103,789 results match your criteria british columbia

Deconvolution-based partial volume correction of PET images with parallel level set regularization.

Phys Med Biol 2021 Jun 22. Epub 2021 Jun 22.

Radiology and Physics, The University of British Columbia, Vancouver, British Columbia, V6T 1Z4, CANADA.

The partial volume effect (PVE), caused by the limited spatial resolution of positron emission tomography (PET), degrades images both qualitatively and quantitatively. Anatomical information provided by magnetic resonance (MR) images has the potential to play an important role in partial volume correction (PVC) methods. Post-reconstruction MR-guided PVC methods typically use segmented MR tissue maps, and further, assume that PET activity distribution is uniform in each region, imposing considerable constraints through anatomical guidance. Read More

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An Examination of Dweck's Psychological Needs Model in Relation to Exercise-Related Well-Being.

J Sport Exerc Psychol 2021 Jun 21:1-12. Epub 2021 Jun 21.

University of British Columbia.

This two-part study examined Dweck's psychological needs model in relation to exercise-related well-being and particularly focused on the basic need for optimal predictability and compound needs for identity and meaning. In Part 1 (N = 559), using exploratory factor analysis, scores derived from items assessing optimal predictability (prediction of affect and instrumental utility in exercise) were empirically distinct from scores derived from items assessing competence, relatedness, and autonomy. In Part 2, participants from Part 1 (N = 403) completed measures of exercise-related well-being 4 weeks after baseline assessment. Read More

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Therapeutic delivery of siRNA with polymeric carriers to down-regulate STAT5A expression in high-risk B-cell acute lymphoblastic leukemia (B-ALL).

PLoS One 2021 22;16(6):e0251719. Epub 2021 Jun 22.

Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Overexpression and persistent activation of STAT5 play an important role in the development and progression of acute lymphoblastic leukemia (ALL), the most common pediatric cancer. Small interfering RNA (siRNA)-mediated downregulation of STAT5 represents a promising therapeutic approach for ALL to overcome the limitations of current treatment modalities such as high relapse rates and poor prognosis. However, to effectively transport siRNA molecules to target cells, development of potent carriers is of utmost importance to surpass hurdles of delivery. Read More

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The Effect of Posterior Lumbar Spinal Surgery on Biomechanical Properties of Rat Paraspinal Muscles 13 Weeks Post-Surgery.

Spine (Phila Pa 1976) 2021 Mar 22. Epub 2021 Mar 22.

aDepartment of Orthopaedics, The University of British Columbia, Vancouver Canada bInternational Collaboration on Repair Discoveries (ICORD), The University of British Columbia cDepartment of Orthopaedic Surgery, Jikei University School of Medicine,Tokyo, Japan dDepartment of Mechanical Engineering, The University of British Columbia eSchool of Biomedical Engineering, The University of British Columbia fDepartment of Medical Genetics, The University of British Columbia gDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada.

Study Design: Pre-clinical study in rodents.

Objective: To investigate changes in biomechanical properties of paraspinal muscles following a posterior spinal surgery in an animal model SUMMARY OF BACKGROUND DATA.: Posterior spine surgery damages paraspinal musculature per histological and imaging studies. Read More

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Evaluating delays for emergent CT scans from a rural British Columbia hospital.

CJEM 2021 Jun 22. Epub 2021 Jun 22.

University of British Columbia, Vancouver, BC, Canada.

Objectives: Computed Tomography (CT) scans help diagnose and triage life-threatening and time-sensitive emergency conditions, but most rural hospitals in British Columbia do not have access to a local CT scanner. We investigate how many transfers from a rural British Columbia hospital were for CT scans and describe the time delays to emergent CT imaging.

Methods: This was a prospective cohort study, over a 1-year period, on all patients requiring a transfer from the Golden and District Hospital, located 247 km from the closest CT scanner. Read More

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Economic Evidence on Potentially Curative Gene Therapy Products: A Systematic Literature Review.

Pharmacoeconomics 2021 Jun 22. Epub 2021 Jun 22.

