711,463 results match your criteria bowel disease


Topical Management of Peristomal Pyoderma Gangrenosum: A Report of 3 Case Studies.

J Wound Ostomy Continence Nurs 2021 May 3. Epub 2021 May 3.

Tomohiro Toyoda, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Shinji Mitsuyama, MD, PhD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Eri Nagao, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Fumihito Abe, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Masaaki Kimura, MD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan. Yurie Seido, RN, WOC Nurse, Department of Nursing Care, Toho University Sakura Medical Center, Sakura, Japan. Tetsuya Higuchi, MD, PhD, Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan.

Background: Peristomal pyoderma gangrenosum (PPG) presents multiple challenges for healthcare providers. The diagnosis of PPG may be delayed, and it may be mistaken for an irritant dermatitis or an infection. Patients with ostomies secondary to inflammatory bowel disease (IBD) may experience PPG. Read More

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Hand-Sewn Versus Stapled Ileal Pouch Anal Anastomoses in Re-Do Setting: Indications, Patient Characteristics, Operative, Functional and Quality of Life Outcomes.

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Inflammatory Bowel Disease Center, NYU Langone Health, NYU Grossman School of Medicine, NY, NY, USA Department of Surgery, Acibadem Mehmet Ali Aydinlar School of Medicine, Istanbul, Turkey.

Background: Impact of the type of anastomosis on the outcomes of re-do ileal pouch anal anastomosis (IPAA) is unknown.

Objective: The aim of this study is to assess the indications, peri-operative and functional outcomes in patients undergoing stapled vs hand-sewn re-do IPAA.

Design: This is a retrospective cohort study. Read More

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Daily intake of a homeopathic agent by dogs modulates white cell defenses and reduces bacterial counts in feces.

Microb Pathog 2021 May 2:104936. Epub 2021 May 2.

Programa de Pós-graduação em Zootecnia, Universidade do Estado de Santa Catarina (UDESC), Chapecó, SC, Brazil; Departamento de Zootecnia, UDESC, Chapecó, SC, Brazil. Electronic address:

Motivated by conventional medicines' ineffectiveness and the appearance of bacterial resistance, homeopathic medicines are being increasingly demanded by the veterinary market. Dog feces contain high bacterial and pathogenic loads, which can cause diseases in animals and facilitate zoonotic transmission. Adequate animal immunity contributes to the elimination of potential pathogens. Read More

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Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis.

Cell Metab 2021 May;33(5):855-856

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Toranomon Hospital, Tokyo, Japan. Electronic address:

The liver consists of different zones that vary in function depending on their lobular localization. It remained unclear which zone serves as a source of repopulating/regenerating hepatocytes; however, experiments by Wei et al. (2021) in 11 CreER knockin murine strains revealed a vital role for zone 2 hepatocytes in liver homeostasis. Read More

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Antibiotic treatment for small intestinal bacterial overgrowth: Is a cocktail better than a single?

Authors:
Uday C Ghoshal

United European Gastroenterol J 2021 May 5. Epub 2021 May 5.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, India.

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Ustekinumab is more effective than azathioprine to prevent endoscopic postoperative recurrence in Crohn's disease.

United European Gastroenterol J 2021 May 5. Epub 2021 May 5.

Department of Gastroenterology, University Hospital of Besançon, University Bourgogne FrancheComté, Besançon, France.

Background: Preventing postoperative recurrence (POR) is a major concern in Crohn's disease (CD). While azathioprine is an option, no data is available on ustekinumab efficacy in this situation.

Aims: We compared the effectiveness of ustekinumab versus azathioprine in preventing endoscopic POR in CD. Read More

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The Interrelationship Among Non-Alcoholic Fatty Liver Disease, Colonic Diverticulosis and Metabolic Syndrome.

J Gastrointestin Liver Dis 2021 May 3. Epub 2021 May 3.

Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia.

