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Safety of a Protective Funnel in Primary Breast Augmentation: A Retrospective Analysis of 380 Multicenter Cases in the United States.

Aesthet Surg J 2021 Apr 17. Epub 2021 Apr 17.

Background: Protective funnels devices are commonly used to deliver implants in primary breast augmentation (BA) yet there is a paucity of evidence-based data describing their safety in the literature.

Objectives: The purpose of the study was to assess the safety of protective funnels in primary BA within the first 30-days postoperatively.

Methods: This multi-center, Level 3 study retrospectively reviewed the surgical records of 380 consecutive patients (760 breasts) who underwent primary BA by nine board-certified plastic surgeons using the iNPLANT Funnel (Proximate Concepts LLC, Allendale, NJ, USA) for implant delivery between November 2019 and December 2020. Read More

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Phyllodes tumors of the breast: Adjuvant radiation therapy revisited.

Breast 2021 Apr 7;58:1-5. Epub 2021 Apr 7.

Radiation Oncology Department, National Cancer Institute, Cairo University, Egypt.

Background: Phyllodes tumors (PT) are rare entity and surgical resection is the cornerstone of treatment. No standard of care exists regarding adjuvant treatment especially radiation therapy (RT).

Patients And Methods: We analyzed all patients with non-metastatic, resected phyllodes tumors who presented to our institution from January 2005 through December 2019. Read More

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Characteristics of clinically node negative breast cancer patients needing preoperative MRI.

Surg Oncol 2021 Mar 31;38:101552. Epub 2021 Mar 31.

Department of Oncology, Turku University Hospital, Finland; University of Turku, Turku, Finland; Finnish Nuclear and Radiation Safety, Helsinki, Finland.

Background: International guidelines do not recommend magnetic resonance imaging (MRI) for all breast cancer patients at primary diagnostics. This study aimed to understand which patient or tumor characteristics are associated with the use of MRI. The role of MRI among other preoperative imaging methods in clinically node negative breast cancer was studied. Read More

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Decreased serum testosterone levels associated with 17β-hydroxysteroid dehydrogenase activity in 7-year-old children from a dioxin-exposed area of Vietnam.

Sci Total Environ 2021 Mar 30;783:146701. Epub 2021 Mar 30.

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.

Since 2008, we have conducted epidemiological cohort studies on the relationship between dioxin exposure and disruption with children in the area sprayed with defoliants during the Vietnam War. In a long-term survey of children through the age of five, we observed androgen disruption due to decreased dehydroepiandrosterone (DHEA) and testosterone levels. In this study of 7-year-old, we separately elucidated androgen disruption for boys and girls, and discussed with respect to hormone disruption with sex differences on the steroid hormone biosynthesis process. Read More

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Synthesis and evaluation of N-(4-(substituted)-3-(trifluoromethyl) phenyl) isobutyramides and their N-ethyl analogous as anticancer, anti-angiogenic & antioxidant agents: In vitro and in silico analysis.

Comput Biol Chem 2021 Apr 8;92:107484. Epub 2021 Apr 8.

Department of Biotechnology, Savitribai Phule Pune University, Pune, 411007, MS, India. Electronic address:

N-(4-(substituted)-3-(trifluoromethyl) phenyl) isobutyramides and their N-ethyl analogues (flutamides) are versatile scaffolds with a wide spectrum of biological activities. A series of new N-(4-(substituted)-3-(trifluoromethyl) phenyl) isobutyramides (8a-t) and their N-ethyl analogous (9a-t) were synthesized and characterized. The inhibitory potential of the synthesized compounds on the viability of three human cancer cell lines HEP3BPN 11 (liver), MDA-MB 453 (breast), and HL 60 (leukemia) were assessed. Read More

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Multifunctional nanoparticles as theranostic agents for therapy and imaging of breast cancer.

J Photochem Photobiol B 2020 Dec 29;218:112110. Epub 2020 Dec 29.

Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, Toronto, ON M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, M5B 1T8, Canada; Department of Physics, Ryerson University, Toronto, ON M5B 2K3, Canada. Electronic address:

Over the last decade, there has been significant developments in nanotechnology, in particular for combined imaging and therapeutic applications (theranostics). The core or shell of nanoemulsions (NEs) can be loaded with various therapeutic agents, including drugs with low solubility for effective treatment, or various imaging agents for specific imaging modalities (e.g. Read More

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December 2020

Corrigendum to 'Silver nanoparticles synthesis from Bacillus sp KFU36 and its anticancer effect in breast cancer MCF-7 cells via induction of apoptotic mechanism' [Journal of Photochemistry and Photobiology B: Biology, Volume 204, March 2020, 111786].

J Photochem Photobiol B 2021 Apr 14;218:112190. Epub 2021 Apr 14.

Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia; Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt. Electronic address:

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Surgical outcomes of different approaches in robotic assisted thyroidectomy for thyroid cancer: A systematic review and Bayesian network meta-analysis.

Int J Surg 2021 Apr 14:105941. Epub 2021 Apr 14.

Center of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, PR China. Electronic address:

Background: The aim of the study was to assess the feasibility, safety, and potential benefits of four approaches of robotic assisted thyroidectomy (RT). The approaches mentioned above are also compared with traditional open thyroidectomy (OPEN).

Materials And Methods: Medline, Embase, Cochrane library (CENTRAL) and Web of Science databases were searched up to 13 Dec, 2019. Read More

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Multifunctional ZnO@CuS nanoparticles cluster synergize chemotherapy and Photothermal therapy for tumor metastasis.

Nanomedicine 2021 Apr 14:102399. Epub 2021 Apr 14.

School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:

The poor drug delivery and unsatisfying therapeutic effects remain to be the primary challenges for cancer therapy. Nanosystem that combines multiple functions into a single platform is an ideal strategy. Here, a smart drug delivery nanoplatform (Z@C-D/P) based on ZnO@CuS nanoparticles, loaded with doxorubicin (DOX) and pirfenidone (PFD) was constructed. Read More

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Polymeric lipid hybrid nanoparticles as a delivery system enhance the antitumor effect of Emodin in vitro and in vivo.

J Pharm Sci 2021 Apr 14. Epub 2021 Apr 14.

College of Pharmacy, Jinan University, Guangzhou, 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, Guangzhou, 510632, China; Cancer Research Institute of Jinan University, Guangzhou, 510632, China; Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China. Electronic address:

This study aimed to evaluate the therapeutic efficacy of Emodin-loaded polymer lipid hybrid nanoparticles (E-PLNs) for breast cancer. The size, Zeta potential, surface morphology, encapsulation efficiency, stability, in vitro drug release of E-PLNs prepared by the nanoprecipitation method were characterized. The uptake, in-vitro cytotoxicities and apoptosis of free drug, E-PLNs were investigated against MCF-7 cells. Read More

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Establishment of The Tandem Mass Spectrometric Fingerprints of Taxane-Based Anticancer Compounds.

Rapid Commun Mass Spectrom 2021 Apr 17:e9107. Epub 2021 Apr 17.

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.

Compounds in the taxane drug family are among the most successful and effective chemotherapeutic agents used for the treatment of solid tumors, such as breast, ovarian, and prostate cancers. The tandem mass spectrometric (MS/MS) fragmentation behavior of these compounds are described in detail and a generalized MS/MS fingerprint is established for the first time. Five compounds were evaluated, namely paclitaxel, docetaxel, cabazitaxel, cephalomannine, and Baccatin III. Read More

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The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death.

Pharmacol Rep 2021 Apr 17. Epub 2021 Apr 17.

Division of Pharmacokinetics and Pharmacodynamics, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.

Background: Silver is a transition metal that is known to be less toxic than platinum. However, only few studies have reported the anticancer effects of some silver complexes and their possibility as an alternative to platinum complex. This study investigated the anticancer effects of the silver thiosulfate complex (STS), [Ag(SO)], consisting of silver and sodium thiosulfate. Read More

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Prognostic role of proliferating CD8 cytotoxic Tcells in human cancers.

Cell Oncol (Dordr) 2021 Apr 17. Epub 2021 Apr 17.

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, Martinistraße 52, D-20246, Hamburg, Germany.

Purpose: Expansion of CD8 cytotoxic Tlymphocytes is a prerequisite for anti-cancer immune activity and has gained interest in the era of immune checkpoint therapy.

Methods: To understand the CD8 T cell dynamics in the tumor microenvironment, we used multiplex fluorescence immunohistochemistry to quantitate CD8 proliferation (Ki67 co-expression) in tissue microarrays from 1107 colorectal, 642 renal cell, 1066 breast, 375 ovarian, 451 pancreatic and 347 gastric cancer samples.

Results: The density and the percentage of proliferating (Ki67) CD8 T cells were both highly variable between tumor types as well as between patients with the same tumor type. Read More

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LEP (-2548G>A LEP) and LEPR (223Gln>Arg, 109Lys>Arg) polymorphisms as breast cancer risk factors in the Polish female population.

Mol Biol Rep 2021 Apr 17. Epub 2021 Apr 17.

Department of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355, Poznan, Poland.

On a global scale, breast cancer is the most common type of cancer in women, and it is still a growing problem. Therefore, new prognostic or diagnostic markers are required that would facilitate the assessment of patients or provide more efficient therapy, respectively. In these studies, we analyzed the contribution of LEP (2548G>A) and LEPR (109 Lys>Arg and 223Gln>Arg) genes polymorphisms to the risk of breast cancer development. Read More

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Detection of activating mutations in liquid biopsy of Egyptian breast cancer patients using targeted next-generation sequencing: a pilot study.

