7,032 results match your criteria brain atlas

Simpson Grade I Resection of Type II Clinoidal Meningiomal Through Cranio-orbital Zygomatic Approach: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Clinoidal meningiomas have been considered as a separate entity with distinguishing clinical, radiological, and surgical considerations.1-2 Surgical mortality and morbidity associated with anterior clinoidal meningiomas has remained high in the past, with radical resection considered unattainable.3 However, the extent of surgical removal is clearly the most determining factor in tumor recurrence and progression. Read More

View Article and Full-Text PDF

Prevalence of Hyperacusis and Its Relation to Health: The Busselton Healthy Ageing Study.

Laryngoscope 2021 Jul 22. Epub 2021 Jul 22.

Ear Sciences Centre, The University of Western Australia, Nedlands, Australia.

Importance: The prevalence of hyperacusis and its relationship with mental and general health is unknown in a nonclinical sample. Therefore, we aimed to determine the prevalence of hyperacusis and its relation with hearing, general and mental health in a population-based study.

Study Design: Prospective population-based study. Read More

View Article and Full-Text PDF

Knockdown of carbohydrate sulfotransferase 12 decreases the proliferation and mobility of glioblastoma cells via the WNT/β-catenin pathway.

Bioengineered 2021 Dec;12(1):3934-3946

Department of Neurology, Changle People's Hospital, Weifang Shandong, China.

Glioblastoma (GBM) is a common malignant tumor of the brain. Members of the carbohydrate sulfotransferase (CHST) family are deregulated in various cancer types. However, limited data are available on the role of the members of the CHST family in the development of GBM. Read More

View Article and Full-Text PDF
December 2021

FBXW7 induces apoptosis in glioblastoma cells by regulating HDAC7.

Cell Biol Int 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurosurgery, Huzhou Central Hospital, Affiliated Cent Hospital HuZhou University.

Glioblastoma is an aggressive type of brain cancer with an extremely poor prognosis. Additionally, the F-box WD repeat-containing protein 7 (FBXW7) is a component of the ubiquitin-proteasome system that has been widely implicated in human cancers. In this study, we investigated the role and mechanism of FBXW7 in glioblastoma. Read More

View Article and Full-Text PDF

Establish six-gene prognostic model for glioblastoma based on multi-omics data of TCGA database.

Yi Chuan 2021 Jul;43(7):665-679

Laboratory of Medical Genetics, Harbin Medical University, Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China (Harbin Medical University), Ministry of Education, Harbin 150081, China.

Glioblastoma (GBM) is the most common primary intracranial tumor with extremely high malignancy and poor prognosis. In order to identify the GBM prognostic biomarkers and establish a prognostic model, we analyzed the expression profile data of GBM in The Cancer Genome Atlas (TCGA) database as the experimental group. First, we identified the differentially expressed genes of different survival periods among the GBM patients. Read More

View Article and Full-Text PDF

Gene expression atlas of energy balance brain regions.

JCI Insight 2021 Jul 20. Epub 2021 Jul 20.

Naomi Berrie Diabetes Center, Columbia University, New York, United States of America.

Energy balance is controlled by interconnected brain regions in the hypothalamus, brain stem, cortex and limbic system. Gene expression signatures of these regions can help elucidate the pathophysiology underlying obesity. RNA sequencing was conducted on P56 C57BL/6NTac male mice and E14. Read More

View Article and Full-Text PDF

Genome-scale metabolic network reconstruction of model animals as a platform for translational research.

Proc Natl Acad Sci U S A 2021 Jul;118(30)

Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden;

Genome-scale metabolic models (GEMs) are used extensively for analysis of mechanisms underlying human diseases and metabolic malfunctions. However, the lack of comprehensive and high-quality GEMs for model organisms restricts translational utilization of omics data accumulating from the use of various disease models. Here we present a unified platform of GEMs that covers five major model animals, including Mouse1 (), Rat1 (), Zebrafish1 (), Fruitfly1 (), and Worm1 (). Read More

View Article and Full-Text PDF

Quantifying age-related changes in brain and behavior: A longitudinal versus cross-sectional approach.

eNeuro 2021 Jul 19. Epub 2021 Jul 19.

