190 results match your criteria bronchoscope novel


Design and Modelling of a Continuum Robot for Distal Lung Sampling in Mechanically Ventilated Patients in Critical Care.

Front Robot AI 2021 3;8:611866. Epub 2021 May 3.

School of Informatics, University of Edinburgh, Edinburgh, United Kingdom.

In this paper, we design and develop a novel robotic bronchoscope for sampling of the distal lung in mechanically-ventilated (MV) patients in critical care units. Despite the high cost and attributable morbidity and mortality of MV patients with pneumonia which approaches 40%, sampling of the distal lung in MV patients suffering from range of lung diseases such as Covid-19 is not standardised, lacks reproducibility and requires expert operators. We propose a robotic bronchoscope that enables repeatable sampling and guidance to distal lung pathologies by overcoming significant challenges that are encountered whilst performing bronchoscopy in MV patients, namely, limited dexterity, large size of the bronchoscope obstructing ventilation, and poor anatomical registration. Read More

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A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures.

Physiol Rep 2021 May;9(9):e14871

Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI, USA.

To date, existing animal models of the acute respiratory distress syndrome (ARDS) have failed to translate preclinical discoveries into effective pharmacotherapy or diagnostic biomarkers. To address this translational gap, we developed a high-fidelity swine model of ARDS utilizing clinically relevant lung injury exposures. Fourteen male swine were anesthetized, mechanically ventilated, and surgically instrumented for hemodynamic monitoring, blood, and tissue sampling. Read More

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Protecting the tracheal tube cuff: a novel solution.

J Dent Anesth Pain Med 2021 Apr 31;21(2):167-171. Epub 2021 Mar 31.

Department of Anesthesiology, New York Presbyterian Hospital - Weill Cornell Medical Center, New York, NY, USA.

We describe the successful insertion of a nasotracheal tube following repeated cuff rupture. The patient was a 55-year-old woman with a history of nasal trauma and multiple rhinoplasties, who underwent elective Lefort I osteotomy and bilateral sagittal split osteotomy for correction of skeletal facial deformity. During fiberoptic bronchoscope-guided nasal intubation after the induction of general anesthesia, the tracheal tube repeatedly ruptured in both nares, despite extensive preparation of the nasal airways. Read More

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Novel technique for identification of the pulmonary intersegmental plane using manual jet ventilation during pulmonary segmentectomy.

Wideochir Inne Tech Maloinwazyjne 2021 Mar 1;16(1):169-174. Epub 2020 Jun 1.

Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan.

Introduction: For successful pulmonary segmentectomy, the identification of boundaries between segments is important. Previous measures include tracing the intersegmental vessels by staining with a dye via the affected pulmonary artery or bronchus and inflating with oxygen via a high frequency ventilator. However, problems with these methods have been reported. Read More

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Conversion of an oral to nasal intubation in difficult nasal anatomy patients: two case reports.

BMC Anesthesiol 2021 Mar 9;21(1):72. Epub 2021 Mar 9.

Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, 222, Wangsimni-ro, Seongdonggu, Seoul, 133-792, Republic of Korea.

Background: Nasal intubation is indispensable for some cases that require intraoral surgical access, and the fiberoptic bronchoscope is the best tool for difficult airways. However, fiberoptic bronchoscopy is not always possible in cases with altered pharyngeal anatomy.

Case Presentation: In this report, we introduce a novel technique for retrograde endotracheal oral-to-nasal conversion with an ordinary endotracheal tube exchange catheter. Read More

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Transbronchial lung cryobiopsy by twin bronchoscopes (kissing technique).

Indian J Tuberc 2021 Jan 2;68(1):16-19. Epub 2020 Nov 2.

Dr. Baba Saheb Ambedkar Hospital, Rohini, Delhi, India.

Objective: To introduce a new & novel method of obtaining big lung tissue samples by transbronchial lung cryobiopsy by twin bronchoscopes (kissing technique) in an advanced interventional pulmonology suite.

