169,149 results match your criteria blood transfusions

Origin of the Ukrainian minority of Kazakhstan as inferred from HLA-A, -B, -C, -DRB1, and -DQB1 alleles and haplotypes distribution.

HLA 2021 Jul 22. Epub 2021 Jul 22.

Department of Biomedical Sciences, School of Medicine, NazarbayevUniversity, Astana, Kazakhstan.

The present-day population of Kazakhstan comprises more than a hundred ethnic and linguistic groups, of which Ukrainians rates numerically as the fourth, following native Kazakhs, Russians, and Uzbeks. We investigated the HLA profile of Kazakhstani Ukrainians and compared them with those of other populations by applying genetic distances, correspondence analysis, admixture, and haplotype examination. Of the 128 HLA alleles identified, A*02:01 (28. Read More

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Controlling Coagulation in Blood with Red Light.

Angew Chem Int Ed Engl 2021 Jul 22. Epub 2021 Jul 22.

University of Frankfurt, Cluster of Excellence Macromolecular Complexes, Max-von-Laue-Str. 9, 60438, Frankfurt, GERMANY.

Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalysed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood - restoring the blood's natural coagulation capability. Read More

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Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules.

Blood 2021 Jul 22. Epub 2021 Jul 22.

CHU de Quebec, Quebec, Quebec, Canada.

In addition to their hemostatic role, platelets play a significant role in immunity. Once activated, platelets release extracellular vesicles (EVs) formed by budding of their cytoplasmic membranes. Because of their heterogeneity, platelet EVs (PEVs) are thought to perform diverse functions. Read More

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Donor orientation and service quality: Key factors in active blood donors' satisfaction and loyalty.

PLoS One 2021 22;16(7):e0255112. Epub 2021 Jul 22.

Department of Business Economics, Faculty of Legal and Business Sciences, Universidad Rey Juan Carlos, Madrid, Spain.

Faced with the increasing demand for blood and greater restrictions on ensuring the safety of transfusions, voluntary donation is currently the only and best alternative for the health system to have a sustainable and safe blood supply. In this context, one of the primary strategies of blood transfusion centres is to increase the satisfaction of their active donors so that they maintain their intention to donate in the future and, in turn, make the necessary recommendations so that third parties can become new donors. That is why this paper raises a question for research concerning, what should the premises be to guide the management of blood transfusion centres to maintain and even increase the satisfaction and loyalty of their active donors? In order to respond to this issue, a change in paradigm is proposed based on a management model supported by donor orientation and service quality as basic pillars, as well as on the development of a number of key social capital resources that explain this orientation toward the donor. Read More

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Causes of an elevated international normalized ratio in the intensive care unit and the implications for plasma transfusion.

Transfusion 2021 Jul 22. Epub 2021 Jul 22.

Department of Coagulation and Transfusion Medicine, The Miriam Hospital, Providence, Rhode Island, USA.

Background: The presence of an elevated international normalized ratio (INR) is common in patients in the intensive care unit (ICU), but the cause rarely determined. These patients are at risk to receive prophylactic plasma prior to invasive procedures.

Study Design And Methods: Samples from patients with an INR of 1. Read More

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A prognostic model for the preoperative identification of patients at risk for receiving transfusion of packed red blood cells in cardiac surgery.

Transfusion 2021 Jul 22. Epub 2021 Jul 22.

Department of Epidemiology, MCL Academy, Medical Center Leeuwarden, Leeuwarden, The Netherlands.

Background: Patients undergoing cardiothoracic surgery are at substantial risk for blood transfusion. Increased awareness and patient blood management have resulted in a significant reduction over the past years. The next step is preoperative treatment of patients at high risk for packed red blood cells (RBC) transfusion, with the ultimate goal to eventually prevent RBC transfusion. Read More

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Strong association between insufficient plasma exchange and fatal outcomes in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura.

Int J Hematol 2021 Jul 22. Epub 2021 Jul 22.

Department of Blood Transfusion Medicine, Nara Medical University, 840 Shijo-Cho, Kashihara, 634-8522, Japan.

Plasma exchange (PEX) using fresh frozen plasma has considerably reduced the mortality rate in patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP). However, some patients still do not survive even with treatment, but little information is available regarding which treatment these patients received. This study was conducted to obtain this information in 240 patients who met the current iTTP diagnostic criteria and completed at least 30 days of follow-up except for deceased cases. Read More

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T-cell replete haploidentical stem cell transplantation with low dose anti-thymocyte globulin for relapsed/refractory Ewing sarcoma family tumors.

