3,373 results match your criteria burnetii infection


Detection and distribution of zoonotic pathogens in wild Norway rats () from Tehran, Iran.

New Microbes New Infect 2021 Jul 24;42:100908. Epub 2021 Jun 24.

Pediatric Infection Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

This is the first study on the prevalence of vector-borne zoonotic pathogens found in () in urban areas of Tehran, Iran. Serological tests were used to detect IgG antibodies against () and spp. using a commercial qualitative rat ELISA kit. Read More

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APRANK: Computational Prioritization of Antigenic Proteins and Peptides From Complete Pathogen Proteomes.

Front Immunol 2021 15;12:702552. Epub 2021 Jul 15.

Instituto de Investigaciones Biotecnológicas "Rodolfo Ugalde" (IIB), Universidad de San Martín (UNSAM) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Availability of highly parallelized immunoassays has renewed interest in the discovery of serology biomarkers for infectious diseases. Protein and peptide microarrays now provide a rapid, high-throughput platform for immunological testing and validation of potential antigens and B-cell epitopes. However, there is still a need for tools to prioritize and select relevant probes when designing these arrays. Read More

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Ticks on wild boar in the metropolitan area of Barcelona (Spain) are infected with spotted fever group rickettsiae.

Transbound Emerg Dis 2021 Jul 31. Epub 2021 Jul 31.

Wildlife Ecology & Health group and Servei d'Ecopatologia de Fauna Salvatge, Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Travessera dels Turons s/n, Bellaterra, Barcelona, 08193, Spain.

Tick-borne pathogens (TBPs) constitute an emerging public health concern favoured by multidimensional global changes. Amongst these, increase and spread of wild boar (Sus scrofa) populations are of special concern, since this species can act as reservoir of zoonotic pathogens and promote tick abundance. Thus, we aimed to make a first assessment of the risk by TBPs resulting from wild boar and ticks in the vicinity of a highly populated area. Read More

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Shifting proteomes: limitations in using the BioID proximity labeling system to study SNARE protein trafficking during infection with intracellular pathogens.

Pathog Dis 2021 Jul 29. Epub 2021 Jul 29.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

We hypothesize that intracellular trafficking pathways are altered in chlamydial infected cells to maximize the ability of Chlamydia to scavenge nutrients while not overtly stressing the host cell. Previous data demonstrated the importance of two eukaryotic SNARE proteins, VAMP4 and syntaxin 10 (St × 10), in chlamydial growth and development. Although, the mechanism for these effects is still unknown. Read More

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Seroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state.

Trans R Soc Trop Med Hyg 2021 Jul 26. Epub 2021 Jul 26.

Faculty of Pharmacy, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, Minas Gerais, Brazil.

Background: Q fever is among the top 13 global priority zoonoses, however, it is still neglected and under-reported in most of the world, including Brazil. Thus, we evaluated the seroprevalence of and the risk factors for Coxiella burnetii infections in humans from Minas Gerais, a highly urbanised Brazilian state.

Methods: Coxiella burnetii was searched for patient samples (n=437), which were suspected of then later confirmed as negative for dengue fever, by the indirect immunofluorescence technique and real-time PCR. Read More

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The diagnostic challenge of acute Q fever endocarditis.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Internal Medicine Department, Hospital de Santa Marta - Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal.

A 79-year-old man was admitted to our ward with symptomatic heart failure 2 months after aortic valve replacement due to severe aortic stenosis. On the third day following admission, he became febrile (>38°C) while manifesting an increase in inflammatory markers. Endocarditis was suspected despite negative blood cultures. Read More

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The epidemic of Q fever in 2018 to 2019 in Zhuhai city of China determined by metagenomic next-generation sequencing.

PLoS Negl Trop Dis 2021 Jul 15;15(7):e0009520. Epub 2021 Jul 15.

Department of Infectious Diseases, the Fifth Affiliated Hospital of Sun Yat-Sen University (SYSU), Zhuhai, China.

Q fever is a worldwide zoonosis caused by Coxiella burnetii (Cb). From January 2018 to November 2019, plasma samples from 2,382 patients with acute fever of unknown cause at a hospital in Zhuhai city of China were tested using metagenomic next-generation sequencing (mNGS). Of those tested, 138 patients (5. Read More

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Incidence of chronic Q fever and chronic fatigue syndrome: A 6 year follow-up of a large Q fever outbreak.

Transbound Emerg Dis 2021 Jul 9. Epub 2021 Jul 9.

Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.

Acute Q fever is a generally self-limiting infection caused by the intracellular gram-negative bacterium Coxiella burnetii. For yet unknown reasons, a subset of patients develops chronic infection. Furthermore, chronic fatigue syndrome (CFS) as post-acute Q fever sequelae has been described. Read More

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Analysis of environmental dust in goat and sheep farms to assess Coxiella burnetii infection in a Q fever endemic area: Geographical distribution, relationship with human cases and genotypes.

Zoonoses Public Health 2021 Jul 8. Epub 2021 Jul 8.

Department of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Spain.

Real-time PCR analysis of environmental samples (dust and aerosols) is an easy tool to investigate the presence of Coxiella burnetii in the farm environment. The aim of this study was to assess the distribution of C. burnetii DNA in dust collected inside animal premises from 272 small ruminant farms in Bizkaia (northern Spain), a region with recent reports of human Q fever cases and outbreaks. Read More

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Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells.

mSphere 2021 Jul 7:e0044221. Epub 2021 Jul 7.

Department of Microbiology and Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.

Coxiella burnetii is a highly infectious, intracellular, Gram-negative bacterial pathogen that causes human Q fever, an acute flu-like illness that can progress to chronic endocarditis. C. burnetii is transmitted to humans via aerosols and has long been considered a potential biological warfare agent. Read More

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Molecular Detection of Zoonotic Pathogens in the Blood and Tissues of Camels () in Central Desert of Iran.

Yale J Biol Med 2021 Jun 30;94(2):249-258. Epub 2021 Jun 30.

Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.

Dromedary camels () play a major economic role in many countries in Africa and Asia. Although they are resistant to harsh environmental conditions, they are susceptible to a wide range of zoonotic agents. This study aimed to provide an overview on the prevalence of selected zoonotic pathogens in blood and tissues of camels in central Iran. Read More

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Ticks and Tick-Borne Pathogens Associated with Dromedary Camels () in Northern Kenya.

Microorganisms 2021 Jun 30;9(7). Epub 2021 Jun 30.

International Centre of Insect Physiology and Ecology (icipe), Nairobi P.O. Box 30772-00100, Kenya.

Ticks and tick-borne pathogens (TBPs) are major constraints to camel health and production, yet epidemiological data on their diversity and impact on dromedary camels remain limited. We surveyed the diversity of ticks and TBPs associated with camels and co-grazing sheep at 12 sites in Marsabit County, northern Kenya. We screened blood and ticks (858 pools) from 296 camels and 77 sheep for bacterial and protozoan TBPs by high-resolution melting analysis and sequencing of PCR products. Read More

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Flock Management Risk Factors Associated with Q Fever Infection in Sheep in Saudi Arabia.

Animals (Basel) 2021 Jun 30;11(7). Epub 2021 Jun 30.

Al Ahsa Veterinary Diagnostic Lab, Ministry of Environment, Water and Agriculture, Al-Ahsa 31982, Saudi Arabia.

Q fever is a zoonotic disease caused by (), an intracellular, Gram-negative bacterium that infects humans and domestic ruminants. Information on flock management factors associated with Q fever seropositivity in Saudi Arabia is very scarce. Therefore, the objective of this study was to identify the animal and flock management factors associated with Q fever seropositivity. Read More

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Wild Small Mammals and Ticks in Zoos-Reservoir of Agents with Zoonotic Potential?

Pathogens 2021 Jun 21;10(6). Epub 2021 Jun 21.

Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Palackého tř. 1946/1, 61242 Brno, Czech Republic.

Wild small mammals and ticks play an important role in maintaining and spreading zoonoses in nature, as well as in captive animals. The aim of this study was to monitor selected agents with zoonotic potential in their reservoirs and vectors in a zoo, and to draw attention to the risk of possible contact with these pathogens. In total, 117 wild small mammals (rodents) and 166 ticks were collected in the area of Brno Zoo. Read More

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Acute Q Fever in an Ankylosing Spondyloarthritis Patient Treated with Etanercept.

Case Rep Rheumatol 2021 1;2021:9944387. Epub 2021 Jun 1.

Department of Internal Medicine, Farhat Hached Hospital, Sousse, Tunisia.

Q fever is a rare zoonotic infection caused by . Tumor necrosis factor-alpha (TNF-) has an important role in the early control of this infection. However, TNF- blockers increase the risk of infectious diseases. Read More

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Polymicrobial Infections Among Patients with Vascular Q Fever, France, 2004-2020.

