987 results match your criteria bmi 185

Obesity and altered angiogenic-related gene expression in endometrial cancer.

Gynecol Oncol 2021 Sep 15. Epub 2021 Sep 15.

Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA.

Objectives: Evaluate association between obesity and angiogenic-related gene expression in endometrial cancer (EC). Evaluate interaction between diet and metformin on angiogenic-related gene expression.

Methods: We evaluated the association between 168 human angiogenic-related genes and body mass index (BMI) in the TCGA Uterine Corpus Endometrial Carcinoma cohort (endometrioid endometrial cancer (EEC) cohort n = 290, and copy number high cohort n = 55), an independent validation cohort from Gynecologic Cancer Center of Excellence (GYN-COE) (n = 62) and corresponding 185 homologous mouse genes in an LKB1p53 mouse model of EC (n = 20). Read More

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September 2021

Factors Associated With Gestational Diabetes Mellitus: A Cross-Sectional Study.

Cureus 2021 Aug 11;13(8):e17113. Epub 2021 Aug 11.

Obstetrics and Gynaecology, Isra University, Hyderabad, PAK.

Introduction The absence of tolerance in the levels of carbohydrates at the onset or at the time of pregnancy amongst females is known as gestational diabetes mellitus (GDM). This study is designed to determine the frequency of GDM and factors responsible for GDM to assess the actual magnitude of the outcome. Furthermore, it allows for developing strategies to minimize morbidities and improve the pregnancy outcome by early diagnosis and timely management, which can help reduce the frequency of GDM. Read More

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Sleep habits and weight status in Brazilian children aged 4-6 years of age: the PREDI study.

Sleep Med 2021 Aug 30;87:30-37. Epub 2021 Aug 30.

Postgraduate Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, nº 10, Joinville, SC, CEP 89.219-710, Brazil; Health Sciences Department, University of Joinville Region - UNIVILLE, Joinville, SC, Brazil. Electronic address:

Objectives: To evaluate the association of sleep habits with the weight status of children aged 4-6 years.

Methods: Data were obtained from the PREDI Study, a Brazilian birth cohort study. The current study was carried out in the homes of the participants during two follow-ups: 2016/17 and 2018. Read More

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Factors and Prognostic Significance of Impaired Exercise Tolerance in Women over 40 with Arterial Hypertension.

J Pers Med 2021 Jul 30;11(8). Epub 2021 Jul 30.

Heart Failure Unit, Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), 93-338 Lodz, Poland.

The aim of this study was to identify factors influencing maximal oxygen uptake (VO) and early identification of the profile of hypertensive women in the perimenopausal period at risk of heart failure. This study included 185 female patients. Regression analyses determined predictors of the lowest VO (quartile 1: VO < 17 mL/kg/min). Read More

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In Their Own Words: Parents and Key Informants' Views on Nutrition Education and Family Health Behaviors.

Int J Environ Res Public Health 2021 08 1;18(15). Epub 2021 Aug 1.

Department of Health Studies, American University, Washington, DC 20016, USA.

Parents, health professionals, and communities are integral in the development of nutrition behaviors that reduce children's risk for high body mass index (BMI) and chronic disease. The aim of this study was to conduct formative evaluations with key health informants and parents to understand the specific strategies that families use at mealtimes to promote their family's health, along with the barriers they face in attending current nutrition education programming. Focus groups (in English and Spanish) were conducted with parents ( = 22; 63. Read More

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Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled, clinical trial.

Lancet Diabetes Endocrinol 2021 09 3;9(9):595-605. Epub 2021 Aug 3.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Visceral and ectopic fat are key drivers of adverse cardiometabolic outcomes in obesity. We aimed to evaluate the effects of injectable liraglutide 3·0 mg daily on body fat distribution in adults with overweight or obesity without type 2 diabetes at high cardiovascular disease risk.

