5,946 results match your criteria burkitt's

Malaria and Cancer: a critical review on the established associations and new perspectives.

Infect Agent Cancer 2021 May 13;16(1):33. Epub 2021 May 13.

King's College London, School of Cancer and Pharmaceutical Sciences, Institute of Pharmaceutical Science, Waterloo Campus, Franklin Wilkins Building, Stamford Street, London, SE1 9NH, UK.

Objectives: Cancer and malaria both have high incidence rates and are leading causes of mortality worldwide, especially in low and middle-income countries with reduced access to the quality healthcare. The objective of this critical review was to summarize key associations and new perspectives between the two diseases as is reported in existing literature.

Methods: A critical review of research articles published between 1st January 2000 - 1st July 2020 which yielded 1753 articles. Read More

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Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines.

Neoplasia 2021 May 7;23(5):539-550. Epub 2021 May 7.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany. Electronic address:

Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. The clinical outcome in children with BL has improved over the last years but the prognosis for adults is still poor, highlighting the need for novel treatment strategies. Here, we report that the combinational treatment with the Smac mimetic BV6 and TRAIL triggers necroptosis in BL when caspases are blocked by zVAD. Read More

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EBV miRNAs are potent effectors of tumor cell transcriptome remodeling in promoting immune escape.

PLoS Pathog 2021 May 6;17(5):e1009217. Epub 2021 May 6.

Department of Pathology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, Louisiana, United States of America.

The Epstein Barr virus (EBV) contributes to the tumor phenotype through a limited set of primarily non-coding viral RNAs, including 31 mature miRNAs. Here we investigated the impact of EBV miRNAs on remodeling the tumor cell transcriptome. Strikingly, EBV miRNAs displayed exceptionally abundant expression in primary EBV-associated Burkitt's Lymphomas (BLs) and Gastric Carcinomas (GCs). Read More

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PARP1 Is Overexpressed in Hematological Malignant Cell Lines: A Framework for Experimental Oncology.

Anticancer Res 2021 May;41(5):2397-2402

Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.

Background/aim: Experimental oncology commonly uses cells as oncological models, providing a framework for the testing of drugs, and investigation of cytotoxicity, mutagenesis and carcinogenesis. Investigations into poly-ADP-ribose polymerase 1 (PARP1) inhibition have become ever more relevant due to its approval as a therapeutic option for tumors with BRCA1/2 DNA repair-associated mutation and the seemingly high PARP expression levels in some tumor subtypes. In this study, we aimed to determine PARP1 gene expression of different hematological cancer-derived cell lineages and compare them to that of normal cell lines. Read More

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Selenium nanoparticles: Synthesis, cytotoxicity, antioxidant activity and interaction studies with ct-DNA and HSA, HHb and Cyt c serum proteins.

Biotechnol Rep (Amst) 2021 Jun 15;30:e00615. Epub 2021 Apr 15.

Center of Medical Biology Research, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

The aim of this study was the synthesis of selenium nanoparticles (SeNPs) employing vitamin C as a biocompatible and low toxic reducing agent. The synthesized selenium nanoparticles were characterized by using UV-vis, FT-IR, SEM-EDX, TEM, DLS, and zeta potential measurements. The results of the DPPH free radical scavenging assay demonstrate that this synthesized nano-selenium has strong potentials to scavenge the free radicals and cytotoxicity against MCF-7 and Raji Burkitt's lymphoma cancer cell lines. Read More

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Severe type-B lactic acidosis in a patient with bilateral renal Burkitt's lymphoma.

Clin Nephrol Case Stud 2021 26;9:49-53. Epub 2021 Apr 26.

Department of Medicine, Nephrology Section, University of Miami Miller School of Medicine/Miami VAMC, and.

Introduction: Lactic acidosis (LA) can be categorized as type A, which occurs in the presence of tissue hypoxia, or type B, occurring in the absence of tissue hypoxia. Hematologic malignancies are an uncommon cause of type B LA.

