35,579 results match your criteria bone defect


CORR Insights®: The Masquelet Technique: Can Disposable Polypropylene Syringes be an Alternative to Standard PMMA Spacers? A Rat Bone Defect Model.

Authors:
Shawn R Gilbert

Clin Orthop Relat Res 2021 Oct 15. Epub 2021 Oct 15.

Professor, Department of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

View Article and Full-Text PDF
October 2021

[Performance evaluation of two antigen-extracted xenogeneic ostein and experimental study on repairing skull defects in rats].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Oct;35(10):1303-1310

Department of Orthopedics, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, P.R.China.

Objective: To evaluate the physical and chemical properties, immunogenicity, and osteogenesis of two antigen-extracted xenogeneic bone scaffolds-decalcified bone matrix (DBM) and calcined bone.

Methods: By removing the inorganic and organic components of adult pig femus, xenogeneic DBM and calcined bone were prepared respectively. The density and pH value of the two materials were measured and calculated, the material morphology and pore diameter were observed by scanning electron microscope, and the surface contact angle was measured by automatic contact angle measuring instrument. Read More

View Article and Full-Text PDF
October 2021

Surgical approach combining implantoplasty and reconstructive therapy with locally delivered antibiotic in the treatment of peri-implantitis: A prospective clinical case series.

Clin Implant Dent Relat Res 2021 Oct 14. Epub 2021 Oct 14.

School of Dentistry, Complutense University of Madrid, Spain.

Background: Nonsurgical treatment, resective surgery, reconstructive surgery, or combined approaches have been proposed for the treatment of peri-implantitis, with variable results.

Purpose: To evaluate the 1-year clinical and radiographic outcomes following combined resective and reconstructive surgical treatment with topical piperacillin/tazobactam antibiotic in the management of peri-implantitis.

Material And Methods: Forty-three patients diagnosed with peri-implantitis were included. Read More

View Article and Full-Text PDF
October 2021

Bone Grafts in Trauma and Orthopaedics.

Cureus 2021 Sep 4;13(9):e17705. Epub 2021 Sep 4.

Trauma and Orthopaedics, Rīga Stradiņš University, Riga, LVA.

Worldwide, there are millions of patients each year suffering from bone-related illness due to trauma, degenerative diseases, infections or oncology that require orthopaedic intervention involving bone grafts. This literature review aims to analyse the characteristics of the different bone grafts: autografts, allografts and synthetic bone substitutes. The review will assess their medical value based on their effectiveness as well as scrutinising any drawbacks. Read More

View Article and Full-Text PDF
September 2021

Comprehensive Modified Latarjet Technique: What the Masters Taught Us.

JBJS Essent Surg Tech 2021 Jul-Sep;11(3). Epub 2021 Aug 27.

The Shoulder Center, Baylor Scott & White Research Institute, Dallas, Texas.

The Latarjet surgical technique is one of the most effective and well-known techniques in the treatment of anterior shoulder instability. The modified Latarjet technique is a history book of surgical details demonstrated by renowned masters of shoulder surgery. The procedure includes soft-tissue repair and osseous reconstruction to stabilize the glenohumeral joint in recurrent anterior instability. Read More

View Article and Full-Text PDF

Extended Curettage for Giant Cell Tumors of Bone: A Surgeon's View.

JBJS Essent Surg Tech 2021 Jul-Sep;11(3). Epub 2021 Aug 9.

P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India.

The key to intralesional surgical treatment of giant cell tumor of bone (GCTB) is extended curettage. As GCTB is locally aggressive with a high propensity for local recurrence, a primary factor of surgical treatment is the ability to achieve local tumor clearance. GCTB commonly affects the epimetaphyseal region of the bone, which may compromise the integrity of the articular surface. Read More

View Article and Full-Text PDF

Porcine-Derived Collagen-Augmented Chondrogenesis Technique for Treating Knee Cartilage Defects.

JBJS Essent Surg Tech 2021 Jul-Sep;11(3). Epub 2021 Jul 14.

Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Articular cartilage is virtually incapable of self-healing in the event of a defect. Microfracture is the most frequently used bone marrow stimulation technique, but there is the limitation of unpredictable quality of the cartilage repair following bone marrow stimulation. To resolve the shortcomings of the microfracture technique, various reinforcing technologies have been developed, including the porcine-derived collagen-augmented chondrogenesis technique (C-ACT). Read More

View Article and Full-Text PDF

Multiple channels with interconnected pores in a bioceramic scaffold promote bone tissue formation.

