53 results match your criteria bodyweight sucrose

Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway.

Neuropsychiatr Dis Treat 2021 13;17:1057-1067. Epub 2021 Apr 13.

Beijing Bo'ai Hospital, China Rehabilitation Research Center, China Rehabilitation Science Institute, Beijing, People's Republic of China.

Background: Electroacupuncture (EA) is a form of physical therapy that has been widely used in clinical practice in China. Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke. EA has been shown to have beneficial effects on PSD patients. Read More

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Neuroinflammation decreased hippocampal microtubule dynamics in the acute behavioral deficits induced by intracerebroventricular injection of lipopolysaccharide in male adult rats.

Neuroreport 2021 May;32(7):603-611

Department of Psychiatry, Renmin Hospital of Wuhan University, Jiefang, Wuhan, China.

Neuroinflammation plays a vital role in the pathology of depression. Microtubule dynamics produces an immediate response to stress, but the effect of microtubule dynamics in the rats with acute behavioral deficits following a central immune challenge remains elusive. Adult male Sprague-Dawley rats were subjected to the intracerebroventricular (icv) injection of lipopolysaccharide (. Read More

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Environmental Enrichment and Physical Exercise Attenuate the Depressive-Like Effects Induced by Social Isolation Stress in Rats.

Front Pharmacol 2020 29;11:804. Epub 2020 May 29.

Neuroscience Research Center, University of Costa Rica, San José, Costa Rica.

We assessed the antidepressant-like effects of environmental enrichment (EE) and physical exercise (PE) compared with the selective serotonin reuptake inhibitor fluoxetine against the depression-related neurobehavioral alterations induced by postweaning social isolation (SI) in rats. After 1 month of SI, rats were submitted to PE (treadmill), EE, or fluoxetine (10 mg/kg), which were compared with naïve SI and group-housed rats. After 1 month, behavior was analyzed in the open field (OFT), the sucrose preference (SPT), and the forced swimming (FST) tests. Read More

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Glucose lowering and pancreato-protective effects of Abrus Precatorius (L.) leaf extract in normoglycemic and STZ/Nicotinamide - Induced diabetic rats.

J Ethnopharmacol 2020 Aug 30;258:112918. Epub 2020 Apr 30.

Department of Medical Laboratory Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.

Ethnopharmacological Relevance: Abrus precatorius (L.) leaves are used as folk medicine by the local communities in the western region of Ghana to treat diabetes mellitus; however, this health claim remains unverified scientifically.

Objective: The study investigated glucose lowering and pancreato-protective effects of Abrus precatorius leaf extract (APLE) in normoglycemic and STZ/nicotinamide (NIC)-induced diabetic rats. Read More

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Attenuation of the Hepatoprotective Effects of Ileal Apical Sodium Dependent Bile Acid Transporter (ASBT) Inhibition in Choline-Deficient L-Amino Acid-Defined (CDAA) Diet-Fed Mice.

Front Med (Lausanne) 2020 25;7:60. Epub 2020 Feb 25.

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.

Non-alcoholic fatty liver disease (NAFLD) is a major growing worldwide health problem. We previously reported that interruption of the enterohepatic circulation of bile acids using a non-absorbable apical sodium-dependent bile acid transporter inhibitor (ASBTi; SC-435) reduced the development of NAFLD in high fat diet fed mice. However, the ability of ASBTi treatment to impact the progression of NAFLD to non-alcoholic steatohepatitis (NASH) and fibrosis in a diet-induced mouse model remains untested. Read More

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February 2020

Chronic harmine treatment has a delayed effect on mobility in control and socially defeated rats.

Psychopharmacology (Berl) 2020 Jun 22;237(6):1595-1606. Epub 2020 Feb 22.

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713, GZ, Groningen, the Netherlands.

Introduction: Depression is characterized by behavioral, cognitive and physiological changes, imposing a major burden on the overall wellbeing of the patient. Some evidence indicates that social stress, changes in growth factors (e.g. Read More

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[Approach to creating early diabetic peripheral neuropathy rat model].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Dec;51(6):1150-1154

Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.

Objective: To create the early diabetic peripheral neuropathy (DPN) rat model.

