582,084 results match your criteria body metabolism


Metabolomics analysis of urine from rats given long-term high-protein diet using ultra-high-performance liquid chromatography-mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Dec 30;1190:123082. Epub 2021 Dec 30.

National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China. Electronic address:

Previous studies have indicated high-protein diet (HPD) promotes weight loss and improves metabolic parameters, but most of these studies have focused on the impact of short-term, long-term effects remain unclear. In this study, male Wistar rats were fed two diets for 88 weeks: normal control diet (NCD, 20.5% of energy as protein) or HPD (30. Read More

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December 2021

Tanshinone IIA and its derivative activate thermogenesis in adipocytes and induce "beiging" of white adipose tissue.

Mol Cell Endocrinol 2022 Jan 12:111557. Epub 2022 Jan 12.

Department of Biochemistry, Molecular Cancer Research Center, School of Medicine, Sun yat-sen University, Shenzhen, 518107, Guangdong Province, China. Electronic address:

Tanshinone IIA (TAN2A) is a major active ingredient of Salvia miltiorrhiza used in traditional Chinese medicine and tanshinone 20 (TAN20) is a derivative of TAN2A. In this study, we examined the effects of TAN2A and TAN20 on adipogenesis, lipid metabolism, and thermogenesis. Our experiments showed that both TAN2A and TAN20 increased mitochondria content in adipose tissue, enhanced energy expenditure, reduced body weight, and improved insulin sensitivity and metabolic homeostasis in obese and diabetic mouse models. Read More

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January 2022

Associations of variability in body weight and glucose levels with the risk of hip fracture in people with diabetes.

Metabolism 2022 Jan 12:155135. Epub 2022 Jan 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea. Electronic address:

Background: Diabetes is associated with a high risk of fragility fracture. However, there are controversies regarding the effect of fluctuations in metabolic parameters on the risk of fracture. We aimed to investigate the associations of body weight or glucose variability or their combination with the risk of hip fracture in people with diabetes. Read More

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January 2022

[Association of leptin with anthropometric indexes, dyslipidemia and carbohydrate metabolism in Kazakh adults].

Vopr Pitan 2021 26;90(6):85-91. Epub 2021 Oct 26.

West Kazakhstan Marat Ospanov State Medical University, 030019, Aktobe, Republic of Kazakhstan.

Leptin plays an important role in eating behavior, the central action of this hormone is the regulation of appetite and energy expenditure. Anthroponutritiology as a new scientific direction uses the methods of medical anthropology and nutritional science. The study of the relationship between the regulation of energy metabolism, taking into account constitutional features, and anthropometric parameters provides relevance in this direction. Read More

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October 2021

[Nutrition and nutritional status of underweight patients].

Vopr Pitan 2021 26;90(6):77-84. Epub 2021 Oct 26.

Federal Research Centre of Nutrition, Biotechnology and Foоd Safety, 109240, Moscow, Russian Federation.

Insufficient body weight is one of the manifestations of nutritional disorders. Diseases associated with malnutrition occur in 10-12% of the population. of the work was to study indicators of nutritional status and actual nutrient intake in patients with insufficient body weight. Read More

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October 2021

[Effect of per os administration of dihydroquercetin aqueous form on energy exchange in blood lymphocytes of rats with experimental cardiomyopathy].

Vopr Pitan 2021 26;90(6):50-58. Epub 2021 Oct 26.

Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russian Federation.

Cardiomyopathies are among the most severe myocardial pathologies, which are characterized by resistance to therapy and high mortality due to increasing heart failure and arrhythmia. Cardiomyocyte pathological changes upon cardiomyopathies are associated with mitochondrial dysfunction, leading to excessive formation of reactive oxygen species and the development of oxidative stress. In this regard, the study of the therapeutic potential of antioxidants in cardiomyopathies, as well as the mechanisms of their action on the functioning of mitochondria, is relevant and of high practical importance. Read More

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October 2021

[Nutrition status and obesity paradox in chronic obstructive pulmonary disease].

Vopr Pitan 2021 26;90(6):42-49. Epub 2021 Oct 26.

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of the Russian Federation, 394036, Voronezh, Russian Federation.

Chronic obstructive pulmonary disease (COPD) is one of the main causes of increasing morbidity and mortality worldwide, and therefore is becoming a major public health problem. of this research was to summarize the data of observational and clinical studies concerning the influence of nutritional status (both malnutrition and obesity) on the COPD course and outcomes. . Read More

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October 2021

[The role of the gut microbiome in health and diet-related diseases].

Vopr Pitan 2021 26;90(6):31-41. Epub 2021 Oct 26.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.

