58,278 results match your criteria boston scientific


Acute experimental barrier injury triggers ulcerative colitis specific innate hyper-responsiveness and ulcerative colitis-type microbiome changes in humans.

Cell Mol Gastroenterol Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Denmark.

Background And Aims: The trigger hypothesis opens the possibility of anti-flare-initiation therapies by stating that ulcerative colitis (UC) flares originates from inadequate responses to acute mucosal injuries. However, experimental evidence is restricted by a limited use of suitable human models. We thus aimed to investigate the acute mucosal barrier injury responses in humans with and without UC using an experimental injury model. Read More

View Article and Full-Text PDF

Autoimmunity and COVID-19 - The microbiotal connection.

Autoimmun Rev 2021 Jun 9:102865. Epub 2021 Jun 9.

Department of Medicine C, Wolfson Medical Center, Holon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background And Aims: The novel SARS-CoV-2 has been rattling the world since its outbreak in December 2019, leading to the COVID-19 pandemic. The learning curve of this new virus has been steep, with a global scientific community desperate to learn how the virus is transmitted, how it replicates, what cause such a wide spectrum of disease manifestations, causing none or few symptoms in some. Others are burdened by an intense immune response that resembles the cytokine storm syndrome (CSS), which leads to severe disease manifestations, often complicated by fatal acute respiratory distress syndrome and death. Read More

View Article and Full-Text PDF

Tai Chi for health and well-being: A bibliometric analysis of published clinical studies between 2010 and 2020.

Complement Ther Med 2021 Jun 9:102748. Epub 2021 Jun 9.

NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia.

The objective of this bibliometric review was to identify the volume, breadth, and characteristics of clinical studies evaluating Tai Chi published between January 2010 and January 2020. Five English and four Chinese language databases were searched. Following independent screening, 1018 eligible publications representing 987 studies were identified, which was a three-fold increase from the previous decade. Read More

View Article and Full-Text PDF

Books, bones and bodies: The relevance of the history of anatomy in Nazi Germany for medical education today.

Anat Rec (Hoboken) 2021 Jun 12. Epub 2021 Jun 12.

Division of General Pediatrics, Department of Pediatrics, Boston Children' Hospital, Harvard Medical School, Boston, Massachusetts, USA.

The history of anatomy in Nazi Germany highlights the consequences to humanity when the destructive potentials immanent to all science and medicine are enabled by an anti-democratic, totalitarian regime. Anatomy presents an example of ethical transgressions by scientists and health care professionals that were amplified in the criminal political climate of the Nazi regime. This can happen anywhere, as science is never apolitical. Read More

View Article and Full-Text PDF

Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity.

FASEB J 2021 Jul;35(7):e21714

School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.

We tested the hypothesis that cancer cachexia progression would induce oxidative post-translational modifications (Ox-PTMs) associated with skeletal muscle wasting, with different responses in muscles with the prevalence of glycolytic and oxidative fibers. We used cysteine-specific isotopic coded affinity tags (OxICAT) and gel-free mass spectrometry analysis to investigate the cysteine Ox-PTMs profile in the proteome of both plantaris (glycolytic) and soleus (oxidative) muscles in tumor-bearing and control rats. Histological analysis revealed muscle atrophy in type II fibers in plantaris muscle, with no changes in plantaris type I fibers and no differences in both soleus type I and II fibers in tumor-bearing rats when compared to healthy controls. Read More

View Article and Full-Text PDF

Cardiac surgeons' concerns, perceptions, and responses during the COVID-19 pandemic.

J Card Surg 2021 Jun 12. Epub 2021 Jun 12.

Division of Cardiothoracic Surgery, UC Davis Medical Center, Sacramento, California, USA.

Background: The coronavirus disease 2019 (COVID-19) pandemic has had an unprecedented impact on health care and cardiac surgery. We report cardiac surgeons' concerns, perceptions, and responses during the COVID-19 pandemic.

Methods: A detailed survey was sent to recruit participating adult cardiac surgery centers in North America. Read More

View Article and Full-Text PDF

Qualitative Characterization of the Rat Liver Mitochondrial Lipidome Using All Ion Fragmentation on an Exactive Benchtop Orbitrap MS.

