35,382 results match your criteria caffeine

Pharmaceuticals and personal care products' (PPCPs) impact on enriched nitrifying cultures.

Environ Sci Pollut Res Int 2021 Jun 24. Epub 2021 Jun 24.

Centre for Water, Environment, Sustainability & Public Health, Department of Civil & Environmental Engineering, University of Strathclyde, Glasgow, G1 1XJ, UK.

The impact of pharmaceutical and personal care products (PPCPs) on the performance of biological wastewater treatment plants (WWTPs) has been widely studied using whole-community approaches. These contaminants affect the capacity of microbial communities to transform nutrients; however, most have neither honed their examination on the nitrifying communities directly nor considered the impact on individual populations. In this study, six PPCPs commonly found in WWTPs, including a stimulant (caffeine), an antimicrobial agent (triclosan), an insect repellent ingredient (N,N-diethyl-m-toluamide (DEET)) and antibiotics (ampicillin, colistin and ofloxacin), were selected to assess their short-term toxic effect on enriched nitrifying cultures: Nitrosomonas sp. Read More

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High coffee consumption, brain volume and risk of dementia and stroke.

Nutr Neurosci 2021 Jun 24:1-12. Epub 2021 Jun 24.

Australian Centre for Precision Health, University of South Australia, Clinical & Health Sciences, Adelaide, Australia.

Background: Coffee is a highly popular beverage worldwide, containing caffeine which is a central nervous system stimulant.

Objectives: We examined whether habitual coffee consumption is associated with differences in brain volumes or the odds of dementia or stroke.

Methods: We conducted prospective analyses of habitual coffee consumption on 398,646 UK Biobank participants (age 37-73 years), including 17,702 participants with MRI information. Read More

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The data we have: Pregnancy and birth related data collection in Australia, Canada, Europe and the USA - A web-based survey of practice.

Int J Popul Data Sci 2021 Mar 22;6(1):1378. Epub 2021 Mar 22.

Aberdeen Centre for Women's Health Research, Institute of Applied Health Sciences, University of Aberdeen.

Objectives: To determine the feasibility of combining routinely recorded perinatal data from several databases in high-income countries to assess the risk of recurrent stillbirth.

Methods: Web-based questionnaire survey with reminder emails and searching of relevant country websites.

Results: 120 countries/regions in Canada, Europe and the USA were invited to participate and 83 (69%) responded. Read More

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Just "Like Coffee" or Neuroenhancement by Stimulants?

Front Public Health 2021 7;9:640154. Epub 2021 Jun 7.

Department of Psychiatry and Psychotherapy, Hospital of the Ludwig Maximilian University, Munich, Germany.

Pharmacological neuroenhancement (PN) is a topic of increasing importance and prevalence among students. However, there is a lack of differentiating PN substances, according to their psychoactive effects. In particular, there is a lack of data about PN by caffeinated drinks, even if coffee is a common and broadly used Neuroenhancer because of its cognitively enhancing effects regarding wakefulness, alertness and concentration. Read More

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The Association Between Blood Pressure and Headache in Postmenopausal Women: A Prospective Hospital-Based Study.

Int J Gen Med 2021 16;14:2563-2568. Epub 2021 Jun 16.

The Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai, Shandong Province, People's Republic of China.

Background: Headache is the most frequent condition for outpatient patients because of neurological problems, but little is known about predisposing and enabling factors for headache patients.

Aim: To investigate the association between blood pressure (BP) and headache in postmenopausal women.

Methods: The postmenopausal women who were admitted to our hospital from January 2015 to December 2019 were screening according to the criteria. Read More

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Chem Senses 2021 Jun 23. Epub 2021 Jun 23.

Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA.

