20,839 results match your criteria bone union

Endochondral Bone Tissue Engineering Using Human Induced Pluripotent Stem Cells.

Tissue Eng Part A 2021 Jul 26. Epub 2021 Jul 26.

Kobe University Graduate School of Medicine, Department of Orthopaedic Surgery, Kobe, Japan;

There has been great interest in the use of induced pluripotent stem cells (iPSCs) in bone regenerative strategies for bone defects. In the present study, we investigated whether the implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) could lead to the successful regeneration of bone defects in nude mice. Two clones of human iPSCs (201B7 and 454E2) were used. Read More

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Healing of Artificially Created Gap Non-union Using Autologous Cultured Osteoblasts Impregnated Over Three-Dimensional Biodegradable Scaffold: An Experimental Study (Rabbit).

Indian J Orthop 2021 Jul 19;55(Suppl 2):460-465. Epub 2021 Apr 19.

Department of Orthopaedics, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005 India.

Background: The large bone defect often require bone transplant or its substitutes to restore bone integrity which have some limitations. The study was conducted to analyze role of autologous osteoblast that are amplified in vivo and impregnated in a synthesized three-dimensional gelatin hydroxyapatite scaffold for treating artificially created critical size defect in rabbit's iliac crest.

Methods: In this research, 4-month-old ten healthy white male rabbits of average weight 2-3 kg were chosen. Read More

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Novel Design of Minimal Incision Double Oblique Device for Osteosynthesis (DODO) of Hip: Results of an In-silico Study Based on the Femur Morphometrics of the Northeast (NE) Indian population.

Indian J Orthop 2021 Jul 5;55(Suppl 2):385-394. Epub 2021 May 5.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039 Assam India.

Background: Hip fractures account for a large proportion of hospitalization among the trauma cases. Low cost, simple technique, easy removal, and high rate of the bone union makes extramedullary (EM) fixation techniques a preferred choice. A close-fit bone and plate are essential for the success of such implantation. Read More

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Dorsal or Lateral Approach for Intramedullary Nailing Using Kirschner Wire in Pediatric Radius Diaphyseal Fractures: Does it really matter?

Indian J Orthop 2021 Jul 7;55(Suppl 2):323-329. Epub 2021 Mar 7.

Department of Orthopaedics and Traumatology, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.

Background: Intramedullary nailing is the most preferred fixation method for diaphyseal radius and ulna fractures in the young age group. The aim of this study was to compare the dorsal and lateral entry points in the context of entry site-related complications, fracture union and functional results.

Methods: This retrospective comparative study included pediatric patients who underwent surgery for isolated diaphyseal radius or both bone forearm fractures with intramedullary nailing using Kirschner wire between January 2013 and January 2019. Read More

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CS-semi5 Inhibits NF-κB Activation to Block Synovial Inflammation, Cartilage Loss and Bone Erosion Associated With Collagen-Induced Arthritis.

Front Pharmacol 2021 9;12:655101. Epub 2021 Jul 9.

Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects 1% of the population. CS-semi5 is a semisynthetic chondroitin sulfate. In this study, CS-semi5 was shown to have positive effects on a model of collagen-induced arthritis (CIA). Read More

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Oligometastatic Lung Cancer Defined by Biology, Science, and Secondary Growths.

Thorac Surg Clin 2021 Aug;31(3):337-346

University of Ottawa, Ottawa Hospital - General Campus, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.

Breast cancer was the first malignant tumor for which TNM classification was proposed by the International Union Against Cancer. Volume and distribution of tumor burden were considered clinically important in this cancer. Lung cancer is caused by excessive cigarette smoking. Read More

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Cobalt-doped bioceramic scaffolds fabricated by 3D printing show enhanced osteogenic and angiogenic properties for bone repair.

Biomed Eng Online 2021 Jul 24;20(1):70. Epub 2021 Jul 24.