Cancer Rep (Hoboken) 2021 Jul 22:e1519. Epub 2021 Jul 22.

Department of Pediatric Oncology, Fukushima Medical University Hospital, Fukushima, Japan.

Background: Despite intensive multimodal therapies, the prognosis of relapsed/ refractory Ewing sarcoma family tumors (RR-ESFTs) is dismal. Some case reports using allogeneic stem cell transplantation (allo SCT) for RR-ESFTs have been reported, however, the efficacy of allo SCT is yet to be established.

Aim: The purpose of this study was to evaluate the response and toxicity of T-cell replete haploidentical SCT (TCR-haplo-SCT) in RR-ESFTs. Read More

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A new RHD variant allele caused by an RHD c.1228-1G>C mutation in a Chinese family.

Transfusion 2021 Jul 22. Epub 2021 Jul 22.

Department of Blood Transfusion, The First Affiliated Hospital of Shenzhen University School of Medicine, The Second People's Hospital of Shenzhen, Shenzhen, China.

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Predicting outcome in higher-risk myelodysplastic syndrome patients treated with azacitidine.

Epigenomics 2021 Jul 22. Epub 2021 Jul 22.

Second Department of Internal Medicine & Research Unit Hematology Unit, University General Hospital Attikon, Rimini, 12462 Chaidari, Athens, Greece.

5-Azacitidine (5-AZA) is widely used for the treatment of higher-risk myelodysplastic syndromes. However, response and survival rates vary considerably, while indicated treatment duration remains undefined. For these reasons, factors determining response and survival are of major importance. Read More

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Pure Laparoscopic Versus Robotic Liver Resections: Multicentric Propensity Score Based Analysis With Stratification According To Difficulty Scores.

J Hepatobiliary Pancreat Sci 2021 Jul 22. Epub 2021 Jul 22.

Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: The benefits of pure laparoscopic and robot-assisted liver resections (LLR and RALR) are known in comparison to open surgery. Aim of the present retrospective comparative study is to investigate the role of RALR and LLR according to different levels of difficulty.

Method: The institutional databases of six high-volume hepatobiliary centers were retrospectively reviewed. Read More

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The Effects of Tranexamic Acid on Bleeding Control During and after Percutaneous Nephrolithotomy (PCNL): A Randomized Clinical Trial.

Urol J 2021 Jul 22:6505. Epub 2021 Jul 22.

3. Department of Urology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Purpose: Tranexamic acid is a fibrinolysis suppressor that is used for a variety of bleeding control procedures such as hematuria, surgery bleeding, and trauma caused bleeding. The advantages of using the tranexamic acid are bleeding control and less need for blood transfusion.

Materials And Methods:  This double blind clinical trial was conducted on 108 patients in Imam Khomeni Hospital, Urmia, Iran 2013-14. Read More

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Life-Threatening Mediastinal Hematoma Formation After Removal of the Hemodialysis Catheter in a Boxer: A Case Report.

Front Vet Sci 2021 5;8:691472. Epub 2021 Jul 5.

Department of Veterinary Clinical Sciences, Small Animal Clinic, Justus-Liebig-University Giessen, Giessen, Germany.

A 4-year-old female Boxer was referred for renal replacement therapy 2 days after observed grape ingestion. An 11-French dual-lumen dialysis catheter was placed into the right jugular vein and continuous renal replacement therapy was initiated for 66 h. Afterwards the patient received enoxaparin subcutaneously as a thromboprophylaxis. Read More

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Revision Total Hip Arthroplasty in Jehovah's Witnesses at a Public Hospital: Practical Recommendations for a Low-Resource Setting.

Cureus 2021 Jun 19;13(6):e15761. Epub 2021 Jun 19.

Department of Surgery, Port of Spain General Hospital, Port of Spain, TTO.

Revision total hip arthroplasty (THA) is a major reconstructive procedure traditionally associated with significant blood loss. Jehovah's Witnesses (JW) do not accept blood or blood product transfusions because of their religious beliefs. When confronted with a JW patient requiring a complex arthroplasty procedure, surgeons face moral and ethical questions and may be reluctant to perform surgery. Read More

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Novel Scalable and Simplified System to Generate Microglia-Containing Cerebral Organoids From Human Induced Pluripotent Stem Cells.

