160,160 results match your criteria bone loss


AKR1C3 decreased CML sensitivity to Imatinib in bone marrow microenvironment via dysregulation of miR-379-5p.

Cell Signal 2021 May 10:110038. Epub 2021 May 10.

Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu, China. Electronic address:

Background: Drug resistance is an important cause of death for most patients with chronic myeloid leukemia (CML). The bone marrow microenvironment is believed to be mainly responsible for resistance to BCR-ABL tyrosine kinase inhibitors. The mechanism involved, however, is still unclear. Read More

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PRF versus xenograft in sinus augmentation in case of HA-coating implant placement: A 36-months retrospective study.

Adv Clin Exp Med 2021 May 13. Epub 2021 May 13.

Department of Oral Surgery, Wroclaw Medical University, Poland.

Background: Sinus lift with a simultaneous implant placement in the residual maxilla is a common technique used worldwide. Nevertheless, choosing an ideal grafting material remains an object of dispute. The use of an autologous blood-derived graft, known as platelet rich fibrin (PRF), has not yet been recognized to be as good as xenografts and alloplastic materials. Read More

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Predictors of hearing technology use in children.

Int J Audiol 2021 May 13:1-8. Epub 2021 May 13.

Department of Speech-Language Pathology and Audiology, University of Pretoria, Pretoria, South Africa.

Objective: To identify and describe predictors of daily hearing technology (HT) use in children.

Design: Retrospective review of clinical records. Multiple regression analyses were performed to identify predictors. Read More

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Prospective randomized comparison of bone transport versus Masquelet technique in infected gap nonunion of tibia.

Arch Orthop Trauma Surg 2021 May 13. Epub 2021 May 13.

Department of Sports Medicine, PGIMS, Pt. B. D. Sharma, Health University, Rohtak, 124001, Haryana, India.

Aim: The present prospective randomized study compared the bone transport technique (BT) and Masquelet technique (MT) in the treatment of infected gap non-union of the tibia.

Patients And Methods: Total 25 patients with infected gap non-union of the tibia with bone gap upto 6 cm were randomised into BT group (group I, 13 patients) and MT (group II, 12 patients). The mean age was 31. Read More

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Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs.

Development 2021 May 13. Epub 2021 May 13.

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.

Absence of a specialized wound epidermis is hypothesized to block limb regeneration in higher vertebrates. However, the factors preventing its formation in regeneration-incompetent animals are poorly understood. To characterize the endogenous molecular and cellular regulators of specialized wound epidermis formation in Xenopus laevis tadpoles, and the loss of their regeneration-competency during development, we used single-cell transcriptomics and ex vivo regenerating limb cultures. Read More

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Tranexamic Acid Is Safe in Patients with a History of Coronary Artery Disease Undergoing Total Joint Arthroplasty.

J Bone Joint Surg Am 2021 May;103(10):900-904

Department of Orthopedic Surgery, NYU Langone Health, New York, NY.

Background: Tranexamic acid (TXA) is increasingly used to minimize blood loss during total joint arthroplasty (TJA). Although TXA has been shown to be highly effective in reducing operative blood loss, many surgeons believe that it places patients with coronary artery disease (CAD) or a history of coronary stents at an increased risk for myocardial infarction. The purpose of this study was to determine if TXA is safe to use in patients with a history of CAD or coronary stents. Read More

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Dual threat of comorbidity of celiac disease and systemic lupus erythematosus.

J Int Med Res 2021 May;49(5):3000605211012258

Department of Gastroenterology, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, China.

Celiac disease (CD) is a chronic immune-mediated intestinal disease that is characterized by production of autoantibodies directed against the small intestine. The main clinical manifestations of CD are typically defined as those related to indigestion and malabsorption. These manifestations include unexplained diarrhea or constipation, abdominal pain, bloating, weight loss, anemia, failure-to-thrive in children, and decreased bone density. Read More

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A woman with visual loss, amenorrhoea and polyuria: the first reported case of nodular lymphocyte-predominant Hodgkin lymphoma presenting with hypopituitarism.

Endocrinol Diabetes Metab Case Rep 2021 May 1;2021. Epub 2021 May 1.

Department of Endocrinology and Diabetes, Royal Brisbane and Women's Hospital, Brisbane, Australia.