Faculty of Pharmaceutical Sciences, Collaboration for Outcomes Research and Evaluation, University of British Columbia, Vancouver, BC, Canada.

Objective: The aim of this review was to summarize all available evidence on the cost effectiveness of potentially curative gene therapies and identify challenges that economic evaluations face in this area.

Methods: We conducted a systematic review of four databases (PubMed/MEDLINE, Embase, CINAHL, EconLit) and grey literature sources. We conducted the search on August 23, 2019 and updated it on November 26, 2020. Read More

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Infants' Mapping of New Faces to New Voices.

Child Dev 2021 Jun 22. Epub 2021 Jun 22.

University of British Columbia.

The ability to identify individuals by voice is fundamental for communication. However, little is known about the expectations that infants hold when learning unfamiliar voices. Here, the voice-learning skills of 4- and 8-month-olds (N = 53; 29 girls, 14 boys of various ethnicities) were tested using a preferential-looking task that involved audiovisual stimuli of their mothers and other unfamiliar women. Read More

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Behavior regulation skills are associated with adaptive functioning in children and adolescents with prenatal alcohol exposure.

Appl Neuropsychol Child 2021 Jun 22:1-11. Epub 2021 Jun 22.

Centre for Neuroscience Studies, Queens University, Kingston, Canada.

Children with prenatal alcohol exposure (PAE) experience a range of adverse outcomes that impact multiple domains of functioning, including cognitive, physical, mental health, behavioral, social-emotional, communication, and learning. To inform tailored clinical intervention, the current study examined the relation between caregiver-reported cognitive skills (executive function; EF) and adaptive functioning. The study conducted a secondary analyses of data provided by caregivers of 87 children and adolescents (aged 5-18 years,  = 11. Read More

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Editors' note: 2021 Special Issue on airway management.

Can J Anaesth 2021 Jun 21. Epub 2021 Jun 21.

Departments of Anesthesia & Perioperative Medicine and Epidemiology & Biostatistics, University of Western Ontario, London, ON, Canada.

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Periarticular calcifications.

Skeletal Radiol 2021 Jun 21. Epub 2021 Jun 21.

Department of Radiology, Musculoskeletal Section, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

Periarticular calcification and ossification is a frequent finding on imaging and may sometimes pose a diagnostic challenge. The differential diagnoses for this radiological finding are wide and can be classified into broad groups such as idiopathic, developmental, trauma, burns, infection, tumor, connective tissue disease, crystalline, metabolic, vascular, and foreign bodies. With careful consideration of the clinical and imaging findings as well as awareness of mimickers of periarticular mineralization, the list of differential diagnoses can be narrowed down. Read More

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DNA binding alters ARv7 dimer interactions.

J Cell Sci 2021 Jun 22. Epub 2021 Jun 22.

School of Medicine, Koç University, Istanbul 34450, Turkey.

Androgen receptor (AR) splice variants are described as one of the potential drivers of lethal castration-resistant prostate cancer. Androgen receptor splice variant 7 (ARv7) is the most commonly observed isoform and strongly correlates with resistance to second-generation antiandrogens. Despite this clinical evidence, the interplay between ARv7 and the highly expressed full-length AR (ARfl) remains unclear. Read More

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A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.

Nat Med 2021 Jun 21. Epub 2021 Jun 21.

University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.

Dominantly inherited Alzheimer's disease (DIAD) causes predictable biological changes decades before the onset of clinical symptoms, enabling testing of interventions in the asymptomatic and symptomatic stages to delay or slow disease progression. We conducted a randomized, placebo-controlled, multi-arm trial of gantenerumab or solanezumab in participants with DIAD across asymptomatic and symptomatic disease stages. Mutation carriers were assigned 3:1 to either drug or placebo and received treatment for 4-7 years. Read More

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The multiple sclerosis prodrome.

Nat Rev Neurol 2021 Jun 21. Epub 2021 Jun 21.

Faculty of Medicine (Neurology), The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.