J Egypt Natl Canc Inst 2021 Apr 17;33(1):10. Epub 2021 Apr 17.

Clinical Oncology Department, School of Medicine, Cairo University, Cairo, Egypt.

Background: Breast cancer (BC) is the 2 most prevalent malignancy worldwide and is the most prevalent cancer among Egyptian women. The number of newly described cancer-associated genes has grown exponentially since the emergence of next-generation sequencing (NGS) technology. We aim to identify activating mutations in liquid biopsy of Egyptian breast cancer patients using targeted NGS technology. Read More

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Cardiovascular toxicity of breast cancer treatment: an update.

Cancer Chemother Pharmacol 2021 Apr 17. Epub 2021 Apr 17.

Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528, Athens, Greece.

Novel chemotherapeutic agents have marked a new era in oncology during the past decade, prolonging significantly the overall survival of breast cancer patients. Nevertheless, contemporary antineoplastic treatments can frequently cause adverse cardiovascular side effects. Common manifestations of chemotherapy-induced cardiotoxicity include cardiomyopathy, ischemia, conduction disturbances, hypertension and thromboembolic events, while the type of the treatment regimen administered crucially determines clinical outcome. Read More

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Commentary on: Understanding Breast Implant Illness: Etiology is the Key.

Aesthet Surg J 2021 Apr 17. Epub 2021 Apr 17.

clinical instructor of surgery, Washington University, St. Louis, MO.

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The Prognostic Value of Lymph Node Metastasis and the Eighth Edition of AJCC for Patients with Anaplastic Thyroid Cancer.

Clin Endocrinol (Oxf) 2021 Apr 17. Epub 2021 Apr 17.

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, P. R. China.

Objective: The eighth edition of the American Joint Committee on Cancer (AJCC-v8) for anaplastic thyroid cancer (ATC) made a revision in staging for patients with lymph node metastasis (LNM) based on the seventh edition of AJCC (AJCC-v7). Our study aimed to evaluate the predictive ability of AJCC-v8 for survival in patients with ATC by exploring the association between lymph node stage and prognosis of ATC patients.

Methods: Retrospective study of ATC in Surveillance, Epidemiology and End Results (SEER) database. Read More

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Urban trees in university campus: structure, function, and ecological values.

Environ Sci Pollut Res Int 2021 Apr 16. Epub 2021 Apr 16.

Shenyang Institute of Technology, Fushun, 113122, People's Republic of China.

University campuses usually have more trees and can provide various ecosystem services. However, there are few reports on tree ecosystem services of Chinese university campuses, especially in northern China. This study investigated the trees in the campus of Shenyang Institute of Technology and analyzed its ecological benefits and monetary value through i-Tree Streets. Read More

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DNA repair in primordial follicle oocytes following cisplatin treatment.

J Assist Reprod Genet 2021 Apr 16. Epub 2021 Apr 16.

Ovarian Biology Laboratory, Monash Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, 3800, Australia.

Purpose: Genotoxic chemotherapy and radiotherapy can cause DNA double stranded breaks (DSBs) in primordial follicle (PMF) oocytes, which then undergo apoptosis. The development of effective new fertility preservation agents has been hampered, in part, by a limited understanding of DNA repair in PMF oocytes. This study investigated the induction of classical DSB repair pathways in the follicles of wild type (WT) and apoptosis-deficient Puma mice in response to DSBs caused by the chemotherapy agent cisplatin. Read More

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NSDHL promotes triple-negative breast cancer metastasis through the TGFβ signaling pathway and cholesterol biosynthesis.

Breast Cancer Res Treat 2021 Apr 16. Epub 2021 Apr 16.

Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Build 7, Room 303, Shanghai, 200032, China.

Purpose: Metastasis is the main cause of breast cancer mortality. Recent studies have proved that lipid metabolic reprogramming plays critical roles in breast cancer carcinogenesis and metastasis. We aim to identify critical lipid metabolism genes in breast cancer metastasis. Read More

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The development and initial validation of the Breast Cancer Recurrence instrument (BreastCaRe)-a patient-reported outcome measure for detecting symptoms of recurrence after breast cancer.

Qual Life Res 2021 Apr 16. Epub 2021 Apr 16.

Psychological Aspects of Cancer, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.

Purpose: Patient-reported outomes (PRO) may facilitate prompt treatment. We describe the development and psychometric properties of the first instrument to monitor for symptoms of breast cancer (BC) recurrence.

Methods: This study is nested in the MyHealth randomized trial of nurse-led follow-up based on electronically-collected PROs. Read More

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Cancer Treatment-Induced Bone Loss (CTIBL): State of the Art and Proper Management in Breast Cancer Patients on Endocrine Therapy.