Summary: A 34-year-old woman presented 18 months post-partum with blurred vision, polyuria, amenorrhoea, headache and general malaise. Comprehensive clinical examination showed left superior temporal visual loss only. Initial investigations revealed panhypopituitarism and MRI demonstrated a sellar mass involving the infundibulum and hypothalamus. Read More

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Autogenous Mineralized Dentin versus Xenograft granules in Ridge Preservation for Delayed Implantation in Postextraction Sites: A Randomized controlled clinical trial with an 18 months follow-up.

Clin Oral Implants Res 2021 May 12. Epub 2021 May 12.

Periodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM), Portugal.

Objectives: To test primary stability of delayed implants placed in post-extraction ridges preserved with autogenous mineralized dentin matrix (MDM) versus xenograft granules. Clinical, histological and pain experience outcomes were further assessed.

Material And Methods: From March 2018 to July 2020, patients requiring ridge preservation in preparation for delayed implant placement in post-extraction sites were included. Read More

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Infliximab prevents systemic bone loss and suppresses tendon inflammation in a collagen-induced arthritis rat model.

Inflammopharmacology 2021 May 12. Epub 2021 May 12.

Department of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.

Reduced Bone Mineral Density (BMD) and tendon abnormalities, such as tenosynovitis and enthesitis, are prevalent comorbidities in patients with rheumatoid arthritis (RA). The aim of the present study was to investigate the effect of chronic treatment with infliximab on BMD and tendon inflammation in an animal model of inflammatory arthritis. Collagen-Induced Arthritis (CIA) was induced in rats, followed by long-term intraperitoneal administration of infliximab. Read More

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Tyloxapol inhibits RANKL-stimulated osteoclastogenesis and ovariectomized-induced bone loss by restraining NF-κB and MAPK activation.

J Orthop Translat 2021 May 10;28:148-158. Epub 2021 Apr 10.

Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

Objective: Tyloxapol is a non-ionic surfactant with diverse pharmacological effects including anti-inflammatory, anti-malignant tumor and antioxidant activities. However, the effect of tyloxapol on osteoclastogenesis has not been elucidated. In this study, we intended to clarify the effect of tyloxapol on RANKL-stimulated osteoclastogenesis and the molecular mechanism both ex vivo and in vivo. Read More

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The clinical use of the enriched bone marrow obtained by selective cell retention technology in treating adolescent idiopathic scoliosis.

J Orthop Translat 2021 Mar 5;27:146-152. Epub 2020 Mar 5.

National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China.

Purpose: This retrospective study aimed to evaluate the curative effect of allografts in combination with bone marrow enrichment realised by selective cell retention (SCR) technology in treating adolescent idiopathic scoliosis (AIS).

Methods: From July 2014 to September 2016, 18 consecutive patients with AIS were treated by posterior fusion and pedicle screw instrumentation. Bone marrow aspirates were obtained and enriched by SCR technology to fabricate bone grafts in combination with allogeneic bones, which were implanted for spinal fusion. Read More

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Zirconium dioxide implants as an alternative to titanium: A systematic review.

J Clin Exp Dent 2021 May 1;13(5):e511-e519. Epub 2021 May 1.

Zirconia Implant Research Group, Silver Spring, MD, 20910, USA.

Background: This systematic review evaluates the available scientific literature to demonstrate the aesthetic and clinical benefits and to determine the survival and the success of zirconium dioxide implants concerning titanium implants.

Material And Methods: The electronic databases were searched until January 2020. Outcome measures were pink aesthetic score (PAS), white aesthetic score (WAS), bleeding on probing (BOP) and probing depth (PD). Read More

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Corrigendum: A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5.

Front Pharmacol 2021 29;12. Epub 2021 Mar 29.

Department of Orthopedics, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China.

[This corrects the article DOI: 10.3389/fphar.2018. Read More

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Non-Endoscopic Endo-nasal Dacryocystorhinostomy in a Saddle shaped nose: A Case Report.

Nepal J Ophthalmol 2021 Jan;13(25):152-156

Lumbini Eye Institute and Research Centre, Bhairahawa, Nepal.

Introduction: Non Endoscopic endo-nasal dacryocystorhinostomy retains the benefit of an Endo-nasal approach and can be done without using an expensive video endoscope or laser system.

Case Presentation: A 22 years old female presented with epiphora and medial canthal mass in her left eye, accompanied by discharge and recurrent conjunctival congestion since childhood. Physical examination revealed loss of height of the nose with discharge in her left eye, and am immobile and non-tender mass below the level of medial canthal tendon. Read More

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January 2021

The impact of preoperative vitamin administration on skeletal status following sleeve gastrectomy in young and middle-aged women: a randomized controlled trial.