Department of Orthopaedics, Fujian Medical University Union Hospital, Fuzhou, 350001, China.

Background: The bone regeneration of artificial bone grafts is still in need of a breakthrough to improve the processes of bone defect repair. Artificial bone grafts should be modified to enable angiogenesis and thus improve osteogenesis. We have previously revealed that crystalline CaLi(PO) (CLP) possesses higher compressive strength and better biocompatibility than that of pure beta-tricalcium phosphate (β-TCP). Read More

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Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones.

Biomaterials 2021 Jun 3;275:120936. Epub 2021 Jun 3.

Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, 4102, Australia. Electronic address:

Macrophage-targeted therapies, including macrophage colony-stimulating factor 1 (CSF1), have been shown to have pro-repair impacts post-fracture. Preclinical/clinical applications of CSF1 have been expedited by development of chimeric CSF1-Fc which has extended circulating half-life. Here, we used mouse models to investigate the bone regenerative potential of CSF1-Fc in healthy and osteoporotic fracture. Read More

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Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration.

Basic Res Cardiol 2021 Jul 24;116(1):46. Epub 2021 Jul 24.

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Overactivated inflammatory responses contribute to adverse ventricular remodeling after myocardial infarction (MI). Regulatory B cells (Bregs) are a newly discovered subset of B cells with immunomodulatory roles in many immune and inflammation-related diseases. Our study aims to determine whether the expansion of Bregs exerts a beneficial effect on ventricular remodeling and explore the mechanisms involved. Read More

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BCMA-specific ADC MEDI2228 and Daratumumab induce synergistic myeloma cytotoxicity via IFN-driven immune responses and enhanced CD38 expression.

Clin Cancer Res 2021 Jul 23. Epub 2021 Jul 23.

Dana-Farber Cancer Institute, Harvard Medical School

Purpose: Efforts are required to improve potency and durability of CD38- and BCMA-based immunotherapies in human multiple myeloma (MM). We here delineated the molecular and cellular mechanisms underlying novel immunomodulatory effects triggered by BCMA pyrrolobenzodiazepine (PBD) antibody drug conjugate MEDI2228 which can augment efficacy of these immunotherapies.

Experimental Design: MEDI2228-induced transcriptional and protein changes were investigated to define significantly impacted genes and signaling cascades in MM cells. Read More

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In Vitro and In Vivo Characterization of PLLA-316L Stainless Steel Electromechanical Devices for Bone Tissue Engineering-A Preliminary Study.

Int J Mol Sci 2021 Jul 17;22(14). Epub 2021 Jul 17.

Veterinary Clinics Department, Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.

Bone injuries represent a major social and financial impairment, commonly requiring surgical intervention due to a limited healing capacity of the tissue, particularly regarding critical-sized defects and non-union fractures. Regenerative medicine with the application of bone implants has been developing in the past decades towards the manufacturing of appropriate devices. This work intended to evaluate medical 316L stainless steel (SS)-based devices covered by a polymer poly (L-lactic acid) (PLLA) coating for bone lesion mechanical and functional support. Read More

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A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis.

J Gastrointest Oncol 2021 Jun;12(3):933-943

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Our understanding in prognosis of bone metastasis (BM) from colorectal cancer (CRC) is limited. We aimed to establish a clinical risk stratification for individually predicting the survival of CRC patients with BM.

Methods: A total of 200 CRC patients with BM were included in this study. Read More

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Legg-Calvé-Perthes disease following Ender nail fixation of a pediatric femoral fracture.

Int J Surg Case Rep 2021 Jul 17;85:106209. Epub 2021 Jul 17.

Department of Orthopaedic Surgery, Jichi Medical University, Tochigi, Japan.

Introduction And Importance: Legg-Calvé-Perthes disease (LCPD) sometimes occur in children, however it is difficult to diagnose it at the early stage especially in the cases there are no complaints of symptoms. Femoral shaft fractures in children cause various complications such as leg-length discrepancy, nonunion and malunion, refracture, and osteonecrosis of the femoral head. We presented a rare case in which a pediatric patient developed LCPD after femoral shaft fracture. Read More

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A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation .

J Asian Nat Prod Res 2021 Jul 22:1-12. Epub 2021 Jul 22.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Dimethyl itaconate (DMI) is an analog of dimethyl fumarate (DMF), an approved NF-E2-related Factor 2 (Nrf2) activator for multiple sclerosis. This study evaluated the potential of DMI as an anti-inflammatory agent by comparing DMI with DMF in electrophilicity, Nrf2 activation, and anti-inflammation . The results showed that DMI was less electrophilic but better at inducing a durable activation of Nrf2 when compared with DMF. Read More

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The European Medicines Agency Review of Luspatercept for the Treatment of Adult Patients With Transfusion-dependent Anemia Caused by Low-risk Myelodysplastic Syndromes With Ring Sideroblasts or Beta-thalassemia.

Hemasphere 2021 Aug 19;5(8):e616. Epub 2021 Jul 19.

Oncology and Haematology Office, European Medicines Agency, Amsterdam, The Netherlands.

Luspatercept is a recombinant fusion protein that selectively binds to ligands belonging to the transforming growth factor-beta superfamily, resulting in erythroid maturation and differentiation. On June 25, 2020, a marketing authorization valid through the European Union (EU) was issued for luspatercept for the treatment of adult patients with transfusion-dependent anemia caused by very low-, low-, and intermediate-risk myelodysplastic syndromes (MDS) with ring sideroblasts, or those with transfusion-dependent beta thalassemia (BT). Luspatercept was evaluated in 2 separate phase 3, double-blind, placebo-controlled multicentre trials. Read More

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Automated cortical thickness measurement of the mandibular condyle head on CBCT images using a deep learning method.

Sci Rep 2021 Jul 21;11(1):14852. Epub 2021 Jul 21.

Department of Mathematics, Pohang University of Science and Technology, 150 Jigok-ro Nam-gu, Pohang-si, Gyeongsangbuk-do, 37666, South Korea.

This study proposes a deep learning model for cortical bone segmentation in the mandibular condyle head using cone-beam computed tomography (CBCT) and an automated method for measuring cortical thickness with a color display based on the segmentation results. In total, 12,800 CBCT images from 25 normal subjects, manually labeled by an oral radiologist, served as the gold-standard. The segmentation model combined a modified U-Net and a convolutional neural network for target region classification. Read More

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Tibia gap nonunion following sequestrectomy treated with a nonvascularized fibula strut graft.

Niger J Clin Pract 2021 Jul;24(7):1096-1099

Department of Surgery, Cedarcrest Hospitals, Abuja, Nigeria.

Chronic osteomyelitis of the tibia is a common sequela of acute osteomyelitis which may present with a bone defect following sequestrectomy. Treatment of the gap nonunion can be done with the ipsilateral fibula as a strut graft when harvested subperiosteally and this leads to good outcome. A 7-year-old girl presented to our facility with a 25 cm defect of her right tibia following sequestrectomy for chronic osteomyelitis in another facility. Read More

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The value of multimodal imaging in the diagnosis of primary cardiac angiosarcoma.

Echocardiography 2021 Jul 19. Epub 2021 Jul 19.

Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

A primary cardiac angiosarcoma (PCA) is very rare, highly aggressive, and metastatic in nature. The manifestations are often nonspecific, and the overall prognosis is extremely poor. The diagnosis of PCA can be complex and remains challenging. Read More

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Calcaneal Reconstruction With Free Deep Circumflex Iliac Artery Osseocutaneous Flap Following Aggressive Benign Bone Tumor Resection.

Foot Ankle Int 2021 Jul 21:10711007211025280. Epub 2021 Jul 21.

Hospital Universiti Sains Malaysia, Medical Campus, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.