Case Presentation: A 63-year-old man, HIV-negative, with a history of diabetes mellitus, hypothyroidism, and non-alcoholic fatty liver disease (NAFLD), presented to the ED complaining of acute-on-chronic lumbar pain, and was found to have high serum anion gap (AG) LA. Read More

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Comparison in safety of chemotherapy protocols for blood cancers: toxicity of H-CVAD versus GELA/BURKIMAB/PETHEMA LAL.

Ecancermedicalscience 2021 22;15:1206. Epub 2021 Mar 22.

Haematology Department, Complejo Hospitalario Universitario de Albacete, Calle Hermanos Falcó 37, 02008 Albacete, Spain.

Background And Objective: The Hyper-CVAD/Methotrexate-Cytarabine (H-CVAD/MTX-AraC) chemotherapy protocol has been one of the standard treatments for blood cancers, such as Mantle cell lymphoma (MCL), Burkitt's lymphoma (BL) and B-cell and T-cell acute lymphoblastic leukaemia (ALL). Due to high toxicity, it has been progressively replaced with new specific regimens with a better safety profile (GELA protocol for MCL, BURKIMAB for BL and PETHEMA for B-cell and T-cell ALL). The objective of this study is to analyse the toxicity and infectious complications of these therapeutic regimens, as well as the event free survival (EFS). Read More

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The Construction and Characterization of 1F5 Chimeric Anti-CD20 Monoclonal Antibodies: An Efficient Splicing by Overlap Extension-polymerase Chain Reaction Technique.

Iran J Allergy Asthma Immunol 2021 Apr 17;20(2):205-220. Epub 2021 Apr 17.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Despite the unparalleled success of anti-CD20-targeted immunotherapy, the currently available mAbs are not sufficiently efficacious in the treatment of lymphoma. 1F5 is one of a panel of anti-CD20 mAbs that was used in the B-cell lymphoma serotherapy. Despite the efficacy of murine 1F5 mAbs in lymphoma patients, the 1F5 chimeric antibodies with human effector functionality are yet to be approved and widely used in the treatment of lymphoma. Read More

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Excessive elevation of serum phosphate during tumor lysis syndrome: Lessons from a particularly challenging case.

Clin Nephrol Case Stud 2021 16;9:39-44. Epub 2021 Apr 16.

Medicine Service, Ralph H. Johnson VA Medical Center, Charleston, and.

Burkitt's lymphoma is a common cause of tumor lysis syndrome (TLS) and, in the era of aggressive utilization of prophylactic allopurinol and recombinant uricase enzyme, nephrologists are increasingly witnessing monovalent or divalent cation abnormalities without marked uric acid elevation. An 18-year-old male received his 1 cycle of intensive chemotherapy for Burkitt's lymphoma and developed TLS as defined by the Cairo Bishop criteria. Lactate dehydrogenase peaked at 9,105 U/L (range: 130 - 250) and was accompanied by acute kidney injury, including serum creatinine 2. Read More

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[Effect of Autophagy to Drug Resistance of B-cell Lymphoma Cells].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Apr;29(2):500-507

Department of Hematology, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China,Stem Cell Laboratory Affiliated to Southwest Medical University, Luzhou 646000, China,E-mail:

Objective: To investigate the effect of autophagy on the drug resistance of different human lymphoma cells.

Methods: Human Burkitt's lymphoma cell Daudi, human B lymphoma cell SUDHL-4, and human mantle cell lymphoma cell JeKo-1 were taken as the research subjects. The expression of Atg5 was inhibited by the treatments of autophagy inhibitors or stable interference via lentivirus infection. Read More

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[Cell Function Research of β-Trefoil Lectins from Mytilidae].

Yuki Fujii

Yakugaku Zasshi 2021 ;141(4):481-488

Laboratory of Functional Morphology, Graduate School of Pharmaceutical Sciences, Nagasaki International University.

