89,964 results match your criteria c-reactive protein


C-reactive protein (CRP) trajectory as a predictor of anastomotic leakage after rectal cancer resection: a multicentre cohort study.

Colorectal Dis 2021 Oct 27. Epub 2021 Oct 27.

Department of Surgery, Erasmus University Medical Centre, Rotterdam, the Netherlands.

Aim: The present study aimed to identify whether CRP-trajectory measurement, including increase in CRP-level of 50 mg/l per day, is an accurate predictor of anastomotic leakage (AL) in patients undergoing rectal resection for cancer.

Methods: A prospective multicentre database was used. CRP was recorded on the first three postoperative days. Read More

View Article and Full-Text PDF
October 2021

Myocardial injury in patients with SARS-CoV-2 pneumonia: pivotal role of inflammation in COVID-19.

Eur J Clin Invest 2021 Oct 27:e13703. Epub 2021 Oct 27.

Cardiovascular Imaging Unit, Cardiothoracic Department, San Raffaele Scientific Institute, Milan, Italy.

Aims: Infection by SARS-CoV-2 may result in a systemic disease and a proportion of patients ranging 15-44% experienced cardiac injury (CI) diagnosed by abnormal troponin levels. The aim of the present study was to analyse the clinical characteristics of a large series of hospitalized patients for COVID-19 in order to identify predisposing and/or protective factors of CI and the outcome.

Methods And Results: This is an observational, retrospective study on patients hospitalized in two Italian centres (San Raffaele Hospital and Cremona Hospital) for COVID-19 and at least one high-sensitivity cardiac troponin (hs-cTnt) measurement during hospitalization. Read More

View Article and Full-Text PDF
October 2021

Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial.

Clin Transl Gastroenterol 2021 Oct 27;12(11):e00415. Epub 2021 Oct 27.

Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Introduction: Experimental data suggest that nonsteroidal antiinflammatory drugs may prevent disease severity and mortality in acute pancreatitis (AP). The aim of this study was to compare the efficacy of rectal indomethacin vs placebo in reducing the systemic inflammatory response syndrome (SIRS) score in a high-risk AP population for clinical progression.

Methods: We conducted a single-center, quadruple-blinded, randomized, placebo-controlled trial. Read More

View Article and Full-Text PDF
October 2021

Effectiveness of vitamin D2 supplementation on high-sensitivity C-reactive protein and other metabolic indices in menopausal Thai women: a randomized-controlled trial.

Gynecol Endocrinol 2021 Oct 27:1-7. Epub 2021 Oct 27.

Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Objective: To investigate the effectiveness of vitamin D2 supplementation with ergocalciferol on high-sensitivity C-reactive protein (hsCRP) level and other cardio-metabolic indices in menopausal Thai women.

Materials And Methods: A double-blind, randomized, placebo-controlled trial was conducted at the menopause clinic of a university hospital in Thailand from May 2017 to 2018. Participants were 80 postmenopausal women randomly assigned to treatment ( = 40, receiving vitamin D2 40,000 IU/week) or control ( = 40, receiving placebo) for 12 weeks. Read More

View Article and Full-Text PDF
October 2021

Immunological effects of cerebral palsy and rehabilitation exercises in children.

Brain Behav Immun Health 2021 Dec 9;18:100365. Epub 2021 Oct 9.

Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187, Umeå, Sweden.

Cerebral palsy (CP) is a group of motor disorders caused by non-progressive lesions of the premature brain with lifelong pathophysiological consequences that include dysregulation of innate immunity. Persistent inflammation with increased levels of circulating pro-inflammatory tumor necrosis factor alpha (TNF-a) is negatively associated with rehabilitation outcome in children with CP. Because of the crosstalk between innate and adaptive immunity, we investigated the effect of CP and rehabilitation exercises on the adaptive immune system in children with CP by measuring the levels of CD3, CD4, CD8 Т-cells, and CD22 B-cells and the levels of immunoglobulins. Read More

View Article and Full-Text PDF
December 2021

Clinical Significance of Low-Triiodothyronine Syndrome in Patients Requiring Non-Surgical Intensive Care - Triiodothyronine Is a Comprehensive Prognostic Marker for Critical Patients With Cardiovascular Disease.

