Search Our Scientific Publications & Authors

J Physiol 2021 Apr 20. Epub 2021 Apr 20.

University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Key Points: Fetal glucagon concentrations are elevated in the setting of placental insufficiency, hypoxia, and elevated stress hormones. Chronically elevated glucagon concentrations in the adult result in profound decreases in amino acid concentrations and lean body mass. Experimental elevation of fetal glucagon concentrations in a late-gestation pregnant sheep results in lower fetal amino acid concentrations, lower protein accretion, and lower fetal weight, in addition to decreased placental function. Read More

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Medicine, University Diabetes and Endocrinology Center, University of Utah, Salt Lake City, Utah.

Objective:  The aim of the study is to examine the impact of maternal interpregnancy body mass index (BMI) change on subsequent offspring mortality risk.

Study Design:  This is a retrospective cohort study of women who had two consecutive live singleton deliveries of at least 20 weeks' gestation from the Utah Population Database. Our exposure was defined as interpregnancy BMI change from the date of first delivery to the conception date of subsequent pregnancy. Read More

Endocr Connect 2021 Apr 1. Epub 2021 Apr 1.

G Wang, Department of Endocrinology, Beijing Chao-Yang Hospital, Beijing, 100020, China.

Objective: It has been found that both serum homocysteine (Hcy) and serum creatinine levels were increased in hypothyroidism patients. The aim of this study was to investigate the correlation between serum Hcy and kidney function in patients with subclinical hypothyroidism or hypothyroidism.

Methods: A total of 448 subjects were enrolled and divided into three groups: hypothyroidism (n=129), subclinical hypothyroidism (n=141), and control group (n=168). Read More

Int J Surg Case Rep 2021 Apr 15;82:105889. Epub 2021 Apr 15.

Faculty of Medicine, Kilimanjaro Christian Medical University College, Box 2240, Moshi, Tanzania; Department of Urology, Kilimanjaro Christian Medical Centre, Box 3010, Moshi, Tanzania.

Introduction And Importance: Advanced prostate cancer often presents with lower urinary tract symptoms together with features of cancer on digital rectal examination. The commonest sites of metastasis include bone, liver and lungs. Metastasis to axillary lymph nodes is extremely unusual particularly as initial presentation of the disease. Read More

Horm Behav 2021 Apr 17;132:104979. Epub 2021 Apr 17.

Swiss Ornithological Institute, CH-6204 Sempach, Switzerland. Electronic address:

Understanding how vulnerable species are to new stressors, such as anthropogenic changes, is crucial for mitigating their potential negative consequences. Many studies have investigated species sensitivity to human disturbance by focusing on single behavioral or physiological parameters, such as flight initiation distance and glucocorticoid levels. However, little is known about the differential effect that modulating factors might have on behavioral versus physiological stress responses across species. Read More

J Crit Care 2021 Apr 16;64:125-130. Epub 2021 Apr 16.

Dept of Perioperative Medicine and Intensive Care, Karolinska University Hospital, 171 76, Stockholm, Sweden. Electronic address:

Background: Outcome for critically ill patients with COVID-19 treated with continuous renal replacement therapy (CRRT) is largely unknown. We describe mortality and renal outcome in this group.

Methods: This observational study was conducted at a university hospital in Sweden. Read More

Am J Obstet Gynecol MFM 2021 Apr 17:100376. Epub 2021 Apr 17.

Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.

Background: Chronic hypertension complicates up to 5% of pregnancies and is increasing in prevalence. Women with hypertension have increased risks of serious maternal morbidity and mortality in pregnancy including the development of preeclampsia. In 2017, new guidelines reclassified blood pressure into four categories: normal (<120/<80 mmHg), elevated (120-129/<80 mmHg), stage 1 hypertension (130-139/80-89 mmHg), and stage 2 hypertension (>140/>90 mmHg). Read More

Exp Gerontol 2021 Apr 17:111360. Epub 2021 Apr 17.

