3,598 results match your criteria borderline malignant

Total thyroidectomy can still remain the method of choice in some Bethesda III cases.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Jul 20. Epub 2021 Jul 20.

Institute of Pathology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: The latest WHO classification of tumours of endocrine organs defines new units of borderline thyroid tumours (BTT). The aim of our study was to evaluate ultrasonographic and cytological features, mutation profile and surgery treatment in rare thyroid tumours.

Methods: An analysis of 8 BTT out of 487 patients, who underwent thyroid surgery between June 2016 and June 2020. Read More

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External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma.

J Clin Med 2021 Jul 1;10(13). Epub 2021 Jul 1.

Endometriosis Center of Excellence, Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan 5262000, Israel.

The study aimed to perform external validation of the International Ovarian Tumor Analysis (IOTA) classification of adnexal masses as benign or malignant in women with suspected endometrioma. A retrospective study including women referred to an endometriosis tertiary referral center for dedicated transvaginal ultrasound (TVUS). Adnexal masses were evaluated using the IOTA classification simple descriptors, simple rules and expert opinion. Read More

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Pathological features of persistent adnexal masses in pregnancy.

Ann Transl Med 2021 Jun;9(12):973

Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Background: The composition of pelvic masses during pregnancy is complex, and over >70% of masses are physiology. Determining the source and nature of tumor tissue is incredibly important in clinical practice, as the proportion of metastatic and low-grade tumors in adnexal masses increase during pregnancy. This study sought to analyze the pathological features of persistent adnexal masses in pregnancy. Read More

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Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors.

Front Oncol 2021 1;11:694441. Epub 2021 Jul 1.

Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Aim: To retrospectively investigate the pre-operative clinical factors and ultrasonographic features that influence the accuracy of the intraoperative frozen section (IFS) of ovarian tumors.

Patients And Methods: Women with ovarian tumors that underwent IFS in one tertiary medical center were recruited from January 2010 to December 2018. Demographic and clinical data of these women were retrieved from medical records in the hospital's centralized database. Read More

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Endometriosis-associated cancer.

F Guidozzi

Climacteric 2021 Jul 16:1-6. Epub 2021 Jul 16.

Parklane Clinic, Johannesburg, South Africa.

Endometriosis will affect about 10% of the female population and not only can it significantly impact adversely on quality of life and result in infertility, but data are accumulating that malignant transformation is an important consideration. Endometriosis can be histologically typical or atypical, ovarian, superficial peritoneal or deep infiltrating. The precursor for malignant transformation appears to be the ovarian atypical endometriosis component. Read More

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Debulking surgery for malignant tumors: the current status, evidence and future perspectives.

Jpn J Clin Oncol 2021 Jul 12. Epub 2021 Jul 12.

Division of Thoracic Surgery, Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Debulking surgery, also called cytoreductive surgery, is a resection of the tumor as much as possible and an intended incomplete resection for unresectable malignant tumors. Since the most important principle in surgical oncology is complete R0 resection, debulking surgery goes against the basic principle and obscures the concept of operability. However, debulking surgery has been advocated for various types of advanced malignant tumors, including gynecological cancers, urological cancers, gastrointestinal cancers, breast cancers and other malignancies, with or without adjuvant therapy. Read More

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Laparoendoscopic Ovarian-Sparing Surgery of Adnexal Tumors in Children and Adolescents by General Gynecologists: A 10-Year, Retrospective Cohort Study.

J Laparoendosc Adv Surg Tech A 2021 Jul 12. Epub 2021 Jul 12.

Department of General Gynecology, Clinic for Gynecology and Obstetrics, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.

In pediatric and adolescent gynecology, ovarian-sparing surgery (OSS) is an approach for preserving the ovaries affected by tumors and torsion during surgical treatment. We analyzed participants from a tertiary Gynecology and Obstetrics University Hospital. Participants were patients <19 years of age with adnexal tumors managed surgically with removal of pathologically confirmed ovarian tissue in the period from 2008 to 2017. Read More

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Large ovarian tumors in adolescents, a systematic review of reported cases, diagnostic findings and surgical management.

Taiwan J Obstet Gynecol 2021 Jul;60(4):602-608

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.