Emerg Infect Dis 2021 ;27(7):1961-1963

We report 5 cases of vascular Q fever complicated by polymicrobial superinfection in patients who had no risk factors for acute Q fever. Q fever was diagnosed by serologic and molecular assays for Coxiella burnetii. We confirmed additional infections using conventional graft cultures. Read More

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Q Fever Endocarditis in Northeast Iran.

Case Rep Infect Dis 2021 28;2021:5519164. Epub 2021 May 28.

Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.

This report presents a case of chronic Q fever endocarditis. A 60-year-old male farmer and rancher was admitted to the hospital with symptoms of weight loss, fever, severe sweating, weakness, and anorexia. PCR was negative for in the blood sample, but phase I and II IgG antibodies against were positive (1 : 16384 and 1 : 2048, respectively) by the indirect immunofluorescent assay (IFA). Read More

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SEROLOGICAL EVIDENCE OF INFECTION IN THE WHITE RHINOCEROS () IN SOUTH AFRICA.

J Zoo Wildl Med 2021 Jun;52(2):573-579

White Oak Conservation, Yulee, FL 32097, USA.

Coxiellosis, or Query (Q) fever, a disease caused by the intracellular bacteria , was recently described in a managed breeding herd of white rhinoceros () in the southeastern United States. Clinical disease often results in abortion and could represent a conservation challenge for this species. In addition to the reproductive and herd management consequences, coxiellosis is also a zoonotic disease. Read More

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Serological survey of Coxiella burnetii infections in dairy cattle, sheep, goats and zoo animals in Hungary - Short communication.

Acta Vet Hung 2021 Jun 8. Epub 2021 Jun 8.

3Institute for Veterinary Medical Research, Centre for Agricultural Research, Budapest, Hungary.

Q fever is a disease of high zoonotic potential, but interest in its causative agent is rather low although it causes some public health problems in Hungary. The prevalence of Q fever is highly variable by country. The main reservoirs of the disease are the same domestic ruminant species everywhere, but the epidemiological profile depends on the features of the specific reservoir. Read More

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Human Q Fever on the Guiana Shield and Brazil: Recent Findings and Remaining Questions.

Curr Trop Med Rep 2021 Jun 1:1-10. Epub 2021 Jun 1.

Departamento de Tuberculosis, Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela.

Purpose Of Review: In this review, we report on the state of knowledge about human Q fever in Brazil and on the Guiana Shield, an Amazonian region located in northeastern South America. There is a contrast between French Guiana, where the incidence of this disease is the highest in the world, and other countries where this disease is practically non-existent.

Recent Findings: Recent findings are essentially in French Guiana where a unique strain MST17 has been identified; it is probably more virulent than those usually found with a particularly marked pulmonary tropism, a mysterious animal reservoir, a geographical distribution that raises questions. Read More

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Animal board invited review: Risks of zoonotic disease emergence at the interface of wildlife and livestock systems.

Animal 2021 Jun 3;15(6):100241. Epub 2021 Jun 3.

College of Veterinary Medicine, Comparative Medicine Research Institute, Yangzhou University, 225009 Yangzhou, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, 225009 Yangzhou, China.

The ongoing coronavirus disease 19s pandemic has yet again demonstrated the importance of the human-animal interface in the emergence of zoonotic diseases, and in particular the role of wildlife and livestock species as potential hosts and virus reservoirs. As most diseases emerge out of the human-animal interface, a better understanding of the specific drivers and mechanisms involved is crucial to prepare for future disease outbreaks. Interactions between wildlife and livestock systems contribute to the emergence of zoonotic diseases, especially in the face of globalization, habitat fragmentation and destruction and climate change. Read More

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Geographical Variation in Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk.

Pathogens 2021 May 23;10(6). Epub 2021 May 23.

UQ Spatial Epidemiology Laboratory, School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia.

Q fever is a zoonotic disease that is caused by and leads to abortion and infertility in ruminants and debilitating disease in humans. Jimma zone, including Jimma town, located in the Oromia region of Ethiopia, was affected by an outbreak of abortions in ruminants related to Q fever infection between 2013 and 2015. This study aimed to investigate the geo-clustering of seroprevalence in dairy farms of Jimma town and identify the environmental risk factors associated with seroprevalence distribution. Read More

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From Infection to Pregnancy Complications: Key Role of the Immune Response of Placental Cells.

Pathogens 2021 May 19;10(5). Epub 2021 May 19.