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Ciudad de México, Mexico. Electronic address:

Background And Objectives: The excess of body fat and muscle mass loss in adulthood results in sarcopenic obesity, which is associated with disability and poor physical condition. A relationship among obesity, sarcopenia and oxidative stress also has been established. These aspects limit a good muscle function which is crucial in the independence of older women with and without sarcopenic obesity. Read More

Prev Med 2021 Apr 17:106563. Epub 2021 Apr 17.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, United States of America; Department of Oncology, Cumming School of Medicine, University of Calgary, Canada. Electronic address:

The aim of this study was to develop a risk prediction model for HRAs detected at screening colonoscopy based on readily available participant information. The cohort consisted of 3035 participants aged 50 to 74 years with no history of cancer who underwent a primary screening colonoscopy at a centralized colon cancer screening centre between 2008 and 2016. A multivariable logistic regression model was created using CRC risk factors identified from prior research. Read More

Prev Med 2021 Apr 17:106565. Epub 2021 Apr 17.

National Research Centre for the Working Environment, Copenhagen, Denmark.

Many healthcare workers in eldercare are pushed out of the labor market before the official retirement age due to poor health. Identification of early warnings signs is important to avoid complete loss of work ability. The aim of this study was to investigate to what degree sickness absence and presenteeism increase future risk for disability pension among eldercare workers. Read More

J Pharm Pharm Sci 2021 ;24:174-190

Beijing Obstetrics and Gynecology Hospital.

Purpose: Although folic acid (FA) supplementation has been shown to reduce general cardiovascular risks, its impact on hypertensive disorders of pregnancy (HDP) is unclear. We performed a systematic review and meta-analysis to clarify the association between FA and the risk of HDP (pre-eclampsia (PE) and gestational hypertension (GH)).

Methods: PubMed, EmBase, and Cochrane Library were searched up to June 18, 2020, stratified by type of disease, initiation time of FA, form of FA and pre-conception Body Mass Index (BMI). Read More

Klin Lab Diagn 2021 Apr;66(4):205-209

Federal State Budgetary Educational Institution of Higher Education «Academician Ye. A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation.

The number of obese pregnant women increases annually and reaches 20-30%. The metabolism of hormones and minerals changes in the presence of a large amount of adipose tissue in the body of a pregnant woman, which leads to a number of obstetric and perinatal problems. The aim of the work is to study and compare the influence of the gestational process on the indicators of iron and copper metabolism in the blood serum of women with normal body weight and women with obesity. Read More

Anat Histol Embryol 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Vic., Australia.

The lumbosacral joint is where the 7th lumbar vertebra (L.7) articulates within the sacrum. It is a clinically important area in the dog because of its relatively large range of motion. Read More

PLoS One 2021 20;16(4):e0250262. Epub 2021 Apr 20.

Department of Molecular Imaging and Theranostics, NIRS, National Institutes for Quantum and Radiological Science and Technology (QST), Chib, Japan.

Valproic acid (VPA) treatment is associated with autism spectrum disorder in humans, and ferrets can be used as a model to test this; so far, it is not known whether ferrets react to developmental VPA exposure with gyrencephalic abnormalities. The current study characterized gyrification abnormalities in ferrets following VPA exposure during neonatal periods, corresponding to the late stage of cortical neurogenesis as well as the early stage of sulcogyrogenesis. Ferret pups received intraperitoneal VPA injections (200 μg/g of body weight) on postnatal days (PD) 6 and 7. Read More

PLoS One 2021 20;16(4):e0250352. Epub 2021 Apr 20.

Cancer Research and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

1,25-dihydroxyvitamin-D3 and its derivatives have shown anti-arthritic and chondroprotective effects in experimental animal models with prophylactic dosing. The purpose of this preliminary study was to test the efficacy and safety of calcipotriol, vitamin D analog, as a treatment for a fully-developed knee arthritis in Zymosan-induced arthritis (ZIA) model. Forty 5-month-old male Sprague-Dawley rats were randomized into three arthritis groups and a non-arthritic control group with no injections (10 rats/group). Read More

PLoS One 2021 20;16(4):e0248110. Epub 2021 Apr 20.

