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High mean arterial pressure target to improve sepsis-associated acute kidney injury in patients with prior hypertension: a feasibility study.

Ann Intensive Care 2021 Sep 22;11(1):139. Epub 2021 Sep 22.

CHU Bordeaux, Department of Nephrology-Transplantation-Dialysis-Apheresis, Hôpital Pellegrin, F-33000, Bordeaux, France.

Background: The optimal mean arterial pressure (MAP) in cases of septic shock is still a matter of debate in patients with prior hypertension. An MAP between 75 and 85 mmHg can improve glomerular filtration rate (GFR) but its effect on tubular function is unknown. We assessed the effects of high MAP level on glomerular and tubular renal function in two intensive care units of a teaching hospital. Read More

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September 2021

Impact of Preanalytical and Analytical Methods on Cell-Free DNA Diagnostics.

Front Cell Dev Biol 2021 6;9:686149. Epub 2021 Sep 6.

Department of Medical Biology, School of Medicine, University of Zagreb, Zagreb, Croatia.

While tissue biopsy has for the longest time been the gold-standard in biomedicine, precision/personalized medicine is making the shift toward liquid biopsies. Cell-free DNA (cfDNA) based genetic and epigenetic biomarkers reflect the molecular status of its tissue-of-origin allowing for early and non-invasive diagnostics of different pathologies. However, selection of preanalytical procedures (including cfDNA isolation) as well as analytical methods are known to impact the downstream results. Read More

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September 2021

Comparison of Newtonian and Non-newtonian Fluid Models in Blood Flow Simulation in Patients With Intracranial Arterial Stenosis.

Front Physiol 2021 6;12:718540. Epub 2021 Sep 6.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.

Background: Newtonian fluid model has been commonly applied in simulating cerebral blood flow in intracranial atherosclerotic stenosis (ICAS) cases using computational fluid dynamics (CFD) modeling, while blood is a shear-thinning non-Newtonian fluid. We aimed to investigate the differences of cerebral hemodynamic metrics quantified in CFD models built with Newtonian and non-Newtonian fluid assumptions, in patients with ICAS.

Methods: We built a virtual artery model with an eccentric 75% stenosis and performed static CFD simulation. Read More

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September 2021

Triple Oxygen Isotope Measurements (Δ'O) of Body Water Reflect Water Intake, Metabolism, and δO of Ingested Water in Passerines.

Front Physiol 2021 6;12:710026. Epub 2021 Sep 6.

Department of Biological Sciences, Old Dominion University, Norfolk, VA, United States.

Understanding physiological traits and ecological conditions that influence a species reliance on metabolic water is critical to creating accurate physiological models that can assess their ability to adapt to environmental perturbations (e.g., drought) that impact water availability. Read More

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September 2021

Occult blood flow patterns distal to an occluded artery in acute ischemic stroke.

J Cereb Blood Flow Metab 2021 Sep 22:271678X211044941. Epub 2021 Sep 22.

Department of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.

Residual blood flow distal to an arterial occlusion in patients with acute ischemic stroke (AIS) is associated with favorable patient outcome. Both collateral flow and thrombus permeability may contribute to such residual flow. We propose a method for discriminating between these two mechanisms, based on determining the direction of flow in multiple branches distal to the occluding thrombus using dynamic Computed Tomography Angiography (dynamic CTA). Read More

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September 2021

Erythrocyte membranes beta-adrenoreactivity changes after renal denervation in patients with resistant hypertension, relationship with antihypertensive and cardioprotective intervention efficacy.

Kardiologiia 2021 Aug 31;61(8):32-39. Epub 2021 Aug 31.

Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Tomsk.

Aim      To study the functional condition of sympathoadrenal system as evaluated by beta-adrenoreactivity of erythrocyte membranes (beta-ARM) during two years following renal denervation (RD) in patients with resistant arterial hypertension (RAH) and to determine the relationship of this index with long-term antihypertensive and cardioprotective effectivity of this invasive treatment.Material and methods  The study included 48 patients (mean age, 57.2±8. Read More

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Are circulating immune cells a determinant of pancreatic cancer risk? A prospective study using epigenetic cell count measures.

