AIDS 2021 Jul 1. Epub 2021 Jul 1.
The Kirby Institute, University of New South Wales Level 6, Wallace Wurth Building High Street, Kensington NSW 2052 Australia Department of Health Systems and Populations Faculty of Medicine and Health Sciences Macquarie University Level 3 75T Building 75 Talavera Road Immunovirology and Pathogenesis program The Kirby Institute, University of New South Wales Level 5, Wallace Wurth Building High Street, Kensington NSW 2052, Australia Lyell McEwin Hospital University of Adelaide Elizabeth Vale, SA 5112, Australia.
Introduction: We explored associations of inflammatory and immune activation biomarkers at baseline and percentage gain in peripheral and trunk fat and lean mass over 96weeks in patients with confirmed virological failure initiating LPV-anchored second-line antiretroviral (ART) regimens.
Method: We measured baseline plasma concentration of IL-6, TNF, neopterin, IL-6, hs-CRP, D-dimer, soluble CD14 (sCD14), & soluble CD163 in 123 participants of the SECOND-LINE body composition substudy. Linear regression assessed the association between biomarkers and percentage gain in limb/trunk fat and lean mass, adjusting for age, N(t)RTI use, BMI, ethnicity, smoking, viral load, CD4 T cell counts, smoking, duration of ART use, and cholesterol. Read More