Sci Rep 2021 Oct 14;11(1):20447. Epub 2021 Oct 14.

Department of Ocean and Mechanical Engineering, College of Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL, 33431, USA.

Insufficient nutrition exchange and limited transportation of blood supply in a porous only scaffold often hinder bone formation, even though the porous scaffold is loaded with cells or growth factors. To overcome these issues, we developed a cell- and growth factor-free approach to induce bone formation in a critical-size bone defect by using an interconnected porous beta-tricalcium phosphate (β-TCP) scaffold with multiple channels. In vitro cell experimental results showed that multiple channels significantly promoted cell attachment and proliferation of human bone marrow mesenchymal stem cells, stimulated their alkaline phosphatase activity, and up-regulated the osteogenic gene expression. Read More

View Article and Full-Text PDF
October 2021

Tissue Coverage and Functional Reconstruction Outcomes With Use of Serratus Osteomusculocutaneous Free Flap in Lateral Malleolar Reconstruction: A Case Report.

Authors:
Ayhan Okumus

J Foot Ankle Surg 2021 Sep 20. Epub 2021 Sep 20.

Private Aesthetic Plastic and Reconstructive Surgery Office, Bursa, Turkey. Electronic address:

Currently, there is no ideal method defined in the repair of complex lateral malleolar defects, and the existing methods (i.e., bone repair, soft tissue or free flap closure) are far from producing functional results in terms of the ultimate recovery of ankle movements. Read More

View Article and Full-Text PDF
September 2021

Evaluation of the feasibility of acetabular cup pre-determination in revision total hip arthroplasty via X-ray of the bone stock of the anterosuperior acetabulum.

J Orthop Surg Res 2021 Oct 14;16(1):597. Epub 2021 Oct 14.

Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Purpose: This study was aimed to explore (1) location on AP pelvic X-ray that displayed bone stock in anterosuperior acetabulum; (2) whether X-ray could provide enough evidence to evaluate whether bone stock could provide support for acetabular cup; (3) criteria to determine whether anterosuperior bone stock could provide sufficient support for cup on X-ray.

Methods: Our study retrospectively collected 43 patients who underwent revision THA for cup loosening from 2014 to 2019. The position of anterosuperior acetabular bone stock was compared between X-ray and CT-based 3-D reconstruction. Read More

View Article and Full-Text PDF
October 2021

Femoral shaft healing disorder biomechanics and biology case report.

Authors:
P Kmeť L Kopp

Rozhl Chir 2021 ;100(8):409-416

Nonunion is one of the common fracture healing complications. Its diagnosis is based on clinical and X-ray/CT findings. Nonunions can be classified, according to Weber and Cech, as vital and nonvital. Read More

View Article and Full-Text PDF
October 2021

Management of bone defects using the Masquelet technique of induced membrane.

Rozhl Chir 2021 ;100(8):390-397

Introduction: Extensive bone defects are mostly caused by trauma, bone infection or bone tumours. The treatment is one of the most challenging issues of musculoskeletal surgery. Nowadays we have several techniques to deal with this problem. Read More

View Article and Full-Text PDF
October 2021

Neglected Posterior Dislocation Septic Loosening and Prolonged Flexion Contracture of Total Knee Arthroplasty: A Case Report.

Am J Case Rep 2021 Oct 14;22:e931857. Epub 2021 Oct 14.

Department of Orthopaedics, Patras University Hospital, Patra, Greece.

BACKGROUND Chronic posterior knee dislocation after total knee arthroplasty (TKA) is a rare but serious complication, especially when it coexists with septic implant loosening, flexion contracture, and extensive comorbidities. Although the severity is comparable to that in the native knee dislocation, there are few reports in the literature. When TKA dislocation is complicated with infection, bone defect, and patient's comorbidity, treatment becomes even more difficult. Read More

View Article and Full-Text PDF
October 2021

Electrospun PCL/MoS Nanofiber Membranes Combined with NIR-Triggered Photothermal Therapy to Accelerate Bone Regeneration.

Small 2021 Oct 13:e2104747. Epub 2021 Oct 13.

Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.

