22,137 results match your criteria booster

Acceptance and commitment therapy for high frequency episodic migraine without aura: Findings from a randomized pilot investigation.

Headache 2021 Jun 11. Epub 2021 Jun 11.

UO Neurologia Salute Pubblica e Disabilità, Fondazione IRRCS Istituto Neurologico Carlo Besta, Milano, Italy.

Objective: We compared the incremental effects of adding acceptance and commitment therapy (ACT) to pharmacological treatment as usual (TAU) in a sample of patients with high frequency episodic migraine without aura (HFEM), assessing impact on a spectrum of measures across multiple domains.

Background: Patients with HFEM are at risk of developing chronic migraine and medication overuse headache. ACT has been shown to be effective for the treatment of various chronic pain conditions, but little attention has been given to its therapeutic value in the management of recurring headaches. Read More

View Article and Full-Text PDF

Formulation Approach that Enables the Coating of a Stable Influenza Vaccine on a Transdermal Microneedle Patch.

AAPS PharmSciTech 2021 Jun 10;22(5):175. Epub 2021 Jun 10.

Zosano Pharma, Inc., 34790 Ardentech Court, Fremont, CA, 94555, USA.

A trivalent influenza split vaccine was formulated at high concentration for coating on the transdermal microneedle system. Monovalent vaccine bulks of three influenza strains, two influenza A strains, and one B strain were diafiltrated, concentrated, and lyophilized. The lyophilized powder of each vaccine strain was separately reconstituted and subsequently combined into a coating formulation of high concentration trivalent vaccine. Read More

View Article and Full-Text PDF

Feasibility of a 6-Month Home-Based Fall Prevention Exercise Program in Older Adults with COPD.

Int J Chron Obstruct Pulmon Dis 2021 3;16:1569-1579. Epub 2021 Jun 3.

Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, ON, Canada.

Purpose: Older adults with chronic obstructive pulmonary disease (COPD) have a high risk and rate of falls. Home-based fall prevention exercise programs reduce falls in older adults and may be an alternative approach for people with COPD without access to hospital-based rehabilitation. Therefore, we aimed to determine the feasibility of a home-based fall prevention exercise program in older adults with COPD and to examine the effect of the program on fall-related outcomes at baseline, 3 and 6 months. Read More

View Article and Full-Text PDF

Is personality the key in cognitive-behavioral therapy for eating disorders? A review.

Clin Psychol Psychother 2021 Jun 10. Epub 2021 Jun 10.

Catholic University of Milan, Italy.

The efficacy of individual CBT for eating disorders can be assessed by investigating the potential predictors, mediators, and moderators of treatment. The present review focused on personality since its crucial role has been emphasized both by research and practice. Sixteen studies were collected, and data were extracted through a highly operationalized coding system. Read More

View Article and Full-Text PDF

Antibody response to inactivated COVID-19 vaccine (CoronaVac) in immune-mediated diseases: a controlled study among hospital workers and elderly.

Rheumatol Int 2021 Jun 9. Epub 2021 Jun 9.

Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, 81310, Turkey.

Objective: To assess antibody response to inactivated COVID-19 vaccine in patients with immune-mediated diseases (IMD) among hospital workers and people aged 65 and older.

Methods: In this cross-sectional study, we studied 82 hospital workers with IMD (mean age: 42.2 ± 10. Read More

View Article and Full-Text PDF

Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine.

EClinicalMedicine 2021 Jun 4:100928. Epub 2021 Jun 4.

Scientific Direction, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy.

Background: Literature data suggests that age, gender and body mass index (BMI) could be associated with difference in immune responses to vaccines. The first goal of the study was to analyze the antibody titre seven days after the second dose of BNT162b2 vaccine in a group of 248 healthcare workers (HCWs). The second goal was to analyze how antibody titre changes in correlation with age, gender, BMI and hypertension. Read More

View Article and Full-Text PDF

Motivational interviewing with community-dwelling older adults after hip fracture (MIHip): protocol for a randomised controlled trial.

BMJ Open 2021 Jun 9;11(6):e047970. Epub 2021 Jun 9.

La Trobe University College of Science Health and Engineering, Bundoora, Victoria, Australia.

Introduction: Community-dwelling people recovering from hip fracture have the physical capacity to walk in their community but lack the confidence to do so. The primary aim of this trial is to determine whether motivational interviewing increases time spent walking at 12 months in community-dwelling people after hip fracture compared with an attention placebo control group. Secondary aims are to evaluate cost effectiveness, patient and health service outcomes and to complete a process evaluation. Read More

View Article and Full-Text PDF

Building family caregiver skills using a simulation-based intervention for care of patients with cancer: protocol for a randomized controlled trial.

