121,574 results match your criteria board


[When to Test in Biomarker-stratified Therapy of Non-small Cell Lung Cancer - Biomarker-stratified Therapy of Non-small Cell Lung Cancer: When and What to Test?]

Pneumologie 2021 Sep 15;75(9):641-643. Epub 2021 Sep 15.

Internistische Onkologie Thorakaler Tumoren, Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg.

Therapy of non-small cell lung cancer (NSCLC) should be based on biomarker test results in the palliative setting. To this end, testing of all patients in stage IV and in the future also in the earlier stages will be important. In a conference with the patronage of the German Cancer Society, the question of "reflex testing", i. Read More

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September 2021

Interview of Don Ingber with Albert van den Berg and Andries van der Meer (University of Twente, the Netherlands, and EUROoCs board members).

Authors:

Stem Cell Reports 2021 Sep;16(9):2047-2048

Don Ingber is the founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard. His work has led to major advances in mechanobiology, cell structure, tumor angiogenesis, tissue engineering, systems biology, nanobiotechnology, and translational medicine. He is probably most famous for his development of organs-on-chips upon which he founded the company Emulate. Read More

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September 2021

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy.

Cell Stem Cell 2021 Sep 9. Epub 2021 Sep 9.

University of Minnesota, Department of Medicine, Minneapolis, MN 55455, USA. Electronic address:

Select subsets of immune effector cells have the greatest propensity to mediate antitumor responses. However, procuring these subsets is challenging, and cell-based immunotherapy is hampered by limited effector-cell persistence and lack of on-demand availability. To address these limitations, we generated a triple-gene-edited induced pluripotent stem cell (iPSC). Read More

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September 2021

Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response.

Immunity 2021 Sep;54(9):2005-2023.e10

Department of Medicine, Division of Immunology and Allergy, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Cell fate decisions during early B cell activation determine the outcome of responses to pathogens and vaccines. We examined the early B cell response to T-dependent antigen in mice by single-cell RNA sequencing. Early after immunization, a homogeneous population of activated precursors (APs) gave rise to a transient wave of plasmablasts (PBs), followed a day later by the emergence of germinal center B cells (GCBCs). Read More

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September 2021

Effects of COVID-19 on preclinical and clinical research in neurology: Examples from research on neurodegeneration and Alzheimer's disease.

Neuron 2021 Aug 24. Epub 2021 Aug 24.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, 660 S. Euclid Ave., Box 8111, St. Louis, MO 63110, USA. Electronic address:

The COVID-19 pandemic has had a profound impact on neuroscientists, including those involved in translational research. In this NeuroView, we discuss the positive and negative effects of the pandemic on preclinical research and clinical studies in humans. Read More

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How to make the use of recycled paperboard fit for food contact? A contribution to the discussion.

Authors:
Koni Grob

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2021 Sep 15:1-16. Epub 2021 Sep 15.

Retired from Kantonales Labor Zürich (Official Food Control Authority of the Canton of Zurich), Zurich, Switzerland.

Recycled paperboard contains hundreds of non-evaluated or even unidentified substances that could endanger human health if they turn out to be highly toxic. It seems as unrealistic to evaluate each of them as it is to phase out the use of the problematic ones or sort out the papers and boards introducing them into the recyclate. Therefore, measures should be taken that generally reduce migration into food, such as functional barriers or functional sorbents. Read More

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September 2021

Building a bridge between patients and transplant healthcare professionals - A descriptive study.

Transpl Int 2021 Sep 15. Epub 2021 Sep 15.

Donation and Transplant Coordination Unit, Hospital Clinic, Associate Professor Surgical Department, University of Barcelona, Barcelona, Spain.

This paper describes a pathway for collaboration between transplant healthcare professionals and organ recipients. Under the umbrella of the European Society for Organ Transplantation (ESOT) a joint initiative started from three Sections and Committees of ESOT: EDTCO (European Donation and Transplant Coordination Organisation), ETHAP (European Transplant Allied Healthcare Professionals) and ELPAT (Ethical, Legal and Psycho-social Aspects of Transplantation). The formal "kick-off" of the Advisory Board Meeting of the European Transplant Patients' Organisation (ETPO) was during the ESOT congress in 2019. Read More

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September 2021

Suggested visual blockade during hypnosis: Top-down modulation of stimulus processing in a visual oddball task.