Methods: After one-week adaption, 26 male Sprague-Dawley (SD) rats were divided into two groups, the control group (n=6) and the model group (n=20). High-sucrose/high-fat diet (D12451, 35% of energy from carbohydrate, 45% of energy from fat) was given to the model group for six weeks to induce insulin resistance, meanwhile normal diet was given to the control group. Read More

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December 2019

Thiacloprid exposure perturbs the gut microbiota and reduces the survival status in honeybees.

J Hazard Mater 2020 05 3;389:121818. Epub 2019 Dec 3.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Honeybees (Apis mellifera) offer ecosystem services such as pollination, conservation of biodiversity, and provision of food. However, in recent years, the number of honeybee colonies is diminishing rapidly, which is probably linked to the wide use of neonicotinoid insecticides. Middle-aged honeybees were fed with 50% (w/v) sucrose solution containing 0, 0. Read More

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Striatal Dopamine D2 Receptors Regulate Cost Sensitivity and Behavioral Thrift.

Neuroscience 2020 01 3;425:134-145. Epub 2019 Dec 3.

Department of Psychology, Queens College, City University New York, New York, NY, USA; CUNY Neuroscience Collaborative, The Graduate Center, City University New York, New York, NY, USA. Electronic address:

The role of the dopamine D2 receptor (D2R) in regulating appetitive behavior continues to be controversial. Earlier literature suggests that reduced D2R signaling diminishes motivated behavior while more recent theories suggest that reduced D2R, as has been putatively observed in obesity, facilitates compulsive appetitive behavior and promotes overeating. Using a homecage foraging paradigm with mice, we revisit classic neuroleptic pharmacological studies from the 1970s that led to the 'extinction mimicry' hypothesis: that dopamine blockade reduces reinforcement leading to an extinction-like reduction in a learned, motivated behavior. Read More

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January 2020

Safety and effectiveness of intravenous iron sucrose versus standard oral iron therapy in pregnant women with moderate-to-severe anaemia in India: a multicentre, open-label, phase 3, randomised, controlled trial.

Lancet Glob Health 2019 12;7(12):e1706-e1716

Ministry of Health and Family Welfare, Government of India, New Delhi, India.

Background: Intravenous iron sucrose is a promising therapy for increasing haemoglobin concentration; however, its effect on clinical outcomes in pregnancy is not yet established. We aimed to assess the safety and clinical effectiveness of intravenous iron sucrose (intervention) versus standard oral iron (control) therapy in the treatment of women with moderate-to-severe iron deficiency anaemia in pregnancy.

Methods: We did a multicentre, open-label, phase 3, randomised, controlled trial at four government medical colleges in India. Read More

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December 2019

Hypothalamic C2-domain protein involved in MC4R trafficking and control of energy balance.

Metabolism 2020 01 27;102:153990. Epub 2019 Oct 27.

Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA. Electronic address:

Objective: Rates of overweight and obesity epidemic have risen significantly in the past few decades, and 34% of adults and 15-20% of children and adolescents in the United States are now obese. Melanocortin receptor 4 (MC4R), contributes to appetite control in hypothalamic neurons and is a target for future anti-obesity treatments (such as setmelanotide) or novel drug development effort. Proper MC4R trafficking regulation in hypothalamic neurons is crucial for normal neural control of homeostasis and is altered in obesity and in presence of lipids. Read More

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January 2020

Deletion of mu opioid receptors reduces palatable solution intake in a mouse model of binge eating.

Behav Pharmacol 2020 04;31(2&3):249-255

Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Centre de la Recherche Nationale Scientifique, Université de Strasbourg Faculté de Psychologie.

Binge eating in humans is driven by hedonic properties of food, suggesting that brain reward systems may contribute to this behaviour. We examined the role of mu opioid receptors (MOP) in binge eating by examining sweet solution intake in mice with genetic deletion of the MOP. Wildtype and MOP knockout mice had 4 hours access to food in the home cage combined with limited (4 hours) access to sucrose (17. Read More

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Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat.

Neuropharmacology 2018 05 31;133:163-170. Epub 2018 Jan 31.