A prodrome is an early set of signs, symptoms or other findings that occur before the onset of typical symptoms of a disease. Prodromal phases are well recognized in several neurological and inflammatory diseases, but the possibility of a prodrome in multiple sclerosis (MS) has received relatively little attention until the past few years. In this Perspective, we summarize what is currently known about the MS prodrome, including its possible duration, clinical features and potential biomarkers. Read More

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Consider patient risk factors for melanoma when prescribing antihypertensives.

Martin Dawes

CMAJ 2021 Jun;193(25):E996

Family physician, University of British Columbia, Vancouver, BC.

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2021 Update on Safety of Magnetic Resonance Imaging: Joint Statement From Canadian Cardiovascular Society/Canadian Society for Cardiovascular Magnetic Resonance/Canadian Heart Rhythm Society.

Can J Cardiol 2021 Jun;37(6):835-847

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

Magnetic resonance imaging (MRI) is often considered the gold-standard test for characterizing cardiac as well as noncardiac structure and function. However, many patients with cardiac implantable electronic devices (CIEDs) and/or severe renal dysfunction are unable to undergo this test because of safety concerns. In the past 10 years, newer-generation CIEDs and gadolinium-based contrast agents (GBCAs) as well as coordinated care between imaging and heart rhythm device teams have mitigated risk to patients and improved access to MRI at many hospitals. Read More

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Molecular characterization of harmful algal blooms in the Bohai Sea using metabarcoding analysis.

Harmful Algae 2021 Jun 13;106:102066. Epub 2021 Jun 13.

CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China; Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, V5A 1S6, Canada. Electronic address:

Although the occurrences of harmful algal blooms (HABs) have been intensifying, many HABs in coastal waters may have been neglected despite their damaging impact directly on ecology and indirectly on human and animal health. The current detection of HABs depends primarily on the water coloration, chlorophyll intensity, cell density, and mortality due to HAB toxicity. Such methods may not be adequately sensitive to detecting HABs that are relatively transient or small scale. Read More

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Effectiveness of photon-initiated photoacoustic streaming in root canal models with different diameters or tapers.

BMC Oral Health 2021 06 15;21(1):307. Epub 2021 Jun 15.

Department of Endodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medical, Guangzhou, 510182, Guangdong, China.

Background: This study aimed to compare the use of photon-initiated photoacoustic streaming (PIPS) and conventional needle irrigation (CNI) in conjunction with different concentrations of sodium hypochlorite (NaOCl) to remove Enterococcus faecalis (E. faecalis) suspended bacteria and biofilms from root canal systems with different diameters or tapers.

Methods: Artificial root canal samples (n = 480) were randomly divided into three groups (n = 160/group). Read More

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Evening the playing field: microenvironmental control over stem cell competition during fate programming.

Curr Opin Genet Dev 2021 Jun 18;70:66-75. Epub 2021 Jun 18.

School of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, University of British Columbia, Biomedical Research Centre, 2222 Health Sciences Mall, V6T 1Z3, Vancouver, Canada. Electronic address:

Recent advancements in cellular engineering, including reprogramming of somatic cells into pluripotent stem cells, have opened the door to a new era of regenerative medicine. Given that cellular decisions are guided by microenvironmental cues, such as secreted factors and interactions with neighbouring cells, reproducible cell manufacturing requires robust control over cell-cell interactions. Cell competition has recently emerged as a previously unknown interaction that plays a significant role in shaping the growth and death dynamics of multicellular stem cell populations, both in vivo and in vitro. Read More

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The Risk of Allergic Reaction to SARS-CoV-2 Vaccines and Recommended Evaluation and Management: A Systematic Review, Meta-analysis, GRADE Assessment, and International Consensus Approach.

J Allergy Clin Immunol Pract 2021 Jun 18. Epub 2021 Jun 18.

Department of Paediatrics, Royal College of Surgeons, Dublin, Ireland.

