Search Our Scientific Publications & Authors

Z Gastroenterol 2021 Apr 12;59(4):326-330. Epub 2021 Apr 12.

Innere Medizin, Schön Klinik Hamburg Eilbek, Hamburg, Germany.

T-lymphocytic enteral leiomyositis (T-lel) is a rare disorder causing chronic intestinal pseudo-obstruction (CIPO), with cases predominantly being reported in the field of veterinary and pediatric medicine. Here, we present a case of T-lel-associated CIPO in an adult female, who initially presented with a paralytic ileus 2 weeks after a common gastroenteritis. The histological diagnosis was established through full-thickness bowel biopsy, exhibiting a dense lymphocytic infiltrate in the lamina muscularis of the intestinal wall. Read More

Phytomedicine 2021 Feb 24;86:153527. Epub 2021 Feb 24.

College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address:

Background: SiNiSan (SNS) is an ancient Chinese herbal prescription, and the current clinical treatment of irritable bowel syndrome (IBS) is effective. In the previous study of the research team, the multi-functional co-synergism of SNS against IBS was presented. Some potential drug targets and candidate ligands were predicted. Read More

Eur J Oncol Nurs 2021 Mar 22;52:101934. Epub 2021 Mar 22.

Kings College London, James Clerk Maxwell Building, 57 Waterloo Road, Lambeth, London, SE1 8WA, UK.

Purpose: Rectal cancer is common and is frequently treated with surgery which removes the rectum but retains anal sphincters. After sphincter-saving rectal cancer surgery, which can result in a reduced rectal storage capacity and nerve damage, symptoms frequently occur.

Method: A systematic review was undertaken to determine which symptoms occur and their effect on quality of life. Read More

Gastroenterology 2021 Apr 9. Epub 2021 Apr 9.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Background And Aims: Crohn's Disease (CD) and ulcerative colitis (UC) are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the specificity of these responses remains largely undefined. Therefore, we developed a microbiota antigen microarray to characterize microbial antibody reactivity, particularly to human-derived microbiota flagellins, in inflammatory bowel disease.

Methods: Sera from healthy volunteers at the University of Alabama at Birmingham (UAB), n=87; patients recruited from the Kirklin Clinic of UAB Hospital, including patients with Crohn's disease, n=152; and Ulcerative colitis, n=170; was individually probed against microbiota bacterial flagellins of both mouse and human origin and analyzed for IgG and IgA antibody responses. Read More

Arch Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Department of Internal Medicine I, Paracelsus Medical University of Salzburg, Salzburg, Austria.

Treatment-refractory hypothyroidism is a common clinical finding. Substantial causes include poor compliance and intake failure as well as gastrointestinal diseases, such as inflammatory bowel disease and short bowel syndromes. Increasing oral dosage of levothyroxine (LT4) is not always effective. Read More

Rev Med Chil 2020 Dec;148(12):1806-1812

Programa Enfermedad Inflamatoria Intestinal, Departamento de Gastroenterología, Clínica Las Condes, Santiago, Chile.

The prevalence of inflammatory bowel disease (IBD) increased in the last decades. Thus, the number of pregnant women with the condition is also increasing. Given that active disease itself is the main risk factor for complications during pregnancy, it is necessary to achieve a complete remission before planning a pregnancy. Read More

J Perioper Pract 2021 Apr 12:1750458920962029. Epub 2021 Apr 12.

21666Baltimore Washington Medical Center, Glen Burnie, MD, USA.

Aim: Surgical site infections after colorectal surgery are a clinical and financial challenge in healthcare. The purpose of this project was to decrease the rate of surgical site infections in colorectal surgical patients in a community hospital with an academic cancer centre in the United States of America.

Method: The Quality Improvement Department obtained data to measure the hospital's performance with colorectal surgical patients. Read More

Neurogastroenterol Motil 2021 Apr 12:e14148. Epub 2021 Apr 12.

Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Qld, Australia.