In recent years, new data have been obtained on the participation of the organism-associated microbiota in the pathogenesis of many non-communicable diseases. However, these data are mostly multidirectional and require interpretation. - to highlight the role of the intestinal microbiome in the human body in health and some nutritional-dependent pathologies, taking into account modern scientific knowledge. Read More

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October 2021

The brain neuropeptides and STAT3 mediate the inhibitory effect of 17-β Estradiol on central leptin resistance in young but not aged female high-fat diet mice.

Metab Brain Dis 2022 Jan 15. Epub 2022 Jan 15.

Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Aging and menopause effect on body composition and energy balance. Estrogen (E2) plays an important role in body's metabolism. The aim of the present study was to determine changes in leptin function in young intact and ovariectomized (OVX) animals in comparison to the aged animals treated with E2. Read More

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January 2022

Role of anatomical location, cellular phenotype and perfusion of adipose tissue in intermediary metabolism: A narrative review.

Rev Endocr Metab Disord 2022 Jan 15. Epub 2022 Jan 15.

Institute of Clinical Physiology, CNR, Pisa, Italy.

It is well-established that adipose tissue accumulation is associated with insulin resistance through multiple mechanisms. One major metabolic link is the classical Randle cycle: enhanced release of free fatty acids (FFA) from hydrolysis of adipose tissue triglycerides impedes insulin-mediated glucose uptake in muscle tissues. Less well studied are the different routes of this communication. Read More

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January 2022

Robotic Central Pancreatectomy with Roux-en-Y Pancreaticojejunostomy.

J Vis Exp 2021 Nov 20(177). Epub 2021 Nov 20.

Department of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam;

Central pancreatectomy is a parenchyma-sparing alternative to distal pancreatectomy in patients with a benign or low-grade malignant tumor in the body of the pancreas. The aim of central pancreatectomy is to prevent postoperative life-long endocrine and exocrine insufficiency. The downside of central pancreatectomy is the high rate of postoperative pancreatic fistula, which is the main reason that many surgeons do not routinely use central pancreatectomy in eligible patients. Read More

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November 2021

Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression.

Clin Transl Gastroenterol 2022 Jan 13. Epub 2022 Jan 13.

Department of Medicine II, University Hospital, LMU Munich, Germany.

Introduction: Iron deficiency and vitamin D deficiency are common comorbidities in inflammatory bowel disease (IBD). Accumulating evidence indicates that active 1,25-dihydroxyvitamin D (1,25(OH)D) may enhance iron absorption by suppressing hepcidin. We investigated the influence of vitamin D on iron metabolism in patients with IBD and on the expression of genes facilitating intestinal epithelial iron absorption. Read More

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January 2022

The Protective Effect of Electroacupuncture on the Renal Cortex of SHR: A Metabonomic Analysis.

Biomed Chromatogr 2022 Jan 13:e5338. Epub 2022 Jan 13.

School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.

Hypertension will affect multiple organs in the body during the development of the disease. The antihypertensive effect of acupuncture on hypertension has been confirmed. The study of how the protective effect of electroacupuncture on the renal cortex of SHR is achieved has not yet been studied. Read More

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January 2022

Effect of high dose vitamin D supplementation on indices of sarcopenia and obesity assessed by DXA among older adults: A randomized controlled trial.

Endocrine 2022 Jan 14. Epub 2022 Jan 14.

Department of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Hypovitaminosis D is associated with Sarcopenic Obesity (SO), but evidence from randomized Vitamin D 3 (VD3) trials is scarce.

Objective: Compare the effect of VD3 supplementation, at two doses, on SO indices at 12 months.

Methods: Overweight older adults (>65 years) with baseline 25-hydroxyvitamin D (25OHD) of 10-30 ng/mL were recruited in this double-blind, randomized, controlled multicenter trial (clinicaltrial. Read More

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January 2022

Brain-body responses to chronic stress: a brief review.

Fac Rev 2021 16;10:83. Epub 2021 Dec 16.

Department of Psychological and Brain Sciences, Neuroscience and Behavior Program, University of Massachusetts Amherst, Amherst, MA, USA.

In order to survive and thrive, organisms must adapt to constantly changing environmental pressures. When there are significant shifts in the environment, the brain and body engage a set of physiological and behavioral countermeasures collectively known as the "stress response". These responses, which include changes at the cellular, systems, and organismal level, are geared toward protecting homeostasis and adapting physiological operating parameters so as to enable the organism to overcome short-term challenges. Read More

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December 2021

Carbohydrate metabolism is a determinant for the host specificity of baculovirus infections.

iScience 2022 Jan 18;25(1):103648. Epub 2021 Dec 18.

