3,998 results match your criteria bone-implant

Biocompatibility and Osseointegration of Calcium Phosphate-Coated and Non-Coated Titanium Implants with Various Porosities.

Sovrem Tekhnologii Med 2021 1;13(2):52-57. Epub 2021 Jan 1.

Researcher, Laboratory for Plasma Hybrid Systems, National Research Tomsk Polytechnic University, 30 Prospect Lenina, Tomsk, 634050, Russia.

was to study the influence of pore size and the presence of a biologically active calcium phosphate coating in porous 3D printed titanium implants on the process of integration with the bone tissue.

Materials And Methods: Samples of cylindrical implants with three different pore diameters (100, 200, and 400 μm) were fabricated from titanium powder on the Arcam 3D printer (Sweden) using electron beam melting technology. A calcium phosphate coating with a thickness of 20±4 μm was applied to some of the products by microarc oxidation. Read More

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January 2021

Fixation screw minimizes bone graft loss following autogenous lateral block graft augmentation: An experimental in vivo study.

J Stomatol Oral Maxillofac Surg 2021 Sep 8. Epub 2021 Sep 8.

Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Purpose: Assess the role of tenting screws in the remodeling processes of autogenous bone blocks used for mandibular lateral augmentation in rabbits.

Methods: Eighteen rabbits, approximately 3.5-4. Read More

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September 2021

The role of cortical zone level and prosthetic platform angle in dental implant mechanical response: A 3D finite element analysis.

Dent Mater 2021 Sep 6. Epub 2021 Sep 6.

School of Medical Sciences and Photon Science Institute, University of Manchester, UK.

Objective: The aim of this study was to evaluate the influence of three different dental implant neck geometries, under a combined compressive/shear load using finite element analysis (FEA). The implant neck was positioned in D2 quality bone at the crestal level or 2 mm below.

Methods: One dental implant (4. Read More

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September 2021

Incorporation of cerium oxide into zirconia toughened alumina ceramic promotes osteogenic differentiation and osseointegration.

J Biomater Appl 2021 Sep 9:8853282211036535. Epub 2021 Sep 9.

Department of Orthopedics, the First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, Jiangxi, China.

Due to its high wear resistance and good biocompatibility, zirconia toughened alumina (ZTA) is an ideal material used as load-bearing implant. However, ZTA needs to be modified to overcome its bio-inert and thus improve osseointegration. Cerium oxide, which has been proved to be a bone-friendly ceramic, might be a desired material to enhance the bioactivity of ZTA. Read More

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September 2021

Hydroxyapatite-Coated Titanium by Micro-Arc Oxidation and Steam-Hydrothermal Treatment Promotes Osseointegration.

Front Bioeng Biotechnol 2021 19;9:625877. Epub 2021 Aug 19.

Department of Orthopedics, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Zhejiang University Huzhou Hospital, Huzhou, China.

Titanium (Ti)-based alloys are widely used in tissue regeneration with advantages of improved biocompatibility, high mechanical strength, corrosion resistance, and cell attachment. To obtain bioactive bone-implant interfaces with enhanced osteogenic capacity, various methods have been developed to modify the surface physicochemical properties of bio-inert Ti and Ti alloys. Nano-structured hydroxyapatite (HA) formed by micro-arc oxidation (MAO) is a synthetic material, which could facilitate osteoconductivity, osteoinductivity, and angiogenesis on the Ti surface. Read More

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Longitudinally centered embossed structure in the locking compression plate for biodegradable bone implant plate: a finite element analysis.

Comput Methods Biomech Biomed Engin 2021 Sep 6:1-16. Epub 2021 Sep 6.

Department of Mechanical Engineering, Maulana Azad National Institute of Technology, Bhopal, Madhya Pradesh, India.