Methods Mol Biol 2021 ;2275:379-391

Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Untargeted lipidomics profiling by liquid chromatography -mass spectrometry (LC-MS) allows researchers to observe the occurrences of lipids in a biological sample without showing intentional bias to any specific class of lipids and allows retrospective reanalysis of data collected. Typically, and in the specific method described, a general extraction method followed by LC separation is used to achieve nonspecific class coverage of the lipidome prior to high resolution accurate mass (HRAM) MS detection . Here we describe a workflow including the isolation of mitochondria from liver tissue, followed by mitochondrial lipid extraction and the LC-MS conditions used for data acquisition. Read More

View Article and Full-Text PDF
January 2021

Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies.

Clin Infect Dis 2021 Jun 12. Epub 2021 Jun 12.

Unversity of California, San Diego, San Diego, CA, USA.

Background: Development of HIV remission strategies requires precise information on time to HIV rebound after treatment interruption, but there is uncertainty regarding whether modern ART regimens and timing of ART initiation may impact this outcome.

Methods: ACTG A5345 enrolled individuals who initiated ART during chronic or early HIV infection and on suppressive ART for ≥2 years. Participants underwent carefully monitored antiretroviral interruption. Read More

View Article and Full-Text PDF

Traumatic cervical spine fracture patterns on CT: a retrospective analysis at a level 1 trauma center.

Emerg Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA.

Purpose: The purpose of our study was to determine common acute traumatic cervical spine fracture patterns on CT cervical spine (CTCS).

Methods: We retrospectively reviewed 1091 CTCS positive for traumatic fractures performed over a 10-year period at a level 1 trauma center. Fractures were classified by vertebral level, laterality, and anatomic location (anterior/posterior arch, body, odontoid, pedicle, facet, lateral mass, lamina, spinous process, transverse foramina, and transverse processes). Read More

View Article and Full-Text PDF

An integrative investigation of sensory organ development and orientation behavior throughout the larval phase of a coral reef fish.

Sci Rep 2021 Jun 11;11(1):12377. Epub 2021 Jun 11.

Department of Biology and Marine Program, Boston University, Boston, MA, 02215, USA.

The dispersal of marine larvae determines the level of connectivity among populations, influences population dynamics, and affects evolutionary processes. Patterns of dispersal are influenced by both ocean currents and larval behavior, yet the role of behavior remains poorly understood. Here we report the first integrated study of the ontogeny of multiple sensory systems and orientation behavior throughout the larval phase of a coral reef fish-the neon goby, Elacatinus lori. Read More

View Article and Full-Text PDF

Childhood cross-ethnic exposure predicts political behavior seven decades later: Evidence from linked administrative data.

Sci Adv 2021 Jun 11;7(24). Epub 2021 Jun 11.

Institute for Quantitative Social Science and Department of Government, Harvard University, 1737 Cambridge Street, Cambridge, MA 02138, USA.

Does contact across social groups influence sociopolitical behavior? This question is among the most studied in the social sciences with deep implications for the harmony of diverse societies. Yet, despite a voluminous body of scholarship, evidence around this question is limited to cross-sectional surveys that only measure short-term consequences of contact or to panel surveys with small samples covering short time periods. Using advances in machine learning that enable large-scale linkages across datasets, we examine the long-term determinants of sociopolitical behavior through an unprecedented individual-level analysis linking contemporary political records to the 1940 U. Read More

View Article and Full-Text PDF

Statin therapy for patients with aortic stenosis who underwent transcatheter aortic valve implantation: a report from a Japanese multicentre registry.

BMJ Open 2021 Jun 11;11(6):e044319. Epub 2021 Jun 11.

Department of Cardiology, Keio University School of Medicine, Shinjuku-ku, Japan.

Objective: Data on statin for patients with aortic stenosis (AS) who underwent transcatheter aortic valve implantation (TAVI) are limited. The present study aimed to evaluate the impact of statin on midterm mortality of TAVI patients.

Design: Observational study. Read More

View Article and Full-Text PDF

Promoting social emotional development during the paediatric well-child visit: a demonstration project.

BMJ Open Qual 2021 Jun;10(2)

Programs, National Institute for Children's Health Quality (NICHQ), Boston, Massachusetts, USA.

