8,494 results match your criteria bone severely

Is a periacetabular osteotomy as efficacious in retroversion as it is in dysplasia? : The role of femoral anteversion on outcome.

Bone Jt Open 2021 Sep;2(9):757-764

Orthopaedics, University College Hospital, London, UK.

Aims: Periacetabular osteotomy (PAO) is an established treatment for acetabular dysplasia. It has also been proposed as a treatment for patients with acetabular retroversion. By reviewing a large cohort, we aimed to test whether outcome is equivalent for both types of morphology and identify factors that influenced outcome. Read More

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September 2021

Platelet-rich plasma attenuates interleukin-1β-induced apoptosis and inflammation in chondrocytes through targeting hypoxia-inducible factor-2α.

Tissue Cell 2021 Sep 8;73:101646. Epub 2021 Sep 8.

Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, 95 Yong an Road, Xicheng District, Beijing, 100050, China. Electronic address:

Osteoarthritis (OA) is a prevailing chronic disease in Orthopedics that characterized with severely damaged cartilage and subchondral bone, thus leading to profound disorders of synovial joints. Platelet-rich plasma (PRP) has been applied as a popular non-operative treatment option for promoting musculoskeletal healing. Our previous work demonstrated that PRP protected chondrocytes from interleukin-1β (IL-1β)-induced apoptosis in vitro. Read More

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September 2021

Bone Nanomechanical Properties and Relationship to Bone Turnover and Architecture in Patients With Atypical Femur Fractures: A Prospective Nested Case-Control Study.

JBMR Plus 2021 Sep 12;5(9):e10523. Epub 2021 Aug 12.

Bone & Mineral Research Laboratory Henry Ford Health System/Wayne State University Integrative Biosciences (IBio) Research Facility Detroit MI USA.

Atypical femur fractures (AFFs) are well-established serious complication of long-term bisphosphonate and denosumab therapy in patients with osteopenia or osteoporosis. To elucidate underlying mechanism(s) for the development of AFF, we performed a nested case-control study to investigate bone tissue nanomechanical properties and prevailing bone microstructure and tissue-level remodeling status as assessed by bone histomorphometry. We hypothesized that there would be differences in nanomechanical properties between patients with and without AFF and that bone microstructure and remodeling would be related to nanomechanical properties. Read More

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September 2021

Medical management of heavily exposed victims: An experience at the Tokaimura criticality accident.

J Radiol Prot 2021 Sep 15. Epub 2021 Sep 15.

Harada Hospital, Irima, Saitama, JAPAN.

A criticality accident occurred at the uranium conversion plant in Tokaimura, Ibaraki Prefecture, Japan on September 30, 1999. When uranyl nitrate was overloaded to a critical mass level, uncontrolled fission reaction occurred. A procedure was carried out according to the JCO manual, although not an officially approved manual. Read More

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September 2021

Basal Implants: An Asset for Rehabilitation of Atrophied Resorbed Maxillary and Mandibular Jaw - A Prospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):64-69. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, College of Dental Sciences and Research Centre, Ahmedabad, Gujarat, India.

Introduction: Conventional implants have great limitations in case of atrophic maxillary and mandibular ridges. Ultimately, patients who have severely atrophied jawbones paradoxically receive little or no treatment, as long as conventional implants are considered the device of first choice. Basal implants were developed with the goal to overcome the limitations of conventional implantology, primarily for atrophied ridges or inadequate bone with the protocol of immediate loading. Read More

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Calcified cartilage differs in patients with end-stage primary osteoarthritis and secondary osteoarthritis due to rheumatoid arthritis of the hip joint.

Scand J Rheumatol 2021 Sep 13:1-11. Epub 2021 Sep 13.

Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.

: Despite distinct aetiologies, the end-stages of primary osteoarthritis (OA) and secondary OA are described by common radiological features. However, the morphology of the bone-cartilage unit may differ depending on the pathogenesis. In this cross-sectional study, we aimed to investigate the histological differences in the bone-cartilage unit of the femoral head between patients with primary OA and secondary OA due to rheumatoid arthritis (RA). Read More

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September 2021

Closed reduction of severely angulated Rockwood and Wilkins' type C thumb Metacarpal Base fractures in children: case series.

