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3,3'-Diindolylmethane Promotes Gastric Cancer Progression β-TrCP-Mediated NF-κB Activation in Gastric Cancer-Derived MSCs.

Front Oncol 2021 24;11:603533. Epub 2021 Mar 24.

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Institute of Stem Cell, School of Medicine, Jiangsu University, Zhenjiang, China.

Gastric cancer is a malignant tumor characterized by high morbidity and invasion. Surgery combined with chemo-radiotherapy is the most common treatment for gastric cancer, while multiple drug resistance always results in treatment failure. Once the anti-tumor drugs enter the tumor foci, tumor cells as well as those found in the microenvironment are affected. Read More

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The effect of inhibiting exosomes derived from adipose-derived stem cells via the TGF-β1/Smad pathway on the fibrosis of keloid fibroblasts.

Gland Surg 2021 Mar;10(3):1046-1056

Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Background: The main mechanism of keloid formation is that keloid fibroblasts (KFs) apoptosis is inhibited, leading to excessive proliferation. Transforming growth factor-β1 (TGF-β1) is a key signal molecule in the process of regulating cell fibrosis. This paper discusses the effect of adipose-derived stem cell exosomes (ADSCs-EXO) on the proliferation and apoptosis of KFS and its possible mechanism, in order to provide reference for the clinical intervention of hypertrophic scar. Read More

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Management of non-compressible torso hemorrhage: An update.

Chin J Traumatol 2021 Mar 26. Epub 2021 Mar 26.

Medical Center of Trauma and War Injury, Daping Hospital, Army Medical University, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, 400042, China. Electronic address:

With the widespread adoption of advanced tourniquets, the mortality rate of limb wound hemorrhage has decreased significantly, and non-compressible torso hemorrhage has gradually occupied the leading position of potentially preventable death both in military and civilian circumstances. With the emergence of novel hemostatic devices and materials, strategies for the management of non-compressible torso hemorrhage have changed significantly. This review summarizes the current treatment strategies and types of equipment for non-compressible torso hemorrhage and suggests future research directions, hoping to provide a comprehensive review for the medical personnel and researchers engaging in this field. Read More

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Innovative adaptation of the "spare tissues concept" applied for olecranon coverage of a severe burn patient: A case report.

Ann Chir Plast Esthet 2021 Apr 7. Epub 2021 Apr 7.

Department of Maxillo-Facial Surgery, Purpan University Hospital, Toulouse, France.

Background: The management of bone exposure in patients with extensive burns could be a challenge due to the lack of healthy tissue. In such cases, it could be interesting to use any still healthy tissue initially destined for amputation and use it to cover up another site. We present the case of a sever burn patient for whom we used the only healthy palmar hand skin to cover an olecranon exposure. Read More

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The Comparison of Clinical and Histopathological Effects of Topical Psyllium () Powder and Silver Sulfadiazine on Second-Degree Burn Wound Healing in Rats.

World J Plast Surg 2021 Jan;10(1):96-103

Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Burn wounds are a worldwide health problem, leading to physical and psychological disabilities in all age's groups. With regard to absorbent properties of mucilage which can decrease wound moisture, we aimed to compare the effect of silver sulfadiazine (SSD) 1% and powdered on second-degree burn wound healing in rats.

Methods: This experimental study was conducted on 30 male Wistar rats with second-degree burn in three groups. Read More

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January 2021

C-Reactive Protein-to-Albumin Ratio Predicts Sepsis and Prognosis in Patients with Severe Burn Injury.

Mediators Inflamm 2021 24;2021:6621101. Epub 2021 Mar 24.

Department of Plastic and Burn Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, No. 41 Xibei Road, Haishu District, Ningbo City, 315000 Zhejiang Province, China.

Background: Sepsis is a leading cause of mortality among severe burns. This study was conducted to investigate the predictive role of C-reactive protein-to-albumin ratio (CAR) for sepsis and prognosis in severe burns.

Methods: Patients with severe burn injuries from 2013 to 2017 were enrolled and divided into septic and nonseptic groups based on the presence of sepsis within 30 days postburn. Read More

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Transcriptome Analyses of Myometrium from Fibroid Patients Reveals Phenotypic Differences Compared to Non-Diseased Myometrium.

Int J Mol Sci 2021 Mar 31;22(7). Epub 2021 Mar 31.

Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, Grand Rapids, MI 49503, USA.

Uterine fibroid tissues are often compared to their matched myometrium in an effort to understand their pathophysiology, but it is not clear whether the myometria of uterine fibroid patients represent truly non-disease control tissues. We analyzed the transcriptomes of myometrial samples from non-fibroid patients (M) and compared them with fibroid (F) and matched myometrial (MF) samples to determine whether there is a phenotypic difference between fibroid and non-fibroid myometria. Multidimensional scaling plots revealed that M samples clustered separately from both MF and F samples. Read More

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'Should I Stay, or Should I Go?' Psychological Distress Predicts Career Change Ideation among Intensive Care Staff in Lithuania and the UK Amid COVID-19 Pandemic.