Taste and other neurosensory defects have been reported postoperatively in a number of patients who have undergone mandibular third molar extraction (TME). Although the taste deficits are generally believed to resolve within a year, the long-term effects of TME remain unknown. We retrospectively examined the whole-mouth taste function of 891 individuals who had received TMEs, on average, more than two decades earlier, and 364 individuals who had not undergone TME. Read More

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Exploring the bacterial community and fermentation characteristics during silage fermentation of abandoned fresh tea leaves.

Chemosphere 2021 Jun 15;283:131234. Epub 2021 Jun 15.

Institute of Tea Science, Zhejiang University, Hangzhou, 310058, China; Key Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Ministry of Agriculture, Hangzhou, 310058, China. Electronic address:

The potential application of silage fermentation on abandoned fresh tea leaves (AFTL) was investigated. Dynamic profiles of fermentation-related components, characteristic components and the bacterial community of AFTL during ensiling were analysed. The results showed that after ensiling for 60 days, the concentrations of lactic, acetic and propionic acid increased, whereas a high pH value (4. Read More

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Black Tea Quality is Highly Affected during Processing by its Leaf Surface Microbiome.

J Agric Food Chem 2021 Jun 21. Epub 2021 Jun 21.

State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, China.

Microbiomes can greatly affect the quality of fermented food and beverages, including tea. In this study, microbial populations were characterized during black and green tea manufacturing, revealing that tea processing steps can drive both the bacterial and fungal community structure. Tea leaves were found to mostly harbor Proteobacteria, Bacteriodetes, Firmicutes, and Actinobacteria among bacteria and Ascomycetes among fungi. Read More

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The Neurophysiology of Caffeine as a Central Nervous System Stimulant and the Resultant Effects on Cognitive Function.

Cureus 2021 May 14;13(5):e15032. Epub 2021 May 14.

College of Osteopathic Medicine, William Carey University, Hattiesburg, USA.

Caffeine is one of the world's most consumed drugs. According to the Washington Post (2015), two billion cups of coffee are consumed per day worldwide. Caffeine is classified as a central nervous system (CNS) stimulant and an organic molecule called methylxanthine. Read More

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A Randomized Open-Label Study of Two Methods of Proton Pump Inhibitors Discontinuation.

Cureus 2021 May 14;13(5):e15022. Epub 2021 May 14.

Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.

Background Proton pump inhibitors (PPIs) are effective in treating gastroesophageal reflux disease (GERD). Unfortunately, they are often inappropriately prescribed and long-term use has potential adverse effects. A single best method for discontinuation of PPIs does not currently exist. Read More

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Effects of acute ingestion of caffeinated chewing gum on performance in elite judo athletes.

J Int Soc Sports Nutr 2021 Jun 19;18(1):49. Epub 2021 Jun 19.

Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.

Purpose: Previous investigations have found positive effects of acute ingestion of capsules containing 4-to-9 mg of caffeine per kg of body mass on several aspects of judo performance. However, no previous investigation has tested the effectiveness of caffeinated chewing gum as the form of caffeine administration for judoists. The main goal of this study was to assess the effect of acute ingestion of a caffeinated chewing gum on the results of the special judo fitness test (SJFT). Read More

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Pharmacological MRI with Simultaneous Measurement of Cerebral Perfusion and Blood-Cerebrospinal Fluid Barrier Function using Interleaved Echo-Time Arterial Spin Labelling.

Neuroimage 2021 Jun 15;238:118270. Epub 2021 Jun 15.

UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom. Electronic address:

Pharmacological MRI (phMRI) studies seek to capture changes in brain haemodynamics in response to a drug. This provides a methodological platform for the evaluation of novel therapeutics, and when applied to disease states, may provide diagnostic or mechanistic information pertaining to common brain disorders such as dementia. Changes to brain perfusion and blood-cerebrospinal fluid barrier (BCSFB) function can be probed, non-invasively, by arterial spin labelling (ASL) and blood-cerebrospinal fluid barrier arterial spin labelling (BCSFB-ASL) MRI respectively. Read More

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Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing.

PLoS One 2021 18;16(6):e0253669. Epub 2021 Jun 18.