BMC Musculoskelet Disord 2021 Sep 12;22(1):775. Epub 2021 Sep 12.

Department of Pediatric Orthopaedic, Dalian Women and Children's Medical Center (group), Dalian, 116012, Liaoning, China.

Background: Management of severely angulated Rockwood and Wilkins' type C (RW-C) thumb metacarpal base fractures in children is challenging. We report experiences of percutaneous leverage reduction and dual antegrade crossing Kirschner (DACK) wire fixation in these fractures, aiming to assess the results using our reduction technique.

Methods: From October 2011 to September 2015, A total of 17 patients with severely angulated RW-C thumb metacarpal base fractures were treated at our hospital. Read More

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September 2021

Photodynamic therapy outcome modelling for patients with spinal metastases: a simulation-based study.

Sci Rep 2021 Sep 9;11(1):17871. Epub 2021 Sep 9.

Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada.

Spinal metastases often occur in the advanced stages of breast, lung or prostate cancer, resulting in a significant impact on the patient's quality of life. Current treatment modalities for spinal metastases include both systemic and localized treatments that aim to decrease pain, improve mobility and structural stability, and control tumour growth. With the development of non-toxic photosensitizer drugs, photodynamic therapy (PDT) has shown promise as a minimally invasive non-thermal alternative in oncology, including for spinal metastases. Read More

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September 2021

Efficacy of Romosozumab for Osteoporosis in a Patient With Osteogenesis Imperfecta: A Case Report.

Mod Rheumatol Case Rep 2021 Aug 28. Epub 2021 Aug 28.

Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.

The efficacy of romosozumab for severe osteoporosis is uncertain in patients with osteogenesis imperfecta (OI). This report introduced a severe osteoporotic case of OI to examine the effect of romosozumab on bone fragility. A 64-year-old man with OI was referred to our department for finding out the cause of his repeated fractures. Read More

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Hypoxia in Bone and Oxygen Releasing Biomaterials in Fracture Treatments Using Mesenchymal Stem Cell Therapy: A Review.

Front Cell Dev Biol 2021 20;9:634131. Epub 2021 Aug 20.

Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Bone fractures have a high degree of severity. This is usually a result of the physical trauma of diseases that affect bone tissues, such as osteoporosis. Due to its highly vascular nature, the bone is in a constant state of remodeling. Read More

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MPS I: Early diagnosis, bone disease and treatment, where are we now?

J Inherit Metab Dis 2021 Sep 3. Epub 2021 Sep 3.

Centre for Metabolic Diseases, University Hospital Antwerp, University of Antwerp, Edegem, Antwerp, Belgium.

Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder characterized by α-L-iduronidase deficiency. Patients present with a broad spectrum of disease severity ranging from the most severe phenotype (Hurler) with devastating neurocognitive decline, bone disease and early death to intermediate (Hurler-Scheie) and more attenuated (Scheie) phenotypes, with a normal life expectancy. The most severely affected patients are preferably treated with hematopoietic stem cell transplantation, which halts the neurocognitive decline. Read More

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September 2021

The use of a novel deer antler decellularized cartilage-derived matrix scaffold for repair of osteochondral defects.

J Biol Eng 2021 Sep 3;15(1):23. Epub 2021 Sep 3.

School of Life Science, Taizhou University, 1139 Shifu Avenue, Jiaojiang District, Zhejiang, 318000, Taizhou, China.

Background: The physiologic regenerative capacity of cartilage is severely limited. Current studies on the repair of osteochondral defects (OCDs) have mainly focused on the regeneration of cartilage tissues. The antler cartilage is a unique regenerative cartilage that has the potential for cartilage repair. Read More

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September 2021

Consequences of ankle joint immobilisation: insights from a morphometric analysis about fibre typification, intramuscular connective tissue, and muscle spindle in rats.

Histochem Cell Biol 2021 Sep 2. Epub 2021 Sep 2.

Department of Anatomy, University of Sao Paulo, Sao Paulo, SP, Brazil.

