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Pituitary Isograft Transplantation in Mice.

Bio Protoc 2017 Jun 5;7(11):e2317. Epub 2017 Jun 5.

Department of Pathology and Laboratory Medicine, University of Kansas Medical School, Kansas City, KS, USA.

The mouse pituitary isograft is a technique developed to administer persistent hormone stimulation, thereby increasing cellular proliferation in the mammary tissue ( Christov , 1993 ). The pituitary isograft procedure was first described in 'Induction of Mammary Cancer in Mice without the Mammary Tumor Agent by Isografts of Hypophyses' by O. Mühlbock and L. Read More

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A comparison of young children's spatiotemporal gait measures in three common types of footwear with different sole hardness.

Gait Posture 2021 Sep 6;90:276-282. Epub 2021 Sep 6.

Department of Physiotherapy, Monash University, Melbourne, Australia; Peninsula Health, Melbourne, Victoria, Australia.

Background: It is unknown what the impact of sole hardness is on young children's gait. Yet, this feature is commonly marketed as having differing benefits for young children's walking and development.

Research Question: What are the differences in spatiotemporal measures of gait during walking and running in three common types of young children's footwear with a soft sole, compared to a hard sole?

Methods: The study used a quasi-experimental design, with the condition order randomised using a Latin square sequence. Read More

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September 2021

Multiple neoplasia in a patient with Gitelman syndrome harboring germline monoallelic MUTYH mutation.

NPJ Genom Med 2020 Sep 18;5(1):39. Epub 2020 Sep 18.

Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.

Gitelman syndrome is a rare, recessively inherited disease characterized by chronic hypokalemia and hypomagnesemia as a result of defective electrolyte co-transport at the level of the distal convoluted tubule of the kidney. Here, we present the first report of a patient with Gitelman syndrome who developed multiple neoplasia including colorectal polyposis, synchronous colorectal cancers, recurrent breast fibroadenomata and a desmoid tumor. Whole-exome sequencing confirmed germline compound heterozygous mutations of c. Read More

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September 2020

Unna's boot is as efficacious as elastic compression bandage systems in the healing of venous leg ulcers.

Wound Repair Regen 2021 Sep 16. Epub 2021 Sep 16.

Luton Adults Health Services, Cambridgeshire Community Services NHS Trust, Cambridgeshire, UK.

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September 2021

Infodemic vs. Pandemic Factors Associated to Public Anxiety in the Early Stage of the COVID-19 Outbreak: A Cross-Sectional Study in China.

Authors:
Jian Xu Cong Liu

Front Public Health 2021 30;9:723648. Epub 2021 Aug 30.

School of Media and Communication, Shanghai Jiao Tong University, Shanghai, China.

Every outbreak of an epidemic or pandemic disease is accompanied by the tsunami of information, which is also known as the infodemic. Infodemic makes it hard for people to find trustworthy sources and reliable guidance when they need it, and causes social panic about health, widens the gaps between races and regions, and even brings the social chaos all over the world. While most researchers and related parties made efforts to control the inaccurate information spreading online during the COVID-19 pandemic, the infodemic influence caused by the overload of accurate information were almost or completely ignored, and this will hinder the control of infodemic in future public health crises. Read More

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Identification of different attitudes towards paratuberculosis control using cluster analysis applied on data from an anonymous survey among German cattle farmers.

Ir Vet J 2021 Sep 15;74(1):24. Epub 2021 Sep 15.

Thuringian Animal Diseases Fund, Animal Health Service, Jena, Thuringia, Germany.

Background: Paratuberculosis is a common disease in ruminants, causing economic losses in livestock farming, and a relationship between the exposure to its causative agent Mycobacterium avium subsp. paratuberculosis, and Crohn's disease in humans is discussed. Despite this, only a minority of cattle farmers have enroled in voluntary control programmes in most countries. Read More

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September 2021

Multiple comorbid sleep disorders adversely affect quality of life in Parkinson's disease patients.

NPJ Parkinsons Dis 2020 Sep 15;6(1):25. Epub 2020 Sep 15.

Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Sleep disorders are common non-motor symptoms in patients with Parkinson's disease (PD). The characteristics and impact of multiple comorbid sleep disorders remain to be elucidated. Our goal was to investigate the characteristics of various sleep disorder comorbidities, and their association with motor complications and the impact on the quality of life in PD patients. Read More

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September 2020

Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: a longitudinal follow-up study.

Thyroid 2021 Sep 13. Epub 2021 Sep 13.

