Mol Cell Proteomics 2021 Apr 13:100081. Epub 2021 Apr 13.
Department of Chemistry, University of Wisconsin, Madison, WI, 53705, USA; School of Pharmacy, University of Wisconsin, Madison, WI, 53705, USA. Electronic address:
As the body fluid that directly interchanges with the extracellular fluid of central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted for CSF, but studies aimed at unraveling site-specific CSF N-glycoproteome are lacking. Initial efforts into site-specific N-glycoproteomics study in CSF yield limited coverage, hindering further experimental design of glycosylation-based disease biomarker discovery in CSF. Read More