Cancer Epidemiol Biomarkers Prev 2021 Sep 20. Epub 2021 Sep 20.

Nutrition and Metabolism Branch, International Agency For Research On Cancer.

Background: Evidence is accumulating that immune cells play a prominent role in pancreatic cancer aetiology but prospective investigations are missing.

Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study with 502 pairs of incident pancreatic cancer cases and matched controls. Relative counts of circulating immune cells (neutrophils and lymphocyte sub-lineages: total CD3+, CD8+, CD4+, and FOXP3+ regulatory T cells (Tregs) relative to nucleated cells, (white blood cells) were measured by qRT-PCR. Read More

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September 2021

Testosterone, free, bioavailable and total, in patients with COVID-19.

Minerva Endocrinol (Torino) 2021 Sep 21. Epub 2021 Sep 21.

First Department of Critical Care Medicine & Pulmonary Services, Evangelismos Hospital, Medical School of National & Kapodistrian University of Athens, Athens, Greece.

Background: Low Testosterone (mainly total testosterone; TTe) has been noted in patients with COVID-19. Calculated free testosterone (FTe) and bioavailable testosterone (BavTe) may reflect more accurately this hormone's levels. In this study, we sought to assess TTe, FTe as well as BavTe in male patients with COVID-19. Read More

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September 2021

The value of arterial spin labeling imaging in the classification and prognostic evaluation of neonatal hypoxic-ischemic encephalopathy.

Curr Neurovasc Res 2021 Sep 19. Epub 2021 Sep 19.

Department of Radiology, The Second Hospita of Hebei Medical University, Shijiazhuang 050005. China.

Objective: This study aims to investigate the correlation between cerebral blood flow (CBF) values and neonatal behavioral neurological assessment (NBNA) in hypoxic-ischemic encephalopathy (HIE), the relationship between early CBF value changes and the prognosis of neonatal HIE, and the consistency between the clinical grading and magnetic resonance (MR) grading of HIE.

Methods: Forty neonates with HIE were scanned using the three-dimensional arterial spin labeling (ASL) sequencing of the cranial magnetic resonance imaging (MRI). These newborns were classified as having mild, moderate and severe HIE, according to the clinical grading, and as being normal or having mild, moderate, or severe HIE, according to the MRI grading. Read More

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September 2021

Correlation between Perfusion Index and Left Ventricular Output in Healthy Late Preterm Infants.

Am J Perinatol 2021 Sep 20. Epub 2021 Sep 20.

Department of Pediatric Cardiology, Sıtkı Koçman University School of Medicine, Muğla, Turkey.

Aim:  The perfusion index (PI) is a noninvasive marker derived from photoelectric plethysmographic signals in pulse oximetry in the evaluation of peripheral perfusion. This study was aimed to determine the correlation between PI and left ventricular output (LVO) in healthy late preterm infants at 48 hour of life.

Methods:  With new generation pulse oximeter (MASIMO Rad 7 Oximeter) pre- and post-ductal PI values were recorded from healthy late preterm babies at the 48 hour of life. Read More

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September 2021

What Is the Utility of Measuring Lactate Levels in Patients with Sepsis and Septic Shock?

Semin Respir Crit Care Med 2021 Oct 20;42(5):650-661. Epub 2021 Sep 20.

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.

Elevations in blood lactate concentrations have been studied in sepsis and other disease states for decades and are well known to be associated with increased mortality. Many studies have also demonstrated the prognostic accuracy of serial lactate levels, and some have suggested that lactate clearance may be a useful therapeutic target for resuscitation. Lactate measurements have therefore gained an increasingly prominent role in sepsis definitions, screening protocols, management guidelines, and quality measures over the past two decades. Read More

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October 2021

Does reactogenicity after a second injection of the BNT162b2 vaccine predict spike IgG antibody levels in healthy Japanese subjects?

PLoS One 2021 20;16(9):e0257668. Epub 2021 Sep 20.

Department of Laboratory and Transfusion Medicine, Hospital of University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.