Methods: In this randomised, double-blind, placebo-controlled, phase 4, single centre trial, we enrolled community-dwelling adults, recruited from the University of Texas Southwestern Medical Center, with BMI of at least 30 kg/m or BMI of at least 27 kg/m with metabolic syndrome but without diabetes and randomly assigned them, in a 1:1 ratio, to 40 weeks of treatment with once-daily subcutaneous liraglutide 3·0 mg or placebo, in addition to a 500 kcal deficient diet and guideline-recommended physical activity counselling. Read More

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September 2021

Correlation Analysis of Breast and Thyroid Nodules: A Cross-Sectional Study.

Int J Gen Med 2021 27;14:3999-4010. Epub 2021 Jul 27.

Department of Thyroid and Breast Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, People's Republic of China.

Objective: Based on physical examination, to explore the relationship between breast mass (BM) and thyroid nodule (TN) prevalence, and to further explore other related factors that affect the occurrence of BM and TN.

Methods: From January 1, 2018, to January 1, 2021, 12,538 female subjects received breast and thyroid ultrasound examinations at the same time in the health examination center of the Affiliated Hospital of North Sichuan Medical College. Univariate analysis and multivariate logistic analysis were used to screen the relevant factors affecting TN and BM, and propensity score matching was used to further verify the results of the relationship between breast and thyroid. Read More

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Anthropometric indices and the risk of incident sudden cardiac death among adults with and without diabetes: over 15 years of follow-up in The Tehran Lipid and Glucose Study.

Diabetol Metab Syndr 2021 Jul 28;13(1):82. Epub 2021 Jul 28.

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, Parvaneh Street, Velenjak, P.O. Box no19395-4763, Tehran, Iran.

Background: We investigated the association of anthropometric indices including body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and hip circumference (HC) with the risk of incident sudden cardiac death (SCD) among Iranian population with and without type 2 diabetes mellitus (T2DM).

Methods: The study population included 9,089 subjects without and 1,185 subjects with T2DM, aged ≥ 20 years. Participants were recruited in 1999-2001 or 2001-2005, and followed for incident SCD annually, up to 20 March 2018. Read More

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Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort.

Sci Rep 2021 Jul 27;11(1):15245. Epub 2021 Jul 27.

Departamento de Medicina Interna, Hospital General Universitario Gregorio Marañón. Facultad de Medicina, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.

We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. Read More

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A recurrent familial partial lipodystrophy due to a monoallelic or biallelic LMNA founder variant highlights the multifaceted cardiac manifestations of metabolic laminopathies.

Eur J Endocrinol 2021 Aug 27;185(4):453-462. Epub 2021 Aug 27.

Department of Endocrinology, Diabetes and Nutrition, GHSR, Centre Hospitalo-Universitaire de la Réunion, Saint-Pierre, La Réunion, France.

Aims: LMNA-linked familial partial lipodystrophy type 2 (FPLD2) leads to insulin resistance-associated metabolic complications and cardiovascular diseases. We aimed to characterise the disease phenotype in a cohort of patients carrying an LMNA founder variant.

Methods: We collected clinical and biological data from patients carrying the monoallelic or biallelic LMNA p. Read More

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The course of thyroid nodules and thyroid volume over a time period of up to 10 years: a longitudinal analysis of a population-based cohort.

Eur J Endocrinol 2021 Aug 4;185(3):431-439. Epub 2021 Aug 4.

Department of General Practice, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

Objective: Thyroid disorders are common. Information on the long-term progression of morphologic disorders is scarce. The aim of this study was to describe the course of thyroid nodules and volume over a period of up to 10 years. Read More

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Sex differences in clinical characteristics and risk factors for disease severity of hospitalized patients with COVID-19.

MedComm (Beijing) 2021 Jun 8;2(2):247-255. Epub 2021 Apr 8.

Center of Liver Diseases, Beijing Ditan Hospital Capital Medical University Beijing China.

Recent studies reported sex differences in patients with coronavirus disease-2019 (COVID-19). We aim to analyze sex differences in clinical characteristics and risk factors for disease severity of hospitalized patients with COVID-19 in Beijing. All adults (185 cases) diagnosed with COVID-19 and admitted to Beijing Ditan Hospital, Capital Medical University were included in samples. Read More

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Inflammatory biomarker and soft tissue changes among patients commencing second-line ART after first-line virological failure.