Int J Obes (Lond) 2021 May 12. Epub 2021 May 12.

Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: The appropriate strategies to minimize skeletal deterioration following bariatric surgeries are inconclusive. This randomized controlled trial evaluated the effect of preoperative vitamin supplementation on bone mineral density (BMD) and biochemical parameters in females post-sleeve gastrectomy (SG).

Methods: Participants were randomized to a 2-month preoperative treatment with a multivitamin and vitamin D 4000 IU/d (intervention arm) or 1200 IU/d (control arm). Read More

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Osteoblasts are inherently programmed to repel sensory innervation.

Bone Res 2020 May 13;8(1):20. Epub 2020 May 13.

Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135, Porto, Portugal.

Tissue innervation is a complex process controlled by the expression profile of signaling molecules secreted by tissue-resident cells that dictate the growth and guidance of axons. Sensory innervation is part of the neuronal network of the bone tissue with a defined spatiotemporal occurrence during bone development. Yet, the current understanding of the mechanisms regulating the map of sensory innervation in the bone tissue is still limited. Read More

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Lack of brain insulin receptor substrate-1 causes growth retardation, with decreased expression of growth hormone-releasing hormone in the hypothalamus.

Diabetes 2021 May 12. Epub 2021 May 12.

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan

Insulin receptor substrate-1 (Irs1) is one of the major substrates for insulin receptor and Insulin-like growth factor-1 (IGF-1) receptor tyrosine kinases. Systemic Irs1-deficient mice show growth retardation, with resistance to insulin and IGF-1, although the underlying mechanisms remain poorly understood. For this study, we generated mice with brain-specific deletion of Irs1 (NIrs1KO mice). Read More

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Back Pain in Outer Space.

Anesthesiology 2021 May 12. Epub 2021 May 12.

Space travel has grown during the past 2 decades, and is expected to surge in the future with the establishment of an American Space Force, businesses specializing in commercial space travel, and National Aeronautics and Space Administration's planned sustained presence on the moon. Accompanying this rise, treating physicians are bracing for a concomitant increase in space-related medical problems, including back pain. Back pain is highly prevalent in astronauts and space travelers, with most cases being transient and self-limiting (space adaptation back pain). Read More

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Safety and Effectiveness of Modified Expansive Open-door Laminoplasty Using a Ultrasonic Bone Scalpel Compared With a High-speed Drill.

Clin Spine Surg 2021 May 12. Epub 2021 May 12.

Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, China.

Study Design: This was a retrospective study.

Objective: Our study aimed to compare the effectiveness and safety of ultrasonic bone scalpel (UBS) and high-speed drill (HSD) in modified expansive open-door laminoplasty.

Summary Of Background Data: The traditional methods of decompression mostly use HSD and laminectomy forceps to lift the lamina. Read More

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The first non-radiographic axial spondyloarthrits with COVID-19.

Immun Inflamm Dis 2021 May 12. Epub 2021 May 12.

The Rheumatology Group, South Charleston, West Virginia, USA.

Background: Case report of a 21-year-old female developing non-radiographic axialspondyloarthritis in the setting of a preceding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We felt this was a unique case as some cases of psoriatic arthropathy and reactive arthropathy but none, to our knowledge of non-radiographic axial spondyloarthritis.

Case Presentation: Twenty one-year-old female presented in June 2020 with inflammatory symptoms with general work-up per primary care provider being negative. Read More

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Long term effect of bilateral anterior elevation of occlusion on the temporomandibular joints.

Oral Dis 2021 May 12. Epub 2021 May 12.

Department of Oral Anatomy and Physiology and Clinic of temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Objective: Incisors tubed prosthesis with bilateral anterior elevation (BAE) relation had been reported to stimulate the proliferative response in the mandibular condylar cartilage of mice, thus the prosthetic occlusion elevation had been proposed to treat cartilage degeneration. Currently, we aimed to detect the long-term effect of BAE on temporomandibular joints (TMJs).

Materials And Methods: Twelve 6-week-old female mice were assigned to age-matched control and BAE groups (n = 6). Read More

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Maintained Bone Density in Young Hypoestrogenized Women with a High BMI: Case Series.

Calcif Tissue Int 2021 May 12. Epub 2021 May 12.