Background: Adverse reactions are more common after the second injection of messenger RNA vaccines such as Pfizer/BioNTech's BNT162b2. We hypothesized that the degree and severity of reactogenicity after the second injection reflects the magnitude of antibody production against the SARS CoV-2 virus spike protein (spike IgG).

Methods And Results: Blood samples were obtained from 67 Japanese healthcare workers three weeks after the first injection and two weeks after the second injection of the BNT162b2 vaccine to measure spike IgG levels. Read More

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September 2021

Left Atrioventricular Coupling Index to Predict Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis.

Front Cardiovasc Med 2021 1;8:704611. Epub 2021 Sep 1.

Division of Cardiology, Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, Baltimore, MD, United States.

Although left atrial (LA) and left ventricular (LV) structural and functional parameters have independent prognostic value as predictors of heart failure (HF), the close physiological relationship between the LA and LV suggest that the assessment of LA/LV coupling could better reflect left atrioventricular dysfunction and be a better predictor of HF. We investigated the prognostic value of a left atrioventricular coupling index (LACI), measured by cardiovascular magnetic resonance (CMR), as well as change in LACI to predict incident HF in the Multi-Ethnic Study of Atherosclerosis (MESA). In the MESA, 2,250 study participants, free of clinically recognized HF and cardiovascular disease (CVD) at baseline, had LACI assessed by CMR imaging at baseline (Exam 1, 2000-2002), and 10 years later (Exam 5, 2010-2012). Read More

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September 2021

The role of RANKL and FGF23 in Assessing Bone Turnover in Type 2 Diabetic Patients.

Acta Endocrinol (Buchar) 2021 Apr-Jun;17(1):51-59

"Grigore T Popa" University of Medicine and Pharmacy, Faculty of Medicine, Iasi.

Context: Type 2 diabetes is a chronic metabolic disease which affects bone. There is evidence in the literature about some serum markers that reflect the bone turnover metabolism, such as RANKL (Receptor Activator of Nuclear factor Kappa-b Ligand) and Fibroblast Growth Factor (FGF) 23.

Objective: We aimed to investigate the correlations between RANKL and FGF23 and other diabetes-related factors possibly influencing early bone turnover changes. Read More

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October 2021

Case Report: Plasma Biomarkers Reflect Immune Mechanisms of Guillain-Barré Syndrome.

Front Neurol 2021 3;12:720794. Epub 2021 Sep 3.

Department of Neurology, Chang Gung Memorial Hospital, Keelung City, Taiwan.

This case series reported a group of patients with Guillain-Barré syndrome (GBS) and their plasma cytokine changes before and after immunotherapy. We aimed to understand GBS's pathogenesis and pathophysiology through observing the interval differences of the representative cytokines, which were the thymus and activation regulated chemokine (TARC) for T-cell chemotaxis, CD40 ligand (CD40L) for cosimulation of B and T cells, activated complement component C5/C5a, and brain-derived neurotrophic factor (BDNF) for survival and regenerative responses to nerve injuries. The fluorescence magnetic bead-based multiplexing immunoassay simultaneously quantified the five cytokines in a single sample. Read More

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September 2021

The Association Between Risk Factors for Metabolic Syndrome and Meibomian Gland Disease in a Dry Eye Cohort.

Clin Ophthalmol 2021 11;15:3821-3832. Epub 2021 Sep 11.

Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Purpose: Risk factors for metabolic syndrome include abdominal obesity, insulin resistance, hypertension, high triglycerides and/or low high-density lipoprotein cholesterol, and hyperglycemia. Risk factors for metabolic syndrome have been associated with dry eye disease; however, their association with meibomian gland disease (MGD), a subtype of dry eye, is unclear. In the present study, we investigated risk factors for metabolic syndrome in a dry eye cohort with and without MGD. Read More

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September 2021

Recommendations for uniform definitions used in newborn screening for severe combined immunodeficiency.