Circ Rep 2021 Oct 30;3(10):578-588. Epub 2021 Sep 30.

Department of Cardiovascular Medicine, Nippon Medical School Tokyo Japan.

Low-triiodothyronine (T) syndrome is a known complication in intensive care unit (ICU) patients, but the underlying mechanisms and prognostic impact are unclear. This study retrospectively enrolled 2,976 patients who required care in the ICU. Of these patients, 2,425 were euthyroid and were divided into normal (n=1,666; free T [FT] ≥1. Read More

View Article and Full-Text PDF
October 2021

Economic Evaluation of FebriDx®: A Novel Rapid, Point-of-Care Test for Differentiation of Viral versus Bacterial Acute Respiratory Infection in the United States.

J Health Econ Outcomes Res 2021 30;8(2):56-62. Epub 2021 Sep 30.

Avalon Health Economics.

Acute respiratory infections (ARIs) are commonly treated with antibiotics in outpatient settings, but many infections are caused by viruses and antibiotic treatment is therefore inappropriate. FebriDx®, a rapid point-of-care test that can differentiate viral from bacterial infections, can inform antibiotic treatment decisions. The primary aim of this study is to conduct a literature-based US economic evaluation of a novel rapid point-of-care test, FebriDx®, that simultaneously measures two key infection biomarkers, C-reactive protein (CRP) and Myxovirus resistance protein A (MxA), to accurately differentiate viral from bacterial infection. Read More

View Article and Full-Text PDF
September 2021

The effect of lycopene on serum level of cardiac biomarkers in patients undergoing elective percutaneous coronary intervention: A randomized controlled clinical trial.

ARYA Atheroscler 2021 Jan;17(1):1-7

Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Myocardial ischemia may recur in a significant subset of patients following percutaneous coronary intervention (PCI). Lycopene, a carotenoid with antioxidant activity, has evidence for beneficial effects on cardiovascular system. In the present study, we aimed to evaluate the possible preventive effect of lycopene against post-PCI myocardial damage by detection of cardiac biomarkers of ischemia. Read More

View Article and Full-Text PDF
January 2021

Increased circulating platelet and endothelial-derived microparticles in patients with cardiac syndrome X.

ARYA Atheroscler 2021 Jan;17(1):1-10

Professor, Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.

Background: Cardiac syndrome X (CSX) has been associated with endothelial dysfunction and inflammation. We conducted a case-control study to evaluate the association between plateletý and endothelial-derived microparticles (PMPs and EMPs), as specific quantitative plasma markers of endothelial dysfunction, and the presence of CSX.

Methods: The present study was conducted on 40 CSX patients and 19 healthy individuals. Read More

View Article and Full-Text PDF
January 2021

A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast.

Case Rep Oncol 2021 May-Aug;14(2):1175-1181. Epub 2021 Aug 6.

Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon, Japan.

A 34-year-old woman with a rapidly growing right breast mass visited our hospital. The mass was diagnosed as a right breast cancer (cT3N1M0 stage ⦀A). Her serum leucocyte count and C-reactive protein levels were high, and she had persistent fever. Read More

View Article and Full-Text PDF

Utility of positron emission tomography-computed tomography in the evaluation of fever of unknown origin in a resource-limited tropical nation.

World J Nucl Med 2021 Jul-Sep;20(3):237-246. Epub 2021 Aug 20.

Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Positron emission tomography-computed tomography (PET-CT) has been used as an imaging modality in workup of fever of unknown origin (FUO). The aim of our study is to evaluate the diagnostic utility of PET-CT in FUO workup in a resource-limited setting. We also looked at laboratory parameters as predictors of contributory PET-CT scans and propose an algorithm for evaluation of FUO in resource-limited tropical regions. Read More

View Article and Full-Text PDF

Hematologic Profiles and Correlation Between Absolute Lymphocyte Count and Neutrophil/Lymphocyte Ratio with Markers of Inflammation of COVID-19 in an Indonesian National Referral Hospital.

Int J Gen Med 2021 18;14:6919-6924. Epub 2021 Oct 18.

Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Introduction: COVID-19 is a pandemic with significant mortality and it is important to differentiate severe and non-severe cases. We conducted a study to evaluate hematologic profiles with inflammation markers in COVID-19 patients and to determine the correlation of neutrophil-lymphocyte ratio (NLR) with disease severity.

