1,448,351 results match your criteria body fat

A study of effect of on oxidative markers in the hippocampus of offsprings born to alcohol-fed pregnant rats and the correlation with their cognitive functions.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Department of Physiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Objectives: Alcohol consumption causes several harmful effects on the organs, which is hugely understated. Many deformities occur in the fetus when pregnant mothers indulge in alcoholism. Alcohol is a known teratogen, hence organ formation, particularly development of parts brain critical for cognitive function may be affected. Read More

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Bigu-Style Fasting Affects Metabolic Health by Modulating Taurine, Glucose, and Cholesterol Homeostasis in Healthy Young Adults.

J Nutr 2021 May 12. Epub 2021 May 12.

Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Dynamic orchestration of metabolic pathways during continuous fasting remains unclear.

Objective: We investigated the physiological effects of Bigu-style fasting and underlying metabolic reprogramming in healthy adults.

Methods: We conducted a 5-d Bigu trial in 43 healthy subjects [age 23. Read More

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Peristomal Pyoderma Gangrenosum Responding to Risankizumab.

Adv Skin Wound Care 2021 Jun;34(6):327-329

In Miami, Florida, Maximillian A. Weigelt, MD, is Clinical Research Fellow, Dr Phillip Frost Department of Dermatology & Cutaneous Surgery University of Miami Miller School of Medicine; and Robert S. Kirsner, MD, PhD, is Chairman and Harvey Blank Professor, Dr Phillip Frost Department of Dermatology & Cutaneous Surgery, Professor of Public Health Sciences, University of Miami Miller School of Medicine, and Director, University of Miami Hospital and Clinics Wound Center. Acknowledgments: This manuscript describes off-label product use: risankizumab for pyoderma gangrenosum. The authors have disclosed no financial relationships related to this article. Submitted May 6, 2020; accepted in revised form June 19, 2020.

Abstract: Evidence to support available therapies for pyoderma gangrenosum (PG) is limited. Many patients do not respond to topical therapies such as tacrolimus or topical steroids. Currently favored oral systemic treatments (eg, cyclosporine and steroids) achieve complete remission in only 50% of patients and have unfavorable adverse effect profiles. Read More

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Acute Arthrodesis of Ipsilateral Pilon and Talus Fracture: A Case Report.

Drew Sanders

JBJS Case Connect 2021 Apr 14;11(2). Epub 2021 Apr 14.

University of Texas Southwestern Medical Center, Parkland Health and Hospital System, Dallas, Texas.

Case: We report a unique case of an ipsilateral distal tibia pilon fracture and talar body after motor vehicle collision. Our patient was successfully treated with acute arthrodesis of the tibiotalar joint, with return to good function 1-year after surgery.

Conclusion: Pilon and talus fractures are complex injuries. Read More

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Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic Ovary Syndrome.

Obes Facts 2021 May 12:1-8. Epub 2021 May 12.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Frederiksberg, Denmark.

Introduction: Adult obesity is linked with polycystic ovary syndrome (PCOS), but the importance of body size at ages before PCOS is diagnosed is unknown.

Objective: To investigate associations between a woman's own birthweight, childhood body mass index (BMI), height and growth patterns in relation to her risk of PCOS.

Methods: We included 65,665 girls from the Copenhagen School Health Records Register, born in the period 1960-1996, with information on birthweight and measured weight and height at the ages of 7-13 years. Read More

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Novel Algorithm for the Differential Diagnosis of Hyponatraemia in Anuric Patients Undergoing Maintenance Haemodialysis.

Kidney Blood Press Res 2021 May 12:1-6. Epub 2021 May 12.

Department of Internal Medicine, Second faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czechia.

Introduction: Hyponatraemia is associated with increased mortality in patients undergoing maintenance haemodialysis. In anuric patients, hyponatraemia development depends on the water-sodium ratio in retained fluid within the interdialysis interval (IDI).

Objective: This study aimed to calculate the retained sodium-retained water ratio in patients on maintenance haemodialysis and make a differential diagnosis of hyponatraemia according to these data. Read More

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Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography.

J Neural Eng 2021 May 12. Epub 2021 May 12.

Biomedical Engineering, Duke University, 2167 CIEMAS, Duke Box 3382, 101 Science Drive, Durham, North Carolina, 27708, UNITED STATES.