Front Cell Neurosci 2021 5;15:682272. Epub 2021 Jul 5.

Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States.

Human cerebral organoid (CO) is a three-dimensional (3D) cell culture system that recapitulates the developing human brain. While CO has proved an invaluable tool for studying neurological disorders in a more clinically relevant matter, there have still been several shortcomings including CO variability and reproducibility as well as lack of or underrepresentation of certain cell types typically found in the brain. As the technology to generate COs has continued to improve, more efficient and streamlined protocols have addressed some of these issues. Read More

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Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma.

Cell Death Dis 2021 Jul 21;12(8):724. Epub 2021 Jul 21.

Department of Nephrology, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, 450003, Zhengzhou, Henan, China.

Glioblastomas (GBM) is the most common primary malignant brain tumor, and radiotherapy plays a critical role in its therapeutic management. Unfortunately, the development of radioresistance is universal. Here, we identified calcium-regulated heat-stable protein 1 (CARHSP1) as a critical driver for radioresistance utilizing genome-wide CRISPR activation screening. Read More

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Symptoms of acute transfusion reactions at a general referral hospital in Kinshasa, Democratic Republic of Congo: a cross-sectional study.

BMJ Open 2021 Jul 21;11(7):e045081. Epub 2021 Jul 21.

Department of Hematology, Centre Hospitalier Mère-Enfant Monkole, Kinshasa, Democratic Republic of Congo.

Objectives: Blood transfusion is a life-saving procedure and is also associated with a range of risks including the occurrence of symptoms of acute transfusion reactions (ATRs). Very few studies in sub-Saharan Africa have reported on ATRs. The present study addresses this gap in the literature by documenting the prevalence of and factors associated with ATRs in the Democratic Republic of Congo (DRC). Read More

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Prophylactic subcutaneous retention sutures in the prevention of superficial wound separation of midline laparotomy.

Int J Gynecol Cancer 2021 Jul 21. Epub 2021 Jul 21.

Department of Gynecology and Obstetrics, Antalya Training and Research Hospital, Antalya, Turkey.

Objectives: This prospective study aimed to determine the effectiveness of prophylactic subcutaneous retention sutures in the prevention of superficial wound separation in women with a confirmed or suspected cancer who had gynecological surgery by midline laparotomy.

Methods: This was a non-randomized, controlled intervention study including patients who underwent cancer surgery between May 2018 and August 2019. Patients who underwent midline laparotomy with confirmed or suspected cancer were included and patients who had an early post-operative complication or who underwent surgery again before the removal of stitches were excluded. Read More

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Acute coronary syndrome as the first presentation of antiphospholipid antibody syndrome.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Division of Cardiology, University of Florida Department of Medicine, Gainesville, Florida, USA.

We describe a case of a 42-year-old man who presented with anginal chest pain. He had objective evidence of ongoing cardiac injury. After initial treatment for coronary arterial disease, cardiac catheterisation revealed diffuse coronary arterial thrombosis with embolisation. Read More

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Omani experience with the use of factor IX Fc fusion protein.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Department of Child Health, Sultan Qaboos University, Muscat, Oman.

We describe our local experience in the management of haemophilia B patients with factor IX Fc fusion protein. Two children with haemophilia B were managed with the use of a personalised/tailored dosing schedule of factor IX Fc fusion protein. Compared with the standard half-life factor IX, prophylaxis with factor IX Fc fusion protein was cost-effective, with much less injections, better bleeding control, improved tolerability or no inhibitor development. Read More

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Hypocupraemia-induced anaemia, sensory ataxia and cognitive impairment secondary to zinc-containing dental adhesive.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK.

A 67-year-old man presented with 5 months of worsening memory impairment and sensory gait ataxia on the background of symptomatic anaemia. He experienced falls, agitation and became socially withdrawn over 3 weeks, resulting in hospital admission. On examination, he had sensory gait ataxia consistent with a dorsal column syndrome. Read More

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"Low initial pre-hospital end-tidal carbon dioxide predicts inferior clinical outcomes in trauma patients".

Injury 2021 Jul 9. Epub 2021 Jul 9.

Department of General Surgery & Trauma, WakeMed Health & Hospitals, Raleigh, NC, USA. Electronic address:

Introduction: Current guidelines continue to lead to under- and over-triage of injured patients in the pre-hospital setting. End-tidal carbon dioxide (ETCO2) has been correlated with mortality and hemorrhagic shock in trauma patients. This study examines the correlation between ETCO2 and in-hospital outcomes among non-intubated patients in the pre-hospital setting. Read More

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How do I think about blood donor eligibility criteria for medical conditions?