Department of Entomology, National Taiwan University, 27 Lane 113, Roosevelt Road Sec. 4, Taipei 106, Taiwan.

Baculoviruses Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) and Bombyx mori nucleopolyhedrovirus (BmNPV) have highly similar genome sequences but exhibit no overlap in their host range. After baculovirus infects nonpermissive larvae (e.g. Read More

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January 2022

Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.

iScience 2022 Jan 16;25(1):103635. Epub 2021 Dec 16.

Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.

Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD) biosynthesis, mitochondrial function, and/or the activities of NAD-dependent sirtuin deacetylase enzymes. This investigation examined the impact of NRS on whole body energy homeostasis, skeletal muscle mitochondrial function, and corresponding shifts in the acetyl-lysine proteome, in the context of diet-induced obesity using C57BL/6NJ mice. The study also included a genetically modified mouse model that imposes greater demand on sirtuin flux and associated NAD consumption, specifically within muscle tissues. Read More

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January 2022

Alcoholic liver disease-from steatosis to cirrhosis - a biochemistry approach.

J Med Life 2021 Sep-Oct;14(5):594-599

Biochemistry Department, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.

Nowadays, chronic alcoholism and its health implications represent a global concern. Over three million deaths are linked to chronic alcohol intake every year. This article aims to spread awareness about the negative impact ethanol can have on almost every organ in the body, especially the liver. Read More

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A Dose Response Association Between Body Mass Index and Mortality in Patients with Peripheral Artery Disease: A Meta-analysis Including 5 729 272 Individuals.

Eur J Vasc Endovasc Surg 2022 Jan 10. Epub 2022 Jan 10.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Cardiovascular Centre, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Objective: Obesity is a significant risk factor for atherosclerotic cardiovascular disease; however, the "obesity paradox", in which obese patients enjoy superior survival, has been observed in various cardiovascular conditions. Whether this phenomenon exists for peripheral artery disease (PAD) remains uncertain. The goal of this study was to evaluate the relationship between body mass index (BMI) and mortality in patients with PAD. Read More

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January 2022

Diet Supplementation with Madagascar Cockroach Flour (Gromphadorhina portentosa) Improved Malnourished Mice Metabolism and Ameliorated Liver Inflammatory Markers.

Recent Pat Food Nutr Agric 2021 ;12(2):112-122

Laboratory of Health Science, Postgraduate Program in Health Sciences; Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais,Brazil.

Background: Malnutrition and accessible high-quality protein food sources are two of the world's alimentary challenges. Edible insects are nowadays recognized as a possible functional food solution with lower environmental impacts and beneficial health effects.

Objective: In this context, the aim of the present study is to evaluate Madagascar cockroach (Gromphadorhina portentosa) flour supplementation effects on a malnourished mice model, considering its effects on metabolism, adiposity, and inflammatory liver profiles. Read More

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January 2021

Comparative analysis of ketone body metabolism in BALB/c mice infected with Trypanosoma evansi and Toxoplasma gondii.

Res Vet Sci 2021 Dec 20;143:134-141. Epub 2021 Dec 20.

Key Laboratory of Livestock Infectious Diseases, Ministry of Education, China; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. Electronic address:

KBs (ketone bodies), i.e., acetoacetate, acetone, and (R)-3-Hydroxybutanoate, constitute the intermediate products of the incomplete oxidative degradation of fatty acids. Read More

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December 2021

Codonopsis lanceolata ameliorates sarcopenic obesity via recovering PI3K/Akt pathway and lipid metabolism in skeletal muscle.

Phytomedicine 2021 Dec 3;96:153877. Epub 2021 Dec 3.

Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address:

Background: The incidence of sarcopenic obesity, muscle atrophy induced by obesity, has steadily increased and is emerging as a health problem. Although the anti-obesity effect of Codonopsis lanceolata (CL) is known, its efficacy against sarcopenic obesity has not been studied.

Purpose: We aimed to investigate the effect of CL on sarcopenic obesity and the changes in the related mechanisms to confirm the potential of CL as an effective natural therapeutic agent for sarcopenic obesity. Read More

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December 2021

Dietary bile acids reduce liver lipid deposition via activating farnesoid X receptor, and improve gut health by regulating gut microbiota in Chinese perch (Siniperca chuatsi).

Fish Shellfish Immunol 2022 Jan 11;121:265-275. Epub 2022 Jan 11.

College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, Wuhan, 430070, China; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Wuhan, 430070, China.