J Allergy Clin Immunol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pediatrics, Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Background: Public health newborn screening (NBS) programs continuously evolve, taking advantage of international shared learning. NBS for severe combined immunodeficiency (SCID) has recently been introduced in many countries. However, comparison of screening outcomes has been hampered by use of disparate terminology and imprecise or variable case definitions for non-SCID conditions with T-cell lymphopenia. Read More

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September 2021

Consistent patterns in the inconsistent associations of Insulin-like growth factor 1 (IGF-1), C-Reactive Protein (C-RP) and Interleukin 6 (IL-6) levels with delirium in surgical populations. A systematic review and meta-analysis.

Arch Gerontol Geriatr 2021 Sep 4;97:104518. Epub 2021 Sep 4.

GGZinGeest, Amsterdam, the Netherlands. Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands.

Background: Biomarkers for delirium could increase diagnostic accuracy and may help to identify pathological pathways. Until now study findings concerning cytokine levels have been inconsistent.

Aims: Systematic review and meta-analysis investigating the association between peripheral levels of Insulin-like Growth Factor-1 (IGF-1), C-Reactive Protein (C-RP) and Interleukin-6 (IL-6) and delirium in surgical patients, and to explore if there are distinct/specific patterns that may potentially explain inconsistent results. Read More

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September 2021

CD8 cell counting in whole blood by a paper-based time-resolved fluorescence lateral flow immunoassay.

Anal Chim Acta 2021 Sep 6;1179:338820. Epub 2021 Jul 6.

Department of Bioengineering, Guangdong Province Engineering Research Center of Antibody Drug and Immunoassay, Jinan University, Guangzhou, 510632, PR China. Electronic address:

The number of CD8 T lymphocytes (CD8 cells) in peripheral blood can directly reflect the immune status of the body and is widely used for auxiliary diagnosis and prognostic evaluation of diseases. There is an urgent need to develop a simple CD8 cell-counting platform to meet clinical needs. Our group designed a paper-based cell-counting method based on a blocking competition strategy. Read More

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September 2021

Role of Neonatal Behavioral Neurological Assessment combined with magnetic resonance diffusion tensor imaging in evaluating white matter development in preterm infants.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):916-921

Department of Neonatology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China (Xu F-L, Email: com).

Objectives: To study the correlation of fractional anisotropy (FA) on magnetic resonance diffusion tensor imaging with Neonatal Behavioral Neurological Assessment (NBNA) score in preterm infants, and to study the role of FA in evaluating white matter development from the perspective of imaging.

Methods: A prospective study was performed for 98 preterm infants who were admitted to the Neonatal Intensive Care Unit of the Third Affiliated Hospital of Zhengzhou University within 24 hours after birth from October 2016 to January 2020. According to the results of NBNA, they were divided into an abnormal group with 51 infants (NBNA score <37) and a normal group with 47 infants (NBNA score ≥37). Read More

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September 2021

In vitro cultivation of Trypanosoma congolense bloodstream forms: State of the art and advances.

Vet Parasitol 2021 Sep 9;299:109567. Epub 2021 Sep 9.

CIRAD, UMR INTERTRYP, F-34398, Montpellier, France; INTERTRYP, Univ Montpellier, CIRAD, IRD, Montpellier, France.

Animal African Trypanosomosis (AAT or Nagana) is a severe vector-borne disease caused by protozoan parasites belonging to the Trypanosomatidae family and is usually cyclically transmitted by blood-sucking tsetse flies. AAT remains a major problem in sub-Saharan Africa. Among the main AAT causative agents, Trypanosoma congolense (T. Read More

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September 2021

An interactive eye-tracking system for measuring radiologists' visual fixations in volumetric CT images: Implementation and initial eye-tracking accuracy validation.

Med Phys 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology.

Purpose: Eye tracking approaches have been used to understand the visual search process in radiology. However, previous eye tracking work in computer tomography (CT) has been limited largely to single cross-sectional images or video playback of the reconstructed volume, which do not accurately reflect radiologists' visual search activities and their interactivity with 3-dimensional image data at a computer workstation (e.g. Read More

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September 2021

A bibliometric analysis of the research on hematological tumor microenvironment.

Ann Transl Med 2021 Aug;9(16):1337

Senior Department of Hematology, the Fifth Medical Center of PLA General Hospital, Beijing, China.

