Biosens Bioelectron 2018 Jun 15;107:259-265. Epub 2018 Feb 15.
Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 300, Taiwan, ROC; Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan, ROC. Electronic address:
Continued risk assessment by evaluating cardiac biomarkers in healthy and unhealthy individuals can lower the mortality rate of cardiovascular diseases (CVDs). In this research, we have developed a hand-held biosensor system to rapidly screen for brain natriuretic peptide (BNP) from a single drop of whole blood. The sensor methodology is based on extended gate design of electrical double layer (EDL) field effect transistor (FET), that can directly detect BNP in whole blood, without extensive sample pre-treatments, thereby eliminating the limitations of charge screening in high ionic strength solutions. Read More