Two novel β-trefoil lectins, MytiLec-1 and SeviL were found from mussels in the coast of Yokohama and Nagasaki. MytiLec-1 was purified from gill and mantle of Mytilus galloprovincialis. It was consisted of 149 amino acid residues and there was no similarity with any other proteins when it was discovered. Read More

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January 2021

A Case of a 13-Year-Old Adolescent with Burkitt's Lymphoma Presented With Dysphonia: Common Complaint Yet Uncommon Presentation.

Clin Lymphoma Myeloma Leuk 2021 Mar 4. Epub 2021 Mar 4.

Department of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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Role of FNAC in Extramammary Tumors Metastatic to the Breast.

J Cytol 2020 Oct-Dec;37(4):159-165. Epub 2020 Oct 31.

Department of Oncopathology, Gujarat Cancer and Research Institute, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India.

Background: Metastasis to the breast of an extra-mammary origin is very rare. FNAC plays an important role in differentiating non-mammary breast metastasis from primary malignancy. This study aimed to analyze the cytomorphological criteria and its pitfalls in differentiating metastatic lesion of the breast from primary malignancy. Read More

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October 2020

Bilateral Simultaneous Lymphomatous Optic Nerve Infiltration in Sporadic Burkitt's Lymphoma.

Neuroophthalmology 2021 24;45(1):45-47. Epub 2020 Jul 24.

Ophthalmology Department, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

Burkitt's lymphoma is a highly aggressive mature B cell non-Hodgkin's lymphoma. Systemic non-Hodgkin's lymphoma with isolated metastasis to the optic nerve was found only in one case among nearly six thousand cases of all types of non-Hodgkin's lymphoma. However, bilateral simultaneous lymphomatous optic nerve infiltration without central nervous system (CNS) involvement has not been reported previously. Read More

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Triptolide inhibits human telomerase reverse transcriptase by downregulating translation factors SP1 and c-Myc in Epstein-Barr virus-positive B lymphocytes.

Oncol Lett 2021 Apr 10;21(4):280. Epub 2021 Feb 10.

Department of General Surgery, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China.

Epstein-Barr virus (EBV) mainly causes infectious mononucleosis and is associated with several neoplasms, including Burkitt's lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease. Human telomerase reverse transcriptase (hTERT) regulates enzymatic activity of telomerase and is closely associated with tumorigenesis and senescence evasion. Triptolide (TP) is a diterpenoid triepoxide, with a broad-spectrum anticancer and immunosuppressive bioactivity profile. Read More

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The Impact of Epstein-Barr Virus Infection on Epigenetic Regulation of Host Cell Gene Expression in Epithelial and Lymphocytic Malignancies.

Front Oncol 2021 25;11:629780. Epub 2021 Feb 25.

Department of Clinical Oncology, University of Hong Kong, Hong Kong, Hong Kong.

Epstein-Barr virus (EBV) infection is associated with a variety of malignancies including Burkitt's lymphoma (BL), Hodgkin's disease, T cell lymphoma, nasopharyngeal carcinoma (NPC), and ∼10% of cases of gastric cancer (EBVaGC). Disruption of epigenetic regulation in the expression of tumor suppressor genes or oncogenes has been considered as one of the important mechanisms for carcinogenesis. Global hypermethylation is a distinct feature in NPC and EBVaGC, whereas global reduction of H3K27me3 is more prevalent in EBVaGC and EBV-transformed lymphoblastoid cells. Read More

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February 2021

Influence of Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphism on High-Dose Methotrexate-Related Toxicities in Pediatric Non-Hodgkin Lymphoma Patients.

Front Oncol 2021 26;11:598226. Epub 2021 Feb 26.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Purpose: This retrospective study aimed to investigate the relationships between the methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C and high-dose methotrexate (HD-MTX)-related toxicities in pediatric non-Hodgkin lymphoma (NHL) patients.

Patients And Methods: We reviewed the medical records of 93 NHL patients aged under 18 years who received HD-MTX therapy at the dose of 5 g/m with 24-h infusion at Sun Yat-sen University Cancer Center between 2014 and 2019.