In the current revolution of internal fixation implant in orthopaedics, a biodegradable implant is the most awaited and exceptional medical device where biodegradable material has paid more attention to the success of a biodegradable implant than the design of a biodegradable bone implant plate. By far, LCP is the most traditionally used implant plate (using non-biodegradable material) because of its experimental success, but not with qualified biodegradable material (Mg-alloy). This lack of mechanical performance is a major drawback that can be rectified by better structural design. Read More

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September 2021

Qualitative predictions of bone growth over optimally designed macro-textured implant surfaces obtained using NN-GA based machine learning framework.

Med Eng Phys 2021 Sep 12;95:64-75. Epub 2021 Aug 12.

Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781 039, India.

The surface features on implant surface can improve biologic fixation of the implant with the host bone leading to improved secondary (biological) implant stability. Application of finite element (FE) based mechanoregulatory schemes to estimate the amount of bone growth for a wide range of implant surface features is either manually intensive or computationally expensive. This study adopts an integrated approach combining FE, back-propagation neural network (BPNN) and genetic algorithm (GA) based search to evaluate optimum surface macro-textures from three representative implant models so as to enhance bone growth. Read More

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September 2021

Surface treatment of 3D printed porous Ti6Al4V implants by ultraviolet photofunctionalization for improved osseointegration.

Bioact Mater 2022 Jan 25;7:26-38. Epub 2021 Jun 25.

Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China.

Three-dimensional (3D)-printed porous Ti6Al4V implants play an important role in the reconstruction of bone defects. However, its osseointegration capacity needs to be further improved, and related methods are inadequate, especially lacking customized surface treatment technology. Consequently, we aimed to design an omnidirectional radiator based on ultraviolet (UV) photofunctionalization for the surface treatment of 3D-printed porous Ti6Al4V implants, and studied its osseointegration promotion effects and , while elucidating related mechanisms. Read More

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January 2022


Wiad Lek 2021 ;74(7):1566-1574


Objective: The aim: Of the research is to study of the stress distribution in the "bone-implant" system for various cases of elbow flexion and semipronation in the event of the radial head arthroplasty with the developed bipolar radial head (RH) implant and the bipolar KPS endoprosthesis.

Patients And Methods: Materials and methods: We developed a metal-metal bearing bipolar RH endoprosthesis providing an uncemented fixation due to a special porous coating and stem design. Using Solid Works software, we developed a geometrical model of the elbow joint with cartilaginous surfaces. Read More

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September 2021

Systemic ALK-positive anaplastic large cell lymphoma involving implant site: a fortuitous association.

Autops Case Rep 2021 20;11:e2021296. Epub 2021 Aug 20.

Post Graduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India.

Anaplastic lymphoma kinase (ALK) positive, anaplastic large cell lymphoma involving the non-mammary implant is an extremely rare presentation. Irrespective of the type or site, the implant-associated primary ALCL is morphologically and immunophenotypically similar to ALK-negative ALCLs. Herein, we present the case of a 42-year-old male who developed a lytic lesion after an implant for a right femur fracture. Read More

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Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/Borax/CaCO and Demineralized Bone Matrix.

J Funct Biomater 2021 Aug 11;12(3). Epub 2021 Aug 11.

Research and Innovation Group in Chemical Formulations, Life Sciences Faculty, EIA University, Envigado 055420, Colombia.

The occurrence of bone-related disorders and diseases has dramatically increased in recent years around the world. Demineralized bone matrix (DBM) has been widely used as a bone implant due to its osteoinduction and bioactivity. However, the use of DBM is limited because it is a particulate material, which makes it difficult to manipulate and implant with precision. Read More

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Analysis of Surface Morphology and Elemental Composition on Zirconia Implants Before and After Photofunctionalization by Scanning Electron Microscopy and Energy Dispersive X ray Spectroscopy - An Study.

J Pharm Bioallied Sci 2021 Jun 5;13(Suppl 1):S761-S765. Epub 2021 Jun 5.

Oral Medicine and Radiology, Best Dental Science College, Madurai, Tamil Nadu, India.

Background: The purpose of this study is to analyze the surface morphology and elemental composition of zirconia implants before and after photofunctionalization.