Aix-Marseille University, MEPHI, IRD, APHM, 13005 Marseille, France.

The infection of pregnant animals and women by , an intracellular bacterium, compromises both maternal health and foetal development. The placenta is targeted by as demonstrated by bacteriological and histological evidence. It now appears that placental strains of   are highly virulent compared to reference strains and that placental injury involves different types of placental cells. Read More

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One Health Approach: An Overview of Q Fever in Livestock, Wildlife and Humans in Asturias (Northwestern Spain).

Animals (Basel) 2021 May 13;11(5). Epub 2021 May 13.

Department of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.

This study aimed to investigate the seroprevalence of in domestic ruminants, wild ungulates, as well as the current situation of Q fever in humans in a small region in northwestern Spain where a close contact at the wildlife-livestock-human interface exists, and information on infection is scarce. Seroprevalence of was 8.4% in sheep, 18. Read More

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Utility of positron emission tomography imaging in the diagnosis of chronic Q fever: A Systematic Review.

J Med Imaging Radiat Oncol 2021 May 30. Epub 2021 May 30.

Pathology Queensland, Townsville University Hospital, Douglas, Queensland, Australia.

Chronic Q fever is a diagnostic challenge. Diagnosis relies on serology and/or the detection of DNA from blood or tissue samples. PET-CT identifies tissues with increased glucose metabolism, thus identifying foci of inflammation. Read More

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White thrombus as a possible feature of atypical stroke etiology: as the primary cause of acute ischemic stroke.

Interv Neuroradiol 2021 May 29:15910199211021716. Epub 2021 May 29.

Diagnostic and Interventional Neuroradiology, Foch Hospital, Suresnes, France.

Acute ischemic stroke (AIS) is the most common neurologic complication of infective endocarditis. We describe a singular case report of a 62- year-old male with AIS related to the occlusion of the left middle cerebral artery. Thrombus-aspiration allowed retrieving a 6 millimeters white thrombus. Read More

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A one-year descriptive epidemiology of zoonotic abortifacient pathogen bacteria in farm animals in Turkey.

Comp Immunol Microbiol Infect Dis 2021 Aug 15;77:101665. Epub 2021 May 15.

Selcuk University, Department of Microbiology, Faculty of Veterinary Medicine, Konya, Turkey. Electronic address:

This study aimed to investigate the epidemiology of 10 suspicious pathogenic bacteria in 250 stomach contents of aborted calf, lamb, and goat foetuses in 2019. The 155 positive samples obtained from PCR consisted of 53 (58.88 %) bacteria from 90 lamb samples, 10 (43. Read More

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Blood culture-negative infective endocarditis: a worse outcome? Results from a large multicentre retrospective Spanish cohort study.

Infect Dis (Lond) 2021 May 26:1-9. Epub 2021 May 26.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, University Hospital Virgen Macarena, Department of Medicine, University of Seville, Institute of Biomedicine of Seville (IBiS), Sevilla, Spain.

Background: To assess the impact of blood cultures negative infective endocarditis (BCNIE) on in-hospital mortality.

Methods: Prospective multicentre study with retrospective analysis of a Spanish cohort including adult patients with definite IE. Cardiac implantable devices infection were excluded. Read More

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Still new chronic Q fever cases diagnosed eight years after a large Q fever outbreak.

Clin Infect Dis 2021 May 24. Epub 2021 May 24.

Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Chronic Q fever usually develops within two years after primary infection with Coxiella burnetii. We determined the interval between acute Q fever and diagnosis of chronic infection, assessed what factors contribute to a longer interval, and evaluated the long-term follow-up.

Methods: From 2007-2018, patients with chronic Q fever were included from 45 participating hospitals. Read More

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F-Fluorodeoxyglucose positron emission tomography/computed tomography as a diagnostic and follow-up tool in endocarditis of prosthetic valve and aortic valved tube: a case report.

Eur Heart J Case Rep 2021 May 17;5(5):ytab159. Epub 2021 May 17.

Clinic of Emergency Medicine, University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Background : European Society of Cardiology 2015 guidelines approved F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) as a useful diagnostic imaging technique in prosthetic valve endocarditis (PVE) and recent evidence seems to suggest a role of nuclear imaging in the follow-up of cardiovascular infections, but nowadays there are no sufficient data available.

Case Summary : A 67-year-old male presented with fever, weight loss, and fatigue. His medical history included ulcerative colitis and a previous Bentall-De Bono surgical procedure in 2014. Read More

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