Methods: A cross-sectional study involving hospitalized COVID-19 patients confirmed with a positive SARS-CoV-2 PCR test in Dr. Read More

View Article and Full-Text PDF
October 2021

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms.

Cell Res 2021 Oct 26. Epub 2021 Oct 26.

You'an Hospital, Capital Medical University, Beijing, China.

The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, single-blind, placebo-controlled (29 patients/group) phase II clinical trial to validate previous findings and explore the potential mechanisms. Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay (P = 0. Read More

View Article and Full-Text PDF
October 2021

Use of Contrast-Enhanced Ultrasound Sonography in Giant Cell Arteritis: A Proof-of-Concept Study.

Ultrasound Med Biol 2021 Oct 23. Epub 2021 Oct 23.

Medizinische Klinik A, Klinikum der Stadt Ludwigshafen gGmbH, Ludwigshafen, Germany.

C-Reactive protein and erythrocyte sedimentation rate are crucial parameters used to monitor giant cell arteritis (GCA). Given that tocilizumab is approved for the treatment of GCA, these parameters are less sensitive because of the effects of interleukin-6 receptor blockade. Thus, the optimal method for monitoring GCA patients undergoing tocilizumab therapy, especially patients exhibiting a persistent thickened vessel wall in large vessels, remains unclear. Read More

View Article and Full-Text PDF
October 2021

Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms.

BMC Psychiatry 2021 Oct 26;21(1):527. Epub 2021 Oct 26.

Division of Mental Health and Addiction, Vestfold Hospital Trust, Sykehuset i Vestfold, PO Box 2168, 3103, Tonsberg, Norway.

Background: There is evidence of increased low grade inflammation (LGI) in schizophrenia patients. However, the inter-individual variation is large and the association with demographic, somatic and psychiatric factors remains unclear. Our aim was to explore whether levels of the novel LGI marker soluble urokinase plasminogen activator receptor (suPAR) were associated with clinical factors in schizophrenia and if such associations were sex-dependent. Read More

View Article and Full-Text PDF
October 2021

CytoSorb purification in critically ill SARS-CoV-2 patients.

Int J Artif Organs 2021 Oct 26:3913988211052572. Epub 2021 Oct 26.

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objective: To describe the experience with CytoSorb treatment in patients with refractory acute respiratory distress syndrome (ARDS) following SARS-CoV-2 infection.

Methods: Retrospective observational study on 15 patients treated in a University Hospital.

Results: All patients were male, with a mean age of 55 ± 14 years; eight patients (53%) were on venovenous extracorporeal membrane oxygenation (VV ECMO) due to refractory ARDS and all (100%) under mechanical ventilation at the time of CytoSorb use. Read More

View Article and Full-Text PDF
October 2021

Effects of Lifestyle Intervention on Inflammatory Markers and Waist Circumference in Overweight/Obese Adults With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Biol Res Nurs 2021 Oct 26:10998004211044754. Epub 2021 Oct 26.

Department of Physical Education and Sports Sciences, Faculty of Educational Science and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.

Background: Physical inactivity and an imbalanced diet could lead to some cardio metabolic risk factors.

Objective: The objective of this meta-analysis was to investigate the effects of lifestyle modification on inflammatory indicators and waist circumference (WC) in overweight/obese subjects with metabolic syndrome (MS).

Data Sources: A systematic search was conducted in PubMed, CINAHL, MEDLINE, Cochrane, Google Scholar, and Web of Science. Read More

View Article and Full-Text PDF
October 2021

miR-124 Is Downregulated in Serum of Acute Cerebral Infarct Patients and Shows Diagnostic and Prognostic Value.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211035446

Department of Laboratory Medicine, Weifang Traditional Chinese Medicine Hospital, Weifang, Shandong, China.

Acute cerebral infarct (ACI) is a severe subtype of ischemic stroke. microRNAs (miRNAs) are implicated in the pathogenesis of ACI. This study investigated the expression pattern and clinical implication of miR-124 in ACI patients. Read More

View Article and Full-Text PDF
October 2021

Low Dose Radiotherapy in the Management of COVID-19 Pneumonia (LOWRAD-Cov19).

