Search Our Scientific Publications & Authors

BMJ Open 2022 May 26;12(5):e051486. Epub 2022 May 26.

Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, Wuhu, Anhui, China.

Objective: We investigated the moderation/mediation between the age of menarche and obesity parameters in predicting blood pressure (BP) in middle-aged and elderly Chinese.

Design: Our study is a population-based cross-sectional study.

Setting: Participants in this study came from the China Health and Retirement Longitudinal Study (CHARLS). Read More

Genes Dev 2022 May 26. Epub 2022 May 26.

Division of Diabetes Endocrinology and Metabolism, Johns Hopkins University School of Medicine; Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, Florida 33701, USA.

Accumulation of fat above the waist is an important risk factor in developing obesity-related comorbidities independently of BMI or total fat mass. Deciphering the gene regulatory programs of the adipose tissue precursor cells within upper body or abdominal (ABD) and lower body or gluteofemoral (GF) depots is important to understand their differential capacity for lipid accumulation, maturation, and disease risk. Previous studies identified the HOX transcript antisense intergenic RNA (HOTAIR) as a GF-specific lncRNA; however, its role in adipose tissue biology is still unclear. Read More

Motor Control 2022 May 26:1-18. Epub 2022 May 26.

Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, RJ,Brazil.

This paper investigates whether a group of regular Yoga practitioners shows postural control differences compared with healthy controls while performing single-leg Yoga postures. Ten Yoga practitioners were compared with a control group of 10 nonpractitioners performing two single-leg support Yoga postures: Vrksasana (tree posture) and Natarajasana (dancer posture). Rambling and trembling decomposition of the center of pressure trajectories was implemented using a genetic algorithm spectral optimization that avoids using horizontal forces and was validated with bipedal posture data. Read More

J Sport Rehabil 2022 May 26:1-6. Epub 2022 May 26.

School of Health and Kinesiology, University of Nebraska, Omaha, NE,USA.

Context: Ankle sprains result in pain and disability. While factors such as body mass and prior injury contribute to subsequent injury, the association of the number of ankle sprains on body anthropometrics and self-reported function are unclear in this population. Therefore, the purpose of this investigation was to assess differences in anthropometric measurements and self-reported function between the number of ankle sprains utilizing a large, pooled data set. Read More

Eur J Pharm Sci 2022 May 23:106219. Epub 2022 May 23.

Hospital Universitario Severo Ochoa, Avenida de Orellana, 28911 Leganés, Spain; Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana, Majadahona, Madrid, Spain. Electronic address:

Objective: The aim of this study was to characterize the population pharmacokinetics of amikacin in elderly patients by means of nonlinear mixed effects modelling and to propose initial dosing schemes to optimize therapy based on PK/PD targets.

Method: A total of 137 elderly patients from 65 to 94 years receiving intravenous amikacin and routine therapeutic drug monitoring at Hospital Universitario Severo Ochoa were included. Concentration-time data and clinical information were retrospectively collected; initial doses of amikacin ranged from 5. Read More

Sci Total Environ 2022 May 23:156210. Epub 2022 May 23.

Programa de Pós-Graduação em Ecologia, Laboratório de Ecologia de Produtores, Instituto de Ciências Biológicas, Universidade Federal do Pará, Av. Perimetral, 2651 - Terra Firme, Belém, PA, 66077-530, Brazil; Universidade Federal Rural da Amazônia, Instituto Socioambiental e dos Recursos Hídricos, Avenida Perimetral, 660778-30 Belém, PA, Brazil.

The evaluation of extinction risk has typically focused on individual species, although a shift to a focus on ecosystem functioning would appear to be an urgent priority for conservation planning, especially considering that a sixth mass extinction event has already begun. In the present study, we investigated how fish extinction driven by habitat loss may modify the functioning of freshwater Amazonian ecosystems. We sampled the fish and environmental conditions of 63 streams in the eastern Amazon and simulated extinction based on the vulnerability of the species to habitat loss, which is the principal threat to tropical biodiversity. Read More

Int J Cardiol 2022 May 23. Epub 2022 May 23.

CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht University Medical Center, Maastricht, the Netherlands.; Department of Cardiology, Maastricht University, Maastricht University Medical Center, Maastricht, the Netherlands.; Department of Cardiology, Radboud University Medical Centre, Nijmegen, the Netherlands.; Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.. Electronic address:

Background: To identify the association between comorbidities and left atrial (LA) and right atrial (RA) function in patients with paroxysmal atrial fibrillation (AF).