Int J Environ Res Public Health 2021 03 6;18(5). Epub 2021 Mar 6.

Center for Psychotraumatology, Institute of Psychology, Vilnius University, M. K. Ciurlionio Str. 29, LT-03100 Vilnius, Lithuania.

The COVID-19 pandemic had a significant effect on healthcare globally. Additional pressure created by coronavirus adversely affected the mental health and psychological well-being of healthcare workers, leading many to question their desire and willingness to continue working in healthcare. This study aimed to identify predictors for career change ideation among healthcare professionals in two countries; Lithuania and the United Kingdom amid the coronavirus pandemic. Read More

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Plump endothelial cells integrated into pre-existing venules contribute to the formation of 'mother' and 'daughter' vessels in pyogenic granuloma: possible role of galectin-1, -3 and -8.

Scars Burn Heal 2021 Jan-Dec;7:2059513120986687. Epub 2021 Jan 22.

Autonomus Service Institute of Biomedicine, Caracas, Venezuela.

Introduction: Pyogenic granuloma (PG) is a reactive inflammatory vascular lesion of the skin and mucous membranes, characterised by the presence of enlarged venules and seamed and seamless capillaries with plump endothelial cells (EC), and numerous macrophages. EC activation upregulates the synthesis of galectins and induces their translocation to the EC surface promoting angiogenesis and lymphangiogenesis, particularly galectin-1 (Gal-1), Gal-3 and Gal-8. However, the presence and distribution of Gal-1, -3 and -8, as well as their implications in the pathogenesis of PG, has not been considered. Read More

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January 2021

Iron Metabolism Disorders for Cognitive Dysfunction After Mild Traumatic Brain Injury.

Front Neurosci 2021 16;15:587197. Epub 2021 Mar 16.

Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Military Medical University), Chongqing, China.

Traumatic brain injury (TBI) is one of the most harmful forms of acute brain injury and predicted to be one of the three major neurological diseases that cause neurological disabilities by 2030. A series of secondary injury cascades often cause cognitive dysfunction of TBI patients leading to poor prognosis. However, there are still no effective intervention measures, which drive us to explore new therapeutic targets. Read More

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Pyridoxamine ameliorates methylglyoxal-induced macrophage dysfunction to facilitate tissue repair in diabetic wounds.

Int Wound J 2021 Mar 31. Epub 2021 Mar 31.

Department of Burn, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Methylglyoxal (MGO) is a highly reactive dicarbonyl compound formed during hyperglycaemia. MGO combines with proteins to form advanced glycation end products (AGEs), leading to cellular dysfunction and organ damage. In type 2 diabetes mellitus (T2DM), the higher the plasma MGO concentration, the higher the lower extremity amputation rate. Read More

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Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells.

Oxid Med Cell Longev 2021 18;2021:5510663. Epub 2021 Mar 18.

Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen, Guangdong, China.

Bladder cancer is one of the most commonly diagnosed cancers worldwide, especially in males. Current therapeutic interventions, including surgery, radiation therapy, chemotherapy, and immunotherapy, have not been able to improve the clinical outcome of bladder cancer patients with satisfaction. Recombinant human arginase (rhArg, BCT-100) is a novel agent with great anticancer effects on arginine-auxotrophic tumors. Read More

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Role of TRPM7 kinase in cancer.

Cell Calcium 2021 Mar 22;96:102400. Epub 2021 Mar 22.

Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada; Department of Pharmacology, Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada. Electronic address:

Cancer is the second leading cause of death worldwide and accounted for an estimated 9.6 million deaths, or 1 in 6 deaths, in 2018. Despite recent advances in cancer prevention, diagnosis, and treatment strategies, the burden of this disease continues to grow with each year, with dire physical, emotional, and economic consequences for all levels of society. Read More

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Epidemiology and trend of US pediatric burn hospitalizations, 2003-2016.

Burns 2020 May 30. Epub 2020 May 30.

Center for Pediatric Trauma Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Center for Injury Research and Policy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Department of Pediatrics, The Ohio State University, 370 West 9th Avenue, Columbus, OH 43210, USA. Electronic address:

Background: Thermal injury is a leading cause of unintentional pediatric trauma morbidity and mortality.

Methods: This retrospective analysis of the 2003-2016 Kids' Inpatient Database (KID) included children <18 years old with a burn principal diagnosis. The objectives were to describe the trend of US pediatric burn hospital admissions and the patient and hospital characteristics of admitted children in 2016. Read More

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Tracing Ocular Conditions in 15,921 Interwar Refugees, Veria, Greece (1926-1940).

