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Cancers (Basel) 2021 Mar 6;13(5). Epub 2021 Mar 6.

Centre de Recherche Saint-Antoine (CRSA), INSERM UMR_S_938, Cancer Biology and Therapeutics, Sorbonne University, 75012 Paris, France.

The objective of this systematic review is to summarize our current knowledge on the influence of miRNAs in the epigenetic deregulation of tumor-related genes in endometrial cancer (EC). We conducted a literature search on the role of miRNAs in the epigenetic regulation of EC applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following terms were used: microRNA, miRNA, miR, endometrial cancer, endometrium, epigenetic, epimutation, hypermethylation, lynch, deacetylase, DICER, novel biomarker, histone, chromatin. Read More

Br J Sports Med 2021 Mar 29. Epub 2021 Mar 29.

Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: Physical inactivity is a risk factor for premature mortality and several non-communicable diseases. The purpose of this study was to estimate the global burden associated with physical inactivity, and to examine differences by country income and region.

Methods: Population-level, prevalence-based population attributable risks (PAR) were calculated for 168 countries to estimate how much disease could be averted if physical inactivity were eliminated. Read More

Int J Gynecol Pathol 2021 Mar 24. Epub 2021 Mar 24.

Pathology Department (G.K., P.D.C., M.P.) Gynecology and Obstetrics Department (C.C.), North Hospital, University Hospital of Saint-Etienne, France.

FOXA1, a transcription factor essential for the binding of other transcription factors on chromatin, is associated with hormone receptor-associated cancers, such as breast and endometrial cancer. It is also considered an antagonist of epithelial-to-mesenchymal transition (EMT). In endometrial cancer, FOXA1 is considered a tumor suppressor; in carcinosarcoma, one of the most aggressive and rare subtypes of endometrial cancer, thought to be derived through an EMT mechanism, FOXA1 has not been studied. Read More

Clin Nutr ESPEN 2021 Apr 25;42:22-31. Epub 2021 Feb 25.

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background & Aims: It is believed that diets high in glycemic index (GI), glycemic load (GL), Insulin index (II), and Insulin load (IL) are associated with the increased risks of certain cancers through increasing serum glucose or insulin levels.

Methods: We conducted this systematic review of cohort studies to evaluate the possible relation between GI, GL, II, and IL with diabetes-related cancers, including colorectal, bladder, breast, endometrium, liver, pancreas, and prostate cancers. Two separate investigators conducted a literature search through PubMed/Medline, Scopus, and Web of Science databases up to February 2020, plus reference lists of relevant articles. Read More

Pharm Nanotechnol 2021 Mar 10. Epub 2021 Mar 10.

Department of Research, Clinical Cytogenetics Laboratory, Jawaharlal Nehru Cancer Hospital & Research Centre (JNCHRC), Bhopal, Madhya Pradesh. India.

Background: Tamoxifen is widely used for treatment of estrogen receptor positive breast cancer. It is, however, associated with severe side effects of cancerous proliferation on uterus endometrium. The tumor targeting formulation strategies can effectively overcome drug side effects of tamoxifen and provide safer drug treatment. Read More

Br J Cancer 2021 Mar 15. Epub 2021 Mar 15.

Albert Einstein College of Medicine, Bronx, NY, USA.

Background: The association between body fat composition and risk of cancer in normal weight individuals (body mass index (BMI) 18.5-24.9 kg/m) is unclear. Read More

Cells 2021 Feb 15;10(2). Epub 2021 Feb 15.

Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), 69008 Lyon, France.

Bilirubin, an endogenous antioxidant, may play a protective role in cancer development. We applied two-sample Mendelian randomization to investigate whether genetically raised bilirubin levels are causally associated with the risk of ten cancers (pancreas, kidney, endometrium, ovary, breast, prostate, lung, Hodgkin's lymphoma, melanoma, and neuroblastoma). The number of cases and their matched controls of European descent ranged from 122,977 and 105,974 for breast cancer to 1200 and 6417 for Hodgkin's lymphoma, respectively. Read More

Appl Immunohistochem Mol Morphol 2021 Feb 17. Epub 2021 Feb 17.

Department of Pathology; University of Health Sciences, Eskisehir City Hospital Departments of Pathology Urology Biostatistics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.

Renal oncocytoma is a benign renal tumor originated from intercalated cells of collecting ducts like chromophobe renal cell carcinoma (RCC). The differential diagnosis of these 2 tumors is important because while they are histologically and cytologically similar, they show different biological behavior. For the differential diagnosis, several immunohistochemical markers have been investigated. Read More

Ann Ital Chir 2021 Jan 20;10. Epub 2021 Jan 20.