Objective: The peripheral nervous system (PNS) connects the central nervous system (CNS) with the rest of the body to regulate many physiological functions and is therapeutically targeted to treat diseases such as epilepsy, depression, intestinal dysmotility, chronic pain, and more. However, we still lack understanding of PNS innervation in most organs because the large span, diffuse nature, and small terminal nerve bundle fibers have precluded whole-organism, high resolution mapping of the PNS. We sought to produce a comprehensive peripheral nerve atlas for use in future interrogation of neural circuitry and selection of targets for neuromodulation. Read More

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Potential role of folate status on pulmonary function in pediatric asthma.

Nutrition 2021 Apr 7;90:111267. Epub 2021 Apr 7.

La Trobe University, School of Allied Health, Department of Dietetics, Nutrition & Sport, Melbourne, Australia; RMIT University, School of Health and Biomedical Sciences, Melbourne, Australia.

Objective: The aim of this study was to explore the relationship between plasma folate status and measures of airway disease (as reflected by spirometry) in children with asthma on a traditional Mediterranean diet. We hypothesized that folate deficiency is associated with lung function impairment in this group of children.

Methods: This cross-sectional study included 64 children with mild asthma (52% boys, mean age 8 ± 2 y) residing in Athens, Greece. Read More

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The revolting body: Self-disgust as a key factor in anorexia nervosa.

Curr Opin Psychol 2021 Mar 31;41:78-83. Epub 2021 Mar 31.

Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Grote Kruisstraat 2/1, 9712 TS, Groningen, the Netherlands.

In this article, we present a theoretical model that points to disgust-induced avoidance as a mechanism that can help explain the persistent and excessive food restriction in individuals with anorexia nervosa (AN). Disgust is characterized by intense negative feelings of revulsion and an overwhelming and irresistible urge to avoid potential disgust elicitors. When eating, or even the prospect of eating, elicits overwhelming feelings of disgust in individuals with AN, this could explain why food restriction persists even when someone is in a state of starvation. Read More

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Combined healthy lifestyle and depressive symptoms: a meta-analysis of observational studies.

J Affect Disord 2021 Apr 26;289:144-150. Epub 2021 Apr 26.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan. Electronic address:

Background: To systematically summarize the association between combined lifestyle (at least three factors, including but not limited to smoking, drinking, physical activity, body mass index, diet) and depressive symptoms by a meta-analysis in general populations.

Methods: Multiple electronic databases were searched for observational studies investigating combined lifestyle factors and depressive symptoms published before September 2020. Pooled risk estimates were calculated using random-effects models. Read More

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Hyperprolactinemia using domperidone in prepubertal gilts: Effects on hormonal status, mammary development and mammary and pituitary gene expression.

C Farmer M F Palin

Domest Anim Endocrinol 2021 Apr 14;76:106630. Epub 2021 Apr 14.

Agriculture and Agri-Food Canada, Sherbrooke R & D Centre, Sherbrooke, QC, J1M 0C8, Canada.

Objectives of this experiment were to determine if the domperidone protocol previously used for gestating gilts can also lead to hyperprolactinemia in growing gilts, and to assess the effects of such a protocol on hormonal status, mammary development and gene expression in mammary and pituitary tissue of gilts at puberty. The impact on future lactation performance was also determined. At 75 ± 3 kg body weight (BW), gilts were divided between: 1) controls (CTL), receiving daily intramuscular (IM) injections of canola oil (1. Read More

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Heterocapsa busanensis sp. nov. (Peridiniales, Dinophyceae): A new marine thecate dinoflagellate from Korean coastal waters.

Eur J Protistol 2021 Apr 23;79:125797. Epub 2021 Apr 23.

Division of Earth Environmental System Science, Pukyong National University, Busan 48513, Republic of Korea; Department of Oceanography, Pukyong National University, Busan 48513, Republic of Korea. Electronic address:

During daily monitoring in Yongho Bay off Busan, Korea in 2019, an isolate of the dinoflagellate genus Heterocapsa was established in clonal culture. Light and electron microscopic examination revealed that the isolate was ellipsoid in shape, exhibiting a thecal plate arrangement (Po, cp, X, 5', 3a, 7″, 6c, 5s, 5‴, 2'''') consistent with most other Heterocapsa species. A large, elongated nucleus was positioned on the left side of the cell, a single reticulate chloroplast was located peripherally, and a single, starch-sheathed, spherical pyrenoid was present in the episome or near the cingulum. Read More

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Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis.

