903 results match your criteria brains zikv


Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case report with long term follow up.

J Neuroimmunol 2021 Apr 28;356:577590. Epub 2021 Apr 28.

Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka 1212, Bangladesh. Electronic address:

A 50-years old male presented with quadriplegia and paresthesia and was diagnosed as Guillain-Barré syndrome (GBS). He was found positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) six weeks prior to the onset of weakness. GBS disability score was 4. Read More

View Article and Full-Text PDF

Factors associated with increased odds of sensorineural hearing loss in infants exposed to the Zika virus during pregnancy.

J Infect Dev Ctries 2021 Apr 30;15(4):590-594. Epub 2021 Apr 30.

Faculty of Civil Engineering, University of Colima, Coquimatlan, Mexico.

Introduction: The Zika virus (ZIKV) infection in pregnant women has been associated with an increased risk of birth defects. We aimed to estimate the prevalence of sensorineural hearing loss (SNHL) in infants exposed to the ZIKV during their gestation and evaluate the factors associated with its increased odds.

Methodology: A cross-sectional study was performed from July 2016 to June 2019 in a Western state of Mexico and data from 61 infants that presented with laboratory-positive (RT-qPCR) evidence of in utero exposure to ZIKV were analyzed. Read More

View Article and Full-Text PDF

Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: Implications for CNS complications.

Glia 2021 May 4. Epub 2021 May 4.

College of Medical, Veterinary, and Life Sciences, Institute of Infection, Immunity and Inflammation, Glasgow, UK.

Some children with proven intrauterine Zika virus (ZIKV) infection who were born asymptomatic subsequently manifested neurodevelopmental delays, pointing to impairment of development perinatally and postnatally. To model this, we infected postnatal day (P) 5-6 (equivalent to the perinatal period in humans) susceptible mice with a mammalian cell-propagated ZIKV clinical isolate from the Brazilian outbreak in 2015. All infected mice appeared normal up to 4 days post-intraperitoneal inoculation (dpi), but rapidly developed severe clinical signs at 5-6 dpi. Read More

View Article and Full-Text PDF

Plasma lipidome profiling of newborns with antenatal exposure to Zika virus.

PLoS Negl Trop Dis 2021 Apr 30;15(4):e0009388. Epub 2021 Apr 30.

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.

The 2015-2016 Zika virus (ZIKV) outbreak in Brazil was remarkably linked to the incidence of microcephaly and other deleterious clinical manifestations, including eye abnormalities, in newborns. It is known that ZIKV targets the placenta, triggering an inflammatory profile that may cause placental insufficiency. Transplacental lipid transport is delicately regulated during pregnancy and deficiency on the delivery of lipids such as arachidonic and docosahexaenoic acids may lead to deficits in both brain and retina during fetal development. Read More

View Article and Full-Text PDF

Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome.

Front Med (Lausanne) 2021 13;8:499016. Epub 2021 Apr 13.

Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Yucatan, Mexico.

Zika virus was recognized as a teratogen in 2015, when prenatal Zika infection was associated with neonatal microcephaly. The transmission, virulence, tropism, and consequences of Zika virus infection during pregnancy are currently studied. Decreased neural progenitor cells, arrest in neuronal migration and/or disruption of the maturation process of the fetus central nervous system have been associated. Read More

View Article and Full-Text PDF

Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection.

Pathogens 2021 Apr 13;10(4). Epub 2021 Apr 13.

Departamento de Química Analítica, Instituto de Química, Universidade Federal da Bahia, Rua Barao de Jeremoabo, 147, Salvador, BA 40170-115, Brazil.

Zika virus (ZIKV), an emerging virus belonging to the Flaviviridae family, causes severe neurological clinical complications and has been associated with Guillain-Barré syndrome, fetal abnormalities known collectively as congenital Zika syndrome, and microcephaly. Studies have shown that ZIKV infection can alter cellular metabolism, directly affecting neural development. Brain growth requires controlled cellular metabolism, which is essential for cell proliferation and maturation. Read More

View Article and Full-Text PDF

Persistence of Anti-ZIKV-IgG over Time Is Not a Useful Congenital Infection Marker in Infants Born to ZIKV-Infected Mothers: The NATZIG Cohort.

Viruses 2021 04 20;13(4). Epub 2021 Apr 20.

Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.