INSERM U1247, Groupe de Recherche sur l'alcool et les Pharmacodépendances, Centre Universitaire de Recherche en Santé (CURS), Université de Picardie Jules Verne, Amiens, France. Electronic address:

Addiction is a chronic and highly relapsing disorder hypothesized to be produced by an imbalance between excitatory and inhibitory neurotransmission. For more than a decade, emerging evidence indicates that manipulation of glutamatergic neurotransmission, by group III mGlu receptors (mGlu4/7/8), could be a promising approach to develop therapeutic agents for the treatment of addiction. Thus, the aim of the present study is to determine whether LSP2-9166, a mixed mGlu4/mGlu7 orthosteric agonist, could reduce ethanol self-administration, ethanol motivation and reacquisition after protracted abstinence in a preclinical model of excessive ethanol intake. Read More

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Sugar Detection Threshold After Laparoscopic Sleeve Gastrectomy in Adolescents.

Obes Surg 2018 05;28(5):1302-1307

Division of Diabetes, Endocrinology and Metabolism, Imperial College, London, UK.

Introduction: Obesity in young people is one of the most serious public health problems worldwide. Moreover, the mechanisms preventing obese adolescents from losing and maintaining weight loss have been elusive. Laparoscopic sleeve gastrectomy (LSG) is successful at achieving long-term weight loss in patients across all age groups, including children and adolescents. Read More

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Intravenous iron treatments for iron deficiency anemia in inflammatory bowel disease: a budget impact analysis of iron isomaltoside 1000 (Monofer) in the UK.

Expert Opin Drug Deliv 2017 12 24;14(12):1439-1446. Epub 2017 Oct 24.

b International Market Access , Pharmacosmos A/S , Holbaek , Denmark.

Introduction: Iron deficiency is the leading cause of anemia in patients with inflammatory bowel disease (IBD). Intravenous iron is the first-line treatment for clinically active IBD or previous oral iron intolerance. The aim of the present study was to develop a comparative model of iron deficiency and delivery for iron isomaltoside (IIM), ferric carboxymaltose (FCM), low molecular weight iron dextran (LMWID), and iron sucrose (IS) in the treatment of iron deficiency anemia associated with IBD. Read More

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December 2017

A budget impact analysis of parenteral iron treatments for iron deficiency anemia in the UK: reduced resource utilization with iron isomaltoside 1000.

Clinicoecon Outcomes Res 2017 10;9:475-483. Epub 2017 Aug 10.

Pharmacosmos A/S, Holbaek, Denmark.

Background And Aims: The reported prevalence of iron deficiency anemia (IDA) varies widely but estimates suggest that 3% of men and 8% of women have IDA in the UK. Parenteral iron is indicated for patients intolerant or unresponsive to oral iron or requiring rapid iron replenishment. This study evaluated differences in the cost of treating these patients with iron isomaltoside (Monofer, IIM) relative to other intravenous iron formulations. Read More

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Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model.

Mol Med Rep 2017 Oct 2;16(4):5043-5049. Epub 2017 Aug 2.

Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin 130061, P.R. China.

Marasmius androsaceus (M. androsaceus), a medicinal fungus, has various pharmacological activities including antidepression. The present study investigated the effects of exopolysaccharides obtained during M. Read More

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October 2017

The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats.

Appl Biochem Biotechnol 2017 Jul 5;182(3):944-955. Epub 2017 Jan 5.

Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, 212001, China.

Zeaxanthin (ZA), an important compound found in Lycium barbarum, shows various pharmacodynamic effects. In our present study, a high-fat, high-sucrose diet and streptozotocin (STZ)-induced diabetic rat model was used to investigate the antidiabetic activities of ZA. After a 4-week administration of 200 and 400 mg/kg of ZA and 100 mg/kg of metformin hydrochloride, various blood biochemical indexes were detected. Read More

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Gradual reduction of sugar in soft drinks without substitution as a strategy to reduce overweight, obesity, and type 2 diabetes: a modelling study.

Lancet Diabetes Endocrinol 2016 Feb 7;4(2):105-14. Epub 2016 Jan 7.

Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Background: Sugar-sweetened beverages are a major source of free sugar intake in both children and adults, and are an important contributor to obesity and obesity-related diseases, including type 2 diabetes. We proposed an incremental and stepwise reduction in free sugars added to sugar-sweetened beverages by 40% over 5 years without the use of artificial sweeteners and assessed the effect of the proposed strategy on energy intake and weight status.

Methods: In this modelling study, we used nationally representative data from the National Diet and Nutrition Survey rolling programme (NDNS RP) from 2008-12 and British Soft Drinks Association annual reports to calculate sugar-sweetened beverage consumption (both with and without fruit juices) and its contribution to free sugar and energy intake in the UK population. Read More

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February 2016

Feasibility of focal cerebral ischemia and reperfusion surgery combined with chronic unpredictable mild stress to simulate the post-stroke depressive state in rats.

Behav Brain Funct 2015 Dec 24;11:39. Epub 2015 Dec 24.

Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Linjiang Load 76, Chongqing, China.

Objective: To evaluate the feasibility of focal cerebral ischemia and reperfusion (FCIR) surgery combined chronic unpredictable mild stress (CUMS) to simulate the post-stroke depression (PSD) state in rats.

Methods: Sprague-Dawley male rats were divided randomly into five groups: the normal, sham, FCIR, CUMS, and FCIR + CUMS (F/C) groups. Rats in the FCIR and F/C groups underwent an FCIR operation. Read More

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December 2015

Relevance of liver fat to the impact of dietary extrinsic sugars on lipid metabolism.

B A Griffin

Proc Nutr Soc 2015 Aug 20;74(3):208-14. Epub 2015 May 20.

Department of Nutritional Sciences,University of Surrey,Guildford GU2 7WG,UK.

In contrast to the decline in mortality from many non-infectious, chronic diseases in the UK, death from liver disease has increased exponentially in men and women over the past 40 years. This is primarily because of the over consumption of alcohol, but also the increased prevalence of obesity, which is linked to early pathology through the accumulation of liver fat. Supra-physiological intakes of fructose-containing sugar can produce acute, adverse effects on lipid metabolism, and deliver excess energy that increases bodyweight and the deposition of fat in sites other than adipose tissue, including the liver. Read More

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Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-HT1A receptor.

Lipids Health Dis 2015 Mar 24;14:22. Epub 2015 Mar 24.

Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, 16, Jiangsu Road, Qingdao, Shandong Province, 266000, China.

Background: Low serum cholesterol levels are related to an increased risk of depression and its serious consequences. However, the effect of central cholesterol on depressive disorder and its potential regulatory mechanism is poorly understood. Therefore, brain cholesterol in patients with depression may not only decrease the risk for developing this disease but also increase the beneficial effects of treatment for depression. Read More

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Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide.

Curr Drug Metab 2014 ;15(10):953-65

Department of Health Sciences, University of Milan, Renal Division, San Paolo Hospital, Via A. Di Rudinì, 8 20142 Milan, Italy.

Sucroferric oxyhydroxide (VELPHORO) is a polynuclear iron-based phosphate binder recently approved for the treatment of hyperphosphataemia in patients with chronic kidney disease (CKD). As a number of the available phosphate binders do not provide the optimal combination of good efficacy, adequate tolerability and low pill burden, sucroferric oxyhydroxide constitutes a promising alternative. Among the attributes of an ideal phosphate binder is minimal absorption and, hence, low risk of systemic toxicity. Read More

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November 2015

Short-term diabetes- and diuresis-induced alterations of the bladder are mostly reversible in rats.

Int J Urol 2015 Apr 14;22(4):410-5. Epub 2015 Jan 14.

Urology Institute, University Hospitals Case Medical Center and Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; The Second Hospital of Lanzhou University, Lanzhou.

Objectives: To determine whether diabetes mellitus- and diuresis-induced alterations in the bladder can be reversed in rats.

Methods: Male Sprague-Dawley rats were randomly distributed into eight groups (n = 16 per group): 3 weeks and 11 weeks age-matched controls, 3 weeks and 11 weeks after streptozotocin-induced diabetes mellitus, 3 weeks after diabetes mellitus induction then treated with insulin for 8 weeks, 3 weeks and 11 weeks after 5% sucrose-induced diuresis, and 3 weeks after 5% sucrose-induced diuresis followed by removal of 5% sucrose for 8 weeks. Bodyweight, blood glucose and glycated hemoglobin A1c were monitored. Read More

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Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats.