Methods: This is a cross-sectional study. Speckle-tracking echocardiography was performed in 344 patients with paroxysmal AF at baseline, and available in 298 patients after 1-year follow-up. Read More

Chemosphere 2022 May 23:135049. Epub 2022 May 23.

Department of Clinical Epidemiology and Biostatistics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Although evidence suggests that prenatal exposure to polybrominated diphenyl ethers (PBDEs) alter offspring's physical growth, most studies rely upon physical growth at a single timepoint, and little is known regarding their longitudinal effects over time. In the current study, we determined the associations between prenatal PBDEs exposure and child physical growth by following up 207 mother-child pairs from the Laizhou Wan Birth Cohort (LWBC) from pregnancy until the children were seven years old. Child physical growth including weight, height, and body mass index (BMI) was assessed at birth, and at one, two and seven years of age. Read More

Brain Res 2022 May 23:147951. Epub 2022 May 23.

Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, NY, NY, 10029. Electronic address:

Carboxypeptidase E (CPE) is an essential enzyme that contributes to the biosynthesis of the vast majority of neuropeptides and peptide hormones. There are several reports claiming that small decreases in CPE activity cause physiological changes in animals and/or cultured cells, but these studies did not provide evidence that neuropeptide levels were affected by decreased CPE activity. In the present study, we tested if CPE is a rate-limiting enzyme in neuropeptide production using CpeNeo mice, which contain a neomycin cassette within the Cpe gene that eliminates enzyme expression. Read More

Appl Clin Inform 2022 May 26. Epub 2022 May 26.

Medicine, Brigham and Women's Hospital, Boston, United States.

Background: Healthcare institutions have their own "picklist" for clinicians to document adverse drug reactions (ADRs) into the electronic health record (EHR) allergy list. Whether the lack of a nationally standardized picklist impacts clinician data entries is unknown.

Objectives: To assess the impact of defined reaction picklists on clinical documentation and, therefore, downstream analytics and clinical research using these data at two institutions. Read More

Neuropediatrics 2022 May 26. Epub 2022 May 26.

Neurology, Children's National Health System, Washington, United States.

Microdeletion in the 16p11.2 loci lead to a distinct neurodevelopmental disorder with intellectual disability and autism spectrum disorder in addition to dysmorphia, macrocephaly and increased body mass index (BMI). One of the deleted genes in this region is PRRT2 which codes for Proline-rich transmembrane protein 2. Read More

Thromb Haemost 2022 May 26. Epub 2022 May 26.

Thrombosis Research Center, Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.

Background: A high mean platelet volume (MPV), a marker of increased platelet reactivity, is a risk factor for venous thromboembolism (VTE). Whether established prothrombotic single nucleotide polymorphisms (SNPs) further increase the VTE risk in subjects with high MPV because of biological interaction remains unknown.

Aim: To investigate the joint effect of high MPV and prothrombotic genotypes, comprising a 5-SNP genetic risk score (GRS), on the risk of VTE in a population-based case-cohort. Read More

Maturitas 2022 Apr 29;162:58-65. Epub 2022 Apr 29.

Division of Geriatrics, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison Geriatric Research Education and Clinical Center (GRECC), United States.

Objective: The relationships between cardiometabolic indices and cognition were examined in recently menopausal women.

Methods: Cross-sectional analysis of baseline data from the KEEPS (Kronos Early Estrogen Prevention Study)-Cognitive ancillary study (n = 621). Cognitive performance was assessed by the Modified Mini Mental Status (3MS) score (primary outcome). Read More

J Laparoendosc Adv Surg Tech A 2022 May 26. Epub 2022 May 26.

Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, China.

With the development of minimally invasive techniques, laparoscopic adrenalectomy (LA) has become the standard for the treatment of adrenal surgical diseases, but conversion to open adrenalectomy (OA) is also necessary in some cases. The purpose of this study was to investigate the risk factors for conversion from LA to OA. A retrospective study was performed on 911 patients who were diagnosed with adrenal tumors and underwent LA in the Department of Urology, Second Hospital of Lanzhou University from January 2013 to December 2021. Read More

PLoS One 2022 26;17(5):e0268576. Epub 2022 May 26.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.