Masira Research Institute, Faculty of Health Sciences, Universidad de Santander (UDES), Bucaramanga, Colombia.

The aim of this study was to evaluate the impact on muscle strength, aerobic fitness and body composition, of replacing the physical education (PE) class of Colombian adolescents with resistance or aerobic training. 120 tanner stage 3 adolescents attending a state school were randomized to resistance training, aerobic training, or a control group who continued to attend a weekly 2- hour PE class for 16 weeks. The resistance training and aerobic training groups participated in twice weekly supervised after-school exercise sessions of < 1 hour instead of their PE class. Read More

Reproduction 2021 Apr 1. Epub 2021 Apr 1.

J Weitzel, Institut für Fortpflanzungsbiologie, FBN Dummerstorf, Dummerstorf, Germany.

We recently described two outbred mouse lines that were selected for large litter size at first delivery. However, lifetime fecundity appears to be economically more important for the husbandry of many polytocous species for which mouse lines might serve as bona fide animal models (e.g. Read More

Am Surg 2021 Apr 20:31348211011149. Epub 2021 Apr 20.

Department of Surgical Oncology, 4002The University of Texas MD Anderson Cancer Center, Texas, USA.

Background: Chemotherapy is associated with postoperative ventral incisional hernia (PVIH) after right hemicolectomy (RHC) for colon cancer, and abdominal wall closure technique may affect PVIH. We sought to identify clinical predictors of PVIH.

Methods: We retrospectively analyzed patients who underwent RHC for colon cancer from 2008-2018 and later developed PVIH. Read More

Hepatol Res 2021 Apr 20. Epub 2021 Apr 20.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Touon, Ehime, Japan.

Aim: The FibroScan-aspartate aminotransferase (FAST) score comprises an easy and feasible method for identifying advanced non-alcoholic steatohepatitis (NASH). Recently, shear-wave elastography (SWE) and attenuation coefficient measurement on B-mode ultrasound (US) have become widely utilized. We investigated the diagnostic accuracy of the FAST score as calculated using US-elastography compared to that using vibration-controlled transient elastography (VCTE). Read More

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3105-3115

Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Objective: Recent studies have revealed that myo-inositol could be more influential in patients with polycystic ovary syndrome (PCOS). This study was aimed to determine and compare the effects of myo-inositol and metformin on hormonal and metabolic profiles and fertility outcomes.

Materials And Methods: A comprehensive search was carried out among the English-language databases, including PubMed, Scopus, Cochrane Library, Google Scholar, and Web of Science, and the articles published from April 2010 to February 2019 were tracked down. Read More

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3045-3053

Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Indonesia.

Objective: In this study, we aimed to evaluate whether the trimetazidine administration before CAG and/or PCI reduces the incidence of contrast-induced nephropathy (CIN). We also aimed to evaluate the factors affecting the effect and the certainty of the evidence.

Materials And Methods: A systematic literature search was performed to obtain studies that assess trimetazidine's effect on the incidence of CIN in CAG/PCI patients up until 21 January 2021 through PubMed, Embase, and Scopus. Read More

Reprod Sci 2021 Apr 20. Epub 2021 Apr 20.

Department of Health Promotion and Development, School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.

Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality. Chronological age and race are associated with preeclampsia, but the role of these factors is not entirely understood. We hypothesized that DNA methylation age, a measure of biological age, would be higher in individuals with preeclampsia than in individuals with normotensive pregnancy and that DNA methylation age would differ by race across pregnancy. Read More

Curr Med Sci 2021 Apr 20;41(2):219-227. Epub 2021 Apr 20.

Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, China.