BMC Nurs 2021 Jun 9;20(1):93. Epub 2021 Jun 9.

Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA.

Background: Family caregivers of patients with cancer undergoing radiation therapy experience significant distress and challenges related to high symptom burden and complex care demands. This is particularly true for caregivers of patients with head and neck, esophageal, anal, rectal, and lung cancers, who are often receiving combined-modality treatment and may have tracheostomy tubes, gastrostomy tubes, or colostomies/ileostomies. This study aims to evaluate a simulation-based nursing intervention to provide information, support, and training to caregivers during radiation therapy. Read More

View Article and Full-Text PDF

Heterologous immunization with Covishield and Pfizer vaccines against SARS-CoV-2 elicits a robust humoral immune response.

J Infect Dev Ctries 2021 05 31;15(5):653-656. Epub 2021 May 31.

Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Understanding the efficacy and durability of heterologous immunization schedules against SARS-CoV-2 is critical, as supply demands and vaccine choices become significant issues in the global vaccination strategy. Here we characterize the neutralizing antibodies produced in two subjects who received combination immunizations against SARS-CoV-2, first with Covishield (Oxford-AstraZeneca) vaccine, followed 33 days later with a second dose (booster) shot of the Pfizer-BioNTech vaccine. Serum samples were collected 25 days following the primary vaccination and 13 days after the secondary Pfizer vaccination. Read More

View Article and Full-Text PDF

Knowledge, attitudes and practices of smallholder farmers on foot and mouth disease control in two Cambodian provinces.

Transbound Emerg Dis 2021 Jun 8. Epub 2021 Jun 8.

Independent Livestock Consultant, Pursat, Cambodia.

Food-and-mouth disease (FMD) is endemic in Cambodia. The control program for FMD has relied on vaccination, with poor vaccination uptake by smallholder farmers becoming an increasing concern. A study to improve the understanding of farmer knowledge, attitudes and practices of FMD control and vaccination was conducted in two Cambodian provinces (Kampong Cham and Pursat). Read More

View Article and Full-Text PDF

Impairment of left atrial function in pediatric patients with repaired tetralogy of Fallot: a cardiovascular magnetic resonance imaging study.

Int J Cardiovasc Imaging 2021 Jun 8. Epub 2021 Jun 8.

Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated With Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai, 200127, People's Republic of China.

We aimed to assess left atrial (LA) strain before LA dilatation in patients with repaired tetralogy of Fallot (rTOF) compared with healthy controls. We also determined the effects of right atrial (RA) dilatation on LA performance using cardiovascular magnetic resonance-feature tracking (CMR-FT). Forty-nine pediatric patients with rTOF and 36 age- and sex-matched healthy controls were prospectively recruited between June 2017 and August 2019. Read More

View Article and Full-Text PDF

Impaired humoral and cellular immunity after SARS-CoV2 BNT162b2 (Tozinameran) prime-boost vaccination in kidney transplant recipients.

J Clin Invest 2021 Jun 8. Epub 2021 Jun 8.

Department for General and Visceral Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Novel mRNA-based vaccines have been proven powerful tools to combat the global pandemic caused by SARS-CoV2 with BNT162b2 (trade name: Comirnaty) efficiently protecting individuals from COVID-19 across a broad age range. Still, it remains largely unknown how renal insufficiency and immunosuppressive medication affect development of vaccine induced immunity. We therefore comprehensively analyzed humoral and cellular responses in kidney transplant recipients after the standard second vaccination dose. Read More

View Article and Full-Text PDF

Immunomodulatory role and potential utility of various nutrients and dietary components in SARS-CoV-2 infection.

Int J Vitam Nutr Res 2021 Jun 8:1-14. Epub 2021 Jun 8.

Institute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore, Pakistan.

Recently, the outbreak of severe acute respiratory syndrome cornoavirus-2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has become a great perturbation all around the globe and has many devastating effects on every aspect of life. Apart from the oxygen therapy and extracorporeal membrane oxygenation, Remdesivir and Dexamethasone have been proven to be efficacious against COVID-19, along with various vaccine candidates and monoclonal antibody cocktail therapy for Regeneron. All of these are currently at different stages of clinical trials. Read More

View Article and Full-Text PDF

Encapsulated Food Products as a Strategy to Strengthen Immunity Against COVID-19.

Front Nutr 2021 21;8:673174. Epub 2021 May 21.

Bioprocesses Research Group, Food Research Department, School of Chemistry, Universidad Autonoma de Coahuila, Unidad Saltillo, Saltillo, Mexico.

