59,558 results match your criteria bone healing


Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?

J Shoulder Elbow Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Arthroscopy, Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, United Kingdom.

Purpose: Hyperlipidemia is linked to poor tendon to bone healing and progression of fatty infiltration after rotator cuff repair. Statins effectively treat hyperlipidemia, but it is unknown if they have any potential detrimental effects following rotator cuff repair. The aim of this study was to evaluate the effect of statins on rotator cuff healing and fatty infiltration following repair. Read More

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Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicological profile of Glycosmis pentaphylla (Retz.) DC.: A review.

J Ethnopharmacol 2021 Jun 8:114313. Epub 2021 Jun 8.

Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh; Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia. Electronic address:

Ethnopharmacological Relevance: Glycosmis pentaphylla (Retz.) DC. is a perennial shrub indigenous to the tropical and subtropical regions of India, China, Sri Lanka, Myanmar, Bangladesh, Indonesia, Malaysia, Thailand, Vietnam, Philippine, Java, Sumatra, Borneo and Australia. Read More

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Role of chitosan based nanomedicines in the treatment of chronic respiratory diseases.

Int J Biol Macromol 2021 Jun 8. Epub 2021 Jun 8.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India. Electronic address:

Chitosan-loaded nanomedicines provide a greater opportunity for the treatment of respiratory diseases. Natural biopolymer chitosan and its derivatives have a large number of proven pharmacological actions like antioxidant, wound healing, immuno-stimulant, hypocholesterolemic, antimicrobial, obesity treatment, anti-inflammatory, anticancer, bone tissue engineering, antifungal, regenerative medicine, anti-diabetic and mucosal adjuvant, etc. which attracted its use in the pharmaceutical industry. Read More

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Clinical and radiographic performance of self-locking conical connection implants in the posterior mandible: five-year results of a two-centre prospective study.

Clin Oral Implants Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Oral and Maxillofacial Surgery, Johannes Gutenberg-University, Medical Centre, Augustusplatz 2, D-55131, Mainz, Germany.

Objective: This prospective study aims to assess the 5-year clinical performance of implants with internal conical connection and platform-switched abutments in the posterior mandible.

Material And Methods: Healthy adults missing at least two teeth in the posterior mandible and with a natural tooth mesial to the implant site received two or three adjacent implants. After a transmucosal healing period single crown restorations were cemented on platform-switched abutments. Read More

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A double-closed wedge broken-line osteotomy for cubitus varus deformity.

Medicine (Baltimore) 2021 Jun;100(23):e26124

Department of Orthopedic Ward II, Shenzhen Children's Hospital, Shenzhen, China.

Abstract: Various osteotomy methods have been proposed in the treatment of cubitus varus. We designed an improved stepped osteotomy to achieve improved deformity correction. We refer to this new approach as double-closed wedge broken-line osteotomy and report a series of clinical and imaging results (deformity correction, range of motion [ROM], function, osteotomy healing, and complications) of patients with cubitus varus treated with this technique. Read More

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The evaluation of a multiphasic 3D-bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model.

J Biomed Mater Res B Appl Biomater 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopaedics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

There is a need for the development of effective treatments for focal articular cartilage injuries. We previously developed a multiphasic 3D-bioplotted osteochondral scaffold design that can drive site-specific tissue formation when seeded with adipose-derived stem cells (ASC). The objective of this study was to evaluate this scaffold in a large animal model. Read More

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Bone healing around titanium implants in a preclinical model of bile duct ligation-induced liver injury.

Clin Oral Implants Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Objectives: Chronic liver disease increases the risk for periodontal disease and osteoporotic fractures, but its impacts on bone regeneration remain unknown. Herein we studied the impact of liver cirrhosis on peri-implant bone formation.

Material And Methods: A total of 20 male Wistar rats were randomly divided into two groups; one with the common bile duct ligated (BDL) and the respective sham-treated control group (SHAM). Read More

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Icariin contributes to healing skull defects in rabbit model.

J Tradit Chin Med 2021 Jun;41(3):471-478

Department of Oral and maxillofacial surgery, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, 050017, China.