Metastasis of breast cancer to the uterus is quite rare. The majority of reported cases have evolved from previously known invasive ductal and lobular carcinomas of the breast. Herein, a rare case of invasive micropapillary carcinoma of the breast that was diagnosed via endometrial biopsy, without a previous diagnosis or history of breast cancer, was presented. Read More

Front Endocrinol (Lausanne) 2020 21;11:612396. Epub 2021 Jan 21.

Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

Sex hormone-dependent cancers currently contribute to the high number of cancer-related deaths worldwide. The study and elucidation of the molecular mechanisms underlying the progression of these tumors was a double-edged sword, leading to the expansion and development of new treatment options, with the cost of triggering more aggressive, therapy resistant relapses. The interaction of androgen, estrogen and progesterone hormones with specific receptors (AR, ER, PR) has emerged as a key player in the development and progression of breast, ovarian, prostate and endometrium cancers. Read More

Ann Palliat Med 2021 Jan;10(1):818-827

Department of Gynecology, Changzhou First People's Hospital, Changzhou, China. Email:

Endometrial cancer (EC) is the second most common gynecologic malignancy in China, and the incidence and mortality rates have increased in recent years. Brain metastasis from EC is extremely rare, affecting only 0.3-1. Read More

J Obstet Gynaecol Res 2021 Apr 31;47(4):1510-1515. Epub 2021 Jan 31.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Aim: Tamoxifen (TAM) is widely used in adjuvant endocrine therapy for invasive breast cancer as a selective estrogen modulator, but this treatment has a risk of developing endometrial malignancy. However, hysteroscopic findings during or after TAM treatment are unclear. The aim of this study is to examine the association between hysteroscopic patterns and malignant histological findings during or after treatment with TAM. Read More

Clinics (Sao Paulo) 2021 20;76:e2380. Epub 2021 Jan 20.

Departamento de Ginecologia, Escola Paulista de Medicina (EPM), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, BR.

Objectives: To compare the effects of low-dose conjugated estrogen (CE), raloxifene, and the combination thereof on the endometrium of postmenopausal women.

Methods: Postmenopausal women between 45 and 60 years of age, with Gail score≥1.67 and no endometrial disorders, were randomly assigned to receive low-dose CE (0. Read More

Clin Genet 2021 May 12;99(5):662-672. Epub 2021 Feb 12.

Department of Genetics, Normandy Center for Genomic and Personalized Medicine, Normandie Univ, UNIROUEN, Inserm U1245 and Rouen University Hospital, Rouen, France.

Biallelic pathogenic variants in the NTHL1 (Nth like DNA glycosylase 1) gene cause a recently identified autosomal recessive hereditary cancer syndrome predisposing to adenomatous polyposis and colorectal cancer. Half of biallelic carriers also display multiple colonic or extra-colonic primary tumors, mainly breast, endometrium, urothelium, and brain tumors. Published data designate NTHL1 as an important contributor to hereditary cancers but also underline the scarcity of available informations. Read More

Front Cell Dev Biol 2020 15;8:592616. Epub 2020 Dec 15.

Department of Molecular Carcinogenesis, Medical University of Lodz, Lodz, Poland.

The Notch pathway involves evolutionarily conserved signaling regulating the development of the female tract organs such as breast, ovary, cervix, and uterine endometrium. A great number of studies revealed Notch aberrancies in association with their carcinogenesis and disease progression, the management of which is still challenging. The present study is a comprehensive review of the available literature on Notch signaling during the normal development and carcinogenesis of the female tract organs. Read More

J Midlife Health 2020 Jul-Sep;11(3):171-174. Epub 2020 Sep 29.

Department of Pathology, Kalpana Chawla Government Medical College, Karnal, Haryana, India.

The double-edged sword effect of tamoxifen therapy on the female reproductive system including the breast is quite well established. However, it is still poorly understood at the molecular level which significantly affects the management of such patients receiving it in terms of therapeutics and prognosis. An experience of an extremely rare case of secretory endometrial adenocarcinoma developing due to the adverse effect of tamoxifen used for the treatment of breast cancer in a 60-year-old woman is being described herewith so as to create awareness among the dealing clinicians about the occurrence of rare histological types of endometrial cancer after long-term tamoxifen therapy. Read More

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2020 Nov;28(6):1349-1354

N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia.

The integrated approach to diagnosis and dispensary monitoring of women with high risk for breast cancer, the active detection of combined pathology of endometrium are promising directions in prevention and timely diagnosis of breast and uterus malignant neoplasms. The study established that particular correction of measures of secondary prevention of breast cancer is needed, including formation of risk group and organization of dynamic monitoring of women with high risk of breast cancer development. The comprehensive examination of reproductive system organs, including evaluation of risk factors, combined use of mammography and sonography methods to examine mammary glands and condition of endometrium, can to increase accuracy of differential diagnosis and to avoid unneeded invasive interventions with mammary glands and early diagnosis of endometrial pathology. Read More

Sleep Med Rev 2021 Apr 28;56:101409. Epub 2020 Nov 28.