Concerns for anaphylaxis may hamper SARS-CoV-2 immunization efforts. We convened a multi-disciplinary group of international experts in anaphylaxis comprised of allergy, infectious disease, emergency medicine, and front-line clinicians to systematically develop recommendations regarding SARS-CoV-2 vaccine immediate allergic reactions. Medline, EMBASE, Web of Science, the WHO global coronavirus database, and the grey literature (inception-March 19, 2021) were systematically searched. Read More

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Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats.

J Ethnopharmacol 2021 Jun 18:114348. Epub 2021 Jun 18.

Diabetes Research Center, Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:

Ethnopharmacological Relevance: Fructus Ligustri Lucidi (FLL) is an edible herb with anti-osteoporotic activity, yet whether and how the aqueous extract of this herb affect calcium metabolism in preservation of bone quality remain unclear.

Aim Of The Study: To investigate the effects of FLL aqueous extract on calcium balance and short-chain fatty acids (SCFAs) production in ovariectomized (OVX) rats.

Materials And Methods: OVX rats were daily and orally administrated with FLL aqueous extract (3. Read More

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Conservation aquaculture as a tool for imperiled marine species: Evaluation of opportunities and risks for Olympia oysters, Ostrea lurida.

PLoS One 2021 21;16(6):e0252810. Epub 2021 Jun 21.

Department of Environmental Science and Policy, University of California-Davis, Davis, California, United States of America.

Conservation aquaculture is becoming an important tool to support the recovery of declining marine species and meet human needs. However, this tool comes with risks as well as rewards, which must be assessed to guide aquaculture activities and recovery efforts. Olympia oysters (Ostrea lurida) provide key ecosystem functions and services along the west coast of North America, but populations have declined to the point of local extinction in some estuaries. Read More

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Examining the dynamics of Epstein-Barr virus shedding in the tonsils and the impact of HIV-1 coinfection on daily saliva viral loads.

PLoS Comput Biol 2021 Jun 21;17(6):e1009072. Epub 2021 Jun 21.

Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada.

Epstein-Barr virus (EBV) is transmitted by saliva and is a major cause of cancer, particularly in people living with HIV/AIDS. Here, we describe the frequency and quantity of EBV detection in the saliva of Ugandan adults with and without HIV-1 infection and use these data to develop a novel mathematical model of EBV infection in the tonsils. Eligible cohort participants were not taking antiviral medications, and those with HIV-1 infection had a CD4 count >200 cells/mm3. Read More

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Vaccinomics: a cross-sectional survey of public values.

Hum Vaccin Immunother 2021 Jun 21:1-17. Epub 2021 Jun 21.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

: We characterize public values regarding vaccinomics, which aims to improve vaccine safety and effectiveness using genomics. Panel survey (2020) of ≥18-year-olds with embedded animation introduced vaccinomics. Sociodemographic, health, and vaccination-related items were adapted from validated scales. Read More

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Physical therapist guided active intervention of chronic temporomandibular disorder presenting as ear pain: A case report.

Physiother Theory Pract 2021 Jun 21:1-13. Epub 2021 Jun 21.

Rehabilitation Department, Pantai Jerudong Park Medical Centre, Brunei Darussalam.

This case report describes the successful physical therapy management of a 40-year-old female who presented with left ear pain referred from the temporomandibular joint. Diagnosis was primarily based on clinical examination findings and ruling out of red flags. Guidance was given on active self-care approaches consisting of pain neuroscience education designed with individualized pain curriculum, exercise therapy, manual therapy, and breathing exercises for a period of  sixweeks. Read More

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Genomic basis of deep-water adaptation in Arctic Charr (Salvelinus alpinus) morphs.

Mol Ecol 2021 Jun 21. Epub 2021 Jun 21.

Fisheries and Oceans Canada, Northwest Atlantic Fisheries Centre, St. John's, Newfoundland and Labrador, Canada.

The post-glacial colonization of Gander Lake in Newfoundland, Canada, by Arctic Charr (Salvelinus alpinus) provides the opportunity to study the genomic basis of adaptation to extreme deep-water environments. Colonization of deep-water (> 50 m) habitats often requires extensive adaptation to cope with novel environmental challenges from high hydrostatic pressure, low temperature, and low light, but the genomic mechanisms underlying evolution in these environments are rarely known. Here, we compare genomic divergence between a deep-water morph adapted to depths of up to 288m and a larger, piscivorous pelagic morph occupying shallower depths. Read More

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The Effects of a Deliberate Practice Debriefing During a Response to Rescue Patient Simulation With Undergraduate Nursing Students.