Confirming ZIKV congenital infection is challenging because viral RNA is infrequently detected. We compared the presence of anti-ZIKV-IgM and the persistence of anti-ZIKV-IgG antibodies over 18 months in two cohorts of infants born to ZIKV-infected mothers: Cohort one: 30 infants with typical microcephaly or major brain abnormalities (Congenital Zika Syndrome-CZS); Cohort two: 123 asymptomatic infants. Serum samples obtained within 6 months of age were tested for anti-ZIKV-IgM. Read More

View Article and Full-Text PDF

A Live-attenuated Zika Virus Vaccine with High Production Capacity Confers Effective Protection in Neonatal Mice.

J Virol 2021 Apr 28. Epub 2021 Apr 28.

State Key Laboratories of Respiratory Diseases, Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

Zika virus (ZIKV) infection during pregnancy has been linked to congenital abnormalities such as microcephaly in infants. An efficacious vaccine is still desirable for preventing the potential recurrence of ZIKV epidemic. Here, we report the generation of an attenuated ZIKV (rGZ02a) that has sharply decreased virulence in mice but grows to high titers in Vero cells, a widely approved cell line for manufacturing human vaccines. Read More

View Article and Full-Text PDF

Impact of deltamethrin-resistance in Aedes albopictus on its fitness cost and vector competence.

PLoS Negl Trop Dis 2021 Apr 27;15(4):e0009391. Epub 2021 Apr 27.

Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, China.

Background: Aedes albopictus is one of the most invasive species in the world as well as the important vector for mosquito-borne diseases such as dengue fever, chikungunya fever and zika virus disease. Chemical control of mosquitoes is an effective method to control mosquito-borne diseases, however, the wide and improper application of insecticides for vector control has led to serious resistance problems. At present, there have been many reports on the resistance to pyrethroid insecticides in vector mosquitoes including deltamethrin to Aedes albopictus. Read More

View Article and Full-Text PDF

The Neurobiology of Zika Virus: New Models, New Challenges.

Front Neurosci 2021 29;15:654078. Epub 2021 Mar 29.

Hospital Israelita Albert Einstein, São Paulo, Brazil.

The Zika virus (ZIKV) attracted attention due to one striking characteristic: the ability to cross the placental barrier and infect the fetus, possibly causing severe neurodevelopmental disruptions included in the Congenital Zika Syndrome (CZS). Few years after the epidemic, the CZS incidence has begun to decline. However, how ZIKV causes a diversity of outcomes is far from being understood. Read More

View Article and Full-Text PDF

Zika virus dysregulates the expression of astrocytic genes involved in neurodevelopment.

PLoS Negl Trop Dis 2021 Apr 23;15(4):e0009362. Epub 2021 Apr 23.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.

Zika virus (ZIKV) is a kind of flavivirus emerged in French Polynesia and Brazil, and has led to a worldwide public health concern since 2016. ZIKV infection causes various neurological conditions, which are associated with fetus brain development or peripheral and central nervous systems (PNS/CNS) functional problems. To date, no vaccine or any specific antiviral therapy against ZIKV infection are available. Read More

View Article and Full-Text PDF

The Neurobiology of Modern Viral Scourges: ZIKV and COVID-19.

Neuroscientist 2021 Apr 19:10738584211009149. Epub 2021 Apr 19.

Department of Neurosciences and Pediatrics, University of California San Diego, La Jolla, CA, USA.

The interactions of viruses with the nervous system were thought to be well understood until the recent outbreaks of Zika and SARS-CoV-2. In this review, we consider these emerging pathogens, the range and mechanisms of the neurological disease in humans, and how the biomedical research enterprise has pivoted to answer questions about viral pathogenesis, immune response, and the special vulnerability of the nervous system. ZIKV stands out as the only new virus in a generation, associating with congenital brain defects, neurological manifestations of microcephaly in newborns, and radiculopathy in adults. Read More

View Article and Full-Text PDF

Differential expression of miRNAs in a human developing neuronal cell line chronically infected with Zika virus.

Libyan J Med 2021 Dec;16(1):1909902

Department of Aquatic Research, Aqua Cognoscenti LLC, West Columbia, SC, USA.

Zika virus (ZIKV) is a serious public health concern that may lead to neurological disorders in affected individuals. The virus can be transmitted from an infected mother to her fetus, via mosquitoes, or sexually. ZIKV infections are associated with increased risk for Guillain-Barré syndrome (GBS) and congenital microcephaly in newborns infected prenatally. Read More

View Article and Full-Text PDF
December 2021

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly.

Cell Stem Cell 2021 Apr 7. Epub 2021 Apr 7.

