137,635 results match your criteria bone mass


Total elbow arthroplasty as a reconstruction option for distal humerus osteosarcoma: A case report.

Int J Surg Case Rep 2021 Sep 8;87:106392. Epub 2021 Sep 8.

Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Persahabatan General Hospital, Indonesia.

Introduction: Osteosarcoma is the second most common malignant bone tumor. The humerus is the third most common anatomical location for osteosarcoma, however, osteosarcoma around the elbow joint is uncommon. The intricacy of the elbow joint, limited soft tissue coverage, and proximity to nerves and arteries make the surgical resection and reconstruction complicated. Read More

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September 2021

Finite Element derived Femoral Strength is a better Predictor of Hip Fracture Risk than aBMD in the AGES Reykjavik Study Cohort.

Bone 2021 Sep 24:116219. Epub 2021 Sep 24.

Institute for Biomechanics, ETH-Zürich, Zürich, Switzerland.

Hip fractures associated with a high economic burden, loss of independence, and a high rate of post-fracture mortality, are a major health concern for modern societies. Areal bone mineral density is the current clinical metric of choice when assessing an individual's future risk of fracture. However, this metric has been shown to lack sensitivity and specificity in the targeted selection of individuals for preventive interventions. Read More

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September 2021

Differential Risk of Fracture Attributable to Type 2 Diabetes Mellitus According to Skeletal Site.

Bone 2021 Sep 24:116220. Epub 2021 Sep 24.

University of Manitoba, Winnipeg, Canada.

Background: Impaired bone quality, especially related to accumulation of advanced glycation end-products (AGEs) and higher incidence of falls contribute substantially to a higher risk of fracture associated with type 2 diabetes mellitus (T2DM). These factors may predispose to fractures more at skeletal sites where impaired bone toughness and falls play a larger pathogenic role (such as hip fractures) compared to skeletal sites where they are less important (such as vertebral fractures).

Objective: To determine if the associations of T2DM with prevalent and incident vertebral fractures are as strong as they are for hip and other non-vertebral fractures. Read More

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September 2021

The Effect of Short-Term High-Caloric Feeding and Fasting on Bone Microarchitecture.

Bone 2021 Sep 24:116214. Epub 2021 Sep 24.

Neuroendocrine Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114.

Background: States of chronic overnutrition and undernutrition are both associated with impaired bone health and increased fracture risk but there are no data on bone microarchitecture following short-term controlled nutritional challenges.

Objective: The purpose of our study was to evaluate the impact of short-term high-caloric feeding and fasting on bone microarchitecture. We hypothesized that both high-caloric feeding and fasting would have negative effects on microarchitecture. Read More

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September 2021

Development and validation of a one year predictive model for secondary fractures in osteoporosis.

PLoS One 2021 27;16(9):e0257246. Epub 2021 Sep 27.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

The number of osteoporosis-related fractures in the United States is no longer declining. Existing risk-based assessment tools focus on long-term risk. Payers and prescribers need additional tools to identify patients at risk for imminent fracture. Read More

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September 2021

Quantitative Sound Speed Imaging of Cortical Bone and Soft Tissue: Results from Observational Data Sets.

IEEE Trans Med Imaging 2021 Sep 27;PP. Epub 2021 Sep 27.

This work presents the first quantitative ultrasonic sound speed images of ex vivo limb cross-sections containing both soft tissue and bone using Full Waveform Inversion (FWI) with level set (LS) and travel time regularization. The estimated bulk sound speed of bone and soft tissue are within 10% and 1%, respectively, of ground truth estimates. The sound speed imagery shows muscle, connective tissue and bone features. Read More

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September 2021

The influence of snuff and smoking on bone accretion in late adolescence. The Tromsø study, Fit Futures.

Arch Osteoporos 2021 Sep 27;16(1):143. Epub 2021 Sep 27.

Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

Areal bone mineral density (aBMD) predicts future fracture risk. This study explores associations between use of tobacco and bone accretion in Norwegian adolescents. Our results indicate that use of snuff is negatively associated with accretion of aBMD in adolescence and may be a signal of increased future fracture risk. Read More

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September 2021

The associations of statin intake and the trabecular bone score and bone mineral density status in elderly Iranian individuals: a cross-sectional analysis of the Bushehr Elderly Health (BEH) program.

Arch Osteoporos 2021 Sep 27;16(1):144. Epub 2021 Sep 27.

Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran Universityof Medical Sciences, Tehran, Iran.

In recent years, a growing interest on the impact of statin intake on bone health has emerged, although the reported results are controversial. The results of this study revealed that BMD at lumbar spine has a significant association with statin intake. However, such association appears to be weaker regarding TBS values compared to BMD. Read More

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September 2021

In Situ Exploration of Murine Megakaryopoiesis using Transmission Electron Microscopy.

J Vis Exp 2021 Sep 8(175). Epub 2021 Sep 8.

Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S 1255, FMTS;

Differentiation and maturation of megakaryocytes occur in close association with the cellular and extracellular components of the bone marrow. These processes are characterized by the gradual appearance of essential structures in the megakaryocyte cytoplasm such as a polyploid and polylobulated nucleus, an internal membrane network called demarcation membrane system (DMS) and the dense and alpha granules that will be found in circulating platelets. In this article, we describe a standardized protocol for the in situ ultrastructural study of murine megakaryocytes using transmission electron microscopy (TEM), allowing for the identification of key characteristics defining their maturation stage and cellular density in the bone marrow. Read More

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September 2021

Modeling Sympathetic Hyperactivity in Alzheimer's Related Bone Loss.

J Alzheimers Dis 2021 Sep 22. Epub 2021 Sep 22.

Hahn Tissue Lab, Rensselaer Polytechnic Institute, Department of Biomedical Engineering, Troy, NY, USA.

Background: A significant subset of patients with Alzheimer's disease (AD) exhibit low bone mineral density and are therefore more fracture-prone, relative to their similarly aged neurotypical counterparts. In addition to chronic immune hyperactivity, behavioral dysregulation of effector peripheral sympathetic neurons-which densely innervate bone and potently modulate bone remodeling-is implicated in this pathological bone reformation.

Objective: Thus, there exists a pressing need for a robust in vitro model which allows interrogation of the paracrine interactions between the putative mediators of AD-related osteopenia: sympathetic neurons (SNs) and mesenchymal stem cells (MSCs). Read More

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September 2021

SERS and MALDI-TOF MS based plasma exosome profiling for rapid detection of osteosarcoma.

Analyst 2021 Sep 27. Epub 2021 Sep 27.

Department of Chemistry, and Shanghai Stomatological Hospital, Fudan University, Shanghai 200000, China.

Osteosarcoma is the most frequent primary bone cancer, particularly among children and adolescents. The early diagnosis of osteosarcoma is significant for timely clinical treatment to reduce the mortality of patients. Exosomes play a significant role in intercellular communication and serve as promising biomarkers in liquid biopsy for the diagnosis and monitoring of tumors. Read More

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September 2021

Periosteal Myxoid Leiomyosarcoma Histologically Mimicking Extraskeletal Myxoid Chondrosarcoma: Report of a Case with Histopathological and Cytopathological Comparison with Extraskeletal Myxoid Chondrosarcoma.

Acta Cytol 2021 Sep 20:1-8. Epub 2021 Sep 20.

Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.

Myxoid leiomyosarcoma (MLS) is a rare variant of leiomyosarcoma, with most cases occurring in the uterus. A case of MLS arising in the periosteal region of the tibia, mimicking extraskeletal myxoid chondrosarcoma (EMC), is described. The evaluation included histological and cytological comparison with EMC. Read More

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September 2021

Effects of exercise training on bone mineral density in adults living with HIV: a retrospective study.

HIV Res Clin Pract 2021 Sep 25:1-10. Epub 2021 Sep 25.

Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports, University of Rio de Janeiro State, Rio de Janeiro, RJ, Brazil.

Evidence on the effects of exercise training on the bone health of men and women living with HIV (MLHIV and WLHIV) is limited. To investigate the effects of a long-term multimodal exercise program on the bone mineral density (BMD) of MLHIV and WLHIV. A retrospective cohort of 39 patients (13 women; 48. Read More

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September 2021

Body Composition Changes in Hepatocellular Carcinoma: Prediction of Survival to Transcatheter Arterial Chemoembolization in Combination With Clinical Prognostic Factors.

Cancer Control 2021 Jan-Dec;28:10732748211038445

Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, China.

Treatment-related toxicities and decreased levels of patient performance during cancer therapy might contribute to body composition changes (BCC) and thereby impact outcomes. This study investigated the association between BCC during transcatheter arterial chemoembolization (TACE) and outcome in patients with hepatocellular carcinoma (HCC), and developed a nomogram for predicting survival in combination with clinical prognostic factors (CPF). Pretreatment and posttreatment computed tomography (CT) images of 75 patients with HCC who were treated between 2015 and 2018 were analyzed. Read More

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September 2021

Risedronate use to attenuate bone loss following sleeve gastrectomy: Results from a pilot randomized controlled trial.

Clin Obes 2021 Sep 27:e12487. Epub 2021 Sep 27.

Weight Management Center, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

The purpose of this study was to explore the efficacy of 150 mg once monthly oral risedronate use in the prevention of sleeve gastrectomy (SG) associated bone loss. Twenty-four SG patients (56 ± 7 years, 83% female, 21% black) were randomized to risedronate or placebo for 6 months, with an optional 12-month assessment. Outcome measures included 6 (n = 21) and 12 (n = 14) month change in dual energy x-ray absorptiometry-acquired regional areal bone mineral density (aBMD). Read More

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September 2021

The estrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss.

Exp Physiol 2021 Sep 26. Epub 2021 Sep 26.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, United States.

New Findings: What is the central question of this study? Is the estrous cycle affected during disuse atrophies and if so, how do estrous cycle changes relate to musculoskeletal outcomes? What is the main finding and its importance? Rodent estrous cycles are altered during disuse atrophy, which corresponds to musculoskeletal outcomes. However, the estrous cycle does not appear changed in Lewis Lung Carcinoma, which corresponded to no differences in muscle size compared to healthy controls. These findings suggest a relationship between estrous cycle and muscle size during atrophic pathologies. Read More

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September 2021

Reliability and Convergent Construct Validity of Quantitative Ultrasound for Synovitis, Meniscal Extrusion, and Osteophyte in Knee Osteoarthritis With MRI.

J Ultrasound Med 2021 Sep 26. Epub 2021 Sep 26.

Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia.

Aims: To determine: 1) inter-rater reliability of quantitative measurements of ultrasound-detected synovitis, meniscal extrusion, and osteophytes; and 2) construct (convergent) validity via correlations and absolute agreements between ultrasound- and gold-standard magnetic resonance imaging (MRI)-outcomes in knee osteoarthritis.

Methods: Dynamic ultrasound images for supra-patellar synovitis, meniscal extrusion, and osteophytes were acquired and quantified by a physician operator, musculoskeletal ultrasonographer, and medical student independently. On the same day, 3T MRI images were acquired. Read More

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September 2021

Long-term clinical course of immunotactoid glomerulopathy complicated with diffuse large B-cell lymphoma.

CEN Case Rep 2021 Sep 26. Epub 2021 Sep 26.

Department of Nephrology, Kitasato University School of Medicine, Sagamihara, Japan.

We report a case of immunotactoid glomerulopathy (ITG) complicated with diffuse large B-cell lymphoma (DLBCL). A 68-year-old woman presented with leg edema and was diagnosed with nephrotic syndrome (NS). Renal biopsy revealed ITG. Read More

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September 2021

Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus.