Electrospun nanofiber membranes have been widely used for guided bone regeneration (GBR). For assistance in bone healing, photothermal therapy which renders moderate heat stimulation to defect regions by near-infrared (NIR) light irradiation has attracted much attention in recent years. Combined with photothermal therapy, novel electrospun poly(ε-caprolactone)/molybdenum disulfide (PCL/MoS ) nanofiber membranes are innovatively synthesized as GBR for bone therapy, wherein the exfoliated MoS nanosheets served as osteogenic enhancers and NIR photothermal agents. Read More

View Article and Full-Text PDF
October 2021

The spatial form periosteal-bone complex promotes bone regeneration by coordinating macrophage polarization and osteogenic-angiogenic events.

Mater Today Bio 2021 Sep 17;12:100142. Epub 2021 Sep 17.

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.

Bone defects associated with soft tissue injuries are an important cause of deformity that threatens people's health and quality of life. Although bone substitutes have been extensively explored, effective biomaterials that can coordinate early inflammation regulation and subsequent repair events are still lacking. We prepared a spatial form periosteal bone extracellular matrix (ECM) scaffold, which has advantages in terms of low immunogenicity, good retention of bioactive ingredients, and a natural spatial structure. Read More

View Article and Full-Text PDF
September 2021

Bone Regeneration in Load-Bearing Segmental Defects, Guided by Biomorphic, Hierarchically Structured Apatitic Scaffold.

Front Bioeng Biotechnol 2021 27;9:734486. Epub 2021 Sep 27.

Institute of Science and Technology for Ceramics, National Research Council, Faenza, Italy.

The regeneration of load-bearing segmental bone defects remains a significant clinical problem in orthopedics, mainly due to the lack of scaffolds with composition and 3D porous structure effective in guiding and sustaining new bone formation and vascularization in large bone defects. In the present study, biomorphic calcium phosphate bone scaffolds (GreenBone™) featuring osteon-mimicking, hierarchically organized, 3D porous structure and lamellar nano-architecture were implanted in a critical cortical defect in sheep and compared with allograft. Two different types of scaffolds were tested: one made of ion-doped hydroxyapatite/β-tricalcium-phosphate (GB-1) and other made of undoped hydroxyapatite only (GB-2). Read More

View Article and Full-Text PDF
September 2021

Isolated Traumatic Bitemporal Hemianopia.

Cureus 2021 Aug 31;13(8):e17593. Epub 2021 Aug 31.

Department of Ophthalmology and Visual Science, School of Medical Sciences Universiti Sains Malaysia, Kubang Kerian, MYS.

Bitemporal hemianopia is a rare presentation following severe head injury, which causes a delay in detection of the visual symptoms. This is a case of traumatic bitemporal hemianopia in a 20-year-old gentleman after an alleged motorbike accident. He was intubated following a severe head injury. Read More

View Article and Full-Text PDF

rAAV-Mediated Overexpression Improves the Repair of Osteochondral Defects in a Clinically Relevant Large Animal Model Over Time In Vivo and Reduces Perifocal Osteoarthritic Changes.

Am J Sports Med 2021 Oct 13:3635465211049414. Epub 2021 Oct 13.

Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Germany.

Background: Gene transfer of the transcription factor SOX9 with clinically adapted recombinant adeno-associated virus (rAAV) vectors offers a powerful tool to durably enhance the repair process at sites of osteochondral injuries and counteract the development of perifocal osteoarthritis (OA) in the adjacent articular cartilage.

Purpose: To examine the ability of an rAAV construct to improve the repair of focal osteochondral defects and oppose perifocal OA development over time in a large translational model relative to control gene transfer.

Study Design: Controlled laboratory study. Read More

View Article and Full-Text PDF
October 2021

A filled chocolates technique to seal negative-pressure wound therapy around external fixation devices: a randomized controlled trial.

J Orthop Surg Res 2021 Oct 12;16(1):587. Epub 2021 Oct 12.

Department of Orthopedics, The Second Hospital of Shanxi Medical University, No. 382 Wuyi Road, Taiyuan, 030001, Shanxi, People's Republic of China.

Background: In complex injuries, external fixation device represents a challenge to maintain negative-pressure wound therapy (NPWT). In this trial, we compared a combination of bone wax and colostomy paste versus bone wax alone to seal NPWT around external fixation devices.

Methods: Debridement surgeries of limbs with open fracture and large soft tissue defect need NPWT to be applied around the external fixation devices were randomized into two groups. Read More

View Article and Full-Text PDF
October 2021

Cell-derived extracellular matrix materials for tissue engineering.

Tissue Eng Part B Rev 2021 Oct 12. Epub 2021 Oct 12.

Chinese PLA General Hospital, 104607, Institute of Orthopedics; Beijing Key Lab of Regenerative Medicine in Orthopedics; Key Lab of Musculoskeletal Trauma & War Injuries, Beijing, China.