Background: Advances in limb-salvage techniques have made total calcanectomy and primary reconstruction possible in managing calcaneal aggressive benign tumors and selected cases of intraosseous malignant tumors. However, there is still no consensus on the operative approach, oncologic margin, and the best reconstruction method to date. These 2 cases describe our experience in calcaneal reconstruction with the free deep circumflex iliac artery (DCIA) osseocutaneous flap in benign aggressive calcaneal tumors. Read More

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The importance of adequate diagnosis of pediatric forearm bowing fractures: A case report.

Trauma Case Rep 2021 Aug 1;34:100508. Epub 2021 Jul 1.

AZ St-Blasius Dendermonde, Department of Orthopaedic Surgery and Traumatology, Kroonveldlaan 50, 9200 Dendermonde, Belgium.

Introduction: Correct diagnosis of pediatric bowing fractures has proven to be challenging. Consequently, these entities are often underdiagnosed both at the initial presentation and at further follow-up. We present a case of an ulnar fracture with subsequent non-union and initially missed associated plastic deformity of the radius to highlight the importance of adequate diagnosis of bowing fractures and obtaining appropriate imaging in pediatric forearm trauma to prevent sequelae. Read More

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Exposed versus buried K-wire fixation in paediatric lateral condyle humerus fractures: preliminary communication of a prospective comparative study.

J Pediatr Orthop B 2021 Jul 19. Epub 2021 Jul 19.

Department of Orthopaedics Department of Community Medicine, SCB Medical College and Hospital, Cuttack, Odisha, India.

Buried Kirschner's wires (K-wires) following internal fixation of paediatric Lateral condyle fracture of humerus allow them to hold the bone until radiological consolidation but requires another surgical procedure for implant removal. Exposed wires need meticulous pin tract care, earlier implant removal and may carry a higher risk of infection. The objective of this study was to compare the outcomes of buried versus exposed K-wires for these fractures. Read More

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Repetitive brief ischemia accelerates tibial shaft fracture healing: a 5-years prospective preliminary clinical trial (PCT).

BMC Musculoskelet Disord 2021 Jul 20;22(1):631. Epub 2021 Jul 20.

Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.

Background: This study was to evaluate the effects of repetitive brief ischemia (RBI) on bone healing in patients with tibial shaft fractures.

Methods: In this prospective clinical trial, patients with tibia shaft fractures were enrolled between January 2016 and January 2021. The intermittent pneumatic compression (IPC) device was used to make RBI on the affected limb after surgical operation 24 h. Read More

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Role of Matrix-Associated Autologous Chondrocyte Implantation with Spheroids in the Treatment of Large Chondral Defects in the Knee: A Systematic Review.

Int J Mol Sci 2021 Jul 1;22(13). Epub 2021 Jul 1.

Department of Orthopaedic Surgery, Faculty of Medicine, UPEC (University Paris-Est, Créteil), 94000 Créteil, France.

Autologous chondrocyte implantation (ACI) is a cell therapy for the treatment of focal cartilage defects. The ACI product that is currently approved for use in the European Union (EU) consists of spheroids of autologous matrix-associated chondrocytes. These spheroids are spherical aggregates of ex vivo expanded human autologous chondrocytes and their self-synthesized extracellular matrix. Read More

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Comparative effect of eldecalcitol and alfacalcidol on bone microstructure: A preliminary report of secondary analysis of a prospective trial.

Osteoporos Sarcopenia 2021 Jun 3;7(2):47-53. Epub 2021 Jun 3.

Department of Endocrinology, Key Laboratory of Endocrinology, National Commission of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Objectives: To compare the effect of eldecalcitol and alfacalcidol on skeletal microstructure by high-resolution peripheral QCT (HR-pQCT).

Methods: This was a substudy of a randomized, double-blind, active comparator trial. Five female osteoporotic patients with 1-year 0. Read More

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Femoral Neck Nonunion Associated With Delayed Union of Ipsilateral Femoral Shaft Fracture.