Methods: In patients of diffuse parenchymal lung diseases, transbronchial lung cryobiopsy were taken using this novel approach using simultaneously two bronchoscopes under C- arm guidance under conscious sedation. First, a standard fibreoptic bronchoscope was inserted intranasally and fixed just above the area to be biopsied, then fogarty's catheter was introduced through FOB's suction channel and protruded it at the biopsy site. Read More

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January 2021

DISPOSABLE COVID BOX - A new invention.

Indian J Tuberc 2021 Jan 2;68(1):149-151. Epub 2020 Oct 2.

Dr. Baba Saheb Ambedkar Hospital, Rohini, Delhi, India.

Objective: To introduce a new method to do safe bronchoscopy, a highly aerosol generating procedure through disposable COVID box in this difficult COVID time.

Methods: We have introduced an unbelievably cheap and effective method "DISPOSABLE COVID BOX". We took an acrylic board 70 × 20 cm and attached 3 bars 32 cm long and slide it under the side of the patient. Read More

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January 2021

Bronchoscopic Cryotherapy for Acute Hypoxemic Respiratory Failure in Three Mechanically Ventilated Patients: A Case Series.

Indian J Crit Care Med 2021 Jan;25(1):94-96

Department of Pulmonary and Critical Care Medicine, All India Institute of Medical Sciences, Rishikesh, India.

Endobronchial blood clots or mucus plugs can present with minimal symptoms or acute airway obstruction in the intensive care unit (ICU) patients. Acute airway obstruction can lead to rapid worsening of dyspnea owing to poor oxygenation due to collapse of the lung. Prompt recognition and treatment of this condition can translate into a successful outcome by decreasing morbidity and mortality and facilitating successful weaning of these patients. Read More

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January 2021

Catheter Injectable Hydrogel-Based Scaffolds for Tissue Engineering Applications in lung disease.

Isr Med Assoc J 2020 Dec;22(12):736-740

Department of Materials Science and Engineering, Tel Aviv University, Tel Aviv, Israel.

Background: Chronic lung diseases, especially emphysema and pulmonary fibrosis, are the third leading cause of mortality worldwide. Their treatment includes symptom alleviation, slowing of the disease progression, and ultimately organ transplant. Regenerative medicine represents an attractive alternative. Read More

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December 2020

Anlotinib enhances the antitumor activity of radiofrequency ablation on lung squamous cell carcinoma.

Pharmacol Res 2021 02 7;164:105392. Epub 2021 Jan 7.

Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, PR China. Electronic address:

Anlotinib is a novel molecular targeted drug that has been approved for the treatment of lung adenocarcinoma. Currently these agents are rarely used in the treatment of lung squamous cell carcinoma (LSCC). Bronchoscope-guided radiofrequency ablation (RFA) is a new strategy proposed for the treatment of LSCC that is able to alleviate the obstruction of the respiratory tract caused by LSCC by direct destruction of the tumor tissues. Read More

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February 2021

Placement of self-expanding metallic tracheobronchial Y stent with laryngeal mask airway using conscious sedation under fluoroscopic guidance.

Thorac Cancer 2021 02 15;12(4):484-490. Epub 2020 Dec 15.

The Pulmonary Division, Rabin Medical Center, Petach Tikva, Israel.

Background: Central airway obstruction and fistula are treated with a tracheobronchial Y stent. In the currently used self-expandable metal Y stents, the delivery system is 8 mm in diameter and requires either a 9 mm tracheal tube or rigid bronchoscope to enable airway control during insertion. In this study we present a novel technique of laryngeal mask airway (LMA) assisted Y stent insertion, enabling airway control during deployment of the Y stent. Read More

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February 2021

Current Novel Advances in Bronchoscopy.

Front Surg 2020 16;7:596925. Epub 2020 Nov 16.

Department of Cardiothoracic Surgery, New York University Langone Health, New York, NY, United States.