Acta Diabetol 2021 Sep 26. Epub 2021 Sep 26.

Department of Endocrinology and Diabetes, St Vincent's Hospital, Sydney, NSW, Australia.

Aims: To evaluate the impact of peripheral neuropathy on bone health in people with type 2 diabetes mellitus (T2DM).

Methods: Participants with T2DM were grouped according to the presence of peripheral neuropathy as assessed by vibration perception threshold (VPT). Recruitment ensured groups were balanced for age, sex and body mass index (BMI). Read More

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September 2021

Effect of Demineralized Bone Matrix, Bone Marrow Mesenchymal Stromal Cells, and Platelet-Rich Plasma on Bone Tunnel Healing After Anterior Cruciate Ligament Reconstruction: A Comparative Micro-Computed Tomography Study in a Tendon Allograft Sheep Model.

Orthop J Sports Med 2021 Sep 21;9(9):23259671211034166. Epub 2021 Sep 21.

School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.

Background: The effect of demineralized bone matrix (DBM), bone marrow-derived mesenchymal stromal cells (BMSCs), and platelet-rich plasma (PRP) on bone tunnel healing in anterior cruciate ligament reconstruction (ACLR) has not been comparatively assessed.

Hypothesis: These orthobiologics would reduce tunnel widening, and the effects on tunnel diameter would be correlated with tunnel wall sclerosis.

Study Design: Controlled laboratory study. Read More

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September 2021

A Multi-Institutional Randomized Controlled Trial to Investigate Whether Zoledronate Prevents Bone Loss After Discontinuation of Denosumab: The Study Protocol of Denosumab Sequential Therapy (DST) Trial.

Front Med (Lausanne) 2021 8;8:717168. Epub 2021 Sep 8.

Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.

Though denosumab is an effective treatment for osteoporosis, the rebound effect after discontinuation has drawn investigators' attention. It includes a dramatic loss of gained bone mineral density (BMD) and an increased risk of vertebral fractures. This prospective multi-institutional randomized controlled trial aims to investigate whether zoledronate prevents loss of BMD after discontinuation of denosumab. Read More

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September 2021

Computational Analysis of Bone Remodeling in the Proximal Tibia Under Electrical Stimulation Considering the Piezoelectric Properties.

Front Bioeng Biotechnol 2021 8;9:705199. Epub 2021 Sep 8.

Institute of General Electrical Engineering, University of Rostock, Rostock, Germany.

The piezoelectricity of bone is known to play a crucial role in bone adaptation and remodeling. The application of an external stimulus such as mechanical strain or electric field has the potential to enhance bone formation and implant osseointegration. Therefore, in the present study, the objective is to investigate bone remodeling under electromechanical stimulation as a step towards establishing therapeutic strategies. Read More

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September 2021

Sporadic Burkitt Lymphoma Presenting with Middle Cranial Fossa Masses with Sphenoid Bony Invasion and Acute Pancreatitis in a Child.

Case Rep Oncol Med 2021 14;2021:6610666. Epub 2021 Sep 14.

Department of Pediatric Hematology/Oncology, Cancer Center for Kids, NYU Langone Hospital-Long Island, 120 Mineola Blvd. Suite 460, Mineola, NY 11501, USA.

Acute pancreatitis in children is usually due to infection, trauma, or anatomical abnormalities and is rarely due to obstruction from malignancy. Sporadic Burkitt lymphoma (BL) is an aggressive non-Hodgkin B-cell lymphoma that usually involves the bowel or pelvis, with isolated cases presenting as acute pancreatitis. We report a case of BL in a 12-year-old male presenting as acute pancreatitis with obstructive jaundice and a right middle cranial fossa mass invading the sphenoid bone. Read More

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September 2021

Association of Postoperative Neutrophil Lymphocyte Ratio (NLR) and Monocyte Lymphocyte Ratio (MLR) with the Presence of Osteoporosis in Japanese Patients after Hip Fracture Surgery: A Retrospective Cohort Study.