AIDS 2021 Jul 1. Epub 2021 Jul 1.

The Kirby Institute, University of New South Wales Level 6, Wallace Wurth Building High Street, Kensington NSW 2052 Australia Department of Health Systems and Populations Faculty of Medicine and Health Sciences Macquarie University Level 3 75T Building 75 Talavera Road Immunovirology and Pathogenesis program The Kirby Institute, University of New South Wales Level 5, Wallace Wurth Building High Street, Kensington NSW 2052, Australia Lyell McEwin Hospital University of Adelaide Elizabeth Vale, SA 5112, Australia.

Introduction: We explored associations of inflammatory and immune activation biomarkers at baseline and percentage gain in peripheral and trunk fat and lean mass over 96weeks in patients with confirmed virological failure initiating LPV-anchored second-line antiretroviral (ART) regimens.

Method: We measured baseline plasma concentration of IL-6, TNF, neopterin, IL-6, hs-CRP, D-dimer, soluble CD14 (sCD14), & soluble CD163 in 123 participants of the SECOND-LINE body composition substudy. Linear regression assessed the association between biomarkers and percentage gain in limb/trunk fat and lean mass, adjusting for age, N(t)RTI use, BMI, ethnicity, smoking, viral load, CD4 T cell counts, smoking, duration of ART use, and cholesterol. Read More

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Piloting the objective measurement of eating behaviour at a population scale: a nested study within the Avon Longitudinal Study of Parents and Children.

Wellcome Open Res 2020 4;5:185. Epub 2020 Aug 4.

Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.

Effective measurement and adaption of eating behaviours, such as eating speed, may improve weight loss and weight over time. We assessed whether the Mandometer, a portable weighing scale connected to a computer that generates a graph of food removal rate from the plate to which it is connected, together with photo-imaging of food, might prove an effective approach to measuring eating behaviours at large scale. We deployed the Mandometer in the home environment to measure main meals over three days of 95 21-year-old participants of the Avon Longitudinal Study of Parents and Children. Read More

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Long-term residential exposure to air pollution is associated with hair cortisol concentration and differential leucocyte count in Flemish adolescent boys.

Environ Res 2021 Jun 27;201:111595. Epub 2021 Jun 27.

VITO Health, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

Background: Exposure to air pollution and traffic noise are associated with adverse health outcomes in adolescents. Chronic endocrine stress and systemic inflammation have been hypothesized to underlie the adverse health effects. Simultaneous assessment of inflammation and chronic endocrine stress in epidemiological studies is lacking. Read More

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Impact of obesity on outcomes in patients with acute respiratory syndrome.

J Int Med Res 2021 Jun;49(6):3000605211024860

Department of Anesthesiology, Zhejiang Provincial People?s Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Objectives: We assessed the relationship between obesity and all-cause mortality in patients with acute respiratory distress syndrome (ARDS).

Methods: In this retrospective cohort study, patient data were extracted from the eICU Collaborative Research Database and the Medical Information Mart for Intensive Care Database III. Body mass index (BMI) was grouped according to World Health Organization classifications: underweight, normal weight, overweight, obese. Read More

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Enhanced MCP-1 Release in Early Autosomal Dominant Polycystic Kidney Disease.

Kidney Int Rep 2021 Jun 6;6(6):1687-1698. Epub 2021 Apr 6.

PKD Research Group, Laboratory of Pediatrics, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) causes kidney failure typically in adulthood, but the disease starts . Copeptin, epidermal growth factor (EGF), and monocyte chemoattractant protein-1 (MCP-1) are associated with severity and hold prognostic value in adults but remain unstudied in the early disease stage. Kidneys from adults with ADPKD exhibit macrophage infiltration, and a prominent role of MCP-1 secretion by tubular epithelial cells is suggested from rodent models. Read More

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Functional significance of 8-isoprostanes in sinonasal disease and asthma.

Respir Med 2021 Aug-Sep;185:106506. Epub 2021 Jun 9.