Mindy Goldman

Transfusion 2021 Jul 21. Epub 2021 Jul 21.

Medical Affairs and Innovation, Canadian Blood Services, Ottawa, Ontario, Canada.

Every blood center must determine blood donor eligibility criteria for donors with medical conditions, often based on very limited published data and variable practice. This manuscript briefly outlines possible impacts of donor medical conditions on donor and recipient safety and product quality, and describes the multidisciplinary approach used in Canada to think about donor criteria issues. Many years of experience are distilled into practical considerations in determining criteria, possible sources of information, and factors for successful change implementation, to hopefully assist medical and technical staff engaged in decision-making around donor eligibility. Read More

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Clinical and economic impacts of large volume delayed sampling and pathogen reduction technology platelet processing strategies in the United States.

Transfusion 2021 Jul 21. Epub 2021 Jul 21.

Medical Affairs, Novavax Inc, Gaithersburg, Maryland, USA.

Background: Large volume delayed sampling (LVDS) and pathogen reduction technology (PRT) are strategies for platelet processing to minimize transfusion of contaminated platelet components (PCs). This study holistically compares the economic and clinical impact of LVDS and PRT in the United States.

Study Design And Methods: A decision model was constructed to simulate collection, processing, and use of PCs and to compare processing strategies: PRT with 5-day shelf life, LVDS with 7-day shelf life (LVDS7), and LVDS with 5-day shelf life extended to 7 days with secondary testing (LVDS5/2). Read More

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Blood Loss and Transfusion Risk in Robotic-Assisted Knee Arthroplasty: A Retrospective Analysis.

Int J Med Robot 2021 Jul 19:e2308. Epub 2021 Jul 19.

Department of Orthopaedics, Charing Cross Hospital, Fulham Palace Rd, Hammersmith, London, W6 8RF, United Kingdom.

Background: The purpose of this study was to compare total blood loss and the risk of receiving a blood transfusion in robotic-assisted total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) against conventional jig-based techniques METHODS: Robotic TKA (n=50) and UKA (n=50) patients were matched to contemporary controls for TKA (n=50) and UKA (n=50) and retrospectively analysed RESULTS: Robotic TKA patients experienced 23.7% less blood loss compared to conventional TKA patients (911.0ml vs 1193. Read More

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Long-term outcome in patients with follicular lymphoma following high-dose therapy and autologous stem cell transplantation.

Eur J Haematol 2021 Jul 20. Epub 2021 Jul 20.

Department of Medicine II, University of Schleswig-Holstein, Kiel, Germany.

Objective: To contribute data on long-term outcome and potential curative impact of ASCT in FL, especially following HDT with the BEAM protocol (BCNU, etoposide, cytarabine and melphalan), given very limited data on this topic in the literature.

Patients And Methods: Patients with FL (n=76) were treated in our institution with HDT and ASCT. In the case of long-term remission (≥ 8 years), peripheral blood was tested for minimal residual disease by t(14;18)- and IGH- PCR, including the last follow-up. Read More

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Acute gastrointestinal bleeding: proposed study outcomes for new randomised controlled trials.

Aliment Pharmacol Ther 2021 Jul 20. Epub 2021 Jul 20.


Background: Acute gastrointestinal bleeding (GIB) remains a common cause of hospitalisation. However, interpretation and comparisons of published studies in GIB have been hampered by disparate study methodology.

Aims: To make recommendations about outcome measures to be used in future randomised controlled trials (RCTs) of patients with acute bleeding from any GI source (nonvariceal UGI, variceal, small bowel, or colon) and suggest new RCTs in acute GIB for future peer-reviewed funding. Read More

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A survey of US hospitals on platelet inventory management, transfusion practice, and platelet availability.

Transfusion 2021 Jul 19. Epub 2021 Jul 19.

Medical Affairs, OneBlood, Orlando, Florida, USA.

Background: A survey of US hospitals was conducted to increase our understanding of the current state of platelet (PLT) practice and supply. The survey captures information on transfusion practice and inventory management, including stock levels, outdate rates, ability to return or transfer PLTs, and low dose PLTs. Notably, the survey also elucidates PLT availability challenges and impact to patient care. Read More

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