Epithelial Therapeutics Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, North Bethesda, Maryland, United States of America.

The scratch assay is an in vitro technique used to analyze cell migration, proliferation, and cell-to-cell interaction. In the assay, cells are grown to confluence and then 'scratched' with a sterile instrument. For the cells in the leading edge, the resulting polarity induces migration and proliferation in attempt to 'heal' the modeled wound. Read More

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Combined Urinary Biomarkers to Assess Coffee Intake Using Untargeted Metabolomics: Discovery in Three Pilot Human Intervention Studies and Validation in Cross-Sectional Studies.

J Agric Food Chem 2021 Jun 18. Epub 2021 Jun 18.

Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg 1958, Denmark.

Coffee is a widely consumed beverage worldwide and has a high content of chlorogenic acids, polyphenols, methylxanthines, and volatile flavor compounds. Scientific evidence to support the beneficial health effects of coffee is limited, and validated urinary biomarkers of coffee intake are therefore needed. We observed 23 common putative biomarkers of coffee intake in three separate parallel intervention studies by ultra-high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight-mass spectrometry (UHPLC-ESI-QTOF-MS) and multivariate analyses. Read More

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The effects of caffeine in adults with neurogenic orthostatic hypotension: a systematic review.

Clin Auton Res 2021 Jun 18. Epub 2021 Jun 18.

Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.

Purpose: To systematically review the evidence base for the effectiveness and safety of caffeine for the treatment of neurogenic orthostatic hypotension in adults.

Methods: Eight electronic databases were searched in January 2021. Original research studies or case reports involving adults with neurogenic orthostatic hypotension were included if caffeine was an intervention and outcomes included symptoms, blood pressure or adverse effects. Read More

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Increasing accuracy of field-scale studies to investigate plant uptake and soil dissipation of pharmaceuticals.

Anal Methods 2021 Jun 18. Epub 2021 Jun 18.

Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

Pharmaceuticals and personal care products (PPCPs) can enter agricultural fields through wastewater irrigation, biosolid amendments, or urine fertilization. Numerous studies have assessed the risk of PPCP contamination, however there are no standardized methodologies for sample treatment, making the interpretation of results challenging. Various time periods between sampling and analysis have been reported (shipping, storage, etc. Read More

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Acute caffeine ingestion improves 3-km run performance, cognitive function, and psychological state of young recreational runners.

Pharmacol Biochem Behav 2021 Jun 15;207:173219. Epub 2021 Jun 15.

Laboratory of Pharmacology, UR12 ES13, Faculty of Medicine, University of Sfax, Tunisia.

The current study aimed to assess the effects of caffeine administration on performance time, cognition, psychomotor state, and blood levels of oxidative stress markers following a 3-km run competition. Thirteen recreational runners performed two test sessions in a double-blind randomized order after placebo or 3 mg/kg of body mass of caffeine. At each session, subjects completed a 3-km running competition around a 400 m outdoor athletics track. Read More

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Female Fertility and the Nutritional Approach: The Most Essential Aspects.

Adv Nutr 2021 Jun 17. Epub 2021 Jun 17.

Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, the Heliodor Swiecicki Hospital, Poznan, Poland.

Infertility is an increasing problem that affects couples attempting pregnancy. A growing body of evidence points to a link between diet and female fertility. In fact, data show that a diet high in trans fats, refined carbohydrates, and added sugars can negatively affect fertility. Read More

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Short-term effects of caffeine intake on binocular accommodative facility: a quantitative and qualitative analysis.

Clin Exp Optom 2021 Jun 16:1-5. Epub 2021 Jun 16.

CLARO (Clinical and Laboratory Applications of Research in Optometry) Research Group, Department of Optics, Faculty of Sciences, University of Granada, Granada, Spain.

Clinical Relevance: Caffeine intake has been demonstrated to influence several physiological measures, including some related to eye physiology. The ability to focus at different distances is of paramount importance in real-world situations, and thus, the possible impact of caffeine intake on accommodative facility may have important clinical implications.