Objective: To investigate the efficacy of icariin for healing skull defects in rabbit models.

Methods: Thirty-six 3-month-old female New Zealand white rabbits, weighing 1.8-2. Read More

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Imaging Assessment of the Postoperative Spine: An Updated Pictorial Review of Selected Complications.

Biomed Res Int 2021 18;2021:9940001. Epub 2021 May 18.

Directorate of Research, Hospital General de Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico.

Imaging of the postoperative spine requires the identification of several critical points by the radiologist to be written in the medical report: condition of the underlying cortical and cancellous bone, intervertebral disc, and musculoskeletal tissues; location and integrity of surgical implants; evaluation of the success of decompression procedures; delineation of fusion status; and identification of complications. This article presents a pictorial narrative review of the most common findings observed in and postoperative spines. Complications in the spine were grouped in (hematomas, pseudomeningocele, and postoperative spine infection) and findings (arachnoiditis, radiculitis, recurrent disc herniation, spinal stenosis, and textiloma). Read More

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The One-Bone Forearm in Children: Surgical Technique and a Retrospective Review of Outcomes.

J Hand Surg Am 2021 Jun 7. Epub 2021 Jun 7.

Department of Orthopedic Surgery, Shriners Hospitals for Children, Philadelphia, PA.

Purpose: The purpose of this study was to describe a technique of end-to-end rigid fixation of the distal radius to the proximal ulna. The shortening and radioulnar overlap in this technique yield a high union rate, large corrections, and few complications.

Methods: This retrospective chart review from 2 centers was undertaken in 39 patients (40 forearms) who underwent one-bone forearm operations between 2005 and 2019. Read More

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Intra-iliac bone marrow injection as a novel alternative to intra-tibial inoculation in rat model.

Stem Cell Res Ther 2021 Jun 10;12(1):336. Epub 2021 Jun 10.

Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

Background: Intra-bone marrow injection (IBMI) in rats is adopted in many studies for stem cell and hematopoietic cell transplantation. IBMI in the tibia or the femur results in severe distress to the animal. Therefore, this study aims to evaluate intra-iliac injections as an alternative approach for IBMI. Read More

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Rat perichondrium transplanted to articular cartilage defects forms articular-like, hyaline cartilage.

Bone 2021 Jun 7:116035. Epub 2021 Jun 7.

Division of Pediatric Endocrinology and Center for Molecular Medicine, L8:01, Department of Women's and Children's Health, Karolinska Institutet and University Hospital, Stockholm, Sweden; School of Medical Sciences, Örebro University and University Hospital, Örebro, Sweden. Electronic address:

Objective: Perichondrium autotransplants have been used to reconstruct articular surfaces destroyed by infection or trauma. However, the role of the transplanted perichondrium in the healing of resurfaced joints have not been investigated.

Design: Perichondrial and periosteal tissues were harvested from rats hemizygous for a ubiquitously expressed enhanced green fluorescent protein (EGFP) transgene and transplanted into full-thickness articular cartilage defects at the trochlear groove of distal femur in wild-type littermates. Read More

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Reverse dynamisation: a modern perspective on Stephan Perren's strain theory.

Eur Cell Mater 2021 Jun 10;41:668-679. Epub 2021 Jun 10.

Department of Orthopedic Surgery, University of Texas Health Science Centre San Antonio, 7703 Floyd Curl Drive, MC 7774, San Antonio, TX 78229-3900,

The present review acknowledges the tremendous impact of Stephan Perren's strain theory, considered with respect to the earlier contributions of Roux and Pauwels. Then, it provides further insight by examining how the concept of reverse dynamisation extended Perren's theory within a modern context. A key factor of this more contemporary theory is that it introduces variable mechanical conditions at different time points during bone healing, opening the possibility of manipulating biology through mechanics to achieve the desired clinical outcome. Read More

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Antimicrobial Peptide-Loaded Pectolite Nanorods for Enhancing Wound-Healing and Biocidal Activity of Titanium.