University of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, Groningen, Netherlands;

Background: Survivors of pediatric differentiated thyroid carcinoma (DTC) receive thyrotropin (TSH) suppressive therapy to minimize disease recurrence. However, knowledge about long-term effects of subclinical hyperthyroidism on bone mineral density (BMD) in pediatric DTC survivors is scarce, as is the information regarding long-term consequences of permanent hypoparathyroidism on BMD. We evaluated BMD in pediatric DTC survivors and investigated if BMD was affected by subclinical hyperthyroidism and/or permanent hypoparathyroidism during long-term follow-up. Read More

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September 2021

Pseudarthrosis of distal radial growth plate treated with Blount clip: A case report.

Int J Surg Case Rep 2021 Sep 1;87:106339. Epub 2021 Sep 1.

Orthopedic Traumatology Department of IBN ROCHD University Hospital, Casablanca, Morocco.

Introduction And Importance: Epiphyseal detachement of distal radius are frequent, the richness of the vascular supply at this level favors rapid consolidation, but with the possibility of long-term complications which vary according to the classification of Salter and Harris. In the literature they are dominated by the epiphysiodesis, however, Pseudarthrosis of the growth plate is exceptional. Through this case presentation, we will explain contributing factors of its occurrence and its care management. Read More

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September 2021

Transfer of training from an internal medicine boot camp to the workplace: enhancing and hindering factors.

BMC Med Educ 2021 Sep 10;21(1):485. Epub 2021 Sep 10.

Scottish Centre for Simulation and Clinical Human Factors, Stirling Road, Scotland, FK5 4WR, Larbert, UK.

Background: The transfer of training to the workplace is the aim of training interventions. Three primary factors influence transfer: trainee characteristics, training design and work environment influences. Within medical education, the work environment factors influencing transfer of training remain underexplored. Read More

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September 2021

Methylphenidate for attention-deficit/hyperactivity disorder in patients with Smith-Magenis syndrome: protocol for a series of N-of-1 trials.

Orphanet J Rare Dis 2021 Sep 8;16(1):380. Epub 2021 Sep 8.

Advisium, 's Heeren Loo, Amersfoort, the Netherlands.

Background: Smith-Magenis syndrome (SMS) is a rare genetic neurodevelopmental disorder characterized by intellectual disability and severe behavioural and sleep disturbances. Often, patients with SMS are diagnosed with attention-deficit/hyperactivity disorder (ADHD). However, the effectiveness of methylphenidate (MPH), the first-line pharmacological treatment for ADHD, in patients with SMS is unclear. Read More

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September 2021

Goals and outcomes of hospitalised older people: does the current hospital care match the needs of older people?

Intern Med J 2021 Sep 6. Epub 2021 Sep 6.

Department of Internal Medicin, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Background: Due to the rising number of acutely hospitalised older people in the coming years, there is increased interest in tailoring care to the individual goals and preferences of patients in order to reach patient-centered care.

Aims: This study aimed to investigate the goals of older hospitalised patients and the extent to which these goals were reached during hospitalisation.

Methods: A single centre prospective cohort study was performed in the Netherlands between December 2017 and January 2018. Read More

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September 2021

Exploring Individuals' Willingness to Engage in Interventions to Improve Cognitive Health and Prolong Late-Life Independence: An Extension of Harrell, Kmetz, and Boot (2019).

J Cogn Enhanc 2021 Jun 29;5(2):259-265. Epub 2020 Oct 29.

Department of Psychology, Florida State University, Tallahassee, FL, USA.

Interventions designed to preserve cognition have become increasingly popular as our population ages. In exploring intervention effectiveness, however, researchers have often overlooked a potentially important factor: willingness to engage. Recent findings from Harrell, Kmetz, Boot (2019) showed that perceived cognitive deficits and perceived training efficacy were significant predictors of willingness to engage in a brain training intervention designed to preserve cognition. Read More

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Limitations of current alpine touring ski bindings.

J Sci Med Sport 2021 May 28. Epub 2021 May 28.

TUM Technical University of Munich, School of Engineering and Design, Sport Equipment and Materials, Germany.

Objectives: Quantify various parameters of safety and performance of modern alpine touring bindings in particular their release characteristics.

Design: For n = 16 alpine touring bindings from season 2018/19 and 2019/20, we performed multiple tests under standardized conditions using identical test soles built from one market relevant alpine touring boot.

Methods: Referring to the standard of the International Organization for Standardization for alpine touring bindings ISO 13992 we measured both the impact tolerance as well as the influence of forward and backward lean on the bindings' twist release behavior. Read More

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Impact of an end-of-fourth-year emergency medicine bootcamp.

Int J Emerg Med 2021 Sep 3;14(1):48. Epub 2021 Sep 3.

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, Rosenberg Building 2, Boston, MA, 02215, USA.

Background: The final months of the fourth-year of medical school are variable in educational and clinical experience, and the effect on clinical knowledge and preparedness for residency is unclear. Specialty-specific "bootcamps" are a growing trend in medical education aimed at increasing clinical knowledge, procedural skills, and confidence prior to the start of residency.

