225,463 results match your criteria branch

A multiview feature fusion model for heartbeat classification.

Physiol Meas 2021 May 13. Epub 2021 May 13.

Northeastern University College of Information Science and Engineering, Shenyang, 110819, CHINA.

Objective: Electrocardiogram (ECG) is one of the most common means to diagnose arrhythmia according to different waveforms clinically. Although there are advanced classification methods such as deep learning, the single view feature cannot meet the demand of classification accuracy for new individuals. To this end, a classification model based on multiview fusion was proposed. Read More

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Biofilm characteristics and transcriptomic analysis of Haemophilus parasuis.

Vet Microbiol 2021 Apr 29;258:109073. Epub 2021 Apr 29.

Sichuan Provincial Key Laboratory of Animal Diseases and Human Health, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:

Haemophilus parasuis (H. parasuis) is a conditional pathogen with the ability to form biofilms which can lead to ineffective drug treatment and severe chronic infections resulting in significant economic losses to the pig industry. Currently, knowledge of biofilm formation by H. Read More

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Postoperative adjuvant dose-dense chemotherapy with bevacizumab and maintenance bevacizumab after neoadjuvant chemotherapy for advanced ovarian cancer: A phase II AGOG/TGOG trial.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 18;262:13-20. Epub 2021 Apr 18.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan; Gynecologic Cancer Research Center, Chang Gung Memorial Hospital, Linkou Branch and Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: The objective of this study is to evaluate the safety and efficacy of adding bevacizumab to dose-dense adjuvant chemotherapy with bevacizumab maintenance after neoadjuvant chemotherapy (NAC) and interval debulking surgery (IDS) for stage III/IV ovarian, tubal, and primary peritoneal cancer.

Study Design: This phase II clinical trial using Simon's minimax two-stage design was conducted. At the first stage, 13 subjects were enrolled, and the trial would proceed to second stage if ≤3 subjects discontinued treatment for study-defined significant adverse events (AEs). Read More

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Assessment of metal pollution and subsequent ecological risk in the coastal zone of the Olkhon Island, Lake Baikal, Russia.

Sci Total Environ 2021 May 4;786:147441. Epub 2021 May 4.

V.S. Sobolev Institute of Geology and Mineralogy, Siberian Branch of Russian Academy of Sciences, avenue ak. Kptyuga, 3, Novosibirsk 630090, Russia.

Olkhon Island is the largest island in Lake Baikal and a part of Baikal National Park, Russia. The first objective of this study is to establish relationships between the particle size of accumulating sediments and their elemental composition, as well as the concentrations of heavy metals (Hg, Cd, As, Pb, Cr, Co, Ni, Cu, and Zn). The second goal is to completely assess the contamination level and to identify the possible sources of heavy metals using geochemical indices, including enrichment (EF) and contamination (C) factors, contamination degree (C), geoaccumulation index (I), and pollution load index (PLI). Read More

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Prioritizing cancer hazard assessments for IARC Monographs using an integrated approach of database fusion and text mining.

Environ Int 2021 May 10;156:106624. Epub 2021 May 10.

Evidence Synthesis and Classification Branch, International Agency for Research on Cancer, Lyon, France.

Background: Systematic evaluation of literature data on the cancer hazards of human exposures is an essential process underlying cancer prevention strategies. The scope and volume of evidence for suspected carcinogens can range from very few to thousands of publications, requiring a complex, systematically planned, and critical procedure to nominate, prioritize and evaluate carcinogenic agents. To aid in this process, database fusion, cheminformatics and text mining techniques can be combined into an integrated approach to inform agent prioritization, selection, and grouping. Read More

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Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective cohort study.

Environ Int 2021 May 10;156:106621. Epub 2021 May 10.

Ministry of Education -Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Jiao Tong University School of Public Health, Shanghai, China. Electronic address:

Background: Humans are widely exposed to environmental perfluoroalkyl substances (PFAS), which may affect glucose homeostasis. However, research linking PFAS exposure to glucose homeostasis during pregnancy is limited and the results were inconsistent. We aimed to investigate the association between PFAS exposure and glucose homeostasis in pregnancy in a large prospective cohort. Read More

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Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.