ACS Appl Mater Interfaces 2021 Jun 10. Epub 2021 Jun 10.

Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.

Titanium is widely utilized for manufacturing medical implants due to its inherent mechanical strength and biocompatibility. Recent studies have focused on developing coatings to impart unique properties to Ti implants, such as antimicrobial behavior, enhanced cell adhesion, and osteointegration. Ca- and Si-based ceramic (CS) coatings can enhance bone integration through the release of Ca and Si ions. Read More

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[Local spinal profile following operative treatment of thoracolumbar and lumbar fractures : Impact of reduction technique and bone quality].

Unfallchirurg 2021 Jun 10. Epub 2021 Jun 10.

Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

Background: The goal of surgery for spinal injuries is fracture reduction, fixation and stable healing in a physiological position. Several open and minimally invasive surgical techniques are available.

Objective: The extent of open reduction and the fixation potential achieved by the AOSpine (AT) and Kluger (KT) techniques were compared. Read More

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Effectiveness of xenogeneic and synthetic bone-block substitute materials with/without recombinant human bone morphogenetic protein-2: A preclinical study using a rabbit calvarium model.

J Clin Periodontol 2021 Jun 9. Epub 2021 Jun 9.

Clinic of Reconstructive Dentistry, University of Zurich, Zurich, Switzerland.

Aim: To investigate new bone (NB) formation by using bone-block substitute materials with/without recombinant human bone morphogenetic protein-2 (rhBMP-2).

Materials And Methods: Three synthetic bone-block substitute materials [biphasic calcium phosphate (BCP); nanostructured hydroxyapatite (NH); 3D-printed tricalcium phosphate/hydroxyapatite (3DP)] and one xenogeneic deproteinized bovine bone mineral (DBBM) block substitute were affixed to rabbit calvarium using osteosynthesis screws, either with rhBMP-2 (n = 12) or without rhBMP-2 (n = 16). At 2 or 12 weeks (n = 6 with rhBMP-2 and n = 8 without rhBMP-2 for each week), histologic, histomorphometric and microcomputed tomography analyses were performed. Read More

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[Comparison of apical root resorption of maxillary incisors between adolescents and adults after orthodontic treatment].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):187-190

Department of Stomatology, Inner Mongolia Chifeng College Affiliated Hospital. Chifeng 024000, Inner Mongolia Autonomous Region, China.

Purpose: To compare apical root resorption of maxillary incisors between adolescents and adults after orthodontic treatment.

Methods: Patients receiving orthodontic treatment in Affiliated Hospital of Chifeng University from May 2014 to August 2016 were enrolled, and divided into two age groups: adolescent group (32) and adult group (36). The included subjects received orthodontic fixed appliance treatment with straight-wire technique combined with Hawley type retainer for one year. Read More

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Recent advances in the development of nitric oxide-releasing biomaterials and their application potentials in chronic wound healing.

J Mater Chem B 2021 Jun 10. Epub 2021 Jun 10.

Department of Histology and Embryology, NMPA Key Laboratory for Safety Evaluation of Cosmetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.

Chronic wounds, such as pressure ulcers, vascular ulcers and diabetic foot ulcers (DFUs), often stay in a state of pathological inflammation and suffer from persistent infection, excess inflammation, and hypoxia, thus they are difficult to be healed. Nitric oxide (NO) plays a critical role in the regulation of various wound healing processes, including inflammatory response, cell proliferation, collagen formation, antimicrobial action and angiogenesis. The important role of NO in wound healing attracts intensive research focus on NO-based wound healing therapy. Read More

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Bone Morphogenetic Protein in Scaphoid Nonunion: A Systematic Review.

J Wrist Surg 2021 Jun 23;10(3):184-189. Epub 2021 Jan 23.

Department of Orthopaedic Surgery, William Beaumont Army Medical Center, El Paso, Texas.

 Scaphoid nonunion can lead to carpal collapse and osteoarthritis, a painfully debilitating problem. Bone morphogenetic protein (BMP) has been successfully implemented to augment bone healing in other circumstances, but its use in scaphoid nonunion has yielded conflicting results.  The purpose of this study is to assess the outcomes and complications of scaphoid nonunion treated surgically with BMP. Read More

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Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing.