Screening for lung cancer has changed substantially in the past decade since The National Lung Screening Trial. The resultant increased discovery of incidental pulmonary nodules has led to a growth in the number of lesions requiring tissue diagnosis. Bronchoscopy is one main modality used to sample lesions, but peripheral lesions remain challenging for bronchoscopic biopsy. Read More

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November 2020

A novel method using a single lumen tube and extraluminal bronchial blocker for one-lung ventilation in severe tracheal stenosis: a case report.

Ann Palliat Med 2021 Jan 25;10(1):749-753. Epub 2020 Nov 25.

Department of Anesthesiology, First Hospital of China Medical University, Shenyang, China. Email:

Double-lumen tubes (DLT) and bronchial blockers (BB) are usually used to functionally isolate the lungs during thoracic surgery. However, for patients with tracheal stenosis, management of one lung ventilation (OLV) in the anesthesia is still full of challenges due to mismatching between the trachea lumen and tracheal tube diameter. In the past, a small single-lumen tube (SLT) combined with an endobronchial pediatric BB or extraluminal detached BB of a uninvent obtained successful OLV in patients with tracheal stenosis. Read More

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January 2021

A Bronchoscope Localization Method Using an Augmented Reality Co-Display of Real Bronchoscopy Images with a Virtual 3D Bronchial Tree Model.

Sensors (Basel) 2020 Dec 7;20(23). Epub 2020 Dec 7.

Department of Thoracic Medicine, Chang Gung Memorial Hospital at LinKou, Taoyuan 33305, Taiwan.

In recent years, Image-Guide Navigation Systems (IGNS) have become an important tool for various surgical operations. In the preparations for planning a surgical path, verifying the location of a lesion, etc., it is an essential tool; in operations such as bronchoscopy, which is the procedure for the inspection and retrieval of diagnostic samples for lung-related surgeries, it is even more so. Read More

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December 2020

Pre-emptive extracorporeal membrane oxygenation to support endobronchial stenting for severe airway obstruction.

Eur J Cardiothorac Surg 2021 Jun;59(6):1345-1346

Department of Thoracic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland.

Tracheobronchial stent insertion is a common palliative intervention for the management of dynamic airway collapse due to severe tracheobronchomalacia or tracheal compression due to mass effect [1]. Airway stents are usually placed bronchoscopically with or without fluoroscopy. In more complex cases, airway stents are placed using a rigid bronchoscope under general anaesthesia with conventional or jet ventilation. Read More

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Bronchoscope motion tracking using centerline-guided Gaussian mixture model in navigated bronchoscopy.

Phys Med Biol 2021 01 14;66(2):025001. Epub 2021 Jan 14.

Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran. Research Centre of Biomedical Technology and Robotics (RCBTR), Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Electromagnetic-based navigation bronchoscopy requires accurate and robust estimation of the bronchoscope position inside the bronchial tree. However, respiratory motion, coughing, patient movement, and airway deformation inflicted by bronchoscope significantly hinder the accuracy of intraoperative bronchoscopic localization. In this study, a real-time and automatic registration procedure was proposed to superimpose the current location of the bronchoscope to corresponding locations on a centerline extracted from bronchial computed tomography (CT) images. Read More

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January 2021

Spatial mapping of VOC exhalation by means of bronchoscopic sampling.

J Breath Res 2020 10 6;14(4):046012. Epub 2020 Oct 6.

Department of Anaesthesiology and Intensive Care Medicine, Rostock University Medical Centre, ROMBAT, Germany.

Breath analysis holds promise for non-invasive in vivo monitoring of disease related processes. However, physiological parameters may considerably affect profiles of exhaled volatile organic substances (VOCs). Volatile substances can be released via alveoli, bronchial mucosa or from the upper airways. Read More

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October 2020

Long-term Survival Results following Endobronchial RF Ablation in a Healthy-Porcine Model.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:5252-5258

This paper presents results from long-term survival study where healthy swine were ablated with a novel technology designed for treating early-stage non-small cell lung cancer using an endobronchial flexible catheter.Methods - The radiofrequency ablation (RFA) system has been presented previously and consisted of an ablation catheter, radiofrequency generator, irrigation pump for infusion of hypertonic saline (HS) and a laptop. The catheter carried an occlusion balloon, a 5 mm long RF electrode, with irrigation holes, and a 1 mm long electrode for bipolar impedance measurements. Read More

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A novel protective barrier enclosure for performing bronchoscopy.