Acta Med Acad 2020 Dec;49(3):292-296

Department of History of Medicine and Medical Deontology, Medical School, University of Crete, Greece.

Objective: This historical epidemiological study aims to investigate ocular conditions in Greek refugees during the Interwar period (1926-1940) in the region of Imathia, Greece.

Materials And Methods: The archival material encompasses 15,921 patients who were admitted to the Refugee Hospital of Veria, Imathia, Greece. Descriptive statistics were estimated. Read More

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December 2020

Taming of Covid-19: potential and emerging application of mesenchymal stem cells.

Cytotechnology 2021 Mar 22:1-46. Epub 2021 Mar 22.

Burn and Regenerative Medicine Research Center, Velayat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has turned out to cause a pandemic, with a sky scraping mortality. The virus is thought to cause tissue injury by affecting the renin-angiotensin system. Also, the role of the over-activated immune system is noteworthy, leading to severe tissue injury via the cytokine storms. Read More

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Risk factors for transfusion-related acute lung injury.

Respir Care 2021 Mar 27. Epub 2021 Mar 27.

Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China; Research Unit of key techniques for treatment of burns and combined burns and trauma injury, Chinese Academy of Medical Sciences.

Until now, transfusion-related acute lung injury (TRALI) has been considered to be the leading cause of blood transfusion-related diseases and death. And there is no clinically effective treatment plan for TRALI. The aim of this study was to systematically summarize the literature on risk factors for TRALI in critical patients. Read More

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Chemical Burns from Secondary Exposure to Paraquat Through Mishandling Urine of a Patient with Toxic Exposure.

J Burn Care Res 2021 Mar 26. Epub 2021 Mar 26.

Director of Burn Research, Firefighters Burn Center, Regional One Health, 877 Jefferson Avenue, Memphis, TN, USA.

Paraquat is used throughout the world as an herbicide due to efficacy and relative safety with proper handling. Accidents and misuse still occur, leading to countries banning its use or employing extra safeguards and special handling certifications. Severe toxicity is primarily associated with ingestion, but skin exposure leads to corrosive injury to the dermis, occurs rapidly, and progresses for up to 24 hours. Read More

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Wound healing: what is the NICE guidance from the UK?

J Wound Care 2021 Mar;30(3):172-182

Consultant Burns and Plastic Surgeon, Queen Elizabeth Hospital, Birmingham, England.

Alteration of wound healing increases the risk of a patient's morbidity and mortality. This can lead to scarring, infection, malignant transformation and a reduction in quality of life. Management of wounds costs the UK an estimated £5. Read More

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Influence of agents and mechanisms of injury on anatomical burn locations in children <5 years old with a scald.

Arch Dis Child 2021 Mar 16. Epub 2021 Mar 16.

Division of Population Medicine, Department of Child Health, Cardiff, UK.

Objective: To demonstrate how the mechanism and agent of injury can influence the anatomical location of a scald.

Design: Prospective multicentre cross-sectional study.

Setting: 20 hospital sites across England and Wales including emergency departments, minor injury units and regional burns units. Read More

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Natural Killer Cells: Friend or Foe in Metabolic Diseases?

Front Immunol 2021 24;12:614429. Epub 2021 Feb 24.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

The worldwide epidemic of metabolic diseases, especially obesity and other diseases caused by it, has shown a dramatic increase in incidence. A great deal of attention has been focused on the underlying mechanisms of these pathological processes and potential strategies to solve these problems. Chronic inflammation initiated by abdominal adipose tissues and immune cell activation in obesity is the major cause of the consequent development of complications. Read More

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February 2021

Outcome analysis of biplanar mandibular distraction in adults.

Arch Craniofac Surg 2021 Feb 20;22(1):45-51. Epub 2021 Feb 20.

Department of Burns and Plastic Surgery, All India Institute of Medical Sciences Rishikesh, Rishikesh, India.

Background: Mandibular deficiency leading to facial asymmetry causes cosmetic deformity as well as psychological stigma for the patient. Correction of these mandibular asymmetries is a major challenge. The study investigates the efficacy of bidirectional mandible distraction for the treatment of mandibular deficiency. Read More

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February 2021

Acute Compartment Syndrome of the Leg Following Injury to Perforating Branch of Peroneal Artery After a Severe Ankle Sprain in a Pediatric Patient - A Case and a Review of Literature.

J Orthop Case Rep 2020 Nov;10(8):68-71

Department of Orthopaedics, Southampton General Hospital, Southampton, UK.

Introduction: Acute compartment syndrome (ACS) of the leg is seen most often following severe fractures, crush injuries, burns, tight casts, or dressings but rarely after ankle sprains. Very few cases have been found in the literature of compartment syndrome developing after ankle ligament disruptions. We report a case of ACS secondary to an ankle sprain in a 10-year-old child. Read More

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November 2020

Ginsenoside Rc Ameliorates Endothelial Insulin Resistance via Upregulation of Angiotensin-Converting Enzyme 2.