Background: Certain dietary constituents may provoke symptoms of functional dyspepsia (FD); however, there is an absence of dietary trials testing specific dietary interventions. Empirically derived dietary strategies and the low FODMAP diet are frequently used in practice. This study aimed to compare the effectiveness of low FODMAP dietary advice with standard dietary advice for reducing epigastric and overall gastrointestinal symptoms in individuals with FD. Read More

Neurogastroenterol Motil 2021 Apr 12:e14150. Epub 2021 Apr 12.

Department of Pharmacy, National University of Singapore, Singapore City, Singapore.

Background: Symptoms following fructose ingestion, or fructose intolerance, are common in patients with functional gastrointestinal disorders (FGID) and are generally attributed to intestinal malabsorption. The relationships between absorption, symptoms, and intestinal gas production following fructose ingestion were studied in patients with FGID.

Methods: Thirty FGID patients ingested a single dose of fructose 35 g or water in a randomized, double-blind, crossover study. Read More

J Appl Behav Anal 2021 Apr 12. Epub 2021 Apr 12.

Department of Psychology, University of Florida.

Much of the research evaluating toilet training interventions for children with ASD has focused on urinations as the primary dependent variable. As a result, the effects that toilet training interventions targeting urinations may have on other related dependent variables remains unclear. We conducted a retrospective analysis of data obtained by Perez et al. Read More

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Department of Obstetrics and Gynecology, Health Sciences University Kanuni Sultan Suleyman Suam, Istanbul, Turkey.

Objectives: Crohn's disease (CD) is a repeating bowel disease characterized by remission and exacerbation periods. The disease mostly affects adults of reproductive age. Women with desires to conceive are concerned about the effects of CD on their fertility. Read More

Surg Technol Int 2021 Apr 9;38. Epub 2021 Apr 9.

Division for Endocrine and Minimally Invasive Surgery of the University of Messina, Italy.

Aim: To clarify the advantages of negative pressure therapy (NPT) compared to other methods of temporary abdominal closure (TAC) in the management of secondary peritonitis.

Methods: We retraced the history of known methods of TAC, and analyzed their advantages and disadvantages. We evaluated as the NPT mechanisms, both from the macroscopic that bio-molecular point of view, well suits to manage this difficult condition. Read More

Adv Ther 2021 Apr 12. Epub 2021 Apr 12.

Department of Gastroenterology, Corporal Michael J Crescenz VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA, 19104, USA.

Introduction: Vedolizumab (VDZ) is postulated to have a potentially safer side effect profile than other biologic medications owing to its gut-selective mechanism. However, extrapolating these safety data to older patients is challenging because of their underrepresentation in or exclusion from most clinical trials, higher rates of withdrawal, and higher rates of comorbidities. Our aim was to evaluate the absolute risk of infections and malignancies in an elderly group of patients with inflammatory bowel disease (IBD) exposed to VDZ vs. Read More

J Crohns Colitis 2021 Apr 12. Epub 2021 Apr 12.

Department of Digestive Surgery, Amiens University Medical Center and Jules Verne University of Picardie, Amiens, France.

The management of colorectal stricture complicating inflammatory bowel disease (IBD) remains a challenging condition. Stricture raises concern about neoplastic complications, which cannot be fully ruled out by negative endoscopic biopsies. Also, impassable strictures restrict the endoscopic monitoring of upstream disease activity and dysplasia. Read More

Clin Transl Gastroenterol 2021 Apr 12;12(4):e00329. Epub 2021 Apr 12.

Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, Minnesota, USA.

Introduction: Previous studies in patients with irritable bowel syndrome (IBS) showed immune activation, secretion, and barrier dysfunction in duodenal, jejunal, or colorectal mucosa. This study aimed to measure ileal mucosal expression of genes and proteins associated with mucosal functions.