Sleep Research Centre, Department of Neurology I.C., Oasi Research Institute, IRCCS, Troina 94018, Italy. Electronic address:

A bidirectional connection between sleep and cancer exists; however, the specific associations between individual sleep disorders and particular tumors are not very clear. An accurate assessment of sleep disorders in cancer patients is necessary to improve patient health, survival, response to therapy, quality of life, reduction of comorbidities/complications. Indeed, recent scientific evidence shows that knowledge and management of sleep disorders offer interesting therapeutic perspectives for the treatment of cancer. Read More

J Lab Physicians 2020 Dec 23;12(3):165-170. Epub 2020 Nov 23.

Department of Pathology, Government Medical College, Patiala, Punjab, India.

 Endometrial carcinoma is often preceded by characteristic histopathologic lesions known as endometrial hyperplasia. Estrogen, p53, PTEN, and overexpression of cyclin D1 appear to be involved in the development of endometrial carcinogenesis.  We evaluated and compared the expression profile of cyclin D1 expressions in 50 endometrial samples submitted as either endometrial curetting ( = 34) or hysterectomy ( = 16) specimens, which were diagnosed as simple hyperplasia ( = 10), complex hyperplasia ( = 06), atypical hyperplasia ( = 04), and endometrial carcinoma ( = 20). Read More

J Clin Med 2020 Nov 28;9(12). Epub 2020 Nov 28.

Clinic of Gynecology, Oncological Gynecology and Obstetrics, Municipal Polyclinical Hospital in Olsztyn, Niepodległości Str. 44, 10-045 Olsztyn, Poland.

Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen receptor modulator therapy. Read More

Cancers (Basel) 2020 Nov 23;12(11). Epub 2020 Nov 23.

Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai 600116, India.

Oestrogens and androgens play important roles in normal and cancerous tissue and have been shown to negatively regulate pigment epithelium-derived factor (PEDF) expression in sex hormone-responsive tumours. PEDF suppresses tumour growth and its downregulation by oestrogen is implicated in tumorigenesis, metastasis, and progression. PEDF expression is reduced in cancerous tissue of the prostate, breast, ovary, and endometrium compared to their normal tissue counterparts, with a link between PEDF downregulation and sex hormone signalling observed in pre-clinical studies. Read More

J Natl Cancer Inst 2021 Apr;113(4):381-389

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background: The influence of type 2 diabetes mellitus (T2D) duration on cancer incidence remains poorly understood.

Methods: We prospectively followed for cancer incidence 113 429 women in the Nurses' Health Study (1978-2014) and 45 604 men in the Health Professionals Follow-up Study (1988-2014) who were free of diabetes and cancer at baseline. Cancer incidences were ascertained by review of medical records. Read More

World Neurosurg 2020 Nov 17. Epub 2020 Nov 17.

Department of Electrical and Electronics Engineering, Istanbul University, 34320 Istanbul, Turkey.

The paper used toremifene to study the characteristics of hemodynamic changes before and after neoadjuvant chemotherapy in breast cancer by using resting state functional MRI quantitative method, and to analyse the effect of toremifene on the recent quality of life of advanced breast cancer. Methods: A total of 100 patients who received endocrine therapy after breast cancer surgery in our hospital from January 2016 to January 2019 were collected as the research objects. They were randomly divided into observation group and control group, with 50 cases in each group. Read More

Cancer Epidemiol Biomarkers Prev 2021 Jan 3;30(1):217-228. Epub 2020 Nov 3.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Background: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of GWAS summary statistics from these two cancers. Read More

Clin Genet 2021 Feb 16;99(2):219-225. Epub 2020 Nov 16.

Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.

Patients with PTEN hamartoma tumor syndrome (PHTS, comprising Cowden, Bannayan-Riley-Ruvalcaba, and Proteus-like syndromes) are at increased risk of developing cancer due to pathogenic PTEN germline variants. This review summarizes age-, sex-, and type-specific malignant cancer risks for PHTS patients, which is urgently needed for clinical management. A PubMed literature search for Standardized Incidence Ratios or Cumulative Lifetime cancer risks (CLTRs) resulted in nine cohort studies comprising four independent PHTS cohorts, including mainly index cases and prevalent cancer cases. Read More

Int J Reprod Biomed 2020 Oct 13;18(10):825-836. Epub 2020 Oct 13.

Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Endometriosis is generally considered as a benign condition; however, there is a possibility for it to become cancerous. miR-125b is upregulated in both endometriotic tissues and serum samples of women with endometriosis but its potential targets in endometriosis are still not fully understood.

Objective: The role of miR-125b in the regulation of expression in endometriosis was tested with a bioinformatics approach. Read More

Cells 2020 10 17;9(10). Epub 2020 Oct 17.

Department of Gynecology and Obstetrics, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.

Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts' regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be considered as a potential therapeutic agent for cancer treatment. Read More