Front Endocrinol (Lausanne) 2021 24;12:667480. Epub 2021 May 24.

Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.

Wnt signaling plays a critical role in bone formation, homeostasis, and injury repair. Multiple cell types in bone have been proposed to produce the Wnts required for these processes. The specific role of Wnts produced from cells of hematopoietic origin has not been previously characterized. Read More

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The role of cortical perforations in allogeneic block grafting for lateral augmentation in maxilla: A randomized clinical trial.

Clin Implant Dent Relat Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University, Madrid, Spain.

Background: The need of decortication on the recipient site remains unclear for bone regeneration. To our knowledge, there are no human clinical trials that studied the influence of decortication on cancellous allogeneic block grafting.

Purpose: The aim of the present study is to evaluate the influence of perforating the cortex of the recipient site on cancellous allogeneic block graft integration and revascularization in the maxilla. Read More

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Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence.

Wound Repair Regen 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, McMaster University and The Research Institute of St. Joe's Hamilton, Firestone Institute for Respiratory Health, Hamilton, Ontario, Canada.

Since the discovery of the myofibroblast over 50 years ago, much has been learned about its role in wound healing and fibrosis. Its origin, however, remains controversial, with a number of progenitor cells being proposed. Macrophage-myofibroblast transition (MMT) is a recent term coined in 2014 that describes the mechanism through which macrophages, derived from circulating monocytes originating in the bone marrow, transformed into myofibroblasts and contributed to kidney fibrosis. Read More

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The influence of flap design on patients' experiencing pain, swelling, and trismus after mandibular third molar surgery: a scoping systematic review.

J Appl Oral Sci 2021 4;29:e20200932. Epub 2021 Jun 4.

Campania University Luigi Vanvitelli, Multidisciplinary Department of Medical, Surgical and Dental sciences, Naples, Italy.

Third molar removal surgery usually comes accompanied by postoperative discomfort, which could be influenced by the surgical approach chosen. This scoping systematic review aimed at compiling the available evidence focused on the influence of flap design, including envelope flap (EF), triangular flap (TF), and modified triangular flap (MTF), on postoperative pain, swelling, and trismus, as primary outcome measures, and any result mentioning healing promotion or delay, as secondary outcome measure, after mandibular third molar extraction surgery. An electronic search, complemented by a manual search, of articles published from 1999 to 2020 was conducted in the Medline (PubMed), EMBASE and Web of Science databases including human randomized controlled trials, prospective, and retrospective studies with at least 15 patients. Read More

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Spatiotemporal Immunomodulation Using Biomimetic Scaffold Promotes Endochondral Ossification-Mediated Bone Healing.

Adv Sci (Weinh) 2021 06 16;8(11):e2100143. Epub 2021 Mar 16.

Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, P. R. China.

Biomaterials play an important role in treating bone defects by promoting direct osteogenic healing through intramembranous ossification (IO). However, majority of the body's bones form via cartilaginous intermediates by endochondral ossification (EO), a process that has not been well mimicked by engineered scaffolds, thus limiting their clinical utility in treating large segmental bone defects. Here, by entrapping corticosteroid dexamethasone within biomimetic recombinant human bone morphogenetic protein (rhBMP)-loaded porous mesoporous bioglass scaffolds and regulating their release kinetics, significant degree of ectopic bone formation through endochondral ossification is achieved. Read More

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Maxillary horizontal alveolar ridge augmentation using computer guided ridge splitting with simultaneous implant placement versus conventional technique: A randomized clinical trial.

Clin Implant Dent Relat Res 2021 Jun 8. Epub 2021 Jun 8.

Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Background: Ridge splitting technique is considered one of the successful horizontal bone augmentation procedures especially for the maxillary bone, the aim of this study was to compare marginal bone loss using a novel ridge splitting protocol versus the conventional technique.