Results: There were 61 males and 32 females, with a median age of 8. Read More

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February 2021

Cardiac Burkitt's lymphoma presenting with heart failure.

QJM 2021 Mar 13. Epub 2021 Mar 13.

Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico.

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GSK3 Kinase Inhibitor, CHIR, Suppress Transcription of Tissue Specific POU2F1 Isoform in Burkitt Namalwa Lymphoma Cells.

Dokl Biochem Biophys 2021 May 10;496(1):32-35. Epub 2021 Mar 10.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

POU2F1 (Oct-1) is a transcription factor, the overexpression of which is found in many human malignant tumors; a significant increase in its level in cells determines the malignant potential of the tumor. POU2F1 is represented in cells by several isoforms that are transcribed from alternative promoters. In Burkitt's B-cell lymphoma Namalwa, the concentration of tissue-specific isoform Oct-1L is several times higher than in normal B cells. Read More

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Bilateral jaws involvement of Burkitt's lymphoma in a pediatric patient.

J Clin Exp Dent 2021 Mar 1;13(3):e323-e327. Epub 2021 Mar 1.

Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

A case of Burkitt's lymphoma with bilateral jaws involvement in a 5-year-old boy is reported discussing the dentist's role in the diagnosis and management of this disease. The initial clinical diagnosis established of maxillary swelling causing trismus was a dentoalveolar abscess. The incisional biopsy was performed and histopathological analysis, including immunohistochemistry, confirmed the Burkitt's lymphoma. Read More

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Safety of Eicosapentaenoic Acid in Cancer Treatment: Effect on Cancer Cells and Chemotherapy in Vitro.

Nutr Cancer 2021 17;73(4):568-571. Epub 2020 Jun 17.

Department of Pediatric Oncology, Dokuz Eylul University Institute of Oncology, Izmir, Turkey.

Eicosapentaenoic acid (EPA) is a long-chain polyunsaturated fatty acid that has been used to treat cachectic cancer. However, its efficacy and safety with regard to cancer cells remain unclear. The present study comprised an In Vitro investigation of the effects of EPA on cancers. Read More

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Is EBV Associated with Breast Cancer in Specific Geographic Locations?

Cancers (Basel) 2021 Feb 16;13(4). Epub 2021 Feb 16.

School of Life Sciences, University of Sussex, Brighton BN1 9 QG, UK.

Epstein-Barr virus (EBV) is a virus that establishes a life-long infection in people, and infection with EBV is nearly ubiquitous by adulthood. EBV was identified from biopsy material from a child with Burkitt's lymphoma (BL) in sub-Saharan Africa. EBV has a well-characterised role in the development of some cancers, notably, Burkitt's lymphoma (BL), Hodgkin's disease (HD), gastric carcinoma (GC), and nasopharyngeal carcinoma (NPC). Read More

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February 2021

Selective Cytotoxic Effects of 5-Trifluoromethoxy-1H-indole-2,3-dione 3-Thiosemicarbazone Derivatives on Lymphoid-originated Cells.

Anticancer Agents Med Chem 2021 Mar 1. Epub 2021 Mar 1.

Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 34116 Beyazıt, Istanbul. Turkey.

Aim: The present study aims to identify the anticancer effect of novel 1H-indole-2,3-dione 3-thiosemicarbazone derivatives. These compounds could be promissing anticancer agents in leukemia treatment.

Background: Conventional chemotherapeutic agents accumulate in both normal and tumor cells due to non-specificity. Read More

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The Antimicrobial Peptide, Nisin, Synergistically Enhances the Cytotoxic and Apoptotic Effects of Rituximab Treatment on Human Burkitt's Lymphoma Cell Lines.