Respir Investig 2021 Mar 16;59(2):260-262. Epub 2020 Sep 16.

Department of General Thoracic Surgery, Jichi Medical University, Japan.

Healthcare workers performing bronchoscopy, especially in urgent cases, may be at risk of aerosol-transmitted infection with severe acute respiratory syndrome coronavirus 2. Therefore, such healthcare workers require thorough protection from aerosol droplets. To this end, we developed a novel handmade protective barrier enclosure for performing flexible bronchoscopy. Read More

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Mobile 3D Intraprocedural Fluoroscopy in Combination With Ultrathin Bronchoscopy for Biopsy of Peripheral Lung Nodules.

J Bronchology Interv Pulmonol 2021 Jan;28(1):76-80

Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.

Despite development of multiple technologies, distinguishing benign from malignant lung nodules when they are still small in size is challenging. A high yield and minimally invasive bronchoscopic technology with low cost for diagnosis of small lung lesions is needed in pulmonary and lung cancer clinical practice. Peripheral airway bronchoscopy using thin and most recently ultrathin bronchoscopes improve visualization of small airways. Read More

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January 2021

A visual SLAM-based bronchoscope tracking scheme for bronchoscopic navigation.

Int J Comput Assist Radiol Surg 2020 Oct 7;15(10):1619-1630. Epub 2020 Aug 7.

Graduate School of Informatics, Nagoya university, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8601, Japan.

Purpose: Due to the complex anatomical structure of bronchi and the resembling inner surfaces of airway lumina, bronchoscopic examinations require additional 3D navigational information to assist the physicians. A bronchoscopic navigation system provides the position of the endoscope in CT images with augmented anatomical information. To overcome the shortcomings of previous navigation systems, we propose using a technique known as visual simultaneous localization and mapping (SLAM) to improve bronchoscope tracking in navigation systems. Read More

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October 2020

Prospective Analysis of a Novel Endobronchial Augmented Fluoroscopic Navigation System for Diagnosis of Peripheral Pulmonary Lesions.

J Bronchology Interv Pulmonol 2021 Apr;28(2):107-115

FirstHealth Moore Regional Hospital and Pinehurst Medical Clinic, Pinehurst, NC.

Background: Navigational bronchoscopy has improved upon traditional bronchoscopy to identify suspicious pulmonary lesions, but wide variability exists in the diagnostic yield of various modalities. The aim of this study was to measure localization accuracy and diagnostic yield of a novel endobronchial augmented fluoroscopic navigation system (first-generation LungVision system) for peripheral pulmonary lesions (PPLs).

Methods: This prospective single-center study included adults undergoing guided bronchoscopy to evaluate PPLs. Read More

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Combination of 1.1 mm flexible cryoprobe with conventional guide sheath and therapeutic bronchoscope in biopsy of apical upper lobe solitary pulmonary nodule.

BMC Pulm Med 2020 Jun 3;20(1):158. Epub 2020 Jun 3.

Division of Respiratory Medicine, Department of Medicine, Sarawak General Hospital, Ministry of Health, Kuching, Sarawak, Malaysia.

Background: Lung cancer is frequently situated peripherally in the upper lobes of the lung. Acquiring adequate tissue from this difficult-to-reach area remains a challenge. Transbronchial cryobiopsy (TBCB) has the ability to acquire larger specimens, but the rigidity of the standard 1. Read More

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Novel Percutaneous Tracheostomy for Critically Ill Patients With COVID-19.

Ann Thorac Surg 2020 09 25;110(3):1006-1011. Epub 2020 Apr 25.