PLoS One 2021 13;16(5):e0251598. Epub 2021 May 13.

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.

Background: Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development.

Objective: Our objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage. Read More

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The effect of remuneration schedule on data completion and retention in the pregnancy eating attributes study (PEAS).

PLoS One 2021 13;16(5):e0251533. Epub 2021 May 13.

Division of Intramural Population Health Research, Social and Behavioral Sciences Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America.

Maximizing data completion and study retention is essential in population research. This study examined the effect of remuneration schedule and data collection modality on data completion and retention in the Pregnancy Eating Attributes Study cohort. Participants (n = 458) completed online surveys and attended six in-person study visits. Read More

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Mapping soil salinity using a combined spectral and topographical indices with artificial neural network.

PLoS One 2021 13;16(5):e0228494. Epub 2021 May 13.

Department of Natural Resources and Environment, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Monitoring the status of natural and ecological resources is necessary for conservation and protection. Soil is one of the most important environmental resources in agricultural lands and natural resources. In this research study, we used Landsat 8 and Artificial Neural Network (ANN) to monitor soil salinity in Qom plain. Read More

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Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds.

PLoS Genet 2021 May 13;17(5):e1009543. Epub 2021 May 13.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and clinically similar counterpart affects flat-coated retrievers (FCRs) at unusually high frequency, with 20% developing the lethal disease. The similar clinical presentation combined with the closed population structure of dogs, leading to high genetic homogeneity, makes dogs an excellent model for genetic studies of cancer susceptibility. Read More

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Epidemiology of Heart Failure: A Contemporary Perspective.

Circ Res 2021 May 13;128(10):1421-1434. Epub 2021 May 13.

Department of Quantitative Health Sciences and Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN. Now at Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health. Véronique L Roger, MD, MPH is now at Chief, Epidemiology and Community Health Branch National Heart, Lung and Blood Institute, National Institutes of Health.

Designated as an emerging epidemic in 1997, heart failure (HF) remains a major clinical and public health problem. This review focuses on the most recent studies identified by searching the Medline database for publications with the subject headings HF, epidemiology, prevalence, incidence, trends between 2010 and present. Publications relevant to epidemiology and population sciences were retained for discussion in this review after reviewing abstracts for relevance to these topics. Read More

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-Ammonium Ylide Mediators for Electrochemical C-H Oxidation.

J Am Chem Soc 2021 May 13. Epub 2021 May 13.

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

The site-specific oxidation of strong C(sp)-H bonds is of uncontested utility in organic synthesis. From simplifying access to metabolites and late-stage diversification of lead compounds to truncating retrosynthetic plans, there is a growing need for new reagents and methods for achieving such a transformation in both academic and industrial circles. One main drawback of current chemical reagents is the lack of diversity with regard to structure and reactivity that prevents a combinatorial approach for rapid screening to be employed. Read More

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ToxChip PCR Arrays for Two Arctic-Breeding Seabirds: Applications for Regional Environmental Assessments.

Environ Sci Technol 2021 May 13. Epub 2021 May 13.

National Wildlife Research Centre, Environment and Climate Change Canada, 1125 Colonel By Dr., Ottawa, ON ON K1S, Canada.

Increasing pollution in the Arctic poses challenges in terms of geographical and ecological monitoring. The Baffin Bay-Davis Strait (BBDS) region in the Canadian Arctic Archipelago is of particular concern due to the potential for increased shipping traffic and oil exploration. However, data on background contaminants associated with oil exploration/spills/natural seeps (e. Read More

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RNA externalized by neutrophil extracellular traps promotes inflammatory pathways in endothelial cells.

Arthritis Rheumatol 2021 May 13. Epub 2021 May 13.

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland, USA.