Non-alcoholic fatty liver disease and colonic diverticulosis are widespread, obesity-related diseases. It has recently become clear that non-alcoholic fatty liver disease is a systemic disease and may play a key role in metabolic syndrome; therefore, the term metabolic-dysfunction-associated fatty liver disease has been introduced in the literature. Excess visceral adipose tissue is an important predictor of complications in both non-alcoholic fatty liver disease and colonic diverticulosis. Read More

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Azathioprine-induced toxoplasma gondii infection in a patient with Crohn's disease with NUDT15 variation: A case report.

Medicine (Baltimore) 2021 May;100(18):e25781

Department of Gastroenterology, The Second Xiangya Hospital.

Introduction: Azathioprine (AZA) has been widely used for the treatment of various immune-related diseases and has become a mainstay in the treatment of inflammatory bowel disease. However, patients with genetic mutations may experience severe adverse events when treated with azathioprine. Most of the previous literature focused on the TPMP gene-related adverse reactions, herein, we report a case of Crohn's disease patient with nucleoside diphosphate-linked moiety X motif 15 gene (NUDT15) variation and wild-type TPMP gene who developed toxoplasma gondii infection after azathioprine treatment. Read More

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Intestinal Organoids: Roadmap to the Clinic.

Am J Physiol Gastrointest Liver Physiol 2021 May 5. Epub 2021 May 5.

Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, United Statesgrid.239573.9.

Recent advances in intestinal organoid research, along with encouraging preclinical proof-of-concept studies, have revealed significant therapeutic potential for induced pluripotent stem cell (iPSC) derived organoids in the healing and replacement of severely injured or diseased bowel [1-3]. To fully realize the tremendous promise of stem cell organoid-based therapies, careful planning aligned with significant resources and efforts must be devoted demonstrating their safety and efficacy to meet critical regulatory requirements. Early recognition of the inherent preclinical and clinical obstacles that occur with the novel use of pluripotent stem cell derived products will accelerate their bench to bedside translation [4-6]. Read More

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JAK1 inhibition and inflammatory bowel disease.

Rheumatology (Oxford) 2021 May;60(Supplement_2):ii45-ii51

Department of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Primary non-response and secondary loss of response remain a significant issue with the currently available treatment options for a significant proportion of patients with inflammatory bowel disease (IBD). There are multiple unmet needs in the IBD treatment algorithm and new treatment options are required. As our understanding of the pathogenesis of IBD evolves, new therapeutic targets are being identified. Read More

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Reversal of functional brain activity related to gut microbiome and hormones after VSG surgery in patients with obesity.

J Clin Endocrinol Metab 2021 May 5. Epub 2021 May 5.

Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Commission, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.

Background: Vertical sleeve gastrectomy (VSG) is becoming a prioritized surgical intervention for obese individuals; however, the brain circuits that mediate its effective control of food intake and predict surgical outcome remain largely unclear.

Methods: In this observational cohort study, 80 patients with obesity were screened. 36 patients together with 26 normal-weight subjects were enrolled and evaluated using the 21-item Three-Factor Eating Questionnaire (TFEQ), MRI scanning, plasma intestinal hormone analysis and fecal sample sequencing. Read More

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The gut microbial metabolite imidazole propionate inhibits metformin action.

J Diabetes Investig 2021 May 5. Epub 2021 May 5.

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Recent attention has focused on the relation between the intestinal microbiome and metabolic diseases. Diabetes is one such disease that has been found to be influenced by changes in the composition and function of the gut microbiome. In addition, the intestinal microbiome has also been implicated in modulation of the efficacy and metabolism of certain drugs . Read More

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Association of TYK2 polymorphisms with autoimmune diseases: A comprehensive and updated systematic review with meta-analysis.

Genet Mol Biol 2021 3;44(2):e20200425. Epub 2021 May 3.

Hospital de Clínicas de Porto Alegre, Serviço de Endocrinologia, Porto Alegre, RS, Brazil.

Autoimmune diseases are characterized by the loss of self-tolerance, leading to immune-mediated tissue destruction and chronic inflammation. Tyrosine kinase 2 (TYK2) protein plays a key role in immunity and apoptosis pathways. Studies have reported associations between single nucleotide polymorphisms (SNPs) in the TYK2 gene and autoimmune diseases; however, results are still inconclusive. Read More

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Pruritogenic mechanisms and gut sensation: Putting the 'irritant' into Irritable Bowel Syndrome.

