Cancers (Basel) 2020 Jul 10;12(7). Epub 2020 Jul 10.
INSERM UMRS976, Institut de Recherche Saint Louis, Hôpital Saint Louis, Bâtiment Hayem, 1 avenue Claude Vellefaux, 75010 Paris, France.
In this study, we have identified a novel cell-penetrating sequence, termed hAP10, from the C-terminus of the human protein Acinus. hAP10 was able to efficiently enter various normal and cancerous cells, likely through an endocytosis pathway, and to deliver an EGFP cargo to the cell interior. Cell penetration of a peptide, hAP10DR, derived from hAP10 by mutation of an aspartic acid residue to an arginine was dramatically increased. Read More