Taub Institute, Columbia University, New York, NY

Cross-sectional versus longitudinal comparisons of age-related change have often revealed differing results. In the current study, we employed within-subject task-based fMRI to investigate changes in voxel-based activations and behavioral performance across the lifespan in the Reference Ability Neural Network (RANN) cohort, at both baseline and 5-year follow-up. We analyzed fMRI data from between 127 and 159 participants (20-80 years), on a battery of tests relating to each of four cognitive reference abilities (RAs). Read More

View Article and Full-Text PDF

Expression, methylation and prognostic feature of EMILIN2 in Low-Grade-Glioma.

Brain Res Bull 2021 Jul 16;175:26-36. Epub 2021 Jul 16.

Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, PR China. Electronic address:

Low-grade gliomas (LGGs) are slow-growing brain cancer in central nervous system neoplasms. EMILIN2 is an extracellular matrix (ECM) protein which could influence the progress of some tumour which is unclear in LGG. In our study, the methylation, expression, prognosis and immune value of EMILIN2 in LGG were analysed through bioinformatics analysis. Read More

View Article and Full-Text PDF

Assessing the replicability of spatial gene expression using atlas data from the adult mouse brain.

PLoS Biol 2021 Jul 19;19(7):e3001341. Epub 2021 Jul 19.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.

High-throughput, spatially resolved gene expression techniques are poised to be transformative across biology by overcoming a central limitation in single-cell biology: the lack of information on relationships that organize the cells into the functional groupings characteristic of tissues in complex multicellular organisms. Spatial expression is particularly interesting in the mammalian brain, which has a highly defined structure, strong spatial constraint in its organization, and detailed multimodal phenotypes for cells and ensembles of cells that can be linked to mesoscale properties such as projection patterns, and from there, to circuits generating behavior. However, as with any type of expression data, cross-dataset benchmarking of spatial data is a crucial first step. Read More

View Article and Full-Text PDF

Deep Neural Network Analysis of Pathology Images With Integrated Molecular Data for Enhanced Glioma Classification and Grading.

Front Oncol 2021 1;11:668694. Epub 2021 Jul 1.

Vision Lab, Department of Electrical & Computer Engineering, Old Dominion University, Norfolk, VA, United States.

Gliomas are primary brain tumors that originate from glial cells. Classification and grading of these tumors is critical to prognosis and treatment planning. The current criteria for glioma classification in central nervous system (CNS) was introduced by World Health Organization (WHO) in 2016. Read More

View Article and Full-Text PDF

Cerebellar preference of luminal A and B type and basal ganglial preference of HER2-positive type breast cancer-derived brain metastases.

Mol Clin Oncol 2021 Sep 30;15(3):175. Epub 2021 Jun 30.

Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

The purpose of the current study was to investigate the hypothesis that the spatial distribution of brain metastases could be affected by the biological subtypes of breast cancer. CT (n=1) or MRI (n=66) images of 67 patients with a total of 437 treatment-naive brain metastases from breast cancer were retrospectively reviewed. Patients were grouped according to the biological subtype of the tumor [luminal A, 28; luminal B, 9; human epidermal growth factor receptor 2 (HER2) positive, 14; triple-negative breast cancer (TNBC), 16]. Read More

View Article and Full-Text PDF
September 2021

Bioinformatics Analysis of Expression Profiles and Prognostic Values of the Signal Transducer and Activator of Transcription Family Genes in Glioma.

Front Genet 2021 2;12:625234. Epub 2021 Jul 2.

Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.