Methods: We developed a 4-week Emergency Medicine (EM) bootcamp offered during the final month of medical school. Read More

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September 2021

Investigating message framing to improve adherence to technology-based cognitive interventions.

Psychol Aging 2021 Aug 30. Epub 2021 Aug 30.

Department of Psychology.

A cognitive intervention study was conducted with the purpose of exploring methods to improve adherence to a technology-based cognitive intervention and uncover individual differences that predict adherence (N = 120). The study was divided into two phases: Phase 1, in which participants were asked to follow a prescribed schedule of training that involved gamified neuropsychological tests administered via tablet, and Phase 2, in which participants were asked to play as frequently as they wished. Positive- and negative-framed messages about brain health were delivered via the software program, and measures of cognition, technology proficiency, self-efficacy, technology attitudes, and belief in the benefits of cognitive training were collected. Read More

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Xylose-Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase.

Chembiochem 2021 Aug 30. Epub 2021 Aug 30.

Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

Glucocerebrosidase (GBA), a lysosomal retaining β-d-glucosidase, has recently been shown to hydrolyze β-d-xylosides and to transxylosylate cholesterol. Genetic defects in GBA cause the lysosomal storage disorder Gaucher disease (GD), and also constitute a risk factor for developing Parkinson's disease. GBA and other retaining glycosidases can be selectively visualized by activity-based protein profiling (ABPP) using fluorescent probes composed of a cyclophellitol scaffold having a configuration tailored to the targeted glycosidase family. Read More

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GARLA: Integrating Traditional and Modern Methodologies in Anatomy Education.

Med Sci Educ 2020 Dec 31;30(4):1727-1728. Epub 2020 Aug 31.

Case Western Reserve University School of Medicine, Cleveland, OH USA.

GARLA is an anatomy curriculum that combines dissection with applied anatomy. A two-week intensive dissection Boot-Camp is followed by a tripartite curriculum consisting of Gross Anatomy using a mixed reality headset, radiology, and physical exam/ultrasound skills. Student feedback has generally been positive. Read More

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December 2020

Teaching Psychiatric Emergencies Using Simulation: an Experience During the Boot Camp.

Med Sci Educ 2020 Dec 8;30(4):1481-1486. Epub 2020 Oct 8.

Department of Psychiatry, Texas Tech University Health Science Center El Paso, 5001 El Paso Drive, El Paso, TX 79905 USA.

Objective: The purpose of this study is to prepare fourth-year medical students to recognize psychiatric emergencies using simulation technology. The learning experience is accomplished during the boot camp activity designed to train fourth-year medical students in different competencies before transitioning to residency.

Methods: Ninety-eight fourth-year medical students at Paul L. Read More

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December 2020

Commonly Used Types and Recent Development of Ankle-Foot Orthosis: A Narrative Review.

Healthcare (Basel) 2021 Aug 13;9(8). Epub 2021 Aug 13.

Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea.

(1) Background: ankle-foot orthosis (AFO) is the most commonly prescribed orthosis to patients with foot drop, and ankle and foot problems. In this study, we aimed to review the commonly used types of AFO and introduce the recent development of AFO. (2) Methods: narrative review. Read More

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First Report of Leaf Spot Caused by Colletotrichum siamense on Magnolia grandiflora in China.

Plant Dis 2021 Aug 25. Epub 2021 Aug 25.

Jiangxi Agricultural University, 91595, forest of college, No. 1101, Zhiminda Road, Nanchang, Jiangxi, China, 330045;

Magnolia grandiflora (Southern magnolia) is a popular evergreen tree, planted especially as an ornamental for landscaping. In September 2019, leaf spots were observed on M. grandiflora at the campus of Jiangxi Agricultural University (28°45'56″N, 115°50'21″E). Read More

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Environmental Sampling for Avian Influenza Virus Detection in Commercial Layer Facilities.

Avian Dis 2021 09;65(3):391-400

Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011,

The present study was designed to evaluate the utility of environmental samples for convenient but accurate detection of avian influenza virus (AIV) in commercial poultry houses. First, environmental samples from AIV-negative commercial layer facilities were spiked with an H5N2 low pathogenic AIV and were evaluated for their effect on the detection of viral RNA immediately or after incubation at -20 C, 4 C, 22 C, or 37 C for 24, 48, or 72 hr. Second, Swiffer pads, drag swabs, and boot cover swabs were evaluated for their efficiency in collecting feces and water spiked with the H5N2 LPAIV under a condition simulated for a poultry facility floor. Read More

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September 2021

Handheld ultrasound in training - The future is getting smaller!

J Intensive Care Soc 2021 Aug 15;22(3):220-229. Epub 2020 Apr 15.