Materials And Methods: Ten zirconia implants (white sky implant system- Bredent Company) five each in the study group and control group was taken. Study group samples were treated with ultraviolet light for 48 h. Read More

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Stress Distribution in Cortical Bone around the Basal Implant - A Finite Element Analysis.

J Pharm Bioallied Sci 2021 Jun 5;13(Suppl 1):S633-S636. Epub 2021 Jun 5.

Consultant Prosthodontist, Katihar, Bihar, India.

Aim: The aim of the study was to develop a model that represents a basal implant with stress distribution in the cortical bone on application of loads emulating masticatory forces.

Materials And Methods: In this study, the stress distribution in the bone and the implant is evaluated by applying various loads that emulate the masticatory forces. The geometric models of cortical bone representing the premolar area and a basal implant model of the following specifications, longitudinal oval threaded pin (1. Read More

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Osseointegration of Sandblasted and Acid-Etched Implant Surfaces. A Histological and Histomorphometric Study in the Rabbit.

Int J Mol Sci 2021 Aug 7;22(16). Epub 2021 Aug 7.

Comprehensive Dentistry for Adults and Gerodontology, Master in Implant Dentistry, Faculty of Dentistry, University of Seville, 41009 Seville, Spain.

Titanium surface is an important factor in achieving osseointegration during the early wound healing of dental implants in alveolar bone. The purpose of this study was to evaluate sandblasted-etched surface implants to investigate the osseointegration. In the present study, we used two different types of sandblasted-etched surface implants, an SLA™ surface and a Nanoblast Plus™ surface. Read More

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Benefits and Biosafety of Use of 3D-Printing Technology for Titanium Biomedical Implants: A Pilot Study in the Rabbit Model.

Int J Mol Sci 2021 Aug 6;22(16). Epub 2021 Aug 6.

Department Oral and Maxillofacial Surgery, National Dental Centre Singapore, Singapore 168938, Singapore.

Background: Titanium has been used in osteosynthesis for decades and its compatibility and safety is unquestioned. Studies have shown that there is release and collection of titanium in the organ systems with little note of toxicity. The gold standard is considered to be titanium osteosynthesis plate produced by milling methods. Read More

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Sustainable Surface Modification of Polyetheretherketone (PEEK) Implants by Hydroxyapatite/Silica Coating-An In Vivo Animal Study.

Materials (Basel) 2021 Aug 16;14(16). Epub 2021 Aug 16.

Department of Oral, Maxillofacial and Plastic Surgery, Rostock University Medical Center, 18057 Rostock, Germany.

Polyetheretherketone (PEEK) has the potential to overcome some of the disadvantages of titanium interbody implants in anterior cervical and discectomy and fusion (ACDF). However, PEEK shows an inferior biological behavior regarding osseointegration and bioactivity. Therefore, the aim of the study was to create a bioactive surface coating on PEEK implants with a unique nanopore structure enabling the generation of a long-lasting interfacial composite layer between coating material and implant. Read More

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Bone Response to Conventional Titanium Implants and New Zirconia Implants Produced by Additive Manufacturing.

Materials (Basel) 2021 Aug 6;14(16). Epub 2021 Aug 6.

Department of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea.

The aim of the present study was to evaluate the in vivo bone response to an additively manufactured zirconia surface compared to osseointegration into titanium (Ti) surfaces. Scanning electron microscopy, confocal laser scanning microscopy, and electron spectroscopy for chemical analysis were performed to assess the surface characteristics of implant specimens. For the in vivo evaluation, eight Ti implants and eight 3D-printed zirconia implants were used. Read More

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Influences of screw design features on initial stability in immediate implant placement and restoration.

Clin Biomech (Bristol, Avon) 2021 Aug 20;89:105453. Epub 2021 Aug 20.

School of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:

Background: Self-tapping screws have been extensively used for dental implants. Their biomechanical behavior is highly associated with their clinical success, particularly for screws used for immediate implant placement and restoration, because occlusal forces can directly affect the loading transfer at the bone-implant interface after implantation. The effect of implant design on the initial stability of self-tapping screws remains unclear. Read More

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No significant difference in early clinical outcomes of custom versus off-the-shelf total knee arthroplasty: a systematic review and meta-analysis.