Department of Medicine, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada.

Estrogen deficiency and obesity are factors that affect bone mass in a manner that is independent and in opposing directions. Obesity favours higher bone mass and increased bone formation whereas estrogen deficiency leads to significant bone loss in leaner individuals. To report the impact of the competing effects of a hypoestrogenized state and obesity on long-term bone health, we present two cases of young chronically hypoestrogenized females whose bone parameters were assessed with high-resolution peripheral quantitative computed tomography (HR-pQCT) and revealed a bone mineral density and microstructure that did not change despite the long history of a low estrogen state. Read More

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The duration of denosumab treatment and the efficacy of zoledronate to preserve bone mineral density after its discontinuation.

J Clin Endocrinol Metab 2021 May 12. Epub 2021 May 12.

Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece.

Context: Zoledronate is used to prevent bone loss following denosumab discontinuation but its efficacy differs among studies.

Objective: To test if the duration of denosumab treatment affects the efficacy of subsequent zoledronate infusion.

Design: Multicenter, prospective cohort study. Read More

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Cigarette Smoke Exposure Inhibits Osteoclast Apoptosis via the mtROS Pathway.

J Dent Res 2021 May 12:220345211009471. Epub 2021 May 12.

Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.

It is widely known that smoking is a risk factor for bone loss and plays a key role in osteopenia. Despite this well-known association, the mechanisms by which smoking affects bone have not been definitively established. Since smoking increases bone loss and potentially affects bone resorption in response to mechanical force, we investigated the impact of cigarette smoke on osteoclast numbers and underlying mechanisms in a mouse model of orthodontic tooth movement (OTM). Read More

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[Treatment of patients with metastatic lesions of the long bones].

Khirurgiia (Mosk) 2021 (5):89-94

Herzen Moscow Research Cancer Institute, Moscow, Russia.

Objective: To optimize orthopedic care in patients with complicated course of metastatic lesions of the long bones.

Material And Methods: There were 201 patients (72 men and 129 women) who underwent orthopedic care for metastatic lesions of the long bones for the period from 2006 to 2019. Breast cancer metastases were diagnosed in 71 (35%) cases, kidney cancer - 56 (28%) patients, prostate cancer - 19 (9%) cases, metastases without a primary identified focus - 15 (8%) patients. Read More

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Effect of peri-implant disease on oral health-related quality of life in geriatric patients.

Gerodontology 2021 May 11. Epub 2021 May 11.

Department of Prosthodontics, Gaziantep University, Gaziantep, Turkey.

Objective: This study aimed to evaluate the effect of peri-implant disease on the quality of life in geriatric patients using implant-supported overdentures.

Background: Peri-implant disease and bone loss are two main complications of dental implant treatment that can impact the quality of life in the geriatric population.

Materials And Methods: This cross-sectional study included 109 geriatric individuals treated in the prosthodontics and periodontology departments. Read More

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Variations in vertical mucosal thickness at edentulous ridge according to site and gender measured by cone-beam computed tomography.

Int J Implant Dent 2021 May 12;7(1):34. Epub 2021 May 12.

Department of Implant Dentistry, School of Dentistry, Showa University, 2-1-1, Kita-Senzoku, Ota-ku, Tokyo, 145-8515, Japan.

Background: The vertical thickness of the peri-implant mucosa is associated with the amount of post treatment marginal bone loss. However, the variations in mucosal thickness at the different edentulous sites have been sparsely documented. The purpose of the study was to conduct a survey of the frequency distribution of variations in mucosal thickness at the different sites of the edentulous alveolar ridge and to compare them according to gender. Read More

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Deletion of in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary-Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice.

JBMR Plus 2021 May 24;5(5):e10486. Epub 2021 Mar 24.

Adelaide Medical School, Faculty of Health and Medical Science University of Adelaide Adelaide South Australia Australia.

The mammalian target of rapamycin complex 1 (mTORC1) complex is the major nutrient sensor in mammalian cells that responds to amino acids, energy levels, growth factors, and hormones, such as insulin, to control anabolic and catabolic processes. We have recently shown that suppression of the mTORC1 complex in bone-forming osteoblasts (OBs) improved glucose handling in male mice fed a normal or obesogenic diet. Mechanistically, this occurs, at least in part, by increasing OB insulin sensitivity leading to upregulation of glucose uptake and glycolysis. Read More

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