Horm Behav 2015 Mar 30;69:89-97. Epub 2014 Dec 30.

Department of Science Education, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY 11549, USA.

We have previously demonstrated that adolescent exposure of rats to bisphenol-A (BPA), an environmental endocrine disrupter, increases anxiety, impairs spatial memory, and decreases dendritic spine density in the CA1 region of the hippocampus (CA1) and medial prefrontal cortex (mPFC) when measured in adolescents in both sexes. The present study examined whether the behavioral and morphological alterations following BPA exposure during adolescent development are maintained into adulthood. Male and female, adolescent rats received BPA, 40μg/kg/bodyweight, or control treatments for one week. Read More

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FTO knockdown in rat ventromedial hypothalamus does not affect energy balance.

Physiol Rep 2014 Dec 11;2(12). Epub 2014 Dec 11.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

Single nucleotide polymorphisms (SNPs) clustered in the first intron of the fat mass and obesity-associated (FTO) gene has been associated with obesity. FTO expression is ubiquitous, with particularly high levels in the hypothalamic area of the brain. To investigate the region-specific role of FTO, AAV technology was applied to knockdown FTO in the ventromedial hypothalamus (VMH). Read More

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December 2014

Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males.

J Pak Med Assoc 2014 Jul;64(7):743-7

Objective: To assess how acute consumption of fructose affects flow-mediated dilatation in brachial artery.

Methods: The randomised cross-over study was conducted at the University of Nottingham's Medical School, Nottingham, United Kingdom in July 2009. Ten healthy, white European males visited the laboratory twice, on separate mornings. Read More

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Genipin is active via modulating monoaminergic transmission and levels of brain-derived neurotrophic factor (BDNF) in rat model of depression.

Neuroscience 2014 Sep 24;275:365-73. Epub 2014 Jun 24.

Tianjin State Key Laboratory of Modern Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China.

Genipin, an important bioactive component from Gardenia jasminoides Eills, was demonstrated to possess antidepressant-like effects in a previous study. However, the molecular mechanism of antidepressant-like effects on genipin was not clear. The present study aimed to investigate the possible mechanism of antidepressant-like effects on genipin with a chronic unpredictable mild stress (CUMS)-induced depression model in rats. Read More

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September 2014

Anti-depressive effect of polyphenols and omega-3 fatty acid from pomegranate peel and flax seed in mice exposed to chronic mild stress.

Psychiatry Clin Neurosci 2013 Nov 24;67(7):501-8. Epub 2013 Oct 24.

Department of Applied Nutrition, Defence Food Research Laboratory, Mysore, India.

Aim: In this study polyphenols from pomegranate peel, and n-3 fatty acids with polyphenols from flax seed were evaluated for their anti depression properties in mice exposed to chronic mild stress (CMS).

Methods: A total of 40 mice initially trained to consume 2% sucrose solution for 3 weeks were then divided into five groups of eight each. The first group was the normal control, the remaining four groups were exposed to CMS but were force fed with either: 10 mL water per kg bodyweight per day; imipramine (a standard antidepressant) 15 mg kg bodyweight; 30 mg per kg bodyweight polyphenol equivalent extract from pomegranate peel; or 30 mg polyphenols per kg bodyweight with omega-3 fatty acids present, for 50 days. Read More

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November 2013

Changes in hepatic lipogenic and oxidative enzymes and glucose homeostasis induced by an acetyl-L-carnitine and nicotinamide treatment in dyslipidaemic insulin-resistant rats.

Clin Exp Pharmacol Physiol 2013 Mar;40(3):205-11

Department of Biochemistry, School of Biochemistry, Litoral University, Santa Fe, Argentina.

Normal rats fed a sucrose-rich diet (SRD) develop dyslipidaemia and insulin resistance. The present study examined whether administration of the mitochondrial nutrients nicotinamide and acetyl-L-carnitine reversed or improved these metabolic abnormalities. Male Wistar rats were fed an SRD for 90 days. Read More

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