Orthosis immobilisations are routinely used in orthopaedic procedures. This intervention is applicable in bone fractures, ligament injuries, and tendonitis, among other disorders of the musculoskeletal system. We aimed to evaluate the effects of ankle joint functional immobilisation on muscle fibre morphology, connective tissue, muscle spindle and fibre typification triggered by a novel metallic orthosis. Read More

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September 2021

5-Azacytidine depletes hematopoietic stem cells and synergizes with an anti-CD117 antibody to augment donor engraftment in immunocompetent mice.

Blood Adv 2021 Aug 27. Epub 2021 Aug 27.

2. Institute for Stem Cell and Regenerative Medicine, Stanford University School of Medicine, Stanford CA, United States.

Depletion of hematopoietic stem cells (HSC) is used therapeutically in many malignant and non-malignant blood disorders in the setting of a hematopoietic cell transplantation (HCT) to eradicate diseased HSC allowing donor HSC to engraft. Current treatments to achieve HSC elimination rely on modalities that cause DNA strand breakage (i.e. Read More

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Life-Threatening Panfacial Wild Dog Bites in a Child.

Srinjoy Saha

Wilderness Environ Med 2021 Aug 23. Epub 2021 Aug 23.

Department of Plastic Surgery, Apollo Gleneagles Hospital, Kolkata, India. Electronic address:

Infants and toddlers can sustain grievous craniofacial injuries after dog bites, some of which may be life-threatening. An 18-mo-old male child presented to our emergency department with complex panfacial wounds after being bitten by an unvaccinated wild dog 6 h earlier. Primary management, hemostasis, and rabies postexposure prophylaxis were performed near his home. Read More

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Radiographic Evaluation of Bone Remodeling after Additively Manufactured Subperiosteal Jaw Implantation (AMSJI) in the Maxilla: A One-Year Follow-Up Study.

J Clin Med 2021 Aug 12;10(16). Epub 2021 Aug 12.

Private Clinic Orthoface Ghent, 9830 Ghent, Belgium.

Additively manufactured subperiosteal jaw implants (AMSJI) are patient-specific, 3D-printed, titanium implants that provide an alternative solution for patients with severe maxillary bone atrophy. The aim of this study was to evaluate the bony remodeling of the maxillary crest and supporting bone using AMSJI. Fifteen patients with a Cawood-Howell Class V or greater degree of maxillary atrophy were evaluated using (cone beam) computed tomography scans at set intervals: one month (T1) and twelve months (T2) after definitive masticatory loading of bilateral AMSJI implants in the maxilla. Read More

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Subjective and Objective Change in Cervical Spine Mobility After Single-level Anterior Cervical Decompression and Fusion.

Spine (Phila Pa 1976) 2021 Sep;46(18):1241-1248

Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Study Design: Prospective, observational study.

Objective: The aim of this study was to collect objective and especially subjective data on changes in cervical spine mobility after single-level anterior cervical decompression and fusion (ACDF) and to investigate the impact on quality of life and activities of daily living (ADLs).

Summary Of Background Data: Although there are several studies dealing with the objective change in mobility after single-level ACDF, there are few data on how spondylodesis of a motion segment affects subjective restriction of cervical spine mobility. Read More

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September 2021

Ecological Specialization and Evolutionary Reticulation in Extant Hyaenidae.

Mol Biol Evol 2021 08;38(9):3884-3897

Department of Mathematics and Natural Sciences, Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.

During the Miocene, Hyaenidae was a highly diverse family of Carnivora that has since been severely reduced to four species: the bone-cracking spotted, striped, and brown hyenas, and the specialized insectivorous aardwolf. Previous studies investigated the evolutionary histories of the spotted and brown hyenas, but little is known about the remaining two species. Moreover, the genomic underpinnings of scavenging and insectivory, defining traits of the extant species, remain elusive. Read More

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Deletion of Glut1 in early postnatal cartilage reprograms chondrocytes toward enhanced glutamine oxidation.

Bone Res 2021 Aug 23;9(1):38. Epub 2021 Aug 23.

Department of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO, USA.