Department of Cardiothoracic Surgery, New York University Langone Health, New York, New York. Electronic address:

Background: Coronavirus 2019 (COVID-19) is a worldwide pandemic, with many patients requiring prolonged mechanical ventilation. Tracheostomy is not recommended by current guidelines as it is considered a superspreading event owing to aerosolization that unduly risks health care workers.

Methods: Patients with severe COVID-19 who were on mechanical ventilation for 5 days or longer were evaluated for percutaneous dilational tracheostomy. Read More

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September 2020

A Randomized Controlled Trial Comparing Novel Triple-Cuffed Double-Lumen Endobronchial Tubes with Conventional Double-Lumen Endobronchial Tubes for Lung Isolation.

J Clin Med 2020 Apr 1;9(4). Epub 2020 Apr 1.

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.

Placing a double-lumen endobronchial tube (DLT) in an appropriate position to facilitate lung isolation is essential for thoracic procedures. The novel ANKOR DLT is a DLT developed with three cuffs with a newly added carinal cuff designed to prevent further advancement by being blocked by the carina when the cuff is inflated. In this prospective study, the direction and depth of initial placement of ANKOR DLT were compared with those of conventional DLT. Read More

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Characterization of Applied Forces and Torques During Rigid Bronchoscopy Intubation.

J Bronchology Interv Pulmonol 2020 Oct;27(4):246-252

Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA.

Background: Rigid bronchoscopy intubation poses a significant risk of complication to patients from mechanical trauma. Despite the importance of precision in forces exerted by surgeons during intubation, no prior study has analyzed the overall forces and torques involved in rigid bronchoscopy intubation, and whether existing training modalities accurately replicate them.

Methods: A bronchoscope was equipped with a 6-axis load sensor to measure forces and torques applied during rigid bronchoscopy intubation. Read More

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October 2020

Potential impact of contaminated bronchoscopes on novel coronavirus disease (COVID-19) patients.

Infect Control Hosp Epidemiol 2020 Jul 2;41(7):862-864. Epub 2020 Apr 2.

Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota.

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Bronchoscopic device closure of postoperative bronchopleural fistulae: Novel devices and innovative techniques.

Lung India 2020 Mar-Apr;37(2):107-113

Department of Microbiology, Military Hospital (CTC), Pune, Maharashtra, India.

Background: Bronchoscopic device closure plays a significant role in the nonsurgical management of bronchopleural fistulae (BPF). Herein, we describe our 10-year experience in the management of postoperative BPF using various device closure modalities. This is the largest series of bronchoscopic device closure of BPF being reported from India. Read More

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February 2020

Design of a prospective, multicenter, and cohort study of an innovative electromagnetic navigation bronchoscopy in diagnosing pulmonary nodules among Chinese population.

J Thorac Dis 2019 Dec;11(12):5592-5600

Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.

Electromagnetic navigation bronchoscopy (ENB) has been demonstrated to increase the diagnostic yield of peripheral pulmonary lesions. We designed two prospective clinical trials using an innovative ENB system that can combine with both thick and thin bronchoscope, including a randomized controlled clinical study to assess the usefulness of the ENB system and a real-world study to explore the optimal way to use this system. Patients with peripheral pulmonary nodules (PPNs) suspicious of lung cancer with the long diameter more than 8 mm and no more than 30 mm will be enrolled in the study. Read More

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December 2019

Early Preclinical Experience with a Novel Endobronchial Radiofrequency Ablation System for Lung Cancer Treatment.

Annu Int Conf IEEE Eng Med Biol Soc 2019 Jul;2019:174-180

This paper introduces a novel technology for treating early-stage non-small cell lung cancer using an endobronchial approach via a flexible radiofrequency ablation (RFA) catheter. Methods - The RFA system consisted of an ablation catheter, radiofrequency generator, irrigation pump for infusion of hypertonic saline (HS) and a laptop. The catheter carried an occlusion balloon, a 5 mm long RF electrode, with irrigation holes, and a 1 mm long electrode for bipolar impedance measurements. Read More

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