Supporting social emotional development, beginning at birth, can improve lifelong health. The American Academy of Paediatrics recommends 12 well-child visits between birth and age 3 years. Each well-child visit provides a unique opportunity to interact with and support families to promote social emotional development of children. Read More

View Article and Full-Text PDF

Authors' Response.

Authors:
Parke Wilde

J Acad Nutr Diet 2021 Jun 8. Epub 2021 Jun 8.

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.

View Article and Full-Text PDF

Leadership Titles in Radiology: Usage of Non-Inclusive Terminology among Academic Radiology Departments and Societies.

Acad Radiol 2021 Jun 8. Epub 2021 Jun 8.

University of Maryland Intelligent Imaging (UMII) Center, Department of Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address:

Rationale And Objectives: To characterize the use of gender-specific (chairman) and non-inclusive terminology (chief) to describe departmental and divisional/sectional leadership within academic radiology department and radiological society websites.

Methods: From a total of 157 unique institutions identified, we gathered a list of 123 departments with functioning websites. We screened for use of "chairman" and "chief" on departmental home pages, welcome messages, faculty listings, and residency program pages, noting location on websites, and alternative terms, if present. Read More

View Article and Full-Text PDF

Implications of Electronic Consultations for Clinician Communication and Relationships: A Qualitative Study.

Med Care 2021 Jun 11. Epub 2021 Jun 11.

Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, Bedford Department of Population and Quantitative Health Sciences, Division of Health Informatics and Implementation Science, University of Massachusetts Medical School, Worcester Section of Endocrinology, Diabetes, and Metabolism, Boston University School of Medicine Medical Service, VA Boston Healthcare System Evans Department of Medicine, Boston University School of Medicine Medical Service and Section of Infectious Diseases, VA Boston Healthcare System, Boston Harvard Medical School, Cambridge Department of Population and Quantitative Health Sciences, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester Section of Pulmonary, Allergy, Sleep, and Critical Care Medicine, Boston University School of Medicine, Boston, MA.

Background: Strong relationships and effective communication between clinicians support care coordination and contribute to care quality. As a new mechanism of clinician communication, electronic consultations (e-consults) may have downstream effects on care provision and coordination.

Objective: The objective of this study was to understand primary care providers' and specialists' perspectives on how e-consults affect communication and relationships between clinicians. Read More

View Article and Full-Text PDF

Classification of visuomotor tasks based on electroencephalographic data depends on age-related differences in brain activity patterns.

Neural Netw 2021 May 13;142:363-374. Epub 2021 May 13.

Institute of Sports Medicine, Paderborn University, Paderborn, Germany; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Classification of physiological data provides a data driven approach to study central aspects of motor control, which changes with age. To implement such results in real-life applications for elderly it is important to identify age-specific characteristics of movement classification. We compared task-classification based on EEG derived activity patterns related to brain network characteristics between older and younger adults performing force tracking with two task characteristics (sinusoidal; constant) with the right or left hand. Read More

View Article and Full-Text PDF

Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.

Bioorg Med Chem 2021 Jun 8;42:116251. Epub 2021 Jun 8.

Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates; College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address:

Selective inhibition of histone deacetylases (HDACs) is an important strategy in the field of anticancer drug discovery. However, lack of inhibitors that possess high selectivity toward certain HDACs isozymes is associated with adverse side effects that limits their clinical applications. We have initiated a collaborative initiatives between multi-institutions aimed at the discovery of novel and selective HDACs inhibitors. Read More

View Article and Full-Text PDF

Maternal phthalate and phthalate alternative metabolites and urinary biomarkers of estrogens and testosterones across pregnancy.

Environ Int 2021 Jun 8;155:106676. Epub 2021 Jun 8.

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA. Electronic address:

Background/objectives: Pregnant women are ubiquitously exposed to phthalates from food packaging materials and personal care products. Phthalates alter estrogen and testosterone concentrations in experimental models, but their ability to impact these hormones in human pregnancy is not well characterized.

Methods: We recruited women ages 18-40 into the Illinois Kids Development Study (I-KIDS) in early pregnancy. Read More

View Article and Full-Text PDF

Structural white matter alterations in carpal tunnel syndrome: A modified TBSS study.