PLoS One 2021 15;16(9):e0257380. Epub 2021 Sep 15.

Institute of Psychology, Friedrich Schiller University of Jena, Jena, Germany.

Several theories of hypnosis assume that responses to hypnotic suggestions are implemented through top-down modulations via a frontoparietal network that is involved in monitoring and cognitive control. The current study addressed this issue re-analyzing previously published event-related-potentials (ERP) (N1, P2, and P3b amplitudes) and combined it with source reconstruction and connectivity analysis methods. ERP data were obtained from participants engaged in a visual oddball paradigm composed of target, standard, and distractor stimuli during a hypnosis (HYP) and a control (CON) condition. Read More

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September 2021

CORR Insights®: A Modeling Study of a Patient-specific Safe Zone for THA: Calculation, Validation, and Key Factors Based on Standing and Sitting Sagittal Pelvic Tilt.

Clin Orthop Relat Res 2021 Sep 15. Epub 2021 Sep 15.

Director, The J. Vernon Luck Sr. Orthopaedic Research Center, Orthopaedic Institute for Children in Alliance with UCLA Department of Orthopaedic Surgery, Los Angeles, CA, USA.

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September 2021

The International Anesthesia Research Society Coronavirus Disease 2019 Pandemic Scientific Advisory Board: Supporting a Pandemic of Positivity.

Anesth Analg 2021 Oct;133(4):903-905

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

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October 2021

Comparative Incidence of Periocular Surgical Site Infections with Increased Surgical Mask Use during the COVID-19 Pandemic.

Ocul Immunol Inflamm 2021 Sep 15:1-6. Epub 2021 Sep 15.

Ophthalmic Plastic Surgery Service, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

Purpose: To evaluate the effect of surgical mask use on infection rates for office-based periocular surgeries during the pandemic.

Methods: An Institutional Review Board-approved retrospective review of medical records identified patients who had an office-based oculofacial plastic surgery procedure during the pandemic between March and December 2020. Statistical analysis was used to compare this group to patients that underwent procedures between March and December 2019, prior to the pandemic when neither surgeon nor patient wore a surgical mask. Read More

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September 2021

Hair Removal Practices: A Literature Review.

Skin Therapy Lett 2021 Sep;26(5):6-11

Lynde Institute for Dermatology (Private Practice), Markham, ON, Canada.

Hair removal practices have evolved from adhering to social, cultural, and religious traditions to meeting aesthetic standards. Hair removal methods can be divided into two categories: 1) depilation, which involves removing the hair shaft and includes shaving and chemical depilatories, and 2) epilation, which involves removing the hair shaft, follicle, and bulb, and includes plucking, threading, waxing, sugaring, lasers, intense pulsed light system, electrolysis, and photodynamic therapy. Furthermore, an eflornithine hydrochloride 13. Read More

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September 2021

Labeling Laws for Personal Care Products: Potential Pitfalls for The Consumer.

Skin Therapy Lett 2021 Sep;26(5):1-6

Baylor College of Medicine, Houston, TX USA.

Consumers of personal care products must be made aware of the potential pitfalls that arise from current labeling practices and regulations. For example, terms such as "hypoallergenic", "sensitive skin", and "baby product" lack legal definitions, and terms such as "fragrance-free" are frequently misinterpreted. Personal care products are a general category that includes such items as cosmetics, drugs, dietary supplements, and consumer goods. Read More

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September 2021

Robotic resection of extrahepatic cholangiocarcinoma: Institutional outcomes of bile duct cancer surgery using a minimally invasive technique.

J Surg Oncol 2021 Sep 15. Epub 2021 Sep 15.

Digestive Health Institute, AdventHealth Tampa, Tampa, Florida, USA.

Background And Objectives: The purpose of this study is to report our early experience and outcomes, the first in North America, of Extrahepatic Cholangiocarcinoma (EHC) resection with Roux-en Y Hepaticojejunostomy reconstruction via the robotic approach.

Methods: With Institutional Review Board approval, 15 patients who underwent robotic resection of EHC were studied.

Results: Patients were 74 (73 ± 8. Read More

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September 2021

Comparison between cystic biliary atresia and choledochal cyst: a clinical controlled study.

Pediatr Surg Int 2021 Sep 15. Epub 2021 Sep 15.

Department of General Surgery, Capital Institute of Pediatrics, Beijing, China.