Knee Surg Sports Traumatol Arthrosc 2021 Aug 25. Epub 2021 Aug 25.

Lyon-Ortho-Clinic, Clinique de la Sauvegarde, Ramsay Santé, 29 Avenue des Sources, 69009, Lyon, France.

Purpose: The purpose of this systematic review and meta-analysis was to collect, synthesise and critically appraise findings of clinical studies that report outcomes of custom total knee arthroplasty (TKA). The hypothesis was that, compared to off-the-shelf (OTS) TKA, custom TKA would yield better surgical, clinical and radiographic outcomes.

Methods: This systematic review and meta-analysis was performed in accordance with the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Read More

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Effect of systemic administration of omeprazole on osseointegration around titanium dental implants: A histomorphometric study in dogs.

Dent Res J (Isfahan) 2021 22;18:43. Epub 2021 Jun 22.

Department of Periodontology, Dental Implant Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Dental implants are widely accepted substitutes for replacing missing teeth. Many factors, including the use of specific drugs such as proton-pump inhibitors (PPIs) (omeprazole), can affect the success of dental implantations. The aim of this study was to investigate the relationship between the use of omeprazole and osseointegration of dental implants. Read More

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Synthesis of silver nanoparticle-decorated hydroxyapatite nanocomposite with combined bioactivity and antibacterial properties.

J Mater Sci Mater Med 2021 Aug 23;32(9):106. Epub 2021 Aug 23.

School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300, Nibong Tebal, Penang, Malaysia.

Combination of bioactive material such as hydroxyapatite (HAp) with antibacterial agents would have great potential to be used as bone implant materials to avert possible bacterial infection that can lead to implant-associated diseases. The present study aimed to develop an antibacterial silver nanoparticle-decorated hydroxyapatite (HAp/AgNPs) nanocomposite using chemical reduction and thermal calcination approaches. In this work, natural HAp that was extracted from chicken bone wastes is used as support matrix for the deposition of silver nanoparticles (AgNPs) to produce HAp/AgNPs nanocomposite. Read More

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Efficacy of platelet-rich fibrin on bone formation, part 2: Guided bone regeneration, sinus elevation and implant therapy.

Int J Oral Implantol (Berl) 2021 08;14(3):285-302

Purpose: To investigate the effect of platelet-rich fibrin on bone formation by investigating its use in guided bone regeneration, sinus elevation and implant therapy.

Materials And Methods: This systematic review and meta-analysis were conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The eligibility criteria comprised human controlled clinical trials comparing the clinical outcomes of platelet-rich fibrin with those of other treatment modalities. Read More

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The revision partial knee classification system: understanding the causative pathology and magnitude of further surgery following partial knee arthroplasty.

Bone Jt Open 2021 Aug;2(8):638-645

MSk Lab, Sir Michael Uren Biomedical Engineering Research Hub, Imperial College London, London, UK.

Aims: Joint registries classify all further arthroplasty procedures to a knee with an existing partial arthroplasty as revision surgery, regardless of the actual procedure performed. Relatively minor procedures, including bearing exchanges, are classified in the same way as major operations requiring augments and stems. A new classification system is proposed to acknowledge and describe the detail of these procedures, which has implications for risk, recovery, and health economics. Read More

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Fixation of Transparent Bone Pins with Photocuring Biocomposites.

ACS Biomater Sci Eng 2021 09 13;7(9):4463-4473. Epub 2021 Aug 13.

School of Materials Science and Engineering (MSE), Nanyang Technological University (NTU), 639798 Singapore.

Bone fractures are in need of rapid fixation methods, but the current strategies are limited to metal pins and screws, which necessitate secondary surgeries upon removal. New techniques are sought to avoid surgical revisions, while maintaining or improving the fixation speed. Herein, a method of bone fixation is proposed with transparent biopolymers anchored in place via light-activated biocomposites based on expanding CaproGlu bioadhesives. Read More

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September 2021

Novel and simplified optimisation pathway using response surface and design of experiments methodologies for dental implants based on the stress of the cortical bone.

