Cell Calcium 2021 Mar 23;96:102399. Epub 2021 Mar 23.
Biomedical Neuroscience Institute, Universidad de Chile, Independencia 1027, Santiago, 8380453, Chile; Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile; Department of Neurosciences and Center for Exercise, Metabolism and Cancer Studies, Facultad de Medicina, Universidad de Chile, Santiago, Chile. Electronic address:
Neuronal Ca signals are fundamental for synaptic transmission and activity-dependent changes in gene expression. Voltage-gated Ca channels and N-methyl-d-aspartate receptors play major roles in mediating external Ca entry during action potential firing and glutamatergic activity. Additionally, the inositol-1,4,5-trisphosphate receptor (IPR) and the ryanodine receptor (RyR) channels expressed in the endoplasmic reticulum (ER) also contribute to the generation of Ca signals in response to neuronal activity. Read More