Background: This placebo-controlled, double-blind, balanced crossover study aimed to assess the acute effects of caffeine ingestion on the frequency and precision of the binocular accommodative facility. Read More

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Areca nut consumption with and without tobacco among the adult population: a nationally representative study from India.

BMJ Open 2021 06 15;11(6):e043987. Epub 2021 Jun 15.

WHO FCTC Global Knowledge Hub on Smokeless Tobacco, ICMR - National Institute of Cancer Prevention and Research, Noida, India.

Objective: Areca nut is one of the most widely consumed substances globally, after nicotine, ethanol and caffeine and classified as carcinogenic to humans. This study examines the disparity and determinants of areca nut consumption with and without tobacco in India.

Design: Nationally representative cross-sectional study. Read More

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[Risk factors for metabolic bone disease of prematurity in very/extremely low birth weight infants: a multicenter investigation in China].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Jun;23(6):555-562

Laboratory of Neonatal Disease, Institute of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To investigate the incidence rate and risk factors for metabolic bone disease of prematurity (MBDP) in very low birth weight/extremely low birth weight (VLBW/ELBW) infants.

Methods: The medical data of 61 786 neonates from multiple centers of China between September 1, 2013 and August 31, 2016 were retrospectively investigated, including 504 VLBW/ELBW preterm infants who met the inclusion criteria. Among the 504 infants, 108 infants diagnosed with MBDP were enrolled as the MBDP group and the remaining 396 infants were enrolled as the non-MBDP group. Read More

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A Comparison of Physical Activity Levels, Sleep Disrupting Behavior, and Stress/Affective Distress as Predictors of Sleep as Indexed by Actigraphy.

J Phys Act Health 2021 Jun 13:1-12. Epub 2021 Jun 13.

Background: Several behaviors have been reported to interfere with sleep in otherwise healthy adults, including low physical activity (PA) levels. However, few studies have compared low PA with the other behavioral risk factors of objective sleep impairment, despite the behavior tending to cooccur in highly stressed and affectively distressed individuals. Thus, the authors compared objective and subjective measures of PA and other potential sleep disrupting behaviors as predictors of objective sleep (sleep onset latency, actual sleep time, total sleep duration, awake time, and sleep efficacy) at baseline (T1) and 3 months later (T2). Read More

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The Effect of Dietary Supplements on Endurance Exercise Performance and Core Temperature in Hot Environments: A Meta-analysis and Meta-regression.

Sports Med 2021 Jun 15. Epub 2021 Jun 15.

A-STEM Centre, College of Engineering, Swansea University, Swansea, UK.

Background: The ergogenic effects of dietary supplements on endurance exercise performance are well-established; however, their efficacy in hot environmental conditions has not been systematically evaluated.

Objectives: (1) To meta-analyse studies investigating the effects of selected dietary supplements on endurance performance and core temperature responses in the heat. Supplements were included if they were deemed to: (a) have a strong evidence base for 'directly' improving thermoneutral endurance performance, based on current position statements, or (b) have a proposed mechanism of action that related to modifiable factors associated with thermal balance. Read More

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Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis.

JAMA 2021 Jun;325(23):2357-2369

Mayo Clinic Evidence-based Practice Center, Rochester, Minnesota.

Importance: Migraine is common and can be associated with significant morbidity, and several treatment options exist for acute therapy.

Objective: To evaluate the benefits and harms associated with acute treatments for episodic migraine in adults.

Data Sources: Multiple databases from database inception to February 24, 2021. Read More

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Caffeine-Derived Noble Carbons as Ball Milling-Resistant Cathode Materials for Lithium-Ion Capacitors.

ACS Appl Mater Interfaces 2021 Jun 15. Epub 2021 Jun 15.

Colloid Chemistry Department, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, Potsdam 14476, Germany.