Glucose metabolism is fundamental for the functions of all tissues, including cartilage. Despite the emerging evidence related to glucose metabolism in the regulation of prenatal cartilage development, little is known about the role of glucose metabolism and its biochemical basis in postnatal cartilage growth and homeostasis. We show here that genetic deletion of the glucose transporter Glut1 in postnatal cartilage impairs cell proliferation and matrix production in growth plate (GPs) but paradoxically increases cartilage remnants in the metaphysis, resulting in shortening of long bones. Read More

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A simple and successful treatment for rupture and defect of the posterior third superior sagittal sinus caused by open depressed skull fracture: A case report.

Chin J Traumatol 2021 Aug 3. Epub 2021 Aug 3.

Department of Neurosurgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China.

It is extremely dangerous to treat the posterior third of the superior sagittal sinus (PTSSS) surgically, since it is usually not completely ligated. In this report, the authors described the case of a 27-year-old man with a ruptured and defective PTSSS caused by an open depressed skull fracture, which was treated by ligation of the PTSSS and the patient achieved a positive recovery. The patient's occiput was hit by a height-limiting rod and was in a mild coma. Read More

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Identification of the Pathway and Appropriate Use of Four Zygomatic Implants in the Atrophic Maxilla: A Cross-Sectional Study.

Int J Oral Maxillofac Implants 2021 Jul-Aug;36(4):807-817

Purpose: This cross-sectional study aimed to identify and characterize the pathway for appropriate placement of four zygomatic implants in the severely atrophic maxilla and to group the anatomical variations of the osteotomy trajectory for anterior zygomatic implants.

Materials And Methods: CBCT images of patients presenting indications for the use of four zygomatic implants to withstand a maxillary rehabilitation were reviewed. Cross-sectional planes corresponding to the implant trajectories, designed according to a zygoma anatomy-guided approach for implants placed in the anterior and posterior maxilla, were assessed separately. Read More

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Partnering With State Health Departments to Address Injection-Related Infections During the Opioid Epidemic: Experience at a Safety Net Hospital.

Open Forum Infect Dis 2021 Aug 27;8(8):ofab208. Epub 2021 Apr 27.

Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.

Massachusetts is one of the epicenters of the opioid epidemic and has been severely impacted by injection-related viral and bacterial infections. A recent increase in newly diagnosed human immunodeficiency virus (HIV) infections among persons who inject drugs in the state highlights the urgent need to address and bridge the overlapping epidemics of opioid use disorder (OUD) and injection-related infections. Building on an established relationship between the Massachusetts Department of Public Health and Boston Medical Center, the Infectious Diseases section has contributed to the development and implementation of a cohesive response involving ambulatory, inpatient, emergency department, and community-based services. Read More

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Are patients with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder so different?

Rheumatol Int 2021 Oct 16;41(10):1785-1794. Epub 2021 Aug 16.

Rheumatology and Rehabilitation, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Diagnosing hypermobile Ehlers-Danlos syndrome (hEDS) remains challenging, despite new 2017 criteria. Patients not fulfilling these criteria are considered to have hypermobile spectrum disorder (HSD). Our first aim was to evaluate whether patients hEDS were more severely affected and had higher prevalence of extra-articular manifestations than HSD. Read More

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October 2021

Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study.

Crit Care 2021 Aug 14;25(1):294. Epub 2021 Aug 14.

Department of Internal Medicine, Division of Nephrology, Bone, and Mineral Metabolism, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.

Background: Preliminary studies have suggested that the renin-angiotensin system is activated in critical illness and associated with mortality and kidney outcomes. We sought to assess in a larger, multicenter study the relationship between serum renin and Major Adverse Kidney Events (MAKE) in intensive care unit (ICU) patients.

Methods: Prospective, multicenter study at two institutions of patients with and without acute kidney injury (AKI). Read More

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3D printed double-network alginate hydrogels containing polyphosphate for bioenergetics and bone regeneration.

Int J Biol Macromol 2021 Oct 12;188:639-648. Epub 2021 Aug 12.