Curr Treat Options Oncol 2021 Apr 16;22(5):45. Epub 2021 Apr 16.

Medical Oncology, Department of Precision Medicine, School of Medicine, "Luigi Vanvitelli" University of Campania, 80131, Naples, Italy.

Opinion Statement: About 70-80% of early breast cancer (BC) patients receive adjuvant endocrine therapy (ET) for at least 5 years. ET includes in the majority of cases the use of aromatase inhibitors, as upfront or switch strategy, that lead to impaired bone health. Given the high incidence and also the high prevalence of BC, cancer treatment-induced bone loss (CTIBL) represents the most common long-term adverse event experimented by patients with hormone receptor positive tumours. Read More

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Embryonic thermal manipulation of Japanese quail: effects on embryonic development, hatchability, and post-hatch performance.

Trop Anim Health Prod 2021 Apr 16;53(2):263. Epub 2021 Apr 16.

Anatomy and Embryology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

Embryonic thermal manipulation led to several modifications in molecular, physiological, and biochemical parameters which affect pre- and post-hatch growth performance. The current study aims to elucidate the onset and long-term effects of intermittent thermal manipulations (TM) during two-time windows, early/late, of embryogenesis in Japanese quail (Coturnix japonica) on embryonic development, hatchability, muscle histogenesis, and post-hatch growth performance. Four groups were created; quail eggs in the control group were incubated at 37. Read More

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Correction to: Invited Discussion on: Muscle-Splitting Transaxillary Breast Implant Revision Surgery: a Single Surgeon's Experience.

Aesthetic Plast Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Surgery, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

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Treating Anisomastia and Tuberous Breast with Fat Grafting: Technique and Evaluation of Outcomes Using BREAST-Q Surveys.

Aesthetic Plast Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Senology, Evangelische Kliniken Gelsenkirchen, Munckelstrasse 27, 45879, Gelsenkirchen, Germany.

Background: In the surgical correction of tuberous breast deformity, implants and regional flaps play a prominent role. Lately, fat grafting has been used as an alternative, but there is evidence that patient satisfaction is higher after correction with implants compared with lipofilling.

Methods: We report a tuberous breasts correction series of ten cases, enrolled between 2015 and 2018. Read More

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Hematoma After Non-Oncologic Breast Procedures: A Comprehensive Review of the Evidence.

Aesthetic Plast Surg 2021 Apr 16. Epub 2021 Apr 16.

Hansjörg Wyss Department of Plastic Surgery, New York University Langone Health, 222 East 41st Street, New York, NY, 10017, USA.

Background: Hematoma after non-oncologic breast surgery is a common concern requiring expeditious treatment. The purpose of this study is to perform an evidence-based review of perioperative factors that may contribute to hematoma in non-oncologic breast procedures.

Methods: A comprehensive literature review was performed of non-oncologic breast procedures: breast augmentation, single-stage augmentation-mastopexy, mastopexy, and reduction. Read More

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Markers of vitamin D metabolism and premenstrual symptoms in healthy women with regular cycles.

Hum Reprod 2021 Apr 16. Epub 2021 Apr 16.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Study Question: Are insufficient 25-hydroxyvitamin D (25(OH)D) concentrations, and other markers of vitamin D metabolism, associated with premenstrual symptoms in healthy women with regular menstrual cycles?

Summary Answer: 25(OH)D insufficiency was associated with specific physical premenstrual symptoms, while no associations were observed with psychological symptoms or with other markers of vitamin D metabolism.

What Is Known Already: Prior studies evaluating vitamin D and premenstrual symptoms have yielded mixed results, and it is unknown whether 25(OH)D insufficiency and other markers of vitamin D metabolism are associated with premenstrual symptoms.

Study Design, Size, Duration: We used two cohorts of women with regular menstrual cycles; 1191 women aged 18-40 years in EAGeR (cross-sectional analysis of a prospective cohort within a randomized trial) and 76 women aged 18-44 years in BioCycle (prospective cohort). Read More

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Precision oncology in metastatic colorectal cancer - from biology to medicine.

Nat Rev Clin Oncol 2021 Apr 16. Epub 2021 Apr 16.

Department of Oncology, University of Torino, Candiolo, Italy.

Remarkable progress has been made in the development of biomarker-driven targeted therapies for patients with multiple cancer types, including melanoma, breast and lung tumours, although precision oncology for patients with colorectal cancer (CRC) continues to lag behind. Nonetheless, the availability of patient-derived CRC models coupled with in vitro and in vivo pharmacological and functional analyses over the past decade has finally led to advances in the field. Gene-specific alterations are not the only determinants that can successfully direct the use of targeted therapy. Read More

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