The purpose of this study was to analyze the published cases regarding large ovarian masses in adolescents, in order to find useful clinical implications for the diagnosis and management of the condition. The methodology employed a systematic review of reported cases of large/giant ovarian tumor in adolescence. The main objective was to assess the imagery findings, histology of the tumor, and the type of surgery performed. Read More

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Predicting the pathological grade of breast phyllodes tumors: a nomogram based on clinical and magnetic resonance imaging features.

Br J Radiol 2021 Aug 8;94(1124):20210342. Epub 2021 Jul 8.

Department of Radiology, Fudan University Shanghai Cancer Center, Xuhui, Shanghai, China.

Objective: To explore the potential factors related to the pathological grade of breast phyllodes tumors (PTs) and to establish a nomogram to improve their differentiation ability.

Methods: Patients with PTs diagnosed by post-operative pathology who underwent pretreatment magnetic resonance imaging (MRI) from January 2015 to June 2020 were retrospectively reviewed. Traditional clinical features and MRI features evaluated according to the fifth BI-RADS were analyzed by statistical methods and introduced to a stepwise multivariate logistic regression analysis to develop a prediction model. Read More

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Successful Treatment of a Locally Recurrent and Metastatic Malignant Phyllodes Tumor with Accelerated Radiotherapy and Nab-Paclitaxel, Cisplatin, and Liposomal Doxorubicin Chemotherapy.

Chemotherapy 2021 Jul 7:1-5. Epub 2021 Jul 7.

Department of Radiotherapy/Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.

Phyllodes tumors are rare breast lesions of fibroepithelial origin. Malignant transformation with metastases is linked with poor prognosis. We present a case of a 62-year-old woman with a recurrent malignant phyllodes tumor of the breast and lung metastases. Read More

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Primary and recurrent serous borderline tumors during pregnancy: a case report and literature review.

Int Cancer Conf J 2021 Jul 26;10(3):160-169. Epub 2021 Feb 26.

Department of Obstetrics and Gynecology, Japanese Red Cross Wakayama Medical Center, 4-20 Komatsubara-dori, Wakayama, 640-8558 Japan.

The diagnosis and management of borderline ovarian tumors during pregnancy are still not standardized, because these tumors are rarely encountered. We report the case of a 27-year-old pregnant woman who presented with an ovarian mass in her first trimester. Magnetic resonance imaging revealed a multilocular cystic component with papillary lesions in the background of endometriosis, suggesting a seromucinous borderline tumor or ovarian cancer. Read More

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Case report: Transformation of juvenile fibroadenoma to borderline phyllodes tumor in young lady.

Int J Surg Case Rep 2021 Jul 30;84:106143. Epub 2021 Jun 30.

Department of Anatomical Pathology, Faculty of Medicine, Sebelas Maret University, Indonesia.

Introduction: Fibroadenoma is the most common benign tumor found in young women. Transformation for Fibroadenoma to borderline phyllodes tumor is rare. Phyllodes tumor tends to recur locally due to the aggressive nature of the phyllodes tumor tissue, which tends to become malignant when recurrence occurs. Read More

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Differential gene expression identifies a transcriptional regulatory network involving ER-alpha and PITX1 in invasive epithelial ovarian cancer.

BMC Cancer 2021 Jul 3;21(1):768. Epub 2021 Jul 3.

Translational Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Background: The heterogeneous subtypes and stages of epithelial ovarian cancer (EOC) differ in their biological features, invasiveness, and response to chemotherapy, but the transcriptional regulators causing their differences remain nebulous.

Methods: In this study, we compared high-grade serous ovarian cancers (HGSOCs) to low malignant potential or serous borderline tumors (SBTs). Our aim was to discover new regulatory factors causing distinct biological properties of HGSOCs and SBTs. Read More

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Total Pancreatectomy with Autologous Islet Cell Transplantation-The Current Indications.

J Clin Med 2021 Jun 20;10(12). Epub 2021 Jun 20.

Department of Digestive Tract Surgery, Medical University of Silesia, 40-752 Katowice, Poland.

Total pancreatectomy is a major complex surgical procedure involving removal of the whole pancreatic parenchyma and duodenum. It leads to lifelong pancreatic exocrine and endocrine insufficiency. The control of surgery-induced diabetes (type 3) requires insulin therapy. Read More

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Race-Related Differences in the Clinical Presentation and Histopathologic Features of Phyllodes Tumor.

Am Surg 2021 Jun 30:31348211029841. Epub 2021 Jun 30.

Department of Surgery, 12278East Carolina University Brody School of Medicine, Greenville, NC, USA.