School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China; Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou 510006, PR China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, PR China; Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China. Electronic address:

Low mechanical strength, poor processability, and low bioactivity of hydrogels limit their application in bone tissue engineering severely. Herein, a new 3D-printable, osteoinductive, and bioenergetic-active double-network (DN) hydrogel containing sodium alginate (SA), poly (ethylene glycol) diacrylate (PEGDA), and sodium polyphosphate (PolyP) was developed via a two-step method. The synergy of the covalent cross-linking network and the ionic cross-linking network improves the mechanical properties of the hydrogel. Read More

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October 2021

Physiology-based toxicokinetic modelling of aluminium in rat and man.

Arch Toxicol 2021 09 14;95(9):2977-3000. Epub 2021 Aug 14.

Institute of Mathematics, Mathematical Modelling and Systems Biology, University of Potsdam, Potsdam, Germany.

A sufficient quantitative understanding of aluminium (Al) toxicokinetics (TK) in man is still lacking, although highly desirable for risk assessment of Al exposure. Baseline exposure and the risk of contamination severely limit the feasibility of TK studies administering the naturally occurring isotope Al, both in animals and man. These limitations are absent in studies with Al as a tracer, but tissue data are limited to animal studies. Read More

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September 2021

Antineoplastic agents aggravate the damages caused by nicotine on the peri-implant bone: an in vivo histomorphometric and immunohistochemical study in rats.

Clin Oral Investig 2021 Aug 13. Epub 2021 Aug 13.

Department of Diagnosis and Surgery-Periodontics Division, School of Dentistry, São Paulo State University (Unesp), St. José Bonifácio 1193, Vila Mendonça, Araçatuba, SP, 16015-050, Brazil.

Objective: To assess the interaction between chemotherapy and normal tissues is critical to assure quality of life during and after the treatment of cancer. This study evaluated the influence of cisplatin (CIS) and 5-fluorouracil (5-FU) over the peri-implant tissues around osseointegrated titanium implants in animals previously exposed to nicotine. Materials and methods One hundred twenty male rats were divided into two groups, receiving via subcutaneous injection, either physiological saline solution (PSS) (n = 30) or nicotine hemissulfate (NIC) (n = 90) for 30 days prior to implants' placement. Read More

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Gamma-irradiation fluctuates the mRNA N-methyladenosine (mA) spectrum of bone marrow in hematopoietic injury.

Environ Pollut 2021 Sep 4;285:117509. Epub 2021 Jun 4.

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 238 Baidi Road, 300192, Tianjin, China. Electronic address:

Humans benefit from nuclear technologies but consequently experience nuclear disasters or side effects of iatrogenic radiation. Hematopoietic system injury first arises upon radiation exposure. As an intricate new layer of genetic control, the posttranscriptional mA modification of RNA has recently come under investigation and has been demonstrated to play pivotal roles in multiple physiological and pathological processes. Read More

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September 2021

Correction to: Prediction of mortality in severely injured patients with facial bone fractures.

Oral Maxillofac Surg 2021 Aug 11. Epub 2021 Aug 11.

Department of Dentistry, Institute of Postgraduate Education, O. Bogomolets National Medical University, 34, Peremohy Avenue, the 2nd floor of the "physical‑chemical" building, Kyiv, Ukraine.

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Effects of bioactive strontium-substituted hydroxyapatite on osseointegration of polyethylene terephthalate artificial ligaments.

J Mater Chem B 2021 Sep 9;9(33):6600-6613. Epub 2021 Aug 9.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, P. R. China.

The insufficient bioactivity of polyethylene terephthalate (PET) artificial ligaments severely weakens the ligament-bone healing in anterior cruciate ligament (ACL) reconstruction, while osteogenic modification is a prevailing method to enhance osseointegration of PET artificial ligaments. In the present study, strontium-substituted hydroxyapatite (SrHA) nanoparticles with different strontium (Sr) contents were synthesized via microwave-hydrothermal method and subsequently were coated on the surface of PET artificial ligaments. The results of XRD, FT-IR, TEM and ICP-OES revealed that the doping of Sr ions had no great influences on the phase composition, morphology and particle size of HA, but affected its chemical compositions and crystallinity. Read More

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September 2021