text PDF

Bavachinin Induces G2/M Cell Cycle Arrest and Apoptosis via the ATM/ATR Signaling Pathway in Human Small Cell Lung Cancer and Shows an Antitumor Effect in the Xenograft Model.

J Agric Food Chem 2021 Jun 27;69(22):6260-6270. Epub 2021 May 27.

Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, Hubei Province, China.

Lung cancer is grouped into small cell lung cancer (SCLC) and non-SCLC (NSCLC). SCLC exhibits a poor prognosis, and the current anticancer treatment remains unsatisfactory. Bavachinin, present in the seed of , shows anti-inflammatory effects, immune modulation, and anticancer potency. Read More

View Article and Full-Text PDF

Excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats.

Int Endod J 2021 May 26. Epub 2021 May 26.

Department of Preventive and Restorative Dentistry.

Aim: To evaluate the effect of excessive caffeine intake on the inflammation/resorption processes associated with periapical periodontitis (PP) in rats.

Methodology: Sixteen Wistar rats were used. Periapical periodontitis was induced in the four first molars in each animal. Read More

View Article and Full-Text PDF

Renal tissue oxygenation after caffeine administration in preterm neonates.

Pediatr Res 2021 May 18. Epub 2021 May 18.

University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Background: Caffeine has been associated with reduced rates of acute kidney injury (AKI) in preterm neonates. The effect of caffeine on preterm neonatal renal regional saturation of oxygen (RrSO) is unknown.

Methods: RrSO was recorded continuously in neonates < 32 weeks' gestation until 7 days of age with INVOS™ neonatal near-infrared spectroscopy (NIRS) sensors. Read More

View Article and Full-Text PDF

Caffeine, a natural methylxanthine nutraceutical, exerts dopaminergic neuroprotection.

Neurochem Int 2021 May 15;148:105066. Epub 2021 May 15.

Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA. Electronic address:

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects more than 10 million people worldwide. Oxidative stress and mitochondrial dysfunction play a significant role in altering the homeostasis of energy production and free radical generation. Current PD therapies are focused on reducing the cardinal symptoms rather than preventing disease progression in the patients. Read More

View Article and Full-Text PDF

Protective effect of caffeine and/or taurine on the 6-hydroxydopamine-induced rat model of Parkinson's disease: Behavioral and neurochemical evidence.

Restor Neurol Neurosci 2021 ;39(2):149-157

Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Background: Caffeine and taurine, which possess neuro-modulatory activity happen to be consumed together as part of the constituents of energy drinks, could have beneficial effects and prevent neuronal deterioration in Parkinson's disease (PD).

Objective: This study aimed to investigate behavioral and neurochemical effects of these two agents in an animal model of PD at two time points to evaluate possible neuro-protective or neuro-modulatory effects.

Methods: Stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum was used to model PD-like behavior in animals. Read More

View Article and Full-Text PDF
January 2021

Inhibition of Caffeine Metabolism by and Families of Plant Products in Humans: and Studies.

Front Pharmacol 2021 29;12:641090. Epub 2021 Apr 29.

Department of Biological Sciences, Faculty of Science, Simon Fraser University, Burnaby, BC, Canada.

Daily consumption of caffeinated beverages is considered safe but serious health consequences do happen in some individuals. The and families of plant (ARFP) products are popular foods and medicines in the world. We previously reported significant amounts of furanocoumarin bioactive such as 8-methoxypsoralen, 5-methoxypsoralen, and isopimpinellin in ARFP products. Read More

View Article and Full-Text PDF

Online Marketing of Weight Loss Supplements: Labeling and Marketing Compliance with the U.S. Food and Drug Administration Ban on Ephedra.

J Altern Complement Med 2021 May 12. Epub 2021 May 12.

Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, CA, USA.

To characterize dietary supplements marketed online as "ephedra-containing or ephedra-like products" for weight management and to assess labeling/marketing compliance with the ban on the sale of ephedrine alkaloids. This cross-sectional study assessed websites selling ephedra-like supplements using the search term "buy ephedra." For each website, the first three featured products were characterized by evaluating the label for (1) sp. Read More

View Article and Full-Text PDF

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy through regulation of gut microbiota and bile acid metabolism.