Am J Physiol Gastrointest Liver Physiol 2021 May 5. Epub 2021 May 5.

Visceral Pain Research Group, CMPH, FHMRI, Flinders University, Australiagrid.1014.4.

Chronic abdominal pain is a common clinical condition experienced by patients with irritable bowel syndrome (IBS). A general lack of suitable treatment options for the management of visceral pain is the major contributing factor to the debilitating nature of the disease. Understanding the underlying causes of chronic visceral pain is pivotal to identifying new effective therapies for IBS. Read More

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Exfoliated Epithelial Cell Transcriptome Reflects Both Small and Large Intestinal Cell Signatures in Piglets.

Am J Physiol Gastrointest Liver Physiol 2021 May 5. Epub 2021 May 5.

Department of Nutrition, Texas A&M University, United Statesgrid.264756.4.

Assessing intestinal development and host-microbe interactions in healthy human infants requires non-invasive approaches. We have shown that the transcriptome of exfoliated epithelial cells in feces can differentiate breast and formula-fed infants and term and preterm infants. However, it is not fully understood which regions of the intestine that the exfoliated cells represent. Read More

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Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.

EMBO Mol Med 2021 May 5:e13548. Epub 2021 May 5.

Rudolf-Virchow-Zentrum, Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.

Lipids are the most energy-dense components of the diet, and their overconsumption promotes obesity and diabetes. Dietary fat content has been linked to the lipid processing activity by the intestine and its overall capacity to absorb triglycerides (TG). However, the signaling cascades driving intestinal lipid absorption in response to elevated dietary fat are largely unknown. Read More

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Association Between Portal Vein Thrombosis and Pouchitis in Patients with Ulcerative Colitis.

Dig Dis Sci 2021 May 4. Epub 2021 May 4.

Center for Inflammatory Bowel Disease, Columbia University Irving Medical Center/New York Presbyterian Hospital, Herbert Irving Pavilion-Rm 843, 161 Fort Washington Ave, New York, NY, 10032, USA.

Background: Pouchitis is the most common long-term complication in patients requiring colectomy ileal pouch-anal anastomosis with medically refractory ulcerative colitis or colitis-associated neoplasia. A previous small case series suggests associated between portal vein thrombosis (PVT) and ischemic pouchitis.

Aim: To evaluate the association between PVT and other demographic and clinical factors and pouchitis. Read More

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A highly multiplexed droplet digital PCR assay to measure the intact HIV-1 proviral reservoir.

Cell Rep Med 2021 Apr 12;2(4):100243. Epub 2021 Apr 12.

Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA.

Quantifying the replication-competent HIV reservoir is essential for evaluating curative strategies. Viral outgrowth assays (VOAs) underestimate the reservoir because they fail to induce all replication-competent proviruses. Single- or double-region HIV DNA assays overestimate it because they fail to exclude many defective proviruses. Read More

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Lip swelling with lymphangiectasia.

JAAD Case Rep 2021 May 26;11:93-95. Epub 2021 Mar 26.

Department of Dermatology, Tulane University, New Orleans, Louisiana.

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Pulmonary Manifestations of Inflammatory Bowel Disease.

Cureus 2021 Mar 31;13(3):e14216. Epub 2021 Mar 31.

Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

The frequency of extraintestinal manifestations of inflammatory bowel disease (IBD) is observed in most of the patients. Extraintestinal manifestations of IBD have been implicated in all the anatomic sites of the pulmonary tree, and include airway inflammation of the bronchi and bronchioles and parenchymal inflammation. There is a wide range of pulmonary manifestations in IBD, and most of them look a lot like other diseases. Read More

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An unusual case of chronic abdominal pain: an association between Celiac disease and Crohn's disease.

Oxf Med Case Reports 2021 Apr 28;2021(4):omab008. Epub 2021 Apr 28.

Department of Pathology, Professor of pathology, Tishreen university hospital, Lattakia, Syria.