Levanger Municipal Hospital, Levanger, Norway.

Traditional ultrasound teaching is normally delivered using large, costly and often quite advanced cart-based systems. These carts are often large systems on wheels, usually limited to the departments that own them i.e. Read More

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Nocturnal Sleep Problems Mediate the Impact on Quality of Life of Early Morning Off in Parkinson's Disease.

Front Aging Neurosci 2021 6;13:681773. Epub 2021 Aug 6.

Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Early morning off (EMO) refers to off-states in the morning in people diagnosed with Parkinson's disease (PwPD). This study determined the clinical manifestations of EMO and the association with nocturnal sleep problems and quality of life (QOL) in Chinese PwPD. In this multicenter, observational, cross-sectional study, data concerning the clinical manifestations of EMO were collected from PwPD in Shanghai by questionnaire. Read More

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Assessment of Functional Conservative Treatment of Acute Complete Achilles Tendon Rupture.

Isr Med Assoc J 2021 Aug;23(8):510-515

Department of Orthopedic Surgery, Rambam Health Care Campus, Haifa, Israel.

Background: In recent years, treatment for Achilles tendon rupture (ATR) went through radical changes: from the conservative non-weight bearing approach to a functional protocol. This functional protocol allows complete weight bearing after only 2 weeks by placing the foot in a plastic boot in tapered down equines and using interchangeable wedges under the heel. This change of approach has dramatically lowered the rate of re-rupture. Read More

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Intestinal organoid cocultures with microbes.

Nat Protoc 2021 Aug 11. Epub 2021 Aug 11.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, the Netherlands.

Adult-stem-cell-derived organoids model human epithelial tissues ex vivo, which enables the study of host-microbe interactions with great experimental control. This protocol comprises methods to coculture organoids with microbes, particularly focusing on human small intestinal and colon organoids exposed to individual bacterial species. Microinjection into the lumen and periphery of 3D organoids is discussed, as well as exposure of organoids to microbes in a 2D layer. Read More

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Distraction Osteogenesis Technique for the Management of a Gustillo Type I Tibial Shaft Fracture Initially Managed with an Intramedullary Nail Device.

J Long Term Eff Med Implants 2021 ;31(3):63-67

Trauma and Orthopaedic Department, "Korgialenio-Benakio" Hellenic Red Cross Hospital, Athens, Greece; Trauma and Orthopaedic Department, Ealing Hospital, North West University Healthcare NHS Trust, London, United Kingdom.

Fractures of the tibia shaft are the most common long bone fractures, especially in young male adults. Due to specific anatomical features, these fractures are more common than any other long-bone fracture. This is one of the main reasons they are associated with twice the incidences of deep infection compared with any other bone and can be combined with the presence of segmental bone defect. Read More

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January 2021

Emerging simulation technologies in global craniofacial surgical training.

J Oral Biol Craniofac Res 2021 Oct-Dec;11(4):486-499. Epub 2021 Jun 27.

Emeritus Consultant Maxillofacial Surgeon, Poole Hospital University of Bournemouth, University of Duisburg-Essen, Trinity College, Dublin, Ireland.

The last few decades have seen an exponential growth in the development and adoption of novel technologies in medical and surgical training of residents globally. Simulation is an active and innovative teaching method, and can be achieved via physical or digital models. Simulation allows the learners to repeatedly practice without the risk of causing any error in an actual patient and enhance their surgical skills and efficiency. Read More

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Prevalence and risk factors of hypothalamic-pituitary dysfunction in infant and toddler childhood brain tumor survivors.

Eur J Endocrinol 2021 Sep 6;185(4):597-606. Epub 2021 Sep 6.

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.

Objective: Childhood brain tumor survivors (CBTS) are at risk to develop hypothalamic-pituitary (HP) dysfunction (HPD). The risk for HPD may vary between different age groups due to maturation of the brain and differences in oncologic treatment protocols. Specific studies on HPD in infant brain tumor survivors (infant-BTS, 0-1 years at diagnosis) or toddler brain tumor survivors (toddler-BTS, ≥1-3 years) have not been performed. Read More

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September 2021

Enhanced stress-resilience training for surgical trainees.

BJS Open 2021 07;5(4)

Department of Surgery, Morriston Hospital, Swansea Bay University Health Board, Swansea, UK.

Introduction: Core surgical training programmes are associated with a high risk of burnout. This study aimed to assess the influence of a novel enhanced stress-resilience training (ESRT) course delivered at the start of core surgical training in a single UK statutory education body.

Method: All newly appointed core surgical trainees (CSTs) were invited to participate in a 5-week ESRT course teaching mindfulness-based exercises to develop tools to deal with stress at work and burnout. Read More

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