Objectives: Neutrophil extracellular traps (NETs) are extracellular lattices composed of nucleic material bound to neutrophil granule proteins. NETs may play pathogenic roles in development and severity of autoimmune diseases such as systemic lupus erythematosus (SLE), at least in part, through induction of type I interferon (IFN) responses via externalization of oxidized immunostimulatory DNA. A distinct subset of SLE proinflammatory neutrophils (low density granulocytes; LDGs) displays enhanced ability to form proinflammatory NETs that damage the vasculature. Read More

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Harvesting water from unsaturated atmospheres: deliquescence of salt secreted onto leaf surfaces drives reverse sap flow in a dominant arid climate mangrove, Avicennia marina.

New Phytol 2021 May 13. Epub 2021 May 13.

Plant Science Division, Research School of Biology, The Australian National University, Acton, ACT, 2601, Australia.

The mangrove Avicennia marina adjusts internal salt concentrations by foliar salt secretion. Deliquescence of accumulated salt causes leaf wetting which may provide a water source for salt-secreting plants in arid coastal wetlands where high nocturnal humidity can usually support deliquescence whereas rainfall events are rare. We tested the hypotheses that salt deliquescence on leaf surfaces can drive top-down rehydration, and that such absorption of moisture from unsaturated atmospheres makes a functional contribution to dry season shoot water balances. Read More

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Quaternary ammonium salts based on (-)-borneol as effective inhibitors of influenza virus.

Arch Virol 2021 May 13. Epub 2021 May 13.

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, Novosibirsk, Russia, 630090.

A series of compounds containing a 1,7,7-trimethylbicyclo[2.2.1]heptane fragment were evaluated for their antiviral activity against influenza A virus strain A/Puerto Rico/8/34 (H1N1) in vitro. Read More

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Parametric-based feature selection via spherical harmonic coefficients for the left ventricle myocardial infarction screening.

Med Biol Eng Comput 2021 May 13. Epub 2021 May 13.

Department of Biomedical Engineering and Medical Physics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Computer-aided diagnosis (CAD) of heart diseases using machine learning techniques has recently received much attention. In this study, we present a novel parametric-based feature selection method using the three-dimensional spherical harmonic (SHs) shape descriptors of the left ventricle (LV) for intelligent myocardial infarction (MI) classification. The main hypothesis is that the SH coefficients of the parameterized endocardial shapes in MI patients are recognizable and distinguishable from healthy subjects. Read More

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eCOMPASS: evaluative comparison of multiple protein alignments by statistical score.

Bioinformatics 2021 May 13. Epub 2021 May 13.

Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.

Motivation: Detecting subtle biologically relevant patterns in protein sequences often requires the construction of a large and accurate multiple sequence alignment (MSA). Methods for constructing MSAs are usually evaluated using benchmark alignments, which, however, typically contain very few sequences and are therefore inappropriate when dealing with large numbers of proteins.

Results: eCOMPASS addresses this problem using a statistical measure of relative alignment quality based on direct coupling analysis (DCA): To maintain protein structural integrity over evolutionary time, substitutions at one residue position typically result in compensating substitutions at other positions. Read More

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Prevalence of genital human papillomavirus by age and race/ ethnicity among males.

Clin Infect Dis 2021 May 13. Epub 2021 May 13.

Center for Interdisciplinary Research in Women's Health, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX, USA.

Background: Genital and oral cancers are often caused by human papillomavirus (HPV) types that can be prevented through HPV vaccination. Since HPV is sexually transmitted, knowledge of penile prevalence of vaccine-type HPV among US males can help predict potential disparities in these cancers. This study examines penile HPV prevalence by age and race/ethnicity among males. Read More

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Mutational signatures of replication timing and epigenetic modification persist through the global divergence of mutation spectra across the great ape phylogeny.

Genome Biol Evol 2021 May 13. Epub 2021 May 13.

University of Washington Department of Genome Sciences, 3720 15th Ave NE, Seattle WA 98105, United States of America.