Int J Radiat Oncol Biol Phys 2021 Nov;111(3S):e73

Fundación Investigación Biomédica Hospital Clínico San Carlos, Madrid, Spain.

Purpose/objective(s): To evaluate the safety and efficacy of Low-Dose Radiation (LD-RT) to treat COVID-19 pneumonia.

Materials/methods: We conducted a prospective phase I-II trial enrolling patients ≥ 50 years-old, COVID-19 positive, with lung involvement at imaging study and oxygen requirement. Patients received 100 cGy to total lungs in a single fraction. Read More

View Article and Full-Text PDF
November 2021

Serum Lactate Dehydrogenase is a Predictive Biomarker in Oropharyngeal Cancer Patients Undergoing Radiotherapy.

Int J Radiat Oncol Biol Phys 2021 Nov;111(3S):e397-e398

Department of Radiation Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

Purpose/objective(s): The present study aimed to evaluate prognostic factors, particularly with respect to their role in establishing distinct prognostic subsets of human papillomavirus (HPV)-positive and -negative oropharyngeal cancer (OPC).

Materials/methods: This study retrospectively evaluated 101 patients with OPC who underwent radiotherapy (RT) alone or chemoradiotherapy (CRT) at our institution between August 2008 and December 2018. Whole neck RT (44. Read More

View Article and Full-Text PDF
November 2021

Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.

Cytokine 2021 Oct 23;149:155748. Epub 2021 Oct 23.

UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin 2, Ireland. Electronic address:

Objectives: Elevated circulating levels of complement component 3 (C3) and C-reactive protein (CRP) have been linked with adverse pregnancy outcomes. Lifestyle interventions may hold potential to ameliorate these effects. We investigated the effect of an antenatal healthy lifestyle intervention on maternal C3 and CRP concentrations and assessed their relationship with maternal and fetal metabolic markers and outcomes. Read More

View Article and Full-Text PDF
October 2021

Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety, and chronic fatigue syndrome-like symptoms due to COVID-19: a nomothetic network approach.

J Affect Disord 2021 Oct 23. Epub 2021 Oct 23.

School of Medicine, IMPACT-the Institute for Mental and Physical Health and Clinical Translation, Deakin University, Barwon Health, Geelong, Australia.; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria.; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.. Electronic address:

Background: COVID-19 is associated with neuropsychiatric symptoms including increased depressive, anxiety and chronic fatigue-syndrome (CFS)-like and physiosomatic symptoms.

Aims: To delineate the associations between affective and CFS-like symptoms in COVID-19 and chest computed tomography scan anomalies (CCTAs), oxygen saturation (SpO), interleukin (IL)-6, IL-10, C-Reactive Protein (CRP), albumin, calcium, magnesium, soluble angiotensin converting enzyme (ACE2) and soluble advanced glycation products (sRAGEs).

Method: The above biomarkers were assessed in 60 COVID-19 patients and 30 heathy controls who had measurements of the Hamilton Depression (HDRS) and Anxiety (HAM-A) and the Fibromyalgia and Chronic Fatigue (FF) Rating Scales. Read More

View Article and Full-Text PDF
October 2021

Kawasaki disease and increased cardiovascular risk: Is there a link to circulating glycocalyx biomarkers?

Microvasc Res 2021 Oct 23:104269. Epub 2021 Oct 23.

Ludwig-Maximilians-University of Munich, Department of Pediatric Cardiology, Marchioninistr. 15, 81377 Munich, Germany.

Aims: Kawasaki disease (KD) is an acute systemic vasculitis with possible long-term impact of general cardio-vascular health. An endothelial glycocalyx disorder during the disease's acute phase might predispose to long-term vascular anomalies leading to endothelial dysfunction and atherosclerosis. To investigate any association between increased cardiovascular risk and endothelial glycocalyx, we assessed circulating glycocalyx components in patients with a KD history, and analysed their association with acute-phase clinical features and more importantly, with patients' current cardiovascular risk factors. Read More

View Article and Full-Text PDF
October 2021

Open Circuit Potential as a Tool for the Assessment of Binding Kinetics and Reagentless Protein Quantitation.

Anal Chem 2021 Oct 26. Epub 2021 Oct 26.

Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ, U.K.