Background: Heart failure is a multi-system disease, with non-cardiac systems playing a key role in disease pathogenesis.

Objective: Investigate whether longitudinal multi-system trajectories incrementally predict heart failure risk compared to single-occasion traits.

Methods: We evaluated 3,412 participants from the Framingham Heart Study Offspring cohort, free of heart failure, who attended examination cycle 5 and at least one examination between 1995-2008 (mean age 67 years, 54% women). Read More

PLoS One 2022 26;17(5):e0269081. Epub 2022 May 26.

Burden of Disease Research Unit, South African Medical Research Council, Cape Town, Western Cape, South Africa.

Multimorbidity is a global research priority, yet relatively little is known about it in low and middle income countries. South Africa has the largest burden of HIV worldwide but also has a growing burden of non-communicable diseases; potentially leading to uncommon disease combinations. Information about the prevalence of multimorbidity and factors associated with it can assist in healthcare planning and targeting groups of people for interventions. Read More

PLoS One 2022 26;17(5):e0267845. Epub 2022 May 26.

Graduation Program in Medical Science: Endocrinology, Department of Internal Medicine Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

The kallikrein-kinin system has been implicated in body weight and glucose homeostasis. Their major effectors act by binding to the kinin B2 and B1 receptors. It was assessed the role of the kinin B1 receptor in weight and glucose homeostasis in B1 receptor knockout mice (B1RKO) subjected to a cafeteria diet (CAF). Read More

Ann R Coll Surg Engl 2022 May 26. Epub 2022 May 26.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Emphysematous pyelonephritis (EPN) is a deadly disease due to its associated morbidity and mortality. Attempts have been made to identify predictors of severity, mortality and need for nephrectomy in EPN with little success.

Methods: We conducted an ambispective study of EPN patients between March 2014 and September 2019. Read More

Physiol Biochem Zool 2022 Jul-Aug;95(4):317-325

AbstractHibernation requires balancing energy and water demands over several months. Many studies have noted the importance of fat for hibernation energy budgets, but protein catabolism in hibernation has received less attention, and whole-animal changes in lean mass have not previously been considered. We used quantitative magnetic resonance body composition analysis to measure deposition of fat and lean mass of cave myotis () during the prehibernation period and decreases in fat and lean mass of Townsend's big-eared bats () during hibernation. Read More

JAMA Otolaryngol Head Neck Surg 2022 May 26. Epub 2022 May 26.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

Importance: Early intervention using cone-beam computed tomography (CBCT) and adenotonsillectomy for children with obstructive sleep apnea (OSA) may prevent impaired growth, adverse cardiovascular consequences, learning deficits, and poor quality of life.

Objective: To assess changes in CBCT airway measurements and polysomnography (PSG) parameters that occur after adenotonsillectomy in children with OSA and to determine whether CBCT changes are correlated with apnea-hypopnea index (AHI) reduction.

Design, Setting, And Participants: This prospective cohort study was conducted at a tertiary medical center from 2013 to 2016. Read More

Sports Med 2022 May 26. Epub 2022 May 26.

Performance, Hydration and Thermoregulation Laboratory, Faculty of Physical Activity Sciences, University of Sherbrooke, 2500 boul. de l'Université, Sherbrooke, P.Q., J1K 2R1, Canada.

Background: Heat is associated with physiological strain and endurance performance (EP) impairments. Studies have investigated the impact of caffeine intake upon EP and core temperature (C) in the heat, but results are conflicting. There is a need to systematically determine the impact of pre-exercise caffeine intake in the heat. Read More

Acta Parasitol 2022 May 26. Epub 2022 May 26.

Department of Biological Sciences, Arkansas State University (Emeritus), AZ, 72467, State University, USA.

Purpose: Nothing is known of the coccidian parasites of the Carolina wren, Thryothorus ludovicianus ludovicianus (Latham, 1790). Here, we report a new species of Isospora from T. l. Read More

Ann Surg Oncol 2022 May 26. Epub 2022 May 26.

Department of Thoracic Surgery and Surgical Oncology, Virginia Mason Medical Center, Seattle, WA, USA.