Larner College of Medicine, University of Vermont, Burlington, VT, USA. Electronic address:

Background: The purpose of this study was to investigate how 8-isoprostanes, used as a marker of airway oxidative stress, were related to sinus disease and asthma.

Methods: We analyzed samples and data from two separate studies, one investigating sinonasal disease in asthma, the other investigating the effect of BMI on airway disease. We measured airway (nasal lavage) 8-isoprostanes and investigated the relationship with measures of sinus and asthma symptoms, asthma control and lung function. Read More

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Association of baseline diaphragm, rectus femoris and vastus intermedius muscle thickness with weaning from mechanical ventilation.

Respir Med 2021 Aug-Sep;185:106503. Epub 2021 Jun 12.

Division of Intensive Care Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey. Electronic address:

Background: To determine whether baseline diaphragm (T), rectus femoris (RF) and vastus intermedius (VI) muscle thickness (T and T) are associated with weaning success.

Material And Methods: Right T, T and T were measured by ultrasonography within 36 h of intubation and diaphragmatic excursion (DE) was evaluated at the first spontaneous breathing trial in adult critically-ill patients. Reintubation or death within 7 days after extubation was defined as weaning failure. Read More

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SeDREno study - prevalence of hospital malnutrition according to GLIM criteria, ten years after the PREDyCES study.

Nutr Hosp 2021 Jun 23. Epub 2021 Jun 23.

Facultad de Medicina. Universidad Autónoma de Madrid.

Background & Aims: the last large multicenter study on disease-related malnutrition (DRM) in Spain (the PREDyCES study) showed a 23.7 % prevalence of malnutrition, according to the Nutritional Risk Screening (NRS-2002) tool. The main objective of the SeDREno study was to assess the prevalence of hospital malnutrition upon admission, according to GLIM criteria, ten years later. Read More

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The single-point insulin sensitivity estimator (SPISE) index is a strong predictor of abnormal glucose metabolism in overweight/obese children: a long-term follow-up study.

J Endocrinol Invest 2021 Jun 17. Epub 2021 Jun 17.

Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, L'Aquila, Italy.

Purpose: To investigate the relationship between the single-point insulin sensitivity estimator (SPISE) index, an insulin sensitivity indicator validated in adolescents and adults, and metabolic profile in overweight/obese children, and to evaluate whether basal SPISE is predictive of impaired glucose regulation (IGR) development later in life.

Methods: The SPISE index (= 600 × HDL/Triglycerides × BMI) was calculated in 909 overweight/obese children undergoing metabolic evaluations at University of Cagliari, Italy, and in 99 normal-weight, age-, sex-comparable children, selected as a reference group, together with other insulin-derived indicators of insulin sensitivity/resistance. 200 overweight/obese children were followed-up for 6. Read More

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Objectively Measured Physical Activity Is Associated With Body Composition and Metabolic Profiles of Pacific and New Zealand European Women With Different Metabolic Disease Risks.

Front Physiol 2021 26;12:684782. Epub 2021 May 26.

School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand.

To assess associations between physical activity (PA), body composition, and biomarkers of metabolic health in Pacific and New Zealand European (NZE) women who are known to have different metabolic disease risks. Pacific ( = 142) or NZE ( = 162) women aged 18-45 years with a self-reported body mass index (BMI) of either 18.5-25. Read More

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Neoadjuvant Androgen Deprivation Therapy Effects on Perioperative Outcomes Prior to Radical Prostatectomy: Eleven Years of Experiences at Ramathibodi Hospital.

Res Rep Urol 2021 1;13:303-312. Epub 2021 Jun 1.

Division of Urology, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Objective: The aim of this study was to demonstrate the efficacy of neoadjuvant androgen deprivation therapy (NADT) on perioperative outcomes in patients who underwent radical prostatectomy (RP).

