Pain 2021 Apr 13. Epub 2021 Apr 13.
Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, South Australia, 5042, Australia Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia Discipline of Medicine, University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia Arena Pharmaceuticals, Inc, San Diego, CA, USA.
Abstract: Abdominal pain is a key symptom of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), for which there are inadequate therapeutic options. We tested whether olorinab-a highly selective, full agonist of the cannabinoid receptor 2 (CB2)-reduced visceral hypersensitivity in models of colitis and chronic visceral hypersensitivity (CVH). In rodents, colitis was induced by intrarectal administration of nitrobenzene sulfonic acid derivatives. Read More