J Bacteriol 2011 Apr 21;193(7):1527-32. Epub 2011 Jan 21.
The Scripps Research Institute, Department of Molecular and Experimental Medicine, Mail Code MEM-116, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
The FsrABDC signal transduction system is a major virulence regulator in Enterococcus faecalis. The FsrC sensor histidine kinase, upon activation by the gelatinase biosynthesis-activating pheromone (GBAP) peptide encoded by the fsrBD genes, phosphorylates the FsrA response regulator required for the transcription of the fsrBDC and the gelE-sprE genes from the fsrB promoter and the gelE promoter, respectively. FsrA belongs to the LytTR family of proteins, which includes other virulence regulators, such as AgrA of Staphylococcus aureus, AlgR of Pseudomonas aeruginosa, and VirR of Clostridium perfringens. Read More