Brain Res 2021 Jun 8:147558. Epub 2021 Jun 8.

School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Functional and structural brain alterations have been noted in carpal tunnel syndrome (CTS), the most common entrapment peripheral neuropathy. Previous studies were mainly focused on somatosensory cortices. However, the changes of white matter diffusion properties in nonsensorimotor cortices remain uninvestigated. Read More

View Article and Full-Text PDF

Death in the Fas, ELANE.

Authors:
Anthony Letai

Cell 2021 Jun;184(12):3081-3083

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

In this issue of Cell, Cui et al. demonstrate a previously unknown capacity for neutrophils to selectively kill cancer cells. How this killing is effected unfolds as a story of classical biochemistry, novel cell biology, and innate and adaptive immunity. Read More

View Article and Full-Text PDF

Cayley Graphs of Semigroups Applied to Atom Tracking in Chemistry.

J Comput Biol 2021 Jun 11. Epub 2021 Jun 11.

Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.

While atom tracking with isotope-labeled compounds is an essential and sophisticated wet-lab tool to, for example, illuminate reaction mechanisms, there exists only a limited amount of formal methods to approach the problem. Specifically, when large (bio-)chemical networks are considered where reactions are stereospecific, rigorous techniques are inevitable. We present an approach using the right Cayley graph of a monoid to track atoms concurrently through sequences of reactions and predict their potential location in product molecules. Read More

View Article and Full-Text PDF

"Turn-On" Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer's Disease: Rational Design, Synthesis, and Molecular Docking.

ACS Sens 2021 Jun 11. Epub 2021 Jun 11.

Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

Tau aggregation is believed to have a strong association with the level of cognitive deficits in Alzheimer's disease (AD). Thus, optical brain imaging of tau aggregates has recently gained substantial attention as a promising tool for the early diagnosis of AD. However, selective imaging of tau aggregates is a major challenge due to sharing similar β-sheet structures with homologous Aβ fibrils. Read More

View Article and Full-Text PDF

Experiences with implementation of continuous positive airway pressure for neonates and infants in low-resource settings: A scoping review.

PLoS One 2021 11;16(6):e0252718. Epub 2021 Jun 11.

Vayu Global Health Foundation Boston, Boston, Massachusetts, United States of America.

Background: Continuous positive airway pressure (CPAP) is the gold standard of care in providing non-invasive positive pressure support to neonates in respiratory distress in high-resource settings. While safety has been demonstrated in low-resource settings, there is a lack of knowledge on the barriers and facilitators to proper implementation.

Objective: To identify and describe the barriers, facilitators, and priorities for future implementation of CPAP for neonates and infants in low-resource settings. Read More

View Article and Full-Text PDF

High-grade Papillary Early Gastric Carcinoma With High Risk for Lymph Node Metastasis and Poor Prognosis: A Clinicopathologic Study of 96 Cases Among 1136 Consecutive Radical Gastrectomies.

Am J Surg Pathol 2021 Jun 10. Epub 2021 Jun 10.

Departments of Pathology Oncology Gastroenterology of the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Department of Pathology of the First Affiliated Hospital of Soochow University, Suzhou, China Department of Pathology and Laboratory Medicine of Veterans Affairs Boston Healthcare System, Harvard Medical School and Brigham and Women's Hospital, MA.

Papillary early gastric carcinoma (EGC) is believed to have a low risk of lymph node metastasis (LNM) and thus can be resected endoscopically. We observed anecdotally that some papillary EGC tumors showed conspicuous high-grade dysplastic features, but the significance of these observations is unknown. In this bicenter study we investigated papillary EGCs that were divided into high-grade (n=96) and low-grade (n=118) groups among 1136 consecutive EGC radical resection cases. Read More

View Article and Full-Text PDF

Microfinance, retention in care, and mortality among patients enrolled in HIV 2 Care in East Africa.

AIDS 2021 Jun 10. Epub 2021 Jun 10.

Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 615 N. 12 Wolfe Street, Baltimore, MD 21205 USA Brown University School of Public Health, Department of Epidemiology, 121 South Main 15 Street, Providence, RI 02912 USA Academic Model Providing Access to Healthcare, P.O. Box 4606-30100, Eldoret, Kenya Brown University School of Public Health, Department of Biostatistics, 121 South Main Street, 20 Providence, RI 02912 USA Moi University College of Health Sciences, School of Medicine, Department of Behavioral 23 Science, P.O. Box 4606-30100, Eldoret, Kenya Purdue University College of Pharmacy, Center for Health Equity and Innovation, 640 26 Eskenazi Ave, Indianapolis, IN 46202 USA Temple University School of Pharmacy, Department of Pharmacy Practice, 3307 N Broad St, 28 Philadelphia, PA 19140 USA Boston University School of Public Health, Department of Global Health, Crosstown Center, 31 801 Massachusetts Avenue, Boston, MA 02118 USA Indiana University School of Medicine, Department of Medicine, 702 Rotary Circle, RO 101, 34 Indianapolis, IN 46202 USA Indiana University School of Public Health, Department of Epidemiology and Biostatistics, 1025 E. 7th 37 St., Bloomington, IN 47405 USA Brown University School of Public Health, Department of Health Services, Policy and 40 Practice, 121 South Main Street, Providence, RI 02912 USA.

Objective: To measure associations between participation in community-based microfinance groups, retention in HIV care, and death among people living with HIV (PLHIV) in low-resource settings.

Design And Methods: We prospectively analyzed data from 3,609 patients enrolled in an HIV care program in western Kenya. HIV patients who were eligible and chose to participate in a Group Integrated Savings for Health Empowerment (GISHE) microfinance group were matched 1:2 on age, sex, year of enrollment in HIV care, and location of initial HIV clinic visit to patients not participating in GISHE. Read More

View Article and Full-Text PDF

Trends in Endotracheal Intubation During In-Hospital Cardiac Arrests: 2001-2018.

Crit Care Med 2021 Jun 9. Epub 2021 Jun 9.

Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA. Center for the Study of Healthcare Innovation, Implementation, and Policy, Health Services Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA. Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Division of Hospital Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA. Division of Pulmonary, Critical Care Medicine, and Sleep Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Objectives: Airway management during in-hospital cardiac arrest represents a fundamental component of resuscitative efforts, yet little is known about temporal trends in intubation during in-hospital cardiac arrest. Our objective was to investigate changes in in-hospital cardiac arrest airway management over time and in response to national guideline updates.

Design: Observational cohort study of a prospectively collected database. Read More

View Article and Full-Text PDF

Augmented Package of Palliative Care for Women With Cervical Cancer: Responding to Refractory Suffering.

JCO Glob Oncol 2021 Jun;7:886-895

Department of Non-communicable Diseases, World Health Organization, Geneva, Switzerland.

The essential package of palliative care for cervical cancer (EPPCCC), described elsewhere, is designed to be safe and effective for preventing and relieving most suffering associated with cervical cancer and universally accessible. However, it appears that women with cervical cancer, more frequently than patients with other cancers, experience various types of suffering that are refractory to basic palliative care such as what can be provided with the EPPCCC. In particular, relief of refractory pain, vomiting because of bowel obstruction, bleeding, and psychosocial suffering may require additional expertise, medicines, or equipment. Read More

View Article and Full-Text PDF

Essential Package of Palliative Care for Women With Cervical Cancer: Responding to the Suffering of a Highly Vulnerable Population.

JCO Glob Oncol 2021 Jun;7:873-885

Department of Non-communicable Diseases, World Health Organization, Geneva, Switzerland.

Women with cervical cancer, especially those with advanced disease, appear to experience suffering that is more prevalent, complex, and severe than that caused by other cancers and serious illnesses, and approximately 85% live in low- and middle-income countries where palliative care is rarely accessible. To respond to the highly prevalent and extreme suffering in this vulnerable population, we convened a group of experienced experts in all aspects of care for women with cervical cancer, and from countries of all income levels, to create an essential package of palliative care for cervical cancer (EPPCCC). The EPPCCC consists of a set of interventions, medicines, simple equipment, social supports, and human resources, and is designed to be safe and effective for preventing and relieving all types of suffering associated with cervical cancer. Read More

View Article and Full-Text PDF