Great ape clades exhibit variation in the relative mutation rates of different three-base-pair genomic motifs, with closely related species having more similar mutation spectra than distantly related species. This pattern cannot be explained by classical demographic or selective forces, but imply that DNA replication fidelity has been perturbed in different ways on each branch of the great ape phylogeny. Here, we use whole-genome variation from 88 great apes to investigate whether these species' mutation spectra are broadly differentiated across the entire genome, or whether mutation spectrum differences are driven by DNA compartments that have particular functional features or chromatin states. Read More

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Genomic and Hormonal Biomarkers of Phthalate-Induced Male Rat Reproductive Developmental Toxicity Part II: A Targeted RT-qPCR Array Approach that Defines a Unique Adverse Outcome Pathway.

Toxicol Sci 2021 May 12. Epub 2021 May 12.

Fuquay Varina.

Previously, we demonstrated that exposure to some diortho-phthalate esters during sexual differentiation disrupts male reproductive development by reducing fetal rat testis testosterone production (T Prod) and gene expression in a dose-related manner. The objectives of the current project were to expand the number of test compounds that might reduce fetal T Prod, including phthalates, phthalate alternatives, pesticides, and drugs, and to compare reductions in T Prod with altered testis mRNA expression. We found that PEs that disrupt T Prod also reduced expression of a unique "cluster" of mRNAs for about 35 genes related to sterol transport, testosterone and insl3 hormone syntheses, and lipoprotein signaling and cholesterol synthesis. Read More

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Anatomical Study of the Interosseous Ligament of the Tibiofibular Syndesmosis: An Analysis of Osseous Morphology and Attaching Interposing Structures.

J Bone Joint Surg Am 2021 May;103(10):905-912

Departments of Clinical Anatomy (A.T., M.T., R.Y., and K.A.), Orthopaedic and Spinal Surgery (A.T. and A.O.), and Functional Joint Anatomy (A.N.), Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Background: The morphological features of the interosseous tibiofibular area in relation to the tensile stress of the interosseous ligament (IOL) have rarely been discussed. The purpose of the present study was to investigate the IOL on the basis of osseous surface morphology and macroscopic and histological anatomy. We hypothesized that the osseous surface of the interosseous tibiofibular area has a specific feature corresponding to the fibrous structure in the IOL. Read More

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How Academic Medical Centers Can Navigate the Pandemic and its Aftermath: Solutions for Three Major Issues.

Acad Med 2021 May 11. Epub 2021 May 11.

B.F. Godley is Adjunct Professor, Ophthalmology and Visual Sciences, University of Texas, Medical Branch. T.J. Lawley is William P. Timmie Professor of Dermatology and Former Dean at Emory School of Medicine. A. Rubenstein is Professor in the Department of Medicine and the Division of Endocrinology and Former Dean and Executive Vice President at the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania. P.A. Pizzo is the David and Susan Heckerman Professor of Pediatrics and of Microbiology and Immunology at Stanford and Former Dean, School of Medicine and Founding Director of the Stanford Distinguished Careers Institute, Stanford University; ORCID: https://orcid.org/0000-0002-1000-6516.

The COVID-19 crisis has seriously affected academic medical centers (AMCs) on multiple levels. Combined with many trends that were already under way pre-pandemic, the current situation has generated significant disruption and underscored the need for change within and across AMCs. In this article, the authors explore some of the major issues and propose actionable solutions in 3 areas of concentration. Read More

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Magnetic-Field-Driven Electron Dynamics in Graphene.

J Phys Chem Lett 2021 May 13:4749-4754. Epub 2021 May 13.

Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108, United States.

Graphene exhibits unique optoelectronic properties originating from the band structure at the Dirac points. It is an ideal model structure to study the electronic and optical properties under the influence of the applied magnetic field. In graphene, electric field, laser pulse, and voltage can create electron dynamics which is influenced by momentum dispersion. Read More

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Cross-cultural representations of conjoined twins.

Am J Med Genet C Semin Med Genet 2021 May 13. Epub 2021 May 13.

Genomic Medicine Institute-Geisinger, Danville, Pennsylvania, USA.