The involvement of cell-derived extracellular matrix (CDM) in assembling tissue engineering scaffolds has yielded significant results. CDM possesses excellent characteristics, such as ideal cellular microenvironment mimicry and good biocompatibility, which make it a popular research direction in the field of bionanomaterials. CDM has significant advantages as an expansion culture substrate for stem cells, including stabilization of phenotype, reversal of senescence, and guidance of specific differentiation. Read More

View Article and Full-Text PDF
October 2021

Poly-ε-Caprolactone/Fibrin-Alginate Scaffold: A New Pro-Angiogenic Composite Biomaterial for the Treatment of Bone Defects.

Polymers (Basel) 2021 Oct 2;13(19). Epub 2021 Oct 2.

Regenerative Biomaterials Group, The RAFT Institute & The Griffin Institute, Northwick Park & Saint Mark's Hospital, London HA1 3UJ, UK.

We hypothesized that a composite of 3D porous melt-electrowritten poly-ɛ-caprolactone (PCL) coated throughout with a porous and slowly biodegradable fibrin/alginate (FA) matrix would accelerate bone repair due to its angiogenic potential. Scanning electron microscopy showed that the open pore structure of the FA matrix was maintained in the PCL/FA composites. Fourier transform infrared spectroscopy and differential scanning calorimetry showed complete coverage of the PCL fibres by FA, and the PCL/FA crystallinity was decreased compared with PCL. Read More

View Article and Full-Text PDF
October 2021

Intraosseous Venous Malformation of the Zygomatic Bone: Comparison between Virtual Surgical Planning and Standard Surgery with Review of the Literature.

J Clin Med 2021 Sep 30;10(19). Epub 2021 Sep 30.

Maxilofacial Surgery Department, Hospital Universitario La Paz, 28046 Madrid, Spain.

Intraosseous venous malformations affecting the zygomatic bone are infrequent. Primary reconstruction is usually accomplished with calvarial grafts, although the use of virtual surgical planning, cutting guides and patient-specific implants (PSI) have had a major development in recent years. A retrospective study was designed and implemented in patients diagnosed with intraosseous venous malformation during 2006-2021, and a review of the scientific literature was also performed to clarify diagnostic terms. Read More

View Article and Full-Text PDF
September 2021

Bone Tissue Regeneration by Collagen Scaffolds with Different Calcium Phosphate Coatings: Amorphous Calcium Phosphate and Low-Crystalline Apatite.

Materials (Basel) 2021 Oct 7;14(19). Epub 2021 Oct 7.

Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13W7, Kita-ku, Sapporo, Hokkaido 060-8586, Japan.

Surface-mineralized collagen sponges have attracted much attention as scaffolds for bone tissue engineering. Recently, we developed amorphous calcium phosphate (ACP) and low-crystalline apatite coating processes on collagen sponges. In the present study, we applied these coating processes to granular collagen sponges (referred to as Col) to compare the bone tissue regeneration capabilities of ACP-coated and apatite-coated Col (referred to as Col-ACP and Col-Ap, respectively) using a rat cranial bone defect model. Read More

View Article and Full-Text PDF
October 2021

Congenital Metabolic Bone Disorders as a Cause of Bone Fragility.

Int J Mol Sci 2021 Sep 24;22(19). Epub 2021 Sep 24.

F.I.R.M.O. Fondazione Italiana per la Ricerca sulle Malattie dell'Osso, Italian Foundation for the Research on Bone Diseases, 50141 Florence, Italy.

Bone fragility is a pathological condition caused by altered homeostasis of the mineralized bone mass with deterioration of the microarchitecture of the bone tissue, which results in a reduction of bone strength and an increased risk of fracture, even in the absence of high-impact trauma. The most common cause of bone fragility is primary osteoporosis in the elderly. However, bone fragility can manifest at any age, within the context of a wide spectrum of congenital rare bone metabolic diseases in which the inherited genetic defect alters correct bone modeling and remodeling at different points and aspects of bone synthesis and/or bone resorption, leading to defective bone tissue highly prone to long bone bowing, stress fractures and pseudofractures, and/or fragility fractures. Read More

View Article and Full-Text PDF
September 2021

Personalized and Defect-Specific Antibiotic-Laden Scaffolds for Periodontal Infection Ablation.

ACS Appl Mater Interfaces 2021 Oct 12. Epub 2021 Oct 12.

Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States.

Periodontitis compromises the integrity and function of tooth-supporting structures. Although therapeutic approaches have been offered, predictable regeneration of periodontal tissues remains intangible, particularly in anatomically complex defects. In this work, personalized and defect-specific antibiotic-laden polymeric scaffolds containing metronidazole (MET), tetracycline (TCH), or their combination (MET/TCH) were created via electrospinning. Read More

View Article and Full-Text PDF
October 2021

Femoral defects in revision hip arthroplasty: a therapy-oriented classification.

Arch Orthop Trauma Surg 2021 Oct 12. Epub 2021 Oct 12.

Department of Orthopedics and Trauma Surgery, University Hospital Bonn, Venusberg Campus 1, 53127, Bonn, Germany.

Introduction: The complex field of femoral defects in revision hip arthroplasty displays a lack of standardized, intuitive pre- and intraoperative assessment. To address this issue, the femoral defect classification (FDC) is introduced to offer a reliable, reproducible and an intuitive classification system with a clear therapeutic guideline.

Materials And Methods: The FDC is based on the integrity of the main femoral segments which determine function and structural support. Read More

View Article and Full-Text PDF
October 2021

Establishing a Novel Treatment Algorithm for Pediatric Mandibular Tumor Reconstruction.

J Craniofac Surg 2021 Oct 11. Epub 2021 Oct 11.

Division of Oral and Maxillofacial Surgery, University of Southern California Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles Division of Oral and Maxillofacial Surgery, Ostrow School of Dentistry of University of Southern California, Los Angeles, CA.

Introduction: Guidelines for pediatric mandibular reconstruction (PMR) are not well-established. One must consider the growing craniofacial skeleton, mixed dentition, long-term dental occlusion, need for secondary reconstruction, and speech development. The traditional guideline (bone defect > 5 cm) for use of vascularized bone grafts (VBG) is not applicable given the variation of pediatric mandibular size and growth. Read More

View Article and Full-Text PDF
October 2021

Application of Human Adipose-Derived Stem cells for Bone Regeneration of the Skull in Humans.

J Craniofac Surg 2021 Oct 11. Epub 2021 Oct 11.

Division of Plastic Surgery Department of Neurological Surgery Department of Laboratory Medicine and Pathology, Transfusion Medicines and Stem Cell Therapy, Mayo Clinic, Jacksonville, FL.

Background: Archeological archives report cranioplasty as 1 of the oldest surgical procedures; however, it was not until the last century that true advances have been made. Alternative approaches are necessary to achieve optimal closure of the defect with fewer adverse effects. We aim to evaluate the use of human adipose-derived stem cells (hADSCs) alone or seeded in scaffolds as the main treatment for cranial bone defects and to assess human patient outcomes. Read More

View Article and Full-Text PDF
October 2021

Timing of orthodontic tooth movement in bone defects repaired with synthetic scaffolds: A scoping review of animal studies.

Arch Oral Biol 2021 Oct 6;132:105278. Epub 2021 Oct 6.

Discipline of Pediatric Dentistry, Department of Family Oral Health, Faculty of Dentistry, National University of Malaysia, Malaysia. Electronic address:

Objective: The optimal timing of orthodontic tooth movement (OTM) could allow earlier tooth movements across alveolar bone defects while minimizing the adverse effects. The objective of this scoping systematic review was therefore designed to review pre-clinical animal studies on the ideal protocol for the timing of orthodontic traction across alveolar defects augmented with synthetic scaffolds.

Design: Following the PRISMA-ScR guidelines, three electronic databases were searched (Pubmed, Scopus and Web of Science). Read More

View Article and Full-Text PDF
October 2021

Assessment of fibular regeneration after graft harvesting in patients with benign bone tumors: A retrospective study comparing different age groups.

Orthop Traumatol Surg Res 2021 Oct 8:103108. Epub 2021 Oct 8.

Orthopaedic Surgery, Ain Shams University, Faculty of Medicine Cairo, Egypt.

Introduction: Using non-vascularized fibula as autogenous graft has gained much success in reconstruction after tumor resection owing to its simplicity. Donor-site morbidity related to fibula deficiency include valgus ankle, chronic pain and stress fractures of the ipsilateral tibia.

Hypothesis: Growth potential before skeletal maturity is the most important factor promoting fibular regeneration after non- vascularized harvesting, and its decline with skeletal maturity causes failure of fibular regeneration. Read More

View Article and Full-Text PDF
October 2021