Food Funct 2021 May;12(9):4105-4116

Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha, 410128, China. and Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, 410128, China.

Epigallocatechin-3-gallate (EGCG) and caffeine constitute the most effective ingredients of weight loss in tea. However, whether combination of EGCG and caffeine exhibits anti-obesity synergy remains unclear. Here, we showed low-doses of EGCG and caffeine used in combination led to synergistic anti-obesity effects equivalent to those of high-dose EGCG. Read More

View Article and Full-Text PDF

Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes.

Toxicology 2021 06 7;457:152811. Epub 2021 May 7.

Department of Medicine, USA; Marion Bessin Liver Research Center, USA; Department of Pathology, USA; Diabetes Center, USA; Fleischer Institute for Diabetes and Metabolism, USA; Irwin S. and Sylvia Chanin Institute for Cancer Research, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address:

Preterm infants are at greater risk for adverse drug effects due to hepatic immaturity. Multiple interventions during intensive care increases potential for drug interactions. In this setting, high-dose caffeine used for apnea in premature infants may increase acetaminophen toxicity by inhibiting ataxia telangiectasia mutated (ATM) gene activity during DNA damage response. Read More

View Article and Full-Text PDF

Machine learning of EEG spectra classifies unconsciousness during GABAergic anesthesia.

PLoS One 2021 6;16(5):e0246165. Epub 2021 May 6.

Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States of America.

In current anesthesiology practice, anesthesiologists infer the state of unconsciousness without directly monitoring the brain. Drug- and patient-specific electroencephalographic (EEG) signatures of anesthesia-induced unconsciousness have been identified previously. We applied machine learning approaches to construct classification models for real-time tracking of unconscious state during anesthesia-induced unconsciousness. Read More

View Article and Full-Text PDF

The Effects of Intraoperative Caffeine on Postoperative Opioid Consumption and Related Outcomes After Laparoscopic Surgery: A Randomized Controlled Trial.

Anesth Analg 2021 07;133(1):233-242

From the Department of Anesthesiology.

Background: Surgical patients are vulnerable to opioid dependency and related risks. Clinical-translational data suggest that caffeine may enhance postoperative analgesia. This trial tested the hypothesis that intraoperative caffeine would reduce postoperative opioid consumption. Read More

View Article and Full-Text PDF

Caffeine supplementation in the hospital: Potential role for the treatment of caffeine withdrawal.

Food Chem Toxicol 2021 Jul 28;153:112228. Epub 2021 Apr 28.

Cardiovascular Division, Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA. Electronic address:

Caffeine use in the population is widespread. Caffeine withdrawal in the hospital setting is an underappreciated syndrome with symptoms including drowsiness, difficulty concentrating, mood disturbances, low motivation, flu-like symptoms, and headache. Withdrawal may occur upon abstinence from chronic daily exposure at doses as low as 100 mg/day and following only 3-7 days of consumption at higher doses. Read More

View Article and Full-Text PDF

Caffeine Consumption Habits of New Zealand Tertiary Students.

Nutrients 2021 Apr 28;13(5). Epub 2021 Apr 28.

Centre for Metabolic Health Research, Massey University, Auckland 0632, New Zealand.

Adverse effects associated with excessive caffeine consumption combined with increasing numbers and availability of caffeine-containing products are causes for concern. Tertiary students may be at increased risk of consuming excessive amounts of caffeine due to seeking caffeinated products with well-known wakefulness effects and cognitive benefits. This study explored caffeine consumption habits of New Zealand tertiary students (317; ≥16-years) using a previously validated caffeine consumption habits (CaffCo) questionnaire. Read More

View Article and Full-Text PDF

Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882).

Genes (Basel) 2021 Apr 10;12(4). Epub 2021 Apr 10.

Institut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, France.