Background: Phyllodes tumor (PT) is a rare fibroepithelial lesion of the breast with variable malignant potential. Black women have a higher incidence of a related benign tumor, fibroadenoma, but there are limited epidemiological data on PT. The aim of our study was to evaluate race-related differences in the clinicopathologic features and outcomes of PT. Read More

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Borderline ovarian mucinous tumor with anaplastic carcinomatous mural nodule: A case report.

Gynecol Oncol Rep 2021 Aug 8;37:100809. Epub 2021 Jun 8.

Department of Pathology, Regional Cancer Centre, Trivandrum 695011, Kerala, India.

Malignant mural nodules in borderline ovarian tumors are rare. Among them, anaplastic mural nodules are infrequent and only limited case reports are available. Here we report a patient diagnosed as borderline ovarian mucinous tumor with an anaplastic carcinomatous mural nodule. Read More

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Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws.

Int J Oral Sci 2021 06 30;13(1):21. Epub 2021 Jun 30.

Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.

Ossifying fibroma (OF) and fibrous dysplasia (FD) are two fibro-osseous lesions with overlapping clinicopathological features, making diagnosis challenging. In this study, we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations (CNAs) using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples. Freshly frozen tissue specimens from OF (n = 29) and FD (n = 28) patients were obtained for analysis. Read More

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Borderline serous tumor of the ovary discovered during pregnancy: A case report.

Int J Surg Case Rep 2021 Jul 11;84:106099. Epub 2021 Jun 11.

Department of Gynecology and Obstetrics, University Hospital Center Ibn Rochd, Faculty of Medecine and Pharmacy, Hassan II University, Casablanca, Morocco.

Introduction: OFTs are tumors with low malignant potential. They represent 10 to 15% of all epithelial tumors of the ovary. Their mean age of occurrence is less than 10 years than that of carcinomas. Read More

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STING pathway expression in low-grade serous carcinoma of the ovary: an unexpected therapeutic opportunity?

J Pathol Clin Res 2021 Jun 17. Epub 2021 Jun 17.

Department of Molecular Oncology, BC Cancer Research Center, Vancouver, BC, Canada.

Ovarian carcinoma histotypes are distinct diseases with variable clinical outcomes and response to treatment. There is a need for new subtype-specific treatment modalities, especially for women with widespread and chemo-resistant disease. Stimulator of interferon genes (STING) is a part of the cGAS-STING pathway that mediates innate immune defence against infectious DNA-containing pathogens and also detects tumour-derived DNA and generates intrinsic antitumour immunity. Read More

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CD117/c-KIT Expression in Phyllodes Tumor of the Breast and Its Correlation With Morphology and Clinical Outcome.

Cureus 2021 May 9;13(5):e14914. Epub 2021 May 9.

Pathology, Liaquat National Hospital and Medical College, Karachi, PAK.

Introduction Breast phyllodes tumor's (PT) clinical behavior is difficult to predict on histology. There is limited amount of data available on the role of biological markers. The objective of this study was to assess the expression of CD117 (c-KIT) in PT of the breast and its relationship with morphology and clinical outcome. Read More

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Serous borderline ovarian tumours: an extensive review on MR imaging features.

Br J Radiol 2021 Jul 8:20210116. Epub 2021 Jul 8.

Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK.

Serous borderline ovarian tumours (SBOTs) are an intermediate group of neoplasms, which have features between benign and malignant ovarian tumours and for which, fertility-sparing surgery can be offered. MRI in imaging of SBOTs is, therefore, crucial in raising the possibility of the diagnosis, in order to present the patient with the most appropriate treatment options. There are characteristic MRI features that SBOTs demonstrate. Read More

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Natural-killer cell cytotoxicity as a diagnostic and prognostic marker for adult patients with secondary hemophagocytic lymphohistiocytosis: a prospective phase II observational study.

Ther Adv Hematol 2021 31;12:20406207211020544. Epub 2021 May 31.

Department of Hematology, Catholic Hematology Hospital and Leukemia Research Institute, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Hemophagocytic lymphohistiocytosis (HLH) can be life-threatening if not detected and treated appropriately. The diagnosis of HLH can be confusing due to other similar febrile diseases that present with cytopenia. Natural-killer cell (NK)-cytotoxicity is an important diagnostic parameter for primary HLH; however, its role in secondary HLH in adults has not been well-elucidated. Read More

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A retrospective review of phyllodes tumors of the breast from a single institution.