Materials And Methods: From January 2008 to July 2018, we collected retrospective data of patients with clinically localized prostate cancer who underwent RP to assess their perioperative and pathological outcomes. The data included age, body mass index (BMI), serum prostate specific antigen (PSA) level, clinical stage, neoadjuvant ADT usage, operative time, estimated blood loss (EBL), perioperative complications, blood transfusion rate, adjacent organ injury rate, length of hospital stay, pathological stage, Gleason score (GS) of the biopsy and pathological specimen, specimen weight (g), and margin status. Read More

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Cross-sectional associations between objectively measured sleep characteristics and body mass index in European children and adolescents.

Sleep Med 2021 08 15;84:32-39. Epub 2021 May 15.

School of Public Health and Community Medicine, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 453, 40530 Gothenburg, Sweden.

Background: Short sleep duration has been found to be associated with a higher risk for overweight and obesity. However, previous studies have mainly relied on subjective measures of sleep duration and other sleep characteristics (eg quality, timing) have often been neglected. Therefore, we aimed to investigate associations between several, mainly objectively measured sleep characteristics and body mass index (BMI). Read More

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Acute hypoglycemia and risk of cardiac arrhythmias in insulin-treated type 2 diabetes and controls.

Eur J Endocrinol 2021 Jul 21;185(2):343-353. Epub 2021 Jul 21.

Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.

Objective: Hypoglycemia is associated with an increased risk of cardiovascular disease including cardiac arrhythmias. We investigated the effect of hypoglycemia in the setting of acute glycemic fluctuations on cardiac rhythm and cardiac repolarization in insulin-treated patients with type 2 diabetes compared with matched controls without diabetes.

Design: A non-randomized, mechanistic intervention study. Read More

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Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm.

Eur J Endocrinol 2021 Jul 1;185(2):279-288. Epub 2021 Jul 1.

Finnish Institute for Health and Welfare, Population Health Unit, Oulu and Helsinki, Finland.

Objective: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term.

Design: The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Read More

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Altered endocannabinoid-dynamics in craniopharyngioma patients and their association with HPA-axis disturbances.

Eur J Endocrinol 2021 Jul 1;185(2):231-239. Epub 2021 Jul 1.

Human Behavior Laboratory, Institute for Sex Research and Forensic Psychiatry, University Medical Center Hamburg-Eppendorf, Germany.

Objective: Patients with craniopharyngioma (CP) frequently suffer from morbid obesity. Endocannabinoids (ECs) are involved in weight gain and rewarding behavior but have not been investigated in this context.

Design: Cross-sectional single-center study. Read More

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Thyroid function is not associated with brown adipose tissue volume and 18F-fluorodeoxyglucose uptake in young euthyroid adults.

Eur J Endocrinol 2021 Jul 1;185(2):209-218. Epub 2021 Jul 1.

PROFITH "PROmoting FITness and Health through Physical Activity" Research Group, Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Granada, Spain.

Purpose: Thyroid hormones (THs) are important mediators of brown adipose tissue (BAT) differentiation. However, the association of TH concentrations with human BAT is unclear. The present work examines the associations between circulating thyroid-stimulating hormone (TSH) and THs concentrations (i. Read More

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Opioid users show worse baseline knee osteoarthritis and faster progression of degenerative changes: a retrospective case-control study based on data from the Osteoarthritis Initiative (OAI).

Arthritis Res Ther 2021 05 22;23(1):146. Epub 2021 May 22.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Lobby 6, Suite 350, San Francisco, CA, 94107, USA.

Background: Opioids are frequently prescribed for pain control in knee osteoarthritis patients, despite recommendations by current guidelines. Previous studies have investigated the chondrotoxicity of different opioid subtypes. However, the impact opioids may have on progression of osteoarthritis in vivo remains unknown. Read More

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Are caveolin-1 minor alleles more likely to be risk alleles in insulin resistance mechanisms in metabolic diseases?

BMC Res Notes 2021 May 17;14(1):185. Epub 2021 May 17.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), No. 44, Hojjat-dost Alley, Naderi St., Keshavarz Blvd, P.O. Box, 14155-6117, Tehran, Iran.

Objectives: Obesity and insulin resistance (IR) are interrelated in a range of ways. The IR-obesity relationship is not a cause-and-effect association. Molecular biology research has made tremendous strides in discovering contributors to find this association. Read More

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