Nurs Educ Perspect 2021 Jul-Aug 01;42(4):235-237

About the Authors Barbara Aronson, PhD, RN, CNE, is professor and coordinator, EdD in Nursing Education, Southern Connecticut State University Department of Nursing, New Haven, Connecticut. Arleigh Bell, MN, MAED, RN, is a lecturer, School of Nursing, Thompson Rivers University, Kamloops, British Columbia, Canada. Tia Andrighetti, DNP, APRN, CNM, CHSE, is an associate professor, Frontier Nursing University, Versailles, Kentucky. Mary Meyer, PhD, APRN, is a clinical associate professor, School of Nursing and Health Studies, University of Missouri, Kansas City, Missouri. Karen Shepherd, MSN, RN, CHSE, is an associate professor, College of the Ozarks Armstrong McDonald School of Nursing, Point Lookout, Missouri. Deborah Bambini, PhD, WHNP-BC, CNE, CHSE, ANEF, is an associate professor, Grand Valley State University, Allendale, Michigan. This study was supported by the Kwantlen Polytechnic University Innovation and Technology Research Fund and an INACSL Debra Spunt Research Grant. For more information, contact Dr. Aronson at

Abstract: The purpose of this multisite, randomized, pretest/posttest quasi-experimental study was to compare student nurse competency, learning retention, and perceived student support after exposure to a deliberate practice debriefing versus standardized debriefing. Fifty undergraduate students participated in the complex response to rescue simulation. The intervention group had significantly higher total mean and three subscale scores on the competency tool than the comparison group, although differences in learning retention and student support were not significant. Read More

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Clinical and cost outcomes following genomics-informed treatment for advanced cancers.

Cancer Med 2021 Jun 21. Epub 2021 Jun 21.

Cancer Control Research, BC Cancer, Vancouver, Canada.

Background: Single-arm trials are common in precision oncology. Owing to the lack of randomized counterfactual, resultant data are not amenable to comparative outcomes analyses. Difference-in-difference (DID) methods present an opportunity to generate causal estimates of time-varying treatment outcomes. Read More

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PBP4-mediated β-lactam resistance among clinical strains of Staphylococcus aureus.

J Antimicrob Chemother 2021 Jun 21. Epub 2021 Jun 21.

Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, USA.

Background: PBP4, a low-molecular-weight PBP in Staphylococcus aureus, is not considered to be a classical mediator of β-lactam resistance. Previous studies carried out by our group with laboratory strains of S. aureus demonstrated the ability of PBP4 to produce β-lactam resistance through mutations associated with the pbp4 promoter and/or gene. Read More

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Gaining an understanding of behavioral genetics through studies of foraging in and learning in .

J Neurogenet 2021 Jun 20:1-13. Epub 2021 Jun 20.

Department of Psychology, University of British Columbia, Vancouver, Canada.

The pursuit of understanding behavior has led to investigations of how genes, the environment, and the nervous system all work together to produce and influence behavior, giving rise to a field of research known as behavioral neurogenetics. This review focuses on the research journeys of two pioneers of aspects of behavioral neurogenetic research: Dr. Marla Sokolowski and Dr. Read More

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Multivalent Diffusive Transport.

J Phys Chem B 2021 Jun 20. Epub 2021 Jun 20.

Department of Physics, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada.

We present here a model for multivalent diffusive transport whereby a central point-like hub is coupled to multiple feet, which bind to complementary sites on a two-dimensional landscape. The available number of binding interactions is dependent on the number of feet (multivalency) and on their allowed distance from the central hub (span). Using Monte Carlo simulations that implement the Gillespie algorithm, we simulate multivalent diffusive transport processes for 100 distinct walker designs. Read More

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