Signal transducer and activator of transcription () family genes-of which there are seven members: , and -have been associated with the progression of multiple cancers. However, their prognostic values in glioma remain unclear. In this study, we systematically investigated the expression, the prognostic value, and the potential mechanism of the family genes in glioma. Read More

View Article and Full-Text PDF

Delivery of care for migraine in the Asian Oceanian region: A cross-sectional study.

Cephalalgia 2021 Jul 18:3331024211024153. Epub 2021 Jul 18.

Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Objective: To determine the current availability of care for headaches, in particular migraine in the Asian Oceanian region.

Method: A questionnaire-based, cross-sectional study from August 2020 to February 2021, surveyed country representatives from the member countries of the Asian Oceanian Association of Neurology. The items of the survey were influenced by the findings and recommendations of the 2011 Atlas of Headache by Lifting the Burden and the World Health Organization. Read More

View Article and Full-Text PDF

Graph theoretical structural connectome analysis of the brain in patients with chronic spinal cord injury: preliminary investigation.

Spinal Cord Ser Cases 2021 Jul 17;7(1):60. Epub 2021 Jul 17.

Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.

Study Design: Retrospective study.

Objectives: We aimed to characterize the convergent disruptions of the structural connectivity based on network modeling technique (i.e. Read More

View Article and Full-Text PDF

Cortical metabolic and structural differences in patients with chronic migraine. An exploratory FDG-PET and MRI study.

J Headache Pain 2021 Jul 17;22(1):75. Epub 2021 Jul 17.

Headache and Craniofacial Pain Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

Background: To describe interictal brain structural and metabolic differences between patients with episodic migraine (EM), chronic migraine (CM) and healthy controls (HC).

Methods: This is an exploratory study including right-handed age-matched women with EM, CM and HC. On the same day, a sequential interictal scan was performed with FDG-PET and MRI. Read More

View Article and Full-Text PDF

Relating quantitative 7T MRI across cortical depths to cytoarchitectonics, gene expression and connectomics.

Hum Brain Mapp 2021 Jul 17. Epub 2021 Jul 17.

Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Ultra-high field MRI across the depth of the cortex has the potential to provide anatomically precise biomarkers and mechanistic insights into neurodegenerative disease like Huntington's disease that show layer-selective vulnerability. Here we compare multi-parametric mapping (MPM) measures across cortical depths for a 7T 500 μm whole brain acquisition to (a) layer-specific cell measures from the von Economo histology atlas, (b) layer-specific gene expression, using the Allen Human Brain atlas and (c) white matter connections using high-fidelity diffusion tractography, at a 1.3 mm isotropic voxel resolution, from a 300mT/m Connectom MRI system. Read More

View Article and Full-Text PDF

Localizing microemboli within the rodent brain through block-face imaging and atlas registration.

eNeuro 2021 Jul 16. Epub 2021 Jul 16.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON

Brain microinfarcts are prevalent in humans, however due to the inherent difficulty of identifying and localizing individual microinfarcts, brain-wide quantification is impractical. In mice, microinfarcts have been created by surgically introducing microemboli into the brain, but a major limitation of this model is the absence of automated methods to identify and localize individual occlusions. We present a novel and semi-automated workflow to identify the anatomical location of fluorescent emboli (microspheres) within the mouse brain through histological processing and atlas registration. Read More

View Article and Full-Text PDF

Spatiotemporal Mapping of Early Volume Loss in the Mouse Brain after Cranial Irradiation.

Radiat Res 2021 Jul 16. Epub 2021 Jul 16.

Departments of Medical Biophysics, University of Toronto, Ontario, Canada.

Sequelae after pediatric cranial radiotherapy (CRT) result in long-term changes in brain structure. While past evidence indicates regional differences in brain volume change, it remains unclear how these manifest in the time course of change after CRT. In this study, we spatiotemporally characterized volume losses induced by cranial irradiation in a mouse model, with a dense sampling of measurements over the first week postirradiation. Read More

View Article and Full-Text PDF

Dissecting Prognosis Modules and Biomarkers in Glioblastoma Based on Weighted Gene Co-Expression Network Analysis.