Methods: We measured by reverse transcription polymerase chain reaction messenger RNA (mRNA) expression of 78 genes (reflecting tight junction proteins, chemokines, innate immunity, ion channels, and transmitters) and 5 proteins (barrier, bile acid receptor, and ion exchanger) in terminal ileal mucosa from 11 patients with IBS-diarrhea (IBS-D), 17 patients with IBS-constipation (IBS-C), and 14 healthy controls. Read More

J Clin Rheumatol 2021 Apr 9. Epub 2021 Apr 9.

Department of Rheumatology, Trakya University Medical School, Edirne, Turkey Department of Gastroenterology, Trakya University Medical School, Edirne, Turkey.

Ann Ital Chir 2021 Apr 12;10. Epub 2021 Apr 12.

Aim: Enterocutaneous fistula is a rare but severe complication of prosthetic incisional hernia repair. Management requires re-exploration with intestinal repair/resection and mesh removal. Repair of the parietal defect in this contaminated field is challenging. Read More

J Matern Fetal Neonatal Med 2021 Apr 11:1-3. Epub 2021 Apr 11.

Department of Pathology, Dr. RML Hospital, New Delhi, India.

Microvillous inclusion disease (MVID), also known as congenital microvillus atrophy remains an important differential diagnosis of intractable secretory diarrhea in neonatal period. The condition is inherited as an autosomal recessive disorder with no sex predilection and more commonly reported in those tribes with consanguineous marriages. The pathognomonic electron microscopic findings includes villous atrophy with the formation of intracellular microvillous inclusions. Read More

Acta Radiol 2021 Apr 11:284185121996270. Epub 2021 Apr 11.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Takayasu arteritis (TA), a systemic large-vessel vasculitis, was reported to have high incidence of spondyloarthropathy.

Purpose: To evaluate the prevalence of inflammatory sacroiliitis in patients with TA that underwent abdominal/pelvic magnetic resonance imaging (MRI) examinations as part of their vasculitis work-up.

Material And Methods: Consecutive abdominal/pelvic MRI examinations of 34 patients with TA fulfilling the 1990 ACR criteria and 34 age- and gender-matched controls performed between 2008 and 2020 were retrospectively reviewed for the presence sacroiliitis. Read More

J Manag Care Spec Pharm 2021 Apr 12:1-11. Epub 2021 Apr 12.

AbbVie Inc., North Chicago, IL.

Patient support programs (PSPs) improve medication-taking behavior in the first 12 months of treatment for patients with immune-mediated diseases, but it is unknown if these benefits are sustained. As immune-mediated diseases continue to increase in prevalence and economic burden, understanding the potential value of PSPs in helping patients adhere to their long-term treatment plan and avoid costly hospital visits is crucial. Launched nationally in 2015, HUMIRA Complete (a PSP for adalimumab patients) provides an opportunity to study long-term effects of PSP participation, including the impact on medication-taking behavior and hospital visits. Read More

Helicobacter 2021 Apr 11:e12805. Epub 2021 Apr 11.

Inform Diagnostics Research Institute, Irving, TX, USA.

Aims: Studies investigating the relationship between granulomatous gastritis (GG) and Helicobacter pylori infection have been largely inconclusive. This study was designed to determine whether the analysis of a very large number of patients would provide clearer answers evaluate the association between H. pylori infection and gastric granulomas. Read More

Mamm Genome 2021 Apr 11. Epub 2021 Apr 11.

Rat Resource and Research Center, University of Missouri, Columbia, MO, 65201, USA.

Mutations and single base pair polymorphisms in various genes have been associated with increased susceptibility to inflammatory bowel disease (IBD). We have created a series of rat strains carrying targeted genetic alterations within three IBD susceptibility genes: Nod2, Atg16l1, and Il23r, using CRISPR/Cas9 genome editing technology. Knock-out alleles and alleles with known human susceptibility polymorphisms were generated on three different genetic backgrounds: Fischer, Lewis and Sprague Dawley. Read More

Lancet Healthy Longev 2021 Apr;2(4):e212-e221

Mellanby Centre for Musculoskeletal Research, University of Sheffield, Northern General Hospital, Sheffield, UK.