Background: Malnutrition commonly affects patients with esophageal cancer and has the potential to negatively influence treatment outcomes. The aim of this study was to investigate the impact of early (preoperative) jejunostomy tube feeding (JTF) in nutritionally 'high risk' patients receiving multimodal therapy for esophageal cancer.

Methods: Patients were selected to undergo early JTF during neoadjuvant chemoradiotherapy (nCRT) in accordance with European Society for Clinical Nutrition and Metabolism (ESPEN) and Enhanced Recovery after Surgery (ERAS) Society guidelines. Read More

Lung 2022 May 26. Epub 2022 May 26.

Department of Nutritional Sciences and Dietetics, International Hellenic University, Sindos, Thessaloniki, Greece.

Lung cancer is the most common cause of cancer death and is associated with malnutrition and sarcopenia. The detection of sarcopenia and conduction of simple body composition measurements, such as the phase angle (PhA) deriving from bioelectrical impedance analysis (BIA), can help to early identify, monitor, prevent and treat malnutrition. The present review aims to clarify the relationship between PhA and sarcopenia with the pathophysiology, clinical outcomes, and therapeutic aspects of lung cancer. Read More

J Anat 2022 May 26. Epub 2022 May 26.

A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russian Federation.

This study is the first analysis of mobility in the lumbosacral joint of even-toed ungulates covering the full range of body masses and running forms. In this study, we modified a previously developed osteometry-based method to calculate the available range of motion (aROM) in the lumbosacral joint in artiodactyls. We quantified all three directions of intervertebral mobility: sagittal bending (SB), lateral bending (LB), and axial rotation (AR). Read More

J Exp Med 2022 Jul 26;219(7). Epub 2022 May 26.

Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Given the clinical, economic, and societal impact of obesity, unraveling the mechanisms of adipose tissue expansion remains of fundamental significance. We previously showed that white adipose tissue (WAT) levels of 3-mercaptopyruvate sulfurtransferase (MPST), a mitochondrial cysteine-catabolizing enzyme that yields pyruvate and sulfide species, are downregulated in obesity. Here, we report that Mpst deletion results in fat accumulation in mice fed a high-fat diet (HFD) through transcriptional and metabolic maladaptation. Read More

Eur J Sport Sci 2022 May 26:1-15. Epub 2022 May 26.

Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia.

Evidence suggests the focus for sodium replacement during exercise should be maintenance of plasma sodium concentration ([Na]) for any given total body water (TBW) volume. The sodium intake to achieve stable [Na] given known fluid and electrolyte intakes and losses can be mathematically estimated. Therefore the aim of this investigation was to model sodium requirements of athletes during exercise, observing the influence of sweat rate, exercise duration, body mass, baseline [Na] and sweat potassium [K], and relevance to competition (soccer, elite marathon, and 160 km ultramarathon running). Read More

Diab Vasc Dis Res 2022 May-Jun;19(3):14791641221094322

Department of Medicine, College of Medicine and King Saud Medical City, King Saud University, Riyadh, Saudi Arabia.

Background: Diabetes mellitus is a chronic multisystem disease with a high global prevalence, including in Saudi Arabia. The Glucagon-like Peptide (GLP-1) receptor agonist liraglutide is known to lower glucose levels, reduce weight and improve cardiovascular outcome. However, mechanisms underlying the benefits of liraglutide treatment in patients with type 2 diabetes mellitus (T2DM) remain unclear. Read More

Zhen Ci Yan Jiu 2022 May;47(5):435-42

School of Acupuncture-moxibustion and Orthopedics and Traumatology, Hubei University of Chinese Medicine, Wuhan 430061, China.

Objective: To observe the effect of electroacupuncture (EA) of combined "Biao"- and "Ben"-acupoint (for treating symptoms and root causes of the disease, respectively) on the expression of kidney forkhead box O1 (FoxO1) and peroxi-some proliferator-activated receptor-γ coactivator-1α (PGC-1α) in diabetic nephropathy (DN) rats, so as to explore its potential mechanisms underlying improvement of DN.

Methods: Wistar rats were randomly divided into normal control (=10), DN model (=12), EA (=11), EA+inhibitor (AS1842856 targeting FoxO1, =11) and inhibitor (=11) groups. The DN model was established by high fat and high glucose diet for 6 weeks and intraperitoneal injection of streptozotocin (55 mg/kg). Read More