Front Pharmacol 2021 23;12:620524. Epub 2021 Feb 23.

Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, China.

Type 2 diabetes mellitus (T2DM) is a major health concern which may cause cardiovascular complications. Insulin resistance (IR), regarded as a hallmark of T2DM, is characterized by endothelial dysfunction. Ginsenoside Rc is one of the main protopanaxadiol-type saponins with relatively less research on it. Read More

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February 2021

Pre-Hospital Care Of Patients With Severe Burns In Germany: A Review Of 29 Years Of Experience.

Ann Burns Fire Disasters 2020 Dec;33(4):267-275

Clinic for Plastic and Hand Surgery, Burn Care Center, University of Witten/Herdecke, Cologne Merheim Medical Center (CMMC), Cologne, Germany.

Despite the high number of burn injuries worldwide, pre-hospital care differs across regions. Data documenting pre-hospital care of severe burn injuries in Germany are scarce. Nevertheless, efficient prehospital care of burn patients is crucial for later outcomes. Read More

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December 2020

A Quantitative Systematic Review of Clinical Outcome Measure Use in Peripheral Nerve Injury of the Upper Limb.

Neurosurgery 2021 Mar 8. Epub 2021 Mar 8.

Blond McIndoe Laboratories, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Background: Peripheral nerve injury (PNI) is common, leading to reduced function, pain, and psychological impact. Treatment has not progressed partly due to inability to compare outcomes between centers managing PNI. Numerous outcome measures exist but there is no consensus on which outcome measures to use nor when. Read More

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Bioactive Materials for Soft Tissue Repair.

Front Bioeng Biotechnol 2021 19;9:613787. Epub 2021 Feb 19.

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Over the past decades, age-related pathologies have increased abreast the aging population worldwide. The increased age of the population indicates that new tools, such as biomaterials/scaffolds for damaged tissues, which display high efficiency, effectively and in a limited period of time, for the regeneration of the body's tissue are needed. Indeed, scaffolds can be used as templates for three-dimensional tissue growth in order to promote the tissue healing stimulating the body's own regenerative mechanisms. Read More

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February 2021

Characterization of the T Cell Response to Cell Wall Extract in Children With Kawasaki Disease and Its Potential Role in Vascular Inflammation.

Front Pediatr 2021 19;9:633244. Epub 2021 Feb 19.

Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, La Jolla, CA, United States.

KD is an acute febrile illness and systemic vasculitis of unknown etiology among young children, which can cause coronary artery abnormalities and aneurysms (CAA) and is the leading cause of acquired heart disease among children in the US. cell wall extract (LCWE) induces in mice a vasculitis following intraperitoneal injection defined by the activation of macrophages, dendritic cells and CD8+ cytotoxic T cells leading to aortitis, coronary arteritis, aneurysms and myocarditis that strongly mimic the immunopathology and the cardiac lesions observed in children with Kawasaki disease (KD). To address a potential pathogenic role of LCWE-specific T cells in human vascular inflammation, we studied the activation of circulating CD4+ and CD8+ T cells in response to LCWE in 3 cohorts: (1) KD children 2-3 weeks after fever onset, (2) age-similar healthy children controls, (3) healthy adult controls. Read More

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February 2021

Detailed Case Reports of Surgical Treatment for Intraneural Ganglion Cysts.

Plast Reconstr Surg Glob Open 2021 Feb 16;9(2):e3339. Epub 2021 Feb 16.

Department of Plastic Surgery, University of Texas, SouthWestern Medical Center, Dallas, Tex.

Intraneural ganglion cysts are nonneoplastic mucinous cysts that form by the accumulation of thick mucinous fluid in the epineurium of peripheral nerves. Symptoms arise from mechanical compression of adjacent nerve fascicles from the intraneural ganglion cyst, and include local or radiating pain, paresthesias, weakness, and muscle atrophy.

Methods: Retrospective review of three cases of symptomatic intraneural ganglion cysts affecting the upper and lower extremity. Read More

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February 2021

Improving the Inhibitory Effect of Phages against Isolated from a Burn Patient Using a Combination of Phages and Antibiotics.

Viruses 2021 02 21;13(2). Epub 2021 Feb 21.

Department of Microbiology & Immunology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 0B1, Canada.

Antibiotic resistance causes around 700,000 deaths a year worldwide. Without immediate action, we are fast approaching a post-antibiotic era in which common infections can result in death. is the leading cause of nosocomial infection and is also one of the three bacterial pathogens in the WHO list of priority bacteria for developing new antibiotics against. Read More

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February 2021