Rep Biochem Mol Biol 2020 Oct;9(3):250-256

Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Non-Hodgkin's lymphomas comprise the most common hematological cancers worldwide and consist of a heterogenous group of malignancies affecting the lymphoid system. Treatment of non-Hodgkin's lymphoma has been significantly enhanced with the addition of Rituximab to the standard chemotherapy regimen. However, even with the advancement of treatment patients continue to relapse and develop resistance to Rituximab, rendering subsequent treatments unsuccessful. Read More

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October 2020

Three quinolinone alkaloid - phenylpropanoid adducts from .

Nat Prod Res 2021 Mar 1:1-7. Epub 2021 Mar 1.

Department of Chemistry, HCMC University of Education, Ho Chi Minh city, Vietnam.

Preliminary cytotoxic test on different extracts of collected at Dăk Nong province, Vietnam showed that the -hexane one was the most potent. From this -hexane extract, three new quinolinone alkaloid-phenylpropanoid derivatives () and three known compounds () were isolated. Based on NMR and HR-MS analysis, their chemical structures were elucidated as melicoptines A-C (), flindersine (4), 3,4,5-trimethoxybenzoic acid (5) and (24S)-methylcholestan-1α,3β-diol (6). Read More

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Spontaneous Tumor Lysis Syndrome: A Rare Presentation in Plasmablastic Lymphoma.

J Hematol 2021 Feb 6;10(1):30-34. Epub 2021 Feb 6.

Department of Hematology and Marrow Transplantation, Hospital de Santa Maria, Av. Prof. Egas Moniz MB, 1649-028 Lisbon, Portugal.

Tumor lysis syndrome is an oncological emergency, which can ultimately lead to death if not recognized early and treated accordingly. The institution of adequate prophylactic measures can decrease its incidence and severity; but very rarely, a highly aggressive neoplasm such as acute lymphoblastic leukemia or Burkitt's lymphoma can present with spontaneous tumor lysis syndrome (sTLS). We present the case of a 58-year-old male with newly diagnosed plasmablastic lymphoma with a retroperitoneal bulky mass invading the bladder, who presented with severe sTLS and was admitted to an intensive care unit due to acute renal failure and hyperkalemia requiring emergent renal replacement therapy. Read More

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February 2021

Burkitt's lymphoma: an unexpected cause of dental pain.

J Surg Case Rep 2021 Feb 15;2021(2):rjaa557. Epub 2021 Feb 15.

Head and Neck Unit, Royal Derby Hospital, Derby, UK.

We would like to describe a case of Burkitt's lymphoma in a 37-year-old lady, who initially presented to her General Dental Practitioner (GDP) complaining of pain and episodic numbness in the right lip and chin. The initial diagnosis was irreversible pulpitis of the lower right second molar (LR7) and despite having an extraction of the affected tooth her problems persisted. The patient also developed pain in the spine and limbs, accompanied by lethargy and weakness. Read More

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February 2021

Laterality of lower extremity deep vein thrombosis after colectomy: A retrospective study using the national inpatient sample.

Phlebology 2021 Feb 14:268355521994985. Epub 2021 Feb 14.

Division of Hospital Medicine, Department of Medicine, 4530University of Kentucky, Lexington, USA.

Background And Aims: Deep venous thrombosis (DVT) is known to occur preferentially on the left lower extremity. The renowned surgeon Denis Burkitt advanced the theory that a heavy sigmoid colon would compress the left pelvic veins and predispose to DVT. Our study aimed to evaluate this hypothesis by comparing the laterality distributions with and without a prior colectomy. Read More

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February 2021

CAR19/22 T cell therapy in adult refractory Burkitt's lymphoma.

Cancer Immunol Immunother 2021 Jan 18. Epub 2021 Jan 18.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The treatment of refractory Burkitt's lymphoma (BL) is still a challenge. Although CAR-T cell therapy has achieved good responses in diffuse large B cell lymphoma, there is no case series report about the efficacy of CAR-T cell therapy in adult Burkitt's lymphoma. In this study, we evaluate the efficacy and safety of CAR19/22 T cell therapy in six refractory Burkitt's lymphoma cases with poor genetic prognostic factors. Read More

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January 2021