Proc Inst Mech Eng H 2021 Aug 12:9544119211025375. Epub 2021 Aug 12.

Centre for Simulation in Bioengineering, Biomechanics and Biomaterials (CS3B), Department of Mechanical Engineering, Engineering College of Bauru (FEB), São Paulo State University (UNESP), Bauru, São Paulo State, Brazil.

Dental implants are widely used as a long-term treatment solution for missing teeth. A titanium implant is inserted into the jawbone, acting as a replacement for the lost tooth root and can then support a denture, crown or bridge. This allows discreet and high-quality aesthetic and functional improvement, boosting patient confidence. Read More

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Effects of local application of the ankaferd blood stopper on osseointegration in three different surface titanium implants.

J Oral Biol Craniofac Res 2021 Oct-Dec;11(4):524-528. Epub 2021 Jul 17.

Sanliurfa Harran University, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sanliurfa, Turkiye.

Objective: Researchs of the effects of ankaferd blood stopper (ABS) on bone healing metabolism have revealed that it affects bone regeneration positively. The exact mechanism by which this positive effect on bone tissue metabolism is not known. The aim of this study is to biomechanic and biochemical analysis of the effects of the local ABS application on osseointegration of 3 different surfaced titanium implants. Read More

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Is three-dimensional-printed custom-made ultra-short stem with a porous structure an acceptable reconstructive alternative in peri-knee metaphysis for the tumorous bone defect?

World J Surg Oncol 2021 Aug 8;19(1):235. Epub 2021 Aug 8.

Department of Orthopaedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Background: Long-lasting reconstruction after extensive resection involving peri-knee metaphysis is a challenging problem in orthopedic oncology. Various reconstruction methods have been proposed, but they are characterized by a high complication rate. The purposes of this study were to (1) assess osseointegration at the bone implant interface and correlated incidence of aseptic loosening; (2) identify complications including infection, endoprosthesis fracture, periprosthetic fracture, leg length discrepancy, and wound healing problem in this case series; and (3) evaluate the short-term function of the patient who received this personalized reconstruction system. Read More

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Habitual caffeine intake affects implant osseointegration: An in vivo study.

J Periodontal Res 2021 Aug 7. Epub 2021 Aug 7.

Department of Substitutive Dental Science, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Objectives: This study aimed to evaluate the effect of habitual caffeine (CAF) intake on stability, bone regeneration, and expression of bone markers at the bone-implant interface.

Background: Studies show that habitual CAF alters bone health and remodeling. Yet, there is no information regarding CAF effects on osseointegration of bone-anchored implants. Read More

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Semaphorin3A promotes osseointegration of titanium implants in osteoporotic rabbits.

Clin Oral Investig 2021 Aug 6. Epub 2021 Aug 6.

Department of Stomatology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, No.179, Xiaolingwei Road, Xuanwu District, Nanjing, 210014, Jiangsu, China.

Objective: In the present study, we intend to assess the function of Sema3A in osteointegration of titanium implants both in vivo and in vitro.

Material And Methods: Briefly, Sema3A was transfected in HBMSCs cells to detect its effect on osteogenesis. Subsequently, an in vivo rabbit model was established. Read More

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Biomimetic Zirconia with Cactus-Inspired Meso-Scale Spikes and Nano-Trabeculae for Enhanced Bone Integration.

Int J Mol Sci 2021 Jul 26;22(15). Epub 2021 Jul 26.

Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, UCLA School of Dentistry, Los Angeles, CA 90095-1668, USA.

Biomimetic design provides novel opportunities for enhancing and functionalizing biomaterials. Here we created a zirconia surface with cactus-inspired meso-scale spikes and bone-inspired nano-scale trabecular architecture and examined its biological activity in bone generation and integration. Crisscrossing laser etching successfully engraved 60 μm wide, cactus-inspired spikes on yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) with 200-300 nm trabecular bone-inspired interwoven structures on the entire surface. Read More

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