The aim of this study is to explore the effects of dietary bile acids (BAs) supplementation on lipid metabolism and gut health of Chinese perch (Siniperca chuatsi), and its possible mechanisms. Two isonitrogenous and isolipidic diets were formulated to supplement different levels of BAs (0 and 900 mg BAs kg diet, respectively). All fish (Initial mean body weight: 171. Read More

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January 2022

Relationship between eosinophils counts and muscle mass decline in older people with type 2 diabetes: A prospective study of the KAMOGAWA-DM cohort.

Exp Gerontol 2022 Jan 10;159:111671. Epub 2022 Jan 10.

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Sarcopenia has become an important issue in older individuals with type 2 diabetes. However, no previous studies investigated the relationship between eosinophil count and muscle mass decline. In this prospective cohort study, we aimed to investigate this relationship in older people with type 2 diabetes. Read More

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January 2022

Olfactomedin 2 deficiency protects against diet-induced obesity.

Metabolism 2022 Jan 10:155122. Epub 2022 Jan 10.

Department of Physiology, CiMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain; CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address:

Background And Aims: Olfactomedin 2 (OLFM2; also known as noelin 2) is a pleiotropic protein that plays a major role in olfaction and Olfm2 null mice exhibit reduced olfactory sensitivity, as well as abnormal motor coordination and anxiety-related behavior. Here, we investigated the possible metabolic role of OLFM2.

Methods: Olfm2 null mice were metabolically phenotyped. Read More

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January 2022

Does weight mediate the effect of smoking on coronary heart disease? Parametric mediational g-formula analysis.

PLoS One 2022 13;17(1):e0262403. Epub 2022 Jan 13.

Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

Background: In settings in which there are time-varying confounders affected by previous exposure and a time-varying mediator, natural direct and indirect effects cannot generally be estimated unbiasedly. In the present study, we estimate interventional direct effect and interventional indirect effect of cigarette smoking as a time-varying exposure on coronary heart disease while considering body weight as a time-varying mediator.

Methods: To address this problem, the parametric mediational g-formula was proposed to estimate interventional direct effect and interventional indirect effect. Read More

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January 2022

Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.

PLoS Genet 2022 Jan 13;18(1):e1010003. Epub 2022 Jan 13.

Stem Cells and Regenerative Medicine, Institute of Cardiometabolism and Nutrition (ICAN), INSERM U1166, University of Pierre and Marie Curie Paris VI, Paris, France.

The paternally expressed gene 3 (Pw1/Peg3) is a mammalian-specific parentally imprinted gene expressed in stem/progenitor cells of the brain and endocrine tissues. Here, we compared phenotypic characteristics in Pw1/Peg3 deficient male and female mice. Our findings indicate that Pw1/Peg3 is a key player for the determination of sexual dimorphism in metabolism and behavior. Read More

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January 2022

Changing lanes: seasonal differences in cellular metabolism of adipocytes in grizzly bears (Ursus arctos horribilis).

J Comp Physiol B 2022 Jan 13. Epub 2022 Jan 13.

Department Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164, USA.

Obesity is among the most prevalent of health conditions in humans leading to a multitude of metabolic pathologies such as type 2 diabetes and hyperglycemia. However, there are many wild animals that have large seasonal cycles of fat accumulation and loss that do not result in the health consequences observed in obese humans. One example is the grizzly bear (Ursus arctos horribilis) that can have body fat content > 40% that is then used as the energy source for hibernation. Read More

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January 2022

A randomized clinical trial evaluating the effect of empagliflozin on triglycerides in obese adults: Role of visceral fat.

Metabol Open 2022 Mar 25;13:100161. Epub 2021 Dec 25.

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Background: Empagliflozin, a sodium glucose cotransporter 2 inhibitor, is a medication to treat type 2 diabetes. The effect of empagliflozin in persons without diabetes has received less attention. Here we conducted a randomized, double-blind placebo-controlled clinical trial to examine the effect of empagliflozin on plasma triglycerides in obese non-diabetic adults. Read More

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Paternal Zn-deficiency abolishes metabolic effects in offspring induced by diet type.

Anim Nutr 2022 Mar 10;8(1):310-320. Epub 2021 Nov 10.

Key Laboratory of Agro-Ecological Processess in Subtropical Region, Hunan Research Center of Livestock & Poultry Sciences, South-Central Experimental Station of Animal Nutrition and Feed Science in Ministry of Agriculture, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan 410125, China.

Accumulating evidence implicates that offspring are susceptible to paternal alterations in numerous fetal disorders, such as growth and metabolic defects. However, less study has been conducted to define the relationship between paternal zinc deficiency (ZnD) and energy metabolism of offspring. In the present study, we used a paternal ZnD exposure (Zn at 0. Read More

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