Material & Methods: This was a randomized clinical trial including 20 patients who were randomly assigned to ridge splitting with simultaneous implant placement at the anterior maxillary aesthetic zone (10 patients, 29 dental implant) using patient specific guides (PSGs) or conventional technique (10 patients, 29 dental implant). In the control group free hand ridge splitting was done, while in the study group all the splitting and drilling procedures were done through specific slits and sleeves at the patient specific guides. Read More

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Dental implant placement with inferior alveolar nerve repositioning in severely resorbed mandibles: a retrospective multicenter study of implant success and survival rates, and lower lip sensory disturbances.

Int J Implant Dent 2021 Jun 9;7(1):44. Epub 2021 Jun 9.

S'OS Orthognathic Surgery, Vytenio 22-201, Vilnius, Lithuania.

Background: The purpose of this study was to analyze medium-to-long-term implant success and survival rates, and lower lip sensory disturbance after placement of dental implants with simultaneous inferior alveolar nerve (IAN) repositioning.

Methods: Fifteen patients (3 men, 12 women) treated in two centers were included in this retrospective study. The ages of the participants ranged from 19 to 68. Read More

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A small-cohort study on tumor recurrence and surgery-related complications associated with proximal fibular tumors and the potential utility of biopsy.

J Clin Transl Res 2021 Feb 25;7(1):108-115. Epub 2021 Feb 25.

Department of Radiology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050051, PR China.

Aim: The aim of the study was to assess the incidence of tumor recurrence, iatrogenic peroneal nerve injury, and wound healing problems in a small cohort of patients with proximal fibular tumors who had undergone surgery, and to determine the relative risk of pre-operative biopsies on these outcome variables.

Methods: The study entailed a retrospective single-center analysis of patients with a histologically confirmed tumor in the proximal fibula who had undergone surgery at our institute between 2004 and 2019 ( = 66). The accuracy of diagnosis based on pre-operative biopsy ( = 10) was compared to the histological diagnosis based on resection specimens. Read More

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February 2021

Engaging a polylactide copolymer in oral tissue regeneration: first validation of Suprathel for guided epithelial and osseous healing.

J Med Life 2021 Mar-Apr;14(2):181-197

Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

The present study investigated the capacity of Suprathel (a copolymer membrane, so far validated for skin regeneration) to also regenerate oral tissue - mucosa and bone, by comparing this biomaterial, in a split-mouth rabbit model, to Mucoderm, a xenogeneic collagen matrix certified for keratinized oral mucosa healing. The clinical reason behind this experimental animal model was to determine whether the benefits of this advanced skin regeneration product (Suprathel) could be conveyed for future evaluation in clinical trials of oral tissue regeneration in humans. The outcomes of this study validated the use of Suprathel, a terpolymer of polylactide with trimethylene carbonate and ε-caprolactone, for stimulation of oral epithelium and alveolar bone regeneration in rabbits. Read More

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Healing of a large avulsed mandibular bony segment: report of a unique case.

Int J Oral Maxillofac Surg 2021 Jun 5. Epub 2021 Jun 5.

Department of Oral and Maxillofacial Surgery, King Edward Medical University/Mayo Hospital, Lahore, Pakistan.

This case report puts an emphasis on retaining and re-fixing any avulsed bony segments in the maxillofacial region and maintaining the periosteal layer whenever possible, especially in young patients. Adequate bony fixation and watertight soft tissue closure are vital components for bone healing. The healing potential of facial bones is much higher as compared to the long bones, due to the superior blood supply. Read More

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[The clinical effect and imaging features of accordion maneuver in promoting bone healing at the docking site after tibial transport under ultrasonic monitoring].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):477-483

Department of Orthopaedics,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China.

To explore the imaging features and clinical effect of accordion maneuver in promoting the bone healing at the docking site after tibial transport under ultrasonic monitoring. Retrospective analysis was conducted on the clinical data of 16 patients with tibial bone transport who were admitted to the Department of Orthopedics, the second Hospital of Shanxi Medical University from May 2018 to October 2019. All the patients were treated with accordion maneuver to promote bone healing at the docking site under ultrasound monitoring. Read More

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