Toxins (Basel) 2019 02 19;11(2). Epub 2019 Feb 19.
Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Naka 2-24-16, Koganei, Tokyo 184-8588, Japan.
When ABC transporter family C2 (ABCC2) and ABC transporter family B1 (ABCB1) were heterologously expressed in non-susceptible cultured cells, the cells swelled in response to Cry1A and Cry3 toxins, respectively. Consistent with the notion that 3D-Cry toxins form cation-permeable pores, ABCC2 (BmABCC2) facilitated cation-permeable pore formation by Cry1A when expressed in oocytes. Furthermore, BmABCC2 had a high binding affinity () to Cry1Aa of 3. Read More