Ageing Res Rev 2021 May 9:101358. Epub 2021 May 9.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address:

Huntington disease (HD) is an autosomal dominant neurodegenerative disease that is caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (HTT) gene, which leads to a toxic, aggregation-prone, mutant HTT-polyQ protein. Beyond the well-established mechanisms of HD progression in the central nervous system, growing evidence indicates that also peripheral tissues are affected in HD and that systemic signaling originating from peripheral tissues can influence the progression of HD in the brain. Herein, we review the systemic manifestation of HD in peripheral tissues, and the impact of systemic signaling on HD pathogenesis. Read More

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Screening and identification of microRNAs from plasma-derived extracellular vesicles (EVs) of Dazu black goat (Capra hircus) in early pregnant stages.

Gene 2021 May 9:145706. Epub 2021 May 9.

College of Animal Science and Technology, Southwest University, Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China. Electronic address:

Previous studies have shown that extracellular vesicles (EVs) containing proteins, lipids, nucleic acids and other biological components exist in all kinds of body fluids. EVs, as an intercellular communication carrier, regulate the functions of its target cells by transporting biomacromolecules between cells. In this study, a total of six female Dazu black goats were divided into NP group (NP, non-pregnant group) and P30 (P30, 30-day pregnant group). Read More

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High-frequency repetitive transcranial magnetic stimulation enhances layer II/III morphological dendritic plasticity in mouse primary motor cortex.

Behav Brain Res 2021 May 9:113352. Epub 2021 May 9.

Department of Medical Sciences and Department of Neurology, Hackensack Meridian School of Medicine, Nutley, NJ, 07110, USA. Electronic address:

High-frequency repeated transcranial magnetic stimulation (HF-rTMS) is a safe non-invasive neuromodulatory technique and there is a body of evidence shows that it can modulate plasticity in different brain areas. One of the most interesting application of HF-rTMS is the modulation of plasticity in primary motor cortex (M1) to promote recovery after brain injuries. However, the underlying mechanism by which HF-rTMS modulates motor cortex plasticity remain to be investigated. Read More

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Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes.

Cell Rep 2021 May;35(6):109093

Food Biosciences Department, Teagasc Food Research Centre, Moorepark, Fermoy, County Cork P61 C996, Ireland; VistaMilk Research Centre, Teagasc, Moorepark, Fermoy, County Cork P61 C996, Ireland. Electronic address:

We investigated how protein quantity (10%-30%) and quality (casein and whey) interact with dietary fat (20%-55%) to affect metabolic health in adult mice. Although dietary fat was the main driver of body weight gain and individual tissue weight, high (30%) casein intake accentuated and high whey intake reduced the negative metabolic aspects of high fat. Jejunum and liver transcriptomics revealed increased intestinal permeability, low-grade inflammation, altered lipid metabolism, and liver dysfunction in casein-fed but not whey-fed animals. Read More

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microRNA-132 as a negative regulator in NF-κB signaling pathway via targeting IL-1β in miiuy croaker.

Dev Comp Immunol 2021 May 9:104113. Epub 2021 May 9.

Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China; Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Ministry of Education, Shanghai, China; National Pathogen Collection Center for Aquatic Animals, Shanghai Ocean University, Shanghai, China. Electronic address:

The innate immune system is the first line of defense against the invasion of pathogens. It can make a rapid immune response to the invading pathogenic microorganisms, thereby eliminating the invading pathogens and protecting the body from harm. microRNAs are a family of small non-coding ribonucleic acid molecules, which are important and multifunctional regulator of immune response. Read More

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Vemurafenib plus Rituximab in Refractory or Relapsed Hairy-Cell Leukemia.