In December 2019, the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2)-a novel coronavirus was identified which was quickly distributed to more than 100 countries around the world. There are currently no approved treatments available but only a few preventive measures are available. Among them, maintaining strong immunity through the intake of functional foods is a sustainable solution to resist the virus attack. Read More

View Article and Full-Text PDF

Safety and Tolerability of Active Immunotherapy Targeting α-Synuclein with PD03A in Patients with Early Parkinson's Disease: A Randomized, Placebo-Controlled, Phase 1 Study.

J Parkinsons Dis 2021 May 27. Epub 2021 May 27.

AFFiRiS AG, Vienna, Austria.

Background: Immunotherapies targeting α-synuclein aim to limit its extracellular spread in the brain and prevent progression of pathology in Parkinson's disease (PD). PD03A is a specific active immunotherapy (SAIT) involving immunization with a short peptide formulation.

Objective: This phase 1 study characterized the safety and tolerability of PD03A in patients with early PD. Read More

View Article and Full-Text PDF

Health inequities related to vaccination: An evidence map of potentially influential factors and systematic review of interventions.

Vaccine 2021 Jun 3. Epub 2021 Jun 3.

Alberta Research Centre for Health Evidence (ARCHE), Department of Pediatrics, University of Alberta, Edmonton, Canada.

Introduction: The National Advisory Committee on Immunization (NACI) makes recommendations for vaccines in Canada. To inform considerations for equity when making recommendations, the NACI Secretariat developed a matrix of factors that may influence vaccine equity. To inform the matrix we mapped the evidence for PROGRESS And Other factors potentially associated with unequal levels of illness or death from vaccine-preventable diseases (VPDs) and systematically reviewed the evidence for interventions aimed at reducing inequities. Read More

View Article and Full-Text PDF

Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines.

Aging (Albany NY) 2021 Jun 4;13(undefined). Epub 2021 Jun 4.

National Heart Centre Singapore, Singapore.

Objective: To demonstrate differences in cardiovascular structure and function between diabetic and non-diabetic older adults. To investigate associations between acyl-carnitines and cardiovascular function as indexed by imaging measurements.

Methods: A community-based cohort of older adults without cardiovascular disease underwent current cardiovascular imaging and metabolomics acyl-carnitines profiling based on current and archived sera obtained fifteen years prior to examination. Read More

View Article and Full-Text PDF

Individual and community-level determinants of poor tetanus toxoid immunization among pregnant women in Ethiopia using data from 2016 Ethiopian demographic and health survey; multilevel analysis.

Arch Public Health 2021 Jun 4;79(1):92. Epub 2021 Jun 4.

Department of midwifery, school of nursing and midwifery, college of medicine and health sciences, Wollo University, Dessie, Ethiopia.

Background: Tetanus is a vaccine-preventable disease that can occur in all populations, with neonates and pregnant women being at the most risk. Ethiopia has the highest maternal and neonatal tetanus morbidity and mortality rates. Besides, only 49% of mothers get vaccinated with adequate tetanus toxoid in Ethiopia which is below the world health organization recommendation. Read More

View Article and Full-Text PDF

Rekonvaleszenten-Plasma mildert COVID-19-Verlauf bei Älteren.

Georg Nilius

MMW Fortschr Med 2021 06;163(11):28

Evangelische Kliniken Essen-Mitte, Am Deimelsberg 34 a, 45726, Essen, Deutschland.

View Article and Full-Text PDF

Immunogenicity and safety of an investigational quadrivalent meningococcal conjugate vaccine administered as a booster dose in children vaccinated against meningococcal disease 3 years earlier as toddlers: A Phase III, open-label, multi-center study.

Hum Vaccin Immunother 2021 Jun 4:1-10. Epub 2021 Jun 4.

Global Clinical Development, Sanofi Pasteur, Swiftwater, PA, USA.

Booster doses of meningococcal conjugate vaccines induce long-term protection against invasive meningococcal disease. We evaluated the immunogenicity and safety of a booster dose of MenACYW-TT in pre-school children who were primed 3 years earlier with MenACYW-TT or MCV4-TT (Nimenrix®). In this Phase III, open-label, multi-center study (NCT03476135), children (4-5 years old), who received a primary dose of MenACYW-TT or MCV4-TT as toddlers in a previous study, received a booster dose of MenACYW-TT. Read More

View Article and Full-Text PDF

lncRNA028466 regulates Th1/Th2 cytokine expression and associates with Echinococcus granulosus antigen P29 immunity.

Parasit Vectors 2021 Jun 3;14(1):295. Epub 2021 Jun 3.

Center of Scientific Technology of Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.

Background: Cystic echinococcosis (CE) is a parasitic disease that is caused by Echinococcus granulosus (Eg). The recombinant Echinococcus granulosus antigen P29 (rEg.P29) was shown to confer effective immunity to sheep and mice during E. Read More

View Article and Full-Text PDF

Examining the added value of harm reduction strategies to emailed boosters to extend the effects of online interventions for college drinkers.