Background: Observational and preclinical studies show associations between selenium status, bone health, and physical function. Most adults in Europe have serum selenium below the optimum range. We hypothesised that selenium supplementation could reduce pro-resorptive actions of reactive oxygen species on osteoclasts and improve physical function. Read More

Front Med (Lausanne) 2021 26;8:655956. Epub 2021 Mar 26.

Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

The intestinal epithelium is a complex, dynamic barrier that separates luminal contents from the immune compartment while mediating nutrient absorption and controlled passage of antigens to convey oral tolerance. A compromised epithelial barrier often leads to inflammation because immune cells in the lamina propria come into direct contact with luminal antigens. Defects in epithelial cell function were also shown to be involved in the etiology of inflammatory bowel diseases. Read More

Gland Surg 2021 Mar;10(3):1276-1278

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Tumors infiltrating the recto-sigmoid colon are commonly detected during cytoreductive surgery in patients with advanced ovarian cancer. Although radical excision using low anterior resection (LAR) is traditionally needed for optimal cytoreduction in the patients, LAR commonly decrease postoperative quality of life by changes of bowel habit. Since there is increasing evidence that conservative ablation of tumors on the recto-sigmoid colon may be safe and effective like LAR without compromising quality of life, we developed the surgical technique of visceral segmental serosectomy (VSS) as one of conservative ablation methods for complete resection of serosal implants on the recto-sigmoid colon and scrupulous restoration of extended serosal defect after resection. Read More

Gland Surg 2021 Mar;10(3):1207-1211

Division of Gynecologic Oncology, Ajou University School of Medicine, Suwon, Korea.

Ovarian cancer is known as the second most common cause of death among gynecologic cancers. Survival outcome has been reported to be significantly associated with the efforts to minimize residual disease after cytoreductive surgery. As ovarian cancer often invades the small and large bowel without boundary, bowel surgery has been a crucial part of the cytoreductive surgery to achieve complete tumor removal. Read More

Gland Surg 2021 Mar;10(3):1038-1045

Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: The National Surgical Adjuvant Breast and Bowel Project (NSABP) B32 trial reported that the detection rate of sentinel lymph nodes by core needle biopsy (CNB) is higher than that by segmental resection. However, there are few reports regarding the detection rate of sentinel lymph nodes by vacuum-assisted breast biopsy (VABB). Therefore, we analyzed the impact of preoperative biopsy methods on the surgical modes of 3,966 patients with breast cancer in our center. Read More

Cureus 2021 Mar 9;13(3):e13780. Epub 2021 Mar 9.

Department of Radiation Medicine, Georgetown University Hospital, Washington, USA.

Purpose Stereotactic body radiation therapy (SBRT) delivers large radiation doses to the prostate while minimizing exposure to adjacent normal tissues. Large fraction sizes may increase the risks of functional decrements. Elderly men may be at an increased risk of these toxicities due to poor baseline function and hence limited reserve. Read More

Cureus 2021 Mar 8;13(3):e13770. Epub 2021 Mar 8.

Emergency Medicine, Envision Physician Services, Plantation, USA.

Hematemesis with concomitant small bowel obstruction is an uncommon emergency department presentation. We report the case of a patient who presented with hematemesis and an incarcerated pantaloon hernia. While the patient initially had intact bowel movements and flatus, he eventually developed complete obstruction that required open surgical repair. Read More

Cureus 2021 Mar 8;13(3):e13763. Epub 2021 Mar 8.

Gastroenterology, BronxCare Health System, Bronx, USA.

 species are spore-forming gram-positive anaerobic rod bacteria that cause a broad range of infections in humans, including intra-abdominal infections, myonecrosis, and bacteremia. Pseudomembranous colitis (PMC) is a severe form of infection caused by  .Clostridialbacteremia usually occurs in the settings of neutropenia, alcohol abuse, diabetes mellitus, sickle cell anemia, malignancy, hemodialysis, inflammatory bowel disease, and AIDS. Read More