Cureus 2021 Jun 12;13(6):e15612. Epub 2021 Jun 12.

Orthopaedics, All India Institute of Medical Sciences, Bhopal, IND.

We report the case of a 36-year-old man, who presented to us five months after the initial trauma. He had been treated elsewhere with a cephalomedullary femoral nail. He described severe pain in his right thigh and groin that confined him to a wheelchair. Read More

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Osteochondral Autograft Transplantation for Capitellar Osteochondritis Dissecans.

Dan A Zlotolow

JBJS Essent Surg Tech 2021 Apr-Jun;11(2). Epub 2021 May 12.

Shriners Hospitals for Children, Philadelphia, Pennsylvania.

Background: The goal of the osteochondral autograft transplantation (OAT) procedure is to replace both the bone and cartilage that have been compromised by osteonecrosis of the capitellum, a condition known as osteochondritis dissecans (OCD). In children, the vascularity of the capitellum is limited compared with that in adults because the physis acts as a physical barrier to vascular ingrowth from the metaphysis to the epiphysis. The necrotic subchondral bone cannot keep up with the weight-bearing demands of certain high-level athletes such as gymnasts, accumulating microfractures and eventually crumbling. Read More

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Scaphoid Nonunion Volar Plating with Pure Nonvascularized Cancellous Autograft.

JBJS Essent Surg Tech 2021 Apr-Jun;11(2). Epub 2021 May 27.

Department of Orthopaedic Surgery, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona.

Background: Surgical treatment of scaphoid nonunion has evolved over the years to include a variety of procedures and techniques involving a number of vascularized and nonvascularized bone grafting options and fixation strategies. Volar plating of scaphoid nonunions with use of pure cancellous nonvascularized autograft is a safe and effective treatment method with good functional outcomes and union rates.

Description: Volar plating of the scaphoid nonunion is performed via a volar approach, with debridement and reduction of the nonunion site. Read More

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Clinical Outcomes After First Metatarsophalangeal Joint Arthrodesis by Flat Cut Joint Preparation With Individual Adjustment for Sagittal Alignment.

J Foot Ankle Surg 2021 Jun 20. Epub 2021 Jun 20.

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Sagittal misalignment is a major cause of patient dissatisfaction and re-operation after first metatarsophalangeal (MTP) joint arthrodesis. The stereotypical application of the fixed angle would be undesirable, especially in cases of flat or cavus foot. We retrospectively reviewed 31 cases (27 patients) in which first MTP joint arthrodesis was performed using the flat cut joint preparation technique with reference to the plantar clearance beneath the pulp of the toe while simulating weightbearing by pushing a board against the sole. Read More

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Activation, development, and attenuation of modeling- and remodeling-based bone formation in adult rats.

Biomaterials 2021 Jul 9;276:121015. Epub 2021 Jul 9.

McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

Activation of modeling-based bone formation (MBF - bone formation without prior activation of bone resorption), has been identified as an important mechanism by which anabolic agents, such as intermittent parathyroid hormone (PTH), rapidly elicit new bone formation. Using a novel cryohistology imaging platform, coupled with sequential multicolor fluorochrome injections, we demonstrated that MBF and remodeling-based bone formation (RBF) in the adult rat tibia model have similar contributions to trabecular bone homeostasis. PTH treatment resulted in a 2. Read More

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Open Reduction and Internal Fixation for Humeral Shaft Nonunion: Bone Grafting Is Not Routinely Required and Avoids Donor Site Morbidity.

J Orthop Trauma 2021 Aug;35(8):414-423

Edinburgh Orthopaedics - Edinburgh Orthopaedic Trauma, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; and.

Objectives: To document union rate, complications and patient-reported outcomes after open reduction and internal fixation (ORIF), with and without bone grafting (BG), for humeral diaphyseal nonunion after failed nonoperative management.

Design: Retrospective.

Setting: University teaching hospital. Read More

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