Psychol Addict Behav 2021 Jun 3. Epub 2021 Jun 3.

Department of Behavioral and Social Sciences.

Brief computer-delivered interventions (CDIs) reduce college student drinking and related problems but can be less efficacious and enduring than in-person interventions. The present study examined: (a) the utility of emailed personalized boosters after an evidence-based online CDI for alcohol (i.e. Read More

View Article and Full-Text PDF

IMMUNO-COV v2.0: Development and Validation of a High-Throughput Clinical Assay for Measuring SARS-CoV-2-Neutralizing Antibody Titers.

mSphere 2021 Jun 2:e0017021. Epub 2021 Jun 2.

Imanis Life Sciences, Rochester, Minnesota, USA.

Neutralizing antibodies are key determinants of protection from future infection, yet well-validated high-throughput assays for measuring titers of SARS-CoV-2-neutralizing antibodies are not generally available. Here, we describe the development and validation of IMMUNO-COV v2.0, a scalable surrogate virus assay, which titrates antibodies that block infection of Vero-ACE2 cells by a luciferase-encoding vesicular stomatitis virus displaying SARS-CoV-2 spike glycoproteins (VSV-SARS2-Fluc). Read More

View Article and Full-Text PDF

Epidemiology of Diphtheria in Yemen, 2017-2018: Surveillance Data Analysis.

JMIR Public Health Surveill 2021 Jun 2;7(6):e27590. Epub 2021 Jun 2.

Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: As a consequence of war and the collapse of the health system in Yemen, which prevented many people from accessing health facilities to obtain primary health care, vaccination coverage was affected, leading to a deadly diphtheria epidemic at the end of 2017.

Objective: This study aimed to describe the epidemiology of diphtheria in Yemen and determine its incidence and case fatality rate.

Methods: Data were obtained from the diphtheria surveillance program 2017-2018, using case definitions of the World Health Organization. Read More

View Article and Full-Text PDF

The Uro-oncology Patient and Vaccination Against SARS-CoV-2.

Eur Urol Open Sci 2021 Jul 27;29:77-81. Epub 2021 May 27.

Department of Urology, Hospital Clínico San Carlos, Madrid, Spain.

As of April 13, 2021, 137 million cases of COVID-19 and 2.95 million deaths have been reported worldwide. On December 21, 2020, the Pfizer-BioNTech vaccine was approved for use in the European Union, with efficacy of 95% protection against COVID-19 infection. Read More

View Article and Full-Text PDF

M448R and MGF505-7R: Two African Swine Fever Virus Antigens Commonly Recognized by ASFV-Specific T-Cells and with Protective Potential.

Vaccines (Basel) 2021 May 14;9(5). Epub 2021 May 14.

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

African swine fever (ASF) is today's number one threat for the global swine industry. Neither commercial vaccine nor treatment is available against ASF and, thus far, only live attenuated viruses (LAV) have provided robust protection against lethal ASF virus (ASFV) challenge infections. Identification of ASFV proteins inducing protective immune responses is one of the major challenges to develop safer and efficient subunit vaccines. Read More

View Article and Full-Text PDF

Risk of Absence of Measles Antibody in Healthcare Personnel and Efficacy of Booster Vaccination.

Vaccines (Basel) 2021 May 12;9(5). Epub 2021 May 12.

Ewha Education and Research Center for Infection, Seoul 07985, Korea.

We aimed to identify the presence of the measles IgG antibody (mIgG-Ab) in healthcare personnel and finding out who needs the measles vaccination. The history of measles vaccination was obtained from the national vaccine registry. A baseline mIgG-Ab test was performed, and the measles vaccine was administered to participants who tested negative or equivocal for mIgG-Abs. Read More

View Article and Full-Text PDF

Pharmacokinetics of α-Pyrrolidinovalerophenone in Male Rats with and without Vaccination with an α-Pyrrolidinovalerophenone Vaccine.

J Pharm Pharm Sci 2021 ;24:267-276

University of Arkansas for Medical Sciences.

Purpose: α-Pyrrolidinovalerophenone (α-PVP) is a second-generation synthetic cathinone which acts as an inhibitor at the dopamine and norepinephrine transporters in the brain. These novel studies determined the pharmacokinetics (PK) of α-PVP in rats and then evaluated the effects of an α-PVP vaccine on the PK profile.

Methods: Adult male Sprague-Dawley rats were randomly divided into treatment groups (n = 24/group) in which the vaccinated rats received an initial and two booster immunizations of the α-PVP vaccine at 0, 3, and 9 wks. Read More

View Article and Full-Text PDF
January 2021