Risk factors for adverse pregnancy outcomes among Zhuang ethnic pregnant women are unclear. This study analyzed the incidence and risk factors related to preterm birth (PB), low birth weight (LBW) and macrosomia in Zhuang population. We conducted a prospective cohort study of 9965 Zhuang pregnancy women in Guangxi, China. Read More

Forensic Sci Med Pathol 2021 Apr 20. Epub 2021 Apr 20.

Governmental Institute of Legal Medicine and Forensic Sciences, Turmstraße 21, 10559, Berlin, Germany.

New psychoactive substances are becoming increasingly popular. However, there is a lack of mass spectral information on parent substances and their corresponding metabolites as well as fatal concentrations in body liquids and tissues. Only very few clinical reports and user reports exist. Read More

Cancer Causes Control 2021 Apr 20. Epub 2021 Apr 20.

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Purpose: The role of established breast cancer risk factors and clinical characteristics of the first breast cancer in the development of contralateral breast cancer (CBC) among postmenopausal women is unclear.

Methods: We identified 10,934 postmenopausal women diagnosed with a first primary breast cancer between 1995 and 2011 in the NIH-AARP Diet and Health Study. CBC was defined as a second primary breast cancer diagnosed in the contralateral breast ≥ 3 months after the first breast cancer. Read More

Sports Med Open 2021 Apr 20;7(1):27. Epub 2021 Apr 20.

The University Hospitals Centre for Health Research, University of Copenhagen, Rigshospitalet, Department 9701, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Background: Skeletal metastatic disease excludes many cancer patients from participating in exercise and physical activity due to safety concerns. Empirical evidence from high-quality trials is warranted to guide clinicians and patients.

Objective: To evaluate the safety and potential benefits of high-impact aerobic exercise in patients with prostate cancer with skeletal metastases. Read More

Pediatr Cardiol 2021 Apr 20. Epub 2021 Apr 20.

Stanford University School of Medicine, Palo Alto, CA, USA.

Normalizing cardiovascular measurements for body size allows for comparison among children of different ages and for distinguishing pathologic changes from normal physiologic growth. Because of growing interest to use height for normalization, the aim of this study was to develop height-based normalization models and compare them to body surface area (BSA)-based normalization for aortic and left ventricular (LV) measurements. The study population consisted of healthy, non-obese children between 2 and 18 years of age enrolled in the Pediatric Heart Network Echo Z-Score Project. Read More

Cancer Chemother Pharmacol 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics (Molecular Metabolism and Nutrition), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Purpose: Conditioning therapy with high-dose melphalan (HDM) is associated with a high risk of gut toxicity, fever and infections in haematopoietic stem cell transplant (HSCT) recipients. However, validated preclinical models that adequately reflect clinical features of melphalan-induced toxicity are not available. We therefore aimed to develop a novel preclinical model of melphalan-induced toxicity that reflected well-defined clinical dynamics, as well as to identify targetable mechanisms that drive intestinal injury. Read More

J Bone Joint Surg Am 2021 Mar 11. Epub 2021 Mar 11.

Division of Sports Medicine, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois.

Background: Despite previous reports of improvements for athletes following hip arthroscopy for femoroacetabular impingement syndrome (FAIS), many do not achieve clinically relevant outcomes. The purpose of this study was to develop machine learning algorithms capable of providing patient-specific predictions of which athletes will derive clinically relevant improvement in sports-specific function after undergoing hip arthroscopy for FAIS.

Methods: A registry was queried for patients who had participated in a formal sports program or athletic activities before undergoing primary hip arthroscopy between January 2012 and February 2018. Read More

Exp Clin Transplant 2021 Apr 16. Epub 2021 Apr 16.

From the Division of Transplantation, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Objectives: Liver allograft shortage has necessitated greater use of donations after circulatory death. Limited data are available to compare recipients' health care utilization for donation after circulatory death versus brain death.

Materials And Methods: Liver transplant data for our center from November 2016 until May 2019 were obtained (208 donations after brain death and 39 after circulatory death). Read More