Cancer Manag Res 2021 8;13:5477-5489. Epub 2021 Jul 8.

College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, People's Republic of China.

Introduction: As one of the most prevalent and malignant brain cancers, glioblastoma multiforme (GBM) presents a poor prognosis and the molecular mechanisms remain poorly understood. Consequently, molecular research, including various biomarkers, is essential to exploit the occurrence and development of glioma.

Methods: Weighted gene co-expression network analysis (WGCNA) was used to construct gene co-expression modules and networks based on the Chinese Glioma Genome Atlas (CGGA) glioblastoma specimens. Read More

View Article and Full-Text PDF

Tissue-specific expression atlas of murine mitochondrial tRNAs.

J Biol Chem 2021 Jul 12:100960. Epub 2021 Jul 12.

Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Hangzhou, Zhejiang 310058, China; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Center for Mitochondrial Genetics, Key Lab of Reproductive Genetics, Ministry of Education of PRC, Zhejiang University, Hangzhou, Zhejiang 310058, China; Division of Mitochondrial Biomedicine, Zhejiang University-University of Toronto Joint Institute of Genetics and Genome Medicine, Hangzhou, Zhejiang 310058, China. Electronic address:

Mammalian mitochondrial tRNA (mt-tRNA) plays a central role in the synthesis of the 13 subunits of the oxidative phosphorylation complex system (OXPHOS). However, many aspects of the context-dependent expression of mt-tRNAs in mammals remains unknown. To investigate the tissue-specific effects of mt-tRNAs, we performed a comprehensive analysis of mitochondrial tRNA expression across 5 mice tissues (brain, heart, liver, skeletal muscle, and kidney) using Northern blot analysis. Read More

View Article and Full-Text PDF

Frontal White Matter Hyperintensities and Executive Functioning Performance in Older Adults.

Front Aging Neurosci 2021 28;13:672535. Epub 2021 Jun 28.

Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, United States.

Frontal lobe structures decline faster than most other brain regions in older adults. Age-related change in the frontal lobe is associated with poorer executive function (e.g. Read More

View Article and Full-Text PDF

The integrity of the white matter in first-episode schizophrenia patients with auditory verbal hallucinations: An atlas-based DTI analysis.

Psychiatry Res Neuroimaging 2021 Jul 4;315:111328. Epub 2021 Jul 4.

National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China; Hunan Key Laboratory of Psychiatry and Mental Health, National Technology Institute of Psychiatry, Changsha, China; Institute of Mental Health, Second Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Auditory verbal hallucination (AVH) is one of the most remarkable symptoms of schizophrenia, with great impact on patients' lives and unclear pathogenesis. Neuroimaging studies have indicated that the development of AVHs is associated with white matter alteration, however, there are still inconsistencies in specific findings across previous investigations. The present study aimed to investigate the characteristics of the microstructural integrity of white matter (WM) in first-episode schizophrenia patients who experience auditory hallucinations. Read More

View Article and Full-Text PDF

Fatigue and resting-state functional brain networks in breast cancer patients treated with chemotherapy.

Breast Cancer Res Treat 2021 Jul 14. Epub 2021 Jul 14.

Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Cancer Center Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Purpose: This longitudinal study aimed to disentangle the impact of chemotherapy on fatigue and hypothetically associated functional brain network alterations.

Methods: In total, 34 breast cancer patients treated with chemotherapy (BCC +), 32 patients not treated with chemotherapy (BCC -), and 35 non-cancer controls (NC) were included. Fatigue was assessed using the EORTC QLQ-C30 fatigue subscale at two time points: baseline (T1) and six months after completion of chemotherapy or matched intervals (T2). Read More

View Article and Full-Text PDF

Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas.

Sci Rep 2021 Jul 13;11(1):14377. Epub 2021 Jul 13.

Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.

We evaluate the topographic distribution of diffuse midline gliomas and hemispheric high-grade gliomas in children with respect to their normal gene expression patterns and pathologic driver mutation patterns. We identified 19 pediatric patients with diffuse midline or high-grade glioma with preoperative MRI from tumor board review. 7 of these had 500 gene panel mutation testing, 11 patients had 50 gene panel mutation testing and one 343 gene panel testing from a separate institution were included as validation set. Read More

View Article and Full-Text PDF

GeNePy3D: a quantitative geometry python toolbox for bioimaging.

F1000Res 2020 26;9:1374. Epub 2020 Nov 26.

Laboratory of Optics and Biosciences, CNRS, INSERM, Ecole polytechniqe, Institut polytechnique de Paris, Palaiseau, 91120, France.

The advent of large-scale fluorescence and electronic microscopy techniques along with maturing image analysis is giving life sciences a deluge of geometrical objects in 2D/3D(+t) to deal with. These objects take the form of large scale, localised, precise, single cell, quantitative data such as cells' positions, shapes, trajectories or lineages, axon traces in whole brains atlases or varied intracellular protein localisations, often in multiple experimental conditions. The data mining of those geometrical objects requires a variety of mathematical and computational tools of diverse accessibility and complexity. Read More

View Article and Full-Text PDF

Identification and Validation of an 11-Ferroptosis Related Gene Signature and Its Correlation With Immune Checkpoint Molecules in Glioma.

Front Cell Dev Biol 2021 23;9:652599. Epub 2021 Jun 23.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

Background: Glioma is the most common primary malignant brain tumor with significant mortality and morbidity. Ferroptosis, a novel form of programmed cell death (PCD), is critically involved in tumorigenesis, progression and metastatic processes.

Methods: We revealed the relationship between ferroptosis-related genes and glioma by analyzing the mRNA expression profiles from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), GSE16011, and the Repository of Molecular Brain Neoplasia Data (REMBRANDT) datasets. Read More

View Article and Full-Text PDF

The Stroke Neuro-Imaging Phenotype Repository: An Open Data Science Platform for Stroke Research.

Front Neuroinform 2021 24;15:597708. Epub 2021 Jun 24.

Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States.

Stroke is one of the leading causes of death and disability worldwide. Reducing this disease burden through drug discovery and evaluation of stroke patient outcomes requires broader characterization of stroke pathophysiology, yet the underlying biologic and genetic factors contributing to outcomes are largely unknown. Remedying this critical knowledge gap requires deeper phenotyping, including large-scale integration of demographic, clinical, genomic, and imaging features. Read More

View Article and Full-Text PDF

YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated mA modification to activate NF-κB and promote the malignant progression of glioma.

J Hematol Oncol 2021 Jul 10;14(1):109. Epub 2021 Jul 10.

Department of Molecular Neuropathology, Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, No. 119 Nan Si Huan Xi Road, Fengtai District, Beijing, 100050, China.

Background: The prognosis for diffuse gliomas is very poor and the mechanism underlying their malignant progression remains unclear. Here, we aimed to elucidate the role and mechanism of the RNA N6,2'-O-dimethyladenosine (mA) reader, YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), in regulating the malignant progression of gliomas.

Methods: YTHDF2 mRNA levels and functions were assessed using several independent datasets. Read More

View Article and Full-Text PDF

Genetic influences on hub connectivity of the human connectome.

Nat Commun 2021 07 9;12(1):4237. Epub 2021 Jul 9.

The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.

Brain network hubs are both highly connected and highly inter-connected, forming a critical communication backbone for coherent neural dynamics. The mechanisms driving this organization are poorly understood. Using diffusion-weighted magnetic resonance imaging in twins, we identify a major role for genes, showing that they preferentially influence connectivity strength between network hubs of the human connectome. Read More

View Article and Full-Text PDF