Energy consumption is a growing phenomenon in our society causing many negative effects such as global warming. There is a need for the development of new sustainable materials for energy storage. Carbons are materials derivable from biowaste that can rather easily store energy due to their high conductivity and surface area. Read More

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G2/M Checkpoint Abrogation With Selective Inhibitors Results in Increased Chromatid Breaks and Radiosensitization of 82-6 hTERT and RPE Human Cells.

Front Public Health 2021 28;9:675095. Epub 2021 May 28.

Institute of Medical Radiation Biology, Medical School, University of Duisburg-Essen, Essen, Germany.

While technological advances in radiation oncology have led to a more precise delivery of radiation dose and a decreased risk of side effects, there is still a need to better understand the mechanisms underlying DNA damage response (DDR) at the DNA and cytogenetic levels, and to overcome tumor resistance. To maintain genomic stability, cells have developed sophisticated signaling pathways enabling cell cycle arrest to facilitate DNA repair via the DDR-related kinases and their downstream targets, so that DNA damage or DNA replication stress induced by genotoxic therapies can be resolved. ATM, ATR, and Chk1 kinases are key mediators in DDR activation and crucial factors in treatment resistance. Read More

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Personal Doses of Cocaine and Coca Paste are Adulterated in Cartagena de Indias (Colombia).

ScientificWorldJournal 2021 25;2021:5562315. Epub 2021 May 25.

Grupo de Investigación en Innovación y Desarrollo Agropecuario y Agroindustrial (IDAA), Universidad de Cartagena, Campus Piedra de Bolívar, Cartagena de Indias 130015, Colombia.

Knowledge of drug composition consumed on the streets and the identification and quantification of their adulterants is essential for understanding unexpected side effects, tracking routes, and drug profiling. Therefore, this work aimed to determine the purity and to identify and quantify the main adulterants found in personal doses of cocaine (perico) and coca paste (bazuco) in Cartagena de Indias (Colombia). The data collected in this study describe a first attempt to introduce the qualitative and quantitative analyses of adulterants present in street drugs in Cartagena de Indias to improve surveillance. Read More

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Adolescents' preference for later school start times.

J Sleep Res 2021 Jun 13:e13401. Epub 2021 Jun 13.

Child Development Center, University Children's Hospital Zurich, University of Zurich (UZH), Zürich, Switzerland.

As the chronotype delays progressively throughout puberty, early morning school start times (SSTs) contradict the sleep biology of adolescents. Various studies have demonstrated beneficial effects of later SSTs on sleep and health; however, adolescents' preferences for SSTs have to date never been investigated in detail. The present online survey study aimed to fill this gap and explored influencing factors. Read More

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A new approach on synergistic effect and chemical stability of graphene oxide-magnetic nanocomposite in the heterogeneous Fenton degradation of caffeine.

Environ Sci Pollut Res Int 2021 Jun 14. Epub 2021 Jun 14.

Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, 14800-900, Brazil.

Two compositions of graphene oxide-magnetite nanocomposites were studied as catalysts in the heterogeneous Fenton process. Transmission electron microscopy and X-ray diffraction revealed that the graphene oxide sheets were covered with nanoparticles of magnetite, with an average crystallite size of 7 nm. Infrared spectroscopy analysis indicated that the phases interacted through covalent Fe-O-C bonds. Read More

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Dietary and Ergogenic Supplementation to Improve Elite Soccer Players' Performance.

Haniel Fernandes

Ann Nutr Metab 2021 Jun 11:1-7. Epub 2021 Jun 11.

Nutrition Department, Estácio de Sá College, Fortaleza, Brazil.

Background: Soccer is an extremely competitive sport, where the most match important moments can be defined in detail. Use of ergogenic supplements can be crucial to improve the performance of a high-performance athlete. Therefore, knowing which ergogenic supplements are important for soccer players can be an interesting strategy to maintain high level in this sport until final and decisive moments of the match. Read More

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