Conjoined twinning is a rare birth defect estimated to occur in about 1 in 50,000 to 100,000 births. The mechanism of conjoined twinning is not proven. Different forms of conjoined twinning are observed with the thoracopagus form being the most common. Read More

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An electrochemical sensor based on hierarchical nickel oxide nanostructures doped with indium ions for voltammetric simultaneous determination of sunset yellow and tartrazine colorants in soft drink powders.

Anal Methods 2021 May 13. Epub 2021 May 13.

Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.

The current study was designed to develop a single-step and simple approach to effectively fabricate three-dimensional raspberry-like In3+/NiO hierarchical nanostructures (In3+/NiO RLHNSs) as a modifier, which was subsequently characterized by the techniques of X-ray diffraction (XRD), energy dispersive spectrometry (EDS) and field emission scanning electron microscopy (FE-SEM). The new prepared nano-modifier was practically used to co-detect electrochemically sunset yellow and tartrazine dyes. Potent sensitivity and acceptable selectivity were obtained for the produced In3+/NiO RLHNSs to co-detect both the food colorants, thus providing oxidation peaks in differential pulse voltammetry (DPV) with a peak potential separation of ca. Read More

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[Thinking and practice of key links in design of clinical trial scheme for treatment of influenza with traditional Chinese medicine].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1706-1710

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing 100010, China.

To sort out the key points in "PICOS" design of clinical trial scheme for influenza, and optimize the clinical trial scheme of Chinese patent medicine in the treatment of influenza by strictly following the principle of evidence-based medicine, focusing on the clinical practice of the disease, and highlighting the characteristics of traditional Chinese medicine. "The design of a randomized, double-blind, positive parallel control study of a certain herbal preparation for the treatment of non-severe influenza" was taken as an example in this study, and the key points in the clinical trial design of Chinese patent medicine for the treatment of influenza were specifically discussed from six aspects, including the type of study, object of study, intervention measures, control measures, outcome indicators and frequently asked questions in test design. From methodological suggestions, in the design scheme of clinical trial on efficacy and safety of Chinese patent medicine in the treatment of influenza, the randomized controlled study should be the first choice for type of study; the inclusion criteria should define both the diagnostic criteria of Western medicine and the syndromes of traditional Chinese medicine(TCM); the exclusion criteria should include a comprehensive list of confounding factors and special circumstances lea-ding to bias in the study results; the interventions should be based on a well-defined dosing programme; internationally recognized positive drugs or guidelines should be used as control measures, with median antipyretic time as the main outcome indicator. Read More

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Fungal Ice2p is in the same superfamily as SERINCs, restriction factors for HIV and other viruses.

Proteins 2021 May 13. Epub 2021 May 13.

UCL Institute of Ophthalmology, London, United Kingdom.

Ice2p is an integral endoplasmic reticulum (ER) membrane protein in budding yeast S. cerevisiae named ICE because it is required for Inheritance of Cortical ER. Ice2p has also been reported to be involved in an ER metabolic branch-point that regulates the flux of lipid either to be stored in lipid droplets or to be used as membrane components. Read More

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Racial/ethnic disparities in use of surveillance mammogram among breast cancer survivors: a systematic review.

J Cancer Surviv 2021 May 13. Epub 2021 May 13.

Department of Health Promotion and Behavioral Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.

Background: Increasing number of breast cancer survivors in the USA have led to greater focus on the long-term health outcomes and surveillance care among these women. However limited evidence exists of use of surveillance mammography among breast cancer survivors and how it varies across racial/ethnic groups.

Methods: We conducted a systematic review of the literature to explore disparities in use of surveillance mammogram among women breast cancer survivors by searching for relevant studies published between 2000 and 2020 from Medline (Ovid), PubMed (National Library of Medicine), and PsycINFO (Ovid) bibliographic databases. Read More

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An unresolved issue: Diagnosing coronary artery disease in left bundle branch block.

J Nucl Cardiol 2021 May 12. Epub 2021 May 12.

Department of Cardiology, Gazi Osman Paşa Hospital, Yeni Yüzyıl University Istanbul, Istanbul, Turkey.

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