N Engl J Med 2021 May;384(19):1810-1823

From the Institute of Hematology, Ospedale S. Maria della Misericordia, and the Department of Medicine, University of Perugia, Perugia (E.T., L.D.C., E.S., M.C., S.A., V.M.P., B.F.), the Department of Medicine, Section of Hematology, University of Verona, Verona (A. Ambrosetti), the Hematology Unit, Ospedale di Cosenza, Cosenza (E.L.), the Hematology Unit, Department of Transfusional Medicine-SIMMT, Maria Paternò-Arezzo Hospital, Ragusa (A. Antolino), the Hematology Unit, Department of Translational and Precision Medicine, Sapienza University of Rome (A.P., R.F.), and the Hematology and Stem Cell Transplant Unit, A.O. San Camillo Forlanini (L.R.), Rome, the Department of Hematology, Spedali Civili di Brescia, Brescia (S.F.), IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli" and Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna (P.L.Z.), the Department of Translational Medicine, Division of Hematology, Amedeo Avogadro University of Eastern Piedmont, Novara (G.G.), the Hematology Unit, Ospedale di Carrara, Carrara (R.D.S.), the Hematology Unit, Ospedale di Frosinone, Frosinone (N.F.), the Hematology Unit, Ospedale di Ronciglione, Viterbo (P.F.), the Hematology Unit, Ospedale di Pesaro, Pesaro (G.V.), and the Hematology Unit, Azienda Sanitaria Universitaria Integrata-Ospedale Maggiore, Trieste (F.Z.) - all in Italy.

Background: Hairy-cell leukemia (HCL) is a CD20+ indolent B-cell cancer in which a BRAF V600E kinase-activating mutation plays a pathogenetic role. In clinical trials involving patients with refractory or relapsed HCL, the targeting of BRAF V600E with the oral BRAF inhibitor vemurafenib led to a response in 91% of the patients; 35% of the patients had a complete response. However, the median relapse-free survival was only 9 months after treatment was stopped. Read More

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Brain Damage and Patterns of Neurovascular Disorder after Ionizing Irradiation. Complications in Radiotherapy and Radiation Combined Injury.

Radiat Res 2021 May 12. Epub 2021 May 12.

Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Exposure to ionizing radiation, mechanical trauma, toxic chemicals or infections, or combinations thereof (i.e., combined injury) can induce organic injury to brain tissues, the structural disarrangement of interactive networks of neurovascular and glial cells, as well as on arrays of the paracrine and systemic destruction. Read More

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Pathology of Northern Fulmars (Fulmarus glacialis) and Shearwaters Beached On Sable Island, Nova Scotia, Canada.

J Wildl Dis 2021 May 12. Epub 2021 May 12.

Sable Island Institute, PO Box 11, Halifax Central, Halifax, Nova Scotia B3J 2L4, Canada.

Marine birds are frequently found dead on beaches, either from natural or from anthropogenic causes. Complete necropsies of those carcasses can provide valuable information, particularly for pelagic species, such as Northern Fulmars (Fulmarus glacialis) and shearwaters, which come to land only to breed and for which information on diseases that may affect them is, therefore, sparse. Between 2000 and 2012, 315 carcasses of four species of Procellariiformes (173 Northern Fulmars, 89 Great Shearwaters [Ardenna gravis], 50 Sooty Shearwaters [Ardenna grisea], and three Cory's Shearwaters [Calonectris diomedea]) were collected on Sable Island, Nova Scotia, Canada, an isolated island near the edge of the continental shelf. Read More

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Failla Memorial Lecture: The Many Facets of Heavy-Ion Science.

Marco Durante

Radiat Res 2021 May;195(5):403-411

Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt, Germany; and Technische Universität Darmstadt, Institute of Condensed Matter Physics, 64289 Darmstadt, Germany.

Heavy ions are riveting in radiation biophysics, particularly in the areas of radiotherapy and space radiation protection. Accelerated charged particles can indeed penetrate deeply in the human body to sterilize tumors, exploiting the favorable depth-dose distribution of ions compared to conventional X rays. Conversely, the high biological effectiveness in inducing late effects presents a hazard for manned space exploration. Read More

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Tracking changes in behavioural dynamics using prediction error.

PLoS One 2021 12;16(5):e0251053. Epub 2021 May 12.

Section of Ecology, Behavior, and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America.

Automated analysis of video can now generate extensive time series of pose and motion in freely-moving organisms. This requires new quantitative tools to characterise behavioural dynamics. For the model roundworm Caenorhabditis elegans, body pose can be accurately quantified from video as coordinates in a single low-dimensional space. Read More

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Cerebrospinal fluid dynamics correlate with neurogenic claudication in lumbar spinal stenosis.

PLoS One 2021 12;16(5):e0250742. Epub 2021 May 12.

Department of Brain and Cognitive Engineering, Korea University, Seoul, South Korea.