Institute of Molecular Biotechnology (IMBA), Austrian Academy of Sciences, Vienna BioCenter (VBC), Vienna 1030, Austria; Medical University of Vienna, Vienna 1030, Austria. Electronic address:

Viral infection in early pregnancy is a major cause of microcephaly. However, how distinct viruses impair human brain development remains poorly understood. Here we use human brain organoids to study the mechanisms underlying microcephaly caused by Zika virus (ZIKV) and herpes simplex virus (HSV-1). Read More

View Article and Full-Text PDF

A Possible Association Between Zika Virus Infection and CDK5RAP2 Mutation.

Front Genet 2021 19;12:530028. Epub 2021 Mar 19.

Center for Research on Congenital Anomalies and Rare Diseases (CIACER), Department of Basic Medical Sciences, Universidad Icesi, Cali, Colombia.

Introduction: Flaviviridae family belongs to the Spondweni serocomplex, which is mainly transmitted by vectors from the genus. Zika virus (ZIKV) is part of this genus. It was initially reported in Brazil in December 2014 as an unknown acute generalized exanthematous disease and was subsequently identified as ZIKV infection. Read More

View Article and Full-Text PDF

Immune cells enhance Zika virus-mediated neurologic dysfunction in brain of mice with humanized immune systems.

Dev Neurobiol 2021 Apr 3. Epub 2021 Apr 3.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Zika virus (ZIKV) can generate a number of neurological dysfunctions in infected humans. Here, we tested the potential of human immune cells to protect against ZIKV infection in genetically humanized MISTRG mice. FACS analysis showed robust reconstitution of the mouse spleen with human T cells. Read More

View Article and Full-Text PDF

Association between Viral Infections and Risk of Autistic Disorder: An Overview.

Int J Environ Res Public Health 2021 03 10;18(6). Epub 2021 Mar 10.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

Autism spectrum disorder (ASD) is a neurodevelopmental condition of the central nervous system (CNS) that presents with severe communication problems, impairment of social interactions, and stereotypic behaviours. Emerging studies indicate possible associations between viral infections and neurodegenerative and neurobehavioural conditions including autism. Viral infection during critical periods of early in utero neurodevelopment may lead to increased risk of autism in the offspring. Read More

View Article and Full-Text PDF

ZIKV actively induces calcification in the fetal brain.

Nat Microbiol 2021 Apr;6(4):417-418

Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA.

View Article and Full-Text PDF

Intrauterine Zika virus infection: review of the current findings with emphasis in the prenatal and postnatal brain imaging diagnostic methods.

J Matern Fetal Neonatal Med 2021 Mar 29:1-7. Epub 2021 Mar 29.

Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.

Zika virus (ZIKV) is a widespread flavivirus transmitted to humans through the bite of mosquitoes. The number of ZIKV cases increased significantly between 2015 and 2016, and Brazil was the first to report autochthonous transmission of infection. The main neurological disorder related to ZIKV infection is microcephaly. Read More

View Article and Full-Text PDF

Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys.

Sci Rep 2021 Mar 17;11(1):6099. Epub 2021 Mar 17.

Post-Graduate Programme in Virology, Evandro Chagas Institute, BR-316 Highway, km 7, Ananindeua, Pará, 67030-000, Brazil.

The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a neotropical primate (which mimics the stages of human pregnancy), as a model of Zika virus (ZIKV) infection. Seven pregnant female squirrel monkeys were experimentally infected at three different gestational stages, and we were able reproduce a broad range of clinical manifestations of ZIKV lesions observed in newborn humans. Read More

View Article and Full-Text PDF

Recovery of Synthetic Zika Virus Based on Rio-U1 Isolate Using a Genetically Stable Two Plasmid System and cDNA Amplification.

Front Microbiol 2021 24;12:639655. Epub 2021 Feb 24.

Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

In 2016, the world experienced the unprecedented Zika epidemic. The ZIKV emerged as a major human pathogen due to its association with the impairment of perinatal development and Guillain-Barré syndrome. The occurrence of these severe cases of Zika points to the significance of studies for understanding the molecular determinants of flavivirus pathogenesis. Read More

View Article and Full-Text PDF
February 2021

Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice.

PLoS Negl Trop Dis 2021 Mar 5;15(3):e0009211. Epub 2021 Mar 5.

Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Several studies have demonstrated that Zika virus (ZIKV) damages testis and leads to infertility in mice; however, the infection in the epididymis, another important organ of male reproductive health, has gained less attention. Previously, we detected lesions in the epididymis in interferon type I and II receptor knockout male mice during ZIKV infection. Herein, the pathogenesis of ZIKV in the epididymis was further assessed in the infected mice after footpad inoculation. Read More

View Article and Full-Text PDF

Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells.

PLoS Negl Trop Dis 2021 Mar 3;15(3):e0009183. Epub 2021 Mar 3.

Department of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, Texas, United States of America.

Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. Read More

View Article and Full-Text PDF

Reassessment of the risk of birth defects due to Zika virus in Guadeloupe, 2016.

PLoS Negl Trop Dis 2021 Mar 3;15(3):e0009048. Epub 2021 Mar 3.

Emerging Disease Epidemiology Unit, Institut Pasteur, Paris, France.

Background: In the French Territories in the Americas (FTA), the risk of birth defects possibly associated with Zika virus (ZIKV) infection was 7.0% (95%CI: 5.0 to 9. Read More

View Article and Full-Text PDF

Congenital Zika syndrome: Growth, clinical, and motor development outcomes up to 36 months of age and differences according to microcephaly at birth.

Int J Infect Dis 2021 Apr 18;105:399-408. Epub 2021 Feb 18.

Department of Public Health, Federal University of Maranhão, São Luís, Maranhão, Brazil. Electronic address:

Background: Little is known regarding the developmental consequences of congenital Zika syndrome (CZS) without microcephaly at birth. Most previously published clinical series were descriptive and they had small sample sizes.

Study Design: We conducted a cohort study to compare the growth, clinical, and motor development outcomes for 110 children with CZS born with and without microcephaly up to their third birthday. Read More

View Article and Full-Text PDF

Zika virus infection in pregnant travellers and impact on childhood neurodevelopment in the first two years of life: A prospective observational study.

Travel Med Infect Dis 2021 Mar-Apr;40:101985. Epub 2021 Feb 15.

ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique. Electronic address:

Background: The emergence of Zika virus (ZIKV) represents a threat with consequences on maternal and children's health. We aimed to assess the clinical and epidemiological characteristics of pregnant women returning from ZIKV affected areas, and the effects of maternal ZIKV infection on birth outcomes and children's health.

Methods: This was a hospital-based prospective observational study conducted at the Hospital Clínic of Barcelona and Hospital Sant Joan de Déu, Barcelona, Spain, from January 2016 to February 2020. Read More

View Article and Full-Text PDF
February 2021

New Proteomic Signatures to Distinguish Between Zika and Dengue Infections.

Mol Cell Proteomics 2021 Feb 12;20:100052. Epub 2021 Feb 12.

Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, USA. Electronic address:

Distinguishing between Zika and dengue virus infections is critical for accurate treatment, but we still lack detailed understanding of their impact on their host. To identify new protein signatures of the two infections, we used next-generation proteomics to profile 122 serum samples from 62 Zika and dengue patients. We quantified >500 proteins and identified 13 proteins that were significantly differentially expressed (adjusted p-value < 0. Read More

View Article and Full-Text PDF
February 2021

Zika virus infection induced apoptosis by modulating the recruitment and activation of pro-apoptotic protein Bax.

J Virol 2021 Feb 3. Epub 2021 Feb 3.

Chinese Academy of Inspection and Quarantine, Beijing, P. R. China

Zika virus (ZIKV) infection is associated with microcephaly in newborns and serious neurological complications in adults. Apoptosis of neural progenitor cells induced by ZIKV infection is believed to be a main reason for ZIKV infection-related microcephaly. However, the detailed mechanism of ZIKV infection-induced apoptosis remains to be elucidated. Read More

View Article and Full-Text PDF
February 2021

Urological profile of children with microcephaly and congenital zika syndrome.

J Pediatr Urol 2021 04 14;17(2):255.e1-255.e5. Epub 2020 Oct 14.

Departments of Urology and Neurology, Bahia School of Medicine and Federal University of Bahia, Salvador, Bahia, Brazil. Electronic address:

Introduction: An outbreak of Zika virus disease, a self-limiting arbovirus infection involving skin rash and fever, occurred in Brazil in 2015 and was followed by an increase in newborns with microcephaly and brain malformations. Although two recent studies reported neurogenic bladder in children with microcephaly and congenital Zika syndrome (CZS), urologic evaluation is not yet routine.

Objective: To investigate the urological profile of children with microcephaly and CZS. Read More

View Article and Full-Text PDF