Breast Dis 2021 ;40(S1):S63-S70

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Background: Phyllodes tumors (PTs) are rare fibroepithelial breast tumors with diverse biological behavior.

Objective: This study aimed to analyze the characteristics, management, and outcome of phyllodes tumors.

Methods: Patients diagnosed with PTs in our institution from January 2013 to December 2017 were identified retrospectively by the ICD-10 code. Read More

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January 2021

Squamous Metaplasia in a Borderline Phyllodes Tumor-an Undocumented Histological Finding in Male Breast: Report of a Case and Review of Literature.

Int J Surg Pathol 2021 Jun 3:10668969211022017. Epub 2021 Jun 3.

28730All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Phyllodes tumor is a paradigm of fibroepithelial neoplasm that accounts for <1% of the breast neoplastic lesions usually detected in females and uncommonly in the male breast. The World Health Organization classifies the tumor into benign, borderline, and malignant based on the predefined morphological criteria. Squamous differentiation in phyllodes tumor is epithelial metaplasia, which has been occasionally documented in English literature. Read More

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Transference-Focused Psychotherapy for Pathological Narcissism and Narcissistic Personality Disorder (TFP-N).

Psychodyn Psychiatry 2021 ;49(2):244-272

Weill Medical College of Cornell University, New York.

In this article, we provide an overview of transference-focused psychotherapy for patients with pathological narcissism and narcissistic personality disorder (TFP-N). In TFP-N we have modified and refined the tactics and techniques of TFP, an evidence-based treatment for borderline personality disorder, to meet the specific challenges of working with patients with narcissistic personality pathology whose retreat from reality into an illusory grandiosity makes them particularly difficult to engage in treatment. We first describe a model of narcissistic pathology based on considerations of psychological structure stemming from object relations theory. Read More

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January 2021

Application of contrast-enhanced dual-energy spectral CT for differentiating borderline from malignant epithelial ovarian tumours.

Clin Radiol 2021 Aug 28;76(8):585-592. Epub 2021 May 28.

Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

Aim: To investigate the value of contrast-enhanced dual-energy spectral computed tomography (CT) in differentiating borderline epithelial ovarian tumours (BEOTs) from malignant epithelial ovarian tumours (MEOTs).

Materials And Methods: Sixty patients who underwent pelvic contrast-enhanced spectral CT were divided into two groups for analysis based on the tumour types confirmed at histopathological examination (26 BEOTs and 34 MEOTs). The regions of interest (ROIs) were selected on solid tumour components to measure attenuation values on monochromatic image sets (40-140 keV) in all imaging phases and tumour iodine concentrations (IC) on material decomposition images. Read More

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Massive congenital cervicofacial desmoid-type fibromatosis in a 5-month-old infant.

J Surg Case Rep 2021 May 27;2021(5):rjab206. Epub 2021 May 27.

Pediatric Division, Department of Otolaryngology/Head and Neck Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Desmoid-type fibromatosis (DF) is a borderline tumor of soft tissues that has low malignant potential but described as infiltrative, locally aggressive and rapidly growing. In the pediatric population, it occurs in the head and neck. Presentation varies based on tumor size and location. Read More

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A novel decision tree model based on chromosome imbalances in cell-free DNA and CA-125 in the differential diagnosis of ovarian cancer.

Int J Biol Markers 2021 Jun 31;36(2):3-13. Epub 2021 May 31.

Department of Gynecology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China.

Objective: CA-125 is widely used as biomarker of ovarian cancer. However, CA-125 suffers low accuracy. We developed a hybrid analytical model, the Ovarian Cancer Decision Tree (OCDT), employing a two-layer decision tree, which considers genetic alteration information from cell-free DNA along with CA-125 value to distinguish malignant tumors from benign tumors. Read More

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Nationwide population-based study of prevalence and trend of borderline ovarian tumors in the Republic of Korea.

Sci Rep 2021 May 27;11(1):11158. Epub 2021 May 27.

Department of Obstetrics and Gynecology, Guro Hospital, College of Medicine, Korea University, 148 Gurodong-ro, Guro-gu, Seoul, 08308, Korea.

Borderline ovarian tumors (BOTs) represent noninvasive tumors with uncertain malignant potential. They have a favorable prognosis although they can also recur or be fatal. There are limited population-based data on BOTs, its incidence and surgical treatment approach. Read More

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