Neurogenic claudication is a typical manifestation of lumbar spinal stenosis (LSS). However, its pathophysiology is still unclear. The severity of clinical symptoms has been shown not to correlate with the degree of structural stenosis. Read More

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Infrared thermal imaging monitoring on hands when performing repetitive tasks: An experimental study.

PLoS One 2021 12;16(5):e0250733. Epub 2021 May 12.

Faculty of Chemical Sciences and Engineering, Autonomous University of Baja California, Tijuana, Mexico.

The monitoring of infrared thermal images is reported to analyze changes in skin temperature in the hand fingers when repetitive work is performed to know which finger has a greater risk of injury, besides, the recovery time is analyzed regarding the initial temperature and its relationship with age, sex, weight, height if practice sports, and Body Mass Index (BMI) per individual. For the above, an experimental test was carried out for 10 minutes on a repetitive operation that takes place in the telecommunications industry and 39 subjects participated in which an infrared thermal image of the dorsal and palmar part of both hands was taken in periods of 5 minutes after the 10-minute test has elapsed. The results show that none of the participants recovered their initial temperature after 10 minutes of the experimental test. Read More

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Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians.

PLoS One 2021 12;16(5):e0238555. Epub 2021 May 12.

Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.

Background: Plasma omentin levels have been shown to be associated with circulating adiponectin concentrations and cardiometabolic disease-related outcomes. In this study, we aim to examine the association of omentin gene polymorphism with serum adiponectin levels and cardiometabolic health status using a genetic approach, and investigate whether these associations are modified by lifestyle factors.

Methods: The study included 945 normal glucose tolerant and 941 unrelated individuals with type 2 diabetes randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), in southern India. Read More

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Affirmative action, critical mass, and a predictive model of undergraduate student body demographics.

PLoS One 2021 12;16(5):e0250266. Epub 2021 May 12.

Department of Mathematics and Statistics, Williams College, Williamstown, MA, United States of America.

Black and Latinx students are underrepresented on most public university campuses. At the same time, affirmative action policies are controversial and legally fraught. The Supreme Court has ruled that affirmative action should help a minoritized group achieve a critical mass of representation. Read More

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The Impact of Focus and Context Visualization Techniques on Depth Perception in Optical See-Through Head-Mounted Displays.

IEEE Trans Vis Comput Graph 2021 May 12;PP. Epub 2021 May 12.

Estimating the depth of virtual content has proven to be a challenging task in Augmented Reality (AR) applications. Existing studies have shown that the visual system uses multiple depth cues to infer the distance of objects, occlusion being one of the most important ones. Generating appropriate occlusions becomes particularly important for AR applications that require the visualization of augmented objects placed below a real surface. Read More

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Hypothesis of using albumin to improve drug efficacy in cancers accompanied by hypoalbuminemia.

Xenobiotica 2021 May 12:1-30. Epub 2021 May 12.

Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.

A common problem in many cancers is the resistance of some patients to common drugs or relapse. Hypoalbuminemia has been reported in some of resistant cancer patients.This article evaluates the usefulness of albumin in the treatment of drug-resistant cancers with hypoalbuminemia based on available evidences. Read More

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A qualitative analysis of people's experiences with weight-based discrimination.

Psychol Health 2021 May 12:1-18. Epub 2021 May 12.

Department of Psychology, College of Arts and Sciences, Florida State University, Tallahassee, Florida, USA.

Objective: The aim of this study was to describe people's day-to-day experiences with weight-based discrimination and to distill themes that shed new light on this phenomenon.

Design: A qualitative study was conducted in 2019 using a purposive sampling strategy. A racially and ethnically diverse sample of 32 U. Read More

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Body surface area-based equivalent dose calculation in tree shrew.

Sci Prog 2021 Apr-Jun;104(2):368504211016935

Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Tree shrew (Tupaia belangeri) is a promising experimental animal in biomedical research, but the equivalent doses of drugs between tree shrew and human and other animals has not been explored, which hinders its further application in a wider scope. The main objective of this article is to provide a method of equivalent dose conversion between tree shrews and other species based on body surface area (BSA). BSA of tree shrews were measured by Image J software, and then the average Km value of tree shrews was figured out based on the body weights and BSA, then the conversion coefficients of equivalent dose among tree shrew and other species of experimental animals were calculated based known data. Read More

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