A microfluidic open circuit potential label-free protein assay was developed for the reagentless quantification of C-reactive protein (CRP), a model protein target, and further utilized to assess target-receptor binding kinetics. Generated sensors have very high baseline stabilities (<1% change in 100 min) and high levels of selectivity in complex media. Real-time assays are fast (<20 min), of high sensitivity (1 ng/mL limit of detection for CRP in serum), and resolve kinetic and thermodynamic characteristics that correlate well with those resolved optically. Read More

View Article and Full-Text PDF
October 2021

C-reactive protein but not procalcitonin may predict antibiotic response and outcome in infections following major abdominal surgery.

Updates Surg 2021 Oct 26. Epub 2021 Oct 26.

Intensive Care Unit Hospital A. Cardarelli, Naples, Italy.

We aimed to evaluate the usefulness of C-reactive protein (CRP) and procalcitonin (PCT) as markers of infection, sepsis and as predictors of antibiotic response after non-emergency major abdominal surgery. We enrolled, from June 2015 to June 2019, all patients who underwent surgery due to abdominal infection (peritoneal abscess, peritonitis) or having sepsis episode after surgical procedures (i.e. Read More

View Article and Full-Text PDF
October 2021

A role for CXCR3 ligands as biomarkers of post-operative Crohn's disease recurrence.

J Crohns Colitis 2021 Oct 26. Epub 2021 Oct 26.

Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.

Background And Aims: Crohn's disease (CD) recurrence following ileocolic resection (ICR) is common. We sought to identify blood-based biomarkers associated with CD recurrence.

Methods: CD patients undergoing ICR were recruited across six centres. Read More

View Article and Full-Text PDF
October 2021

Pain catastrophizing hinders Disease Activity Score 28 - erythrocyte sedimentation rate remission of rheumatoid arthritis in patients with normal C-reactive protein levels.

Int J Rheum Dis 2021 Oct 26. Epub 2021 Oct 26.

Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Aim: This study aimed to assess the relationship between pain catastrophizing and achievement of 28-joint Disease Activity Score-defined remission of rheumatoid arthritis (RA), considering the presence or absence of systemic inflammation, and to evaluate associated factors for pain catastrophizing.

Method: This cross-sectional study included 421 RA outpatients. The relationship between pain catastrophizing and remission was analyzed by adjusting several confounding factors. Read More

View Article and Full-Text PDF
October 2021

Getting under the skin: Social isolation and biological markers in the National Health and Aging Trends Study.

J Am Geriatr Soc 2021 Oct 26. Epub 2021 Oct 26.

Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Background: Social isolation is a risk factor for morbidity and mortality comparable to well-established risk factors including smoking, hypertension, and a sedentary lifestyle. The specific biological mechanisms that connect social isolation to morbidity and mortality remain unclear. Interleukin-6 (IL-6) and C-reactive protein (CRP) are biological markers that are upregulated during inflammation and can have long-term negative consequences for the health of individuals as they age. Read More

View Article and Full-Text PDF
October 2021

Multisystem Inflammatory Syndrome Associated with SARS-CoV-2 Infection in an Adult: A Case Report from the Maldives.

Trop Med Infect Dis 2021 Oct 19;6(4). Epub 2021 Oct 19.

Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

The multisystem inflammatory syndrome in adults (MIS-A) is a novel syndrome observed during COVID-19 outbreaks. This hyper-inflammatory syndrome is seen predominantly in children and adolescents. The case of an adult from the Maldives who had asymptomatic SARS-CoV-2 infection three weeks before presenting to the hospital with fever, rash, and shock is presented. Read More

View Article and Full-Text PDF
October 2021

The Value of F-FDG PET/CT in Evaluating Disease Severity and Prognosis in Idiopathic Pulmonary Fibrosis Patients.

J Korean Med Sci 2021 Oct 25;36(41):e257. Epub 2021 Oct 25.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Several parameters are useful for assessing disease severity in idiopathic pulmonary fibrosis (IPF); however, the role of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is not well-defined. We aimed to evaluate the value of F-FDG PET/CT for assessing disease severity and prognosis in IPF patients.

Methods: Clinical data of 89 IPF patients (mean age: 68. Read More

View Article and Full-Text PDF
October 2021