Inflammatory bowel diseases (IBD) and Celiac disease (CeD) are immune-mediated gastrointestinal diseases with incompletely understood etiology. Both diseases show a multifactorial origin with a complex interplay between genetic, environmental factors, and some components of the commensal microbiota. The coexistence of celiac disease with Crohn's disease is rarely reported in the literature. Read More

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Relevance of monitoring transmural disease activity in patients with Crohn's disease: current status and future perspectives.

Therap Adv Gastroenterol 2021 16;14:17562848211006672. Epub 2021 Apr 16.

Department of Gastroenterology, University Teaching Hospital Lueneburg, Bögelstraße 1, Lueneburg 21339, Germany.

Treatment targets of inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) have evolved over the last decade. Goals of therapy consisting of symptom control and steroid sparing have shifted to control of disease activity with endoscopic remission being an important endpoint. Unfortunately, this requires ileocolonoscopy, an invasive procedure. Read More

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Rediscovering histology: what is new in endoscopy for inflammatory bowel disease?

Therap Adv Gastroenterol 2021 16;14:17562848211005692. Epub 2021 Apr 16.

IBD Center, Humanitas Clinical and Research Center, IRCCS, Via Manzoni 56, Rozzano, Milan, 20089, Italy.

The potential of endoscopic evaluation in the management of inflammatory bowel diseases (IBD) has undoubtedly grown over the last few years. When dealing with IBD patients, histological remission (HR) is now considered a desirable target along with symptomatic and endoscopic remission, due to its association with better long-term outcomes. Consequently, the ability of endoscopic techniques to reflect microscopic findings without having to collect biopsies has become of upmost importance. Read More

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Ocrelizumab-induced inflammatory bowel disease-like illness characterized by esophagitis and colitis.

Ann Gastroenterol 2021 27;34(3):447-448. Epub 2021 Jan 27.

Department of Gastroenterology (Alex Barnes, Dirk Hofmann, Réme Mountifield).

Ocrelizumab is an intravenous anti-CD20 monoclonal antibody, approved for use in primary progressive multiple sclerosis due to its selective depletion of B-lymphocytes. Herein we describe the case of a 56-year-old female who developed odynophagia and bloody diarrhea following treatment with ocrelizumab. This was characterized endoscopically by ulcerations in the esophagus and colon. Read More

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January 2021

Conjugal inflammatory bowel disease: a systematic review and European survey.

Ann Gastroenterol 2021 26;34(3):361-369. Epub 2021 Feb 26.

Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal (Maria Pia Costa-Santos, Catarina Frias-Gomes, António Oliveira, Joana Torres).

Background: The frequency of inflammatory bowel disease (IBD) is increased after marriage to an individual with the disease. Importantly, the offspring of these couples have a significant risk for developing the disease. Herein, we aimed to better characterize conjugal IBD. Read More

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February 2021

Bowel preparation in diabetic patients undergoing colonoscopy.

Ann Gastroenterol 2021 26;34(3):310-315. Epub 2021 Feb 26.

Division of Digestive Diseases, Rush University Medical Center, Chicago, Illinois (Muhammad Alsayid, Michael D. Brown), USA.

Diabetes mellitus is a risk factor for poor bowel preparation in patients who undergo colonoscopy, because of their decreased intestinal transit and slow gastric emptying. This might lead to neoplastic or preneoplastic lesions being missed, longer procedural time, a higher risk of procedure-related adverse events, significant cost burden, patient dissatisfaction, and the need for a repeat colonoscopy. Multiple strategies have been suggested to improve bowel preparation in these patients. Read More

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February 2021

Artificial intelligence and capsule endoscopy: unravelling the future.

Ann Gastroenterol 2021 26;34(3):300-309. Epub 2021 Feb 26.

Gastroenterology Department, Hospital de São João, Porto, Portugal.

The applicability of artificial intelligence (AI) in gastroenterology is a hot topic because of its disruptive nature. Capsule endoscopy plays an important role in several areas of digestive pathology, namely in the investigation of obscure hemorrhagic lesions and the management of inflammatory bowel disease. Therefore, there is growing interest in the use of AI in capsule endoscopy. Read More

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February 2021