J Osteoporos 2021 15;2021:5524069. Epub 2021 Sep 15.

Department of Orthopaedic Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan.

Background: The diagnosis of osteoporosis is based on bone mineral density measurements expressed as a percentage of the young adult mean (YAM) in Japan. Osteoporosis is defined as YAM <70%, and intervention is recommended at this cutoff. Because osteoporosis has a strong association with systemic metabolic disorders, we postulated that patients with YAM <70% had higher inflammatory biomarker concentrations owing to the higher systemic stress compared with YAM >70%. Read More

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September 2021

Relationship of Biological Maturation with Muscle Power in Young Female Athletes.

Int J Exerc Sci 2021 1;14(6):696-706. Epub 2021 Aug 1.

Health Sciences Center, Department of Physical Education - Federal University of Rio Grande do Norte, UFRN, Natal, RN, BRAZIL.

There is still no consensus on how biological maturation (BM) affects the muscle power of upper and lower limbs in young people. The objective was to verify associations between BM and muscle power, as well as to compare the muscle power of upper (ULP) and lower limbs (LLP) among young athletes in different stages of BM. The sample consisted of 79 female athletes (10. Read More

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Identification of New Genes and Loci Associated With Bone Mineral Density Based on Mendelian Randomization.

Front Genet 2021 8;12:728563. Epub 2021 Sep 8.

Department of Orthopedics, The First Hospital of Jilin University, Changchun, China.

Bone mineral density (BMD) is a complex and highly hereditary trait that can lead to osteoporotic fractures. It is estimated that BMD is mainly affected by genetic factors (about 85%). BMD has been reported to be associated with both common and rare variants, and numerous loci related to BMD have been identified by genome-wide association studies (GWAS). Read More

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September 2021

Bone Mineral Density in Adults With Cerebral Palsy.

Front Neurol 2021 10;12:733322. Epub 2021 Sep 10.

Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Low bone mineral density (BMD) is an emerging health issue in adults with cerebral palsy (CP). This cross-sectional study aimed to describe the characteristics of BMD in adults with CP, and to elucidate the risk factors for low BMD in this population. People aged ≥20 years and diagnosed with CP were recruited from February 2014 to November 2014. Read More

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September 2021

The Novel Antioxidant Compound JSH-23 Prevents Osteolysis by Scavenging ROS During Both Osteoclastogenesis and Osteoblastogenesis.

Front Pharmacol 2021 9;12:734774. Epub 2021 Sep 9.

Department of Orthopaedics, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.

Inflammatory osteolysis is a pathological skeletal disease associated with not only the production of inflammatory cytokines but also local oxidative status. Excessive reactive oxygen species (ROS) promote bone resorption by osteoclasts and induce the apoptosis of osteoblasts. In consideration of the lack of effective preventive or treatments options against osteolysis, the exploitation of novel pharmacological compounds/agents is critically required. Read More

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September 2021

Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss.

Front Pharmacol 2021 8;12:726361. Epub 2021 Sep 8.

Department of Orthopaedics, Mindong Hospital Affiliated to Fujian Medical University, Fuan, China.

Osteolytic bone disorders are characterized by an overall reduction in bone mineral density which enhances bone ductility and vulnerability to fractures. This disorder is primarily associated with superabundant osteoclast formation and bone resorption activity. Nicorandil (NIC) is a vasodilatory anti-anginal drug with ATP-dependent potassium (K) channel openings. Read More

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September 2021

WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M.

J Inflamm Res 2021 18;14:4723-4741. Epub 2021 Sep 18.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre and Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Bone loss is often observed adjacent to inflammatory processes. The WNT signaling pathways have been implicated as novel regulators of both immune responses and bone metabolism. WNT16 is important for cortical bone mass by inhibiting osteoclast differentiation, and we have here investigated the regulation of WNT16 by several members of the pro-inflammatory gp130 cytokine family. Read More

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September 2021