Purpose: It is difficult to distinguish cystic biliary atresia (CBA) from choledochal cyst (CC) before intraoperative cholangiography in neonates or young infants because of the similar ultrasonographic patterns and clinical manifestations. This study is to investigate the difference of clinical parameters between CBA and CC.

Methods: 96 patients with cyst at hepatic hilum whose ages were less than 120 days during the period from Jan'2013 to Nov'2015 were retrospectively studied, they were divided into CBA group and CC group by intraoperative cholangiography, there were 29 cases of CBA and 67 cases of CC. Read More

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September 2021

Feruloyl esterase Fae1 is required specifically for host colonisation by the rice-blast fungus Magnaporthe oryzae.

Curr Genet 2021 Sep 15. Epub 2021 Sep 15.

Bharat Chattoo Genome Research Centre, Department of Microbiology and Biotechnology Centre, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India, 390002.

Plant cell wall acts as a primary barrier for microbial pathogens during infection. A cell wall-degrading enzyme thus may be a crucial virulence factor, as it may aid the pathogen in successful host invasion. Nine genes coding for feruloyl esterases (Fae), likely involved in plant cell wall degradation, have been annotated in the genome of the cereal-blast fungus Magnaporthe oryzae. Read More

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September 2021

Recent Progress of Biomarkers in Oral Cancers.

J Chin Med Assoc 2021 Sep 3. Epub 2021 Sep 3.

Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Department of Dentistry, School of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Nursing, Veterans General Hospital, Taipei, Taiwan, ROC Department of Ophthalmology, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, Taiwan, ROC.

Oral cancers are the seventh most common cancer globally. While progresses in oral cancer treatment has been made, not all patients respond to these therapies in the same way. To overcome this difficulty, numerous studies have been devoted to identifying biomarkers, which enable early identification of patients who may benefit from a particular treatment modality or at risk for poor prognosis. Read More

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September 2021

Are functional outcomes and reoperation rates really better than those of cementless stems in displaced femoral neck fractures? An updated systematic review and meta-analysis of randomised controlled trials in current-generation stem designs.

J Chin Med Assoc 2021 Sep 9. Epub 2021 Sep 9.

Department of Orthopedic Surgery, Mackay Memorial Hospital, Taipei, Taiwan, ROC Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Department of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of exercise and health science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan, ROC.

Background: The study aim was to conduct a systematic review and meta-analysis to compare the functional outcomes and reoperation rates of cemented and cementless hip arthroplasty for treating displaced femoral neck fractures in elderly patients.

Methods: Systematic searches were conducted of literature up to December 2018 on PubMed, Embase, Cochrane, and Web of Science for randomised controlled trials (RCTs) concerning current-generation stem designs only. Two reviewers independently determined eligibility, extracted the outcome data and assessed the risk of bias of eligible studies. Read More

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September 2021

Extracorporeal Life Support for Respiratory Failure in Patients With Electronic Cigarette or Vaping Product Use-Associated Lung Injury.

Crit Care Med 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center and Children's Memorial Hermann Hospital, Houston, TX. Department of Pediatrics, Division of Pulmonary Medicine and the Lung Transplant Program Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH. Department of Pediatrics-Critical Care, UT Southwestern Medical Center, Dallas, TX. Division of Cardiothoracic Surgery, Department of Surgery, Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, UT. Extracorporeal Life Support Organization, Ann Arbor, MI. Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN. Department of Critical Care Medicine, Mercy Hospital, St Louis, MO. Department of Medicine, Division of Critical Care Medicine, Schulich School of Medicine & Dentistry, Western University, and London Health Sciences Centre, London, ON, Canada. Department of Paediatric Respiratory Medicine, Nottingham University Hospitals, Nottingham, United Kingdom. Department of Radiology, Newark Beth Israel Medical Center, Newark, NJ. Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA. Department of Cardiovascular and Thoracic Surgery, Barbara and Donald Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY.

Objectives: Electronic cigarette or vaping product use-associated lung injury is a clinical entity that can lead to respiratory failure and death. Despite the severity of electronic cigarette or vaping product use-associated lung injury, the role of extracorporeal life support in its management remains unclear. Our objective was to describe the clinical characteristics and outcomes of patients with electronic cigarette or vaping product use-associated lung injury who received extracorporeal life support. Read More

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September 2021