This study investigated whether four single nucleotide polymorphisms (SNPs) moderated caffeine effects on vigilance and performance in a double-blind and crossover total sleep deprivation (TSD) protocol in 37 subjects. In caffeine (2 × 2.5 mg/kg/24 h) or placebo-controlled condition, subjects performed a psychomotor vigilance test (PVT) and reported sleepiness every six hours (Karolinska sleepiness scale (KSS)) during TSD. Read More

View Article and Full-Text PDF

Chronic Intake of Energy Drinks and Their Sugar Free Substitution Similarly Promotes Metabolic Syndrome.

Nutrients 2021 Apr 6;13(4). Epub 2021 Apr 6.

Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6845, Australia.

Energy drinks containing significant quantities of caffeine, taurine and sugar are increasingly consumed, particularly by adolescents and young adults. The putative effects of chronic ingestion of either standard energy drink, Mother (ED), or its sugar-free formulation (sfED) on metabolic syndrome were determined in wild-type C57BL/6J mice, in comparison to a soft drink, Coca-Cola (SD), a Western-styled diet enriched in saturated fatty acids (SFA), and a combination of SFA + ED. Following 13 weeks of intervention, mice treated with ED were hyperglycaemic and hypertriglyceridaemic, indicating higher triglyceride glucose index, which was similar to the mice maintained on SD. Read More

View Article and Full-Text PDF

Preconception lifestyle advice for people with infertility.

Cochrane Database Syst Rev 2021 04 29;4:CD008189. Epub 2021 Apr 29.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Background: Infertility is a prevalent problem that has significant consequences for individuals, families, and the community. Modifiable lifestyle factors may affect the chance of people with infertility having a baby. However, no guideline is available about what preconception advice should be offered. Read More

View Article and Full-Text PDF

[Prevalence of Arterial Hypertension in a neonatal intensive care unit].

Rev Chil Pediatr 2020 Dec 8;91(6):891-898. Epub 2020 Oct 8.

Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina.

Introduction: The prevalence of neonatal hypertension in neonatal intensive care units (NICU) ranges between 3 and 9%. However, there is no current data on Latin America.

Objective: To estimate the prevalence of neonatal hypertension and to assess its association with causes previously related to this condi tion. Read More

View Article and Full-Text PDF
December 2020

Post-operative pain management in dental implant surgery: a systematic review and meta-analysis of randomized clinical trials.

Clin Oral Investig 2021 May 10;25(5):2511-2536. Epub 2021 Apr 10.

Department of Oral and Maxillofacial Pathology, Radiology & Medicine, New York University College of Dentistry, New York, NY, USA.

Purpose: To evaluate the clinical efficacy of various analgesic medications in mitigating orofacial pain following dental implant surgery.

Materials And Methods: A systematic search was conducted to identify randomized controlled clinical trials (RCTs). The primary outcomes examined were post-operative pain (POP) and consumption of rescue analgesics following implant placement; secondary outcomes included adverse effects, post-operative inflammation, infection, swelling, bleeding, patient satisfaction, and quality of life. Read More

View Article and Full-Text PDF

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.

Nat Commun 2021 04 9;12(1):2113. Epub 2021 Apr 9.

Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford, Oxford, UK.

The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian timing system directly and independently of sleep physiology, but how caffeine mediates these effects upon the circadian clock is unclear. Here we identify an adenosine-based regulatory mechanism that allows sleep and circadian processes to interact for the optimisation of sleep/wake timing in mice. Read More

View Article and Full-Text PDF

Microsaccades: Empirical Research and Methodological Advances - Introduction to Part 1 of the Thematic Special Issue.

J Eye Mov Res 2020 Jun 19;12(6). Epub 2020 Jun 19.

University of Bern and SciAns GmbH, Iffwil, Switzerland.

Recent technical developments and increased affordability of high-speed eye tracking devices have brought microsaccades to the forefront of research in many areas of sensory, perceptual, and cognitive processes. The present thematic issue on "Microsaccades: Empirical Research and Methodological Advances" invited authors to submit original research and reviews encompassing measurements and data analyses in fundamental, translational, and applied studies. We present the first volume of this special issue, comprising 14 articles by research teams around the world. Read More

View Article and Full-Text PDF