Background: In recent years, the incidence of hematological tumors has increased. The tumor microenvironment (TME) is the local biological environment in the process of tumor occurrence and development and is closely related to hematological malignancies, including lymphoma and leukemia. This study aims to conduct a bibliometric analysis of the research on the hematological TME, reflect the general situation of the research in this field, and remind the focus of future research. Read More

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Maternal cardiovascular potential and kinetic energy indices in pre-eclamptic and small-for-gestational-age pregnancies.

Ultrasound Obstet Gynecol 2021 Sep 16. Epub 2021 Sep 16.

Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, London, SW17 0RE, UK.

Introduction: Non-invasive assessment of maternal cardiovascular potential and kinetic energy can be used to derive the potential to kinetic energy ratio (PKR) and inotropy index (SMII). The balance of potential to kinetic cardiovascular energy is a measure of the balance between blood pressure and blood flow. The aim of this study is to evaluate PKR and SMII in pregnancies complicated by hypertensive disorders (HDP) and/or small-for-gestational age (SGA) birth. Read More

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September 2021

Contrast-enhanced ultrasound as a valuable imaging modality for characterizing testicular lesions.

Asian J Androl 2021 Sep 14. Epub 2021 Sep 14.

Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.

Contrast-enhanced ultrasound (CEUS) is a new form of ultrasound (US) that can dynamically display microvessels in a highly sensitive manner. The purpose of this study was to investigate the efficacy of CEUS for characterizing testicular lesions in comparison with conventional US. Forty-seven patients with testicular lesions were enrolled. Read More

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September 2021

Use of human PBMC to analyse the impact of obesity on lipid metabolism and metabolic status: a proof-of-concept pilot study.

Sci Rep 2021 Sep 15;11(1):18329. Epub 2021 Sep 15.

Nutrigenomics, Biomarkers and Risk Evaluation (NuBE) Group, University of the Balearic Islands (UIB), Palma, Spain.

Peripheral blood mononuclear cells (PBMC) are widely used as a biomarker source in nutrition/obesity studies because they reflect gene expression profiles of internal tissues. In this pilot proof-of-concept study we analysed in humans if, as we previously suggested in rodents, PBMC could be a surrogate tissue to study overweight/obesity impact on lipid metabolism. Pre-selected key lipid metabolism genes based in our previous preclinical studies were analysed in PBMC of normoglycemic normal-weight (NW), and overweight-obese (OW-OB) subjects before and after a 6-month weight-loss plan. Read More

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September 2021

The consensus from The Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update.

J Hematol Oncol 2021 Sep 15;14(1):145. Epub 2021 Sep 15.

Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Beijing, China.

The consensus recommendations in 2018 from The Chinese Society of Hematology (CSH) on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation (allo-HSCT) facilitated the standardization of clinical practices of allo-HSCT in China and progressive integration with the world. There have been new developments since the initial publication. To integrate recent developments and further improve the consensus, a panel of experts from the CSH recently updated the consensus recommendations, which are summarized as follows: (1) there is a new algorithm for selecting appropriate donors for allo-HSCT candidates. Read More

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September 2021

Medical management of heavily exposed victims: An experience at the Tokaimura criticality accident.

J Radiol Prot 2021 Sep 15. Epub 2021 Sep 15.

Harada Hospital, Irima, Saitama, JAPAN.

A criticality accident occurred at the uranium conversion plant in Tokaimura, Ibaraki Prefecture, Japan on September 30, 1999. When uranyl nitrate was overloaded to a critical mass level, uncontrolled fission reaction occurred. A procedure was carried out according to the JCO manual, although not an officially approved manual. Read More

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September 2021

Imaging faster neural dynamics with fast fMRI: a need for updated models of the hemodynamic response.

Prog Neurobiol 2021 Sep 12:102174. Epub 2021 Sep 12.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; Department of Biomedical Engineering, Boston University, Boston, MA, USA.

Fast fMRI enables the detection of neural dynamics over timescales of hundreds of milliseconds, suggesting it may provide a new avenue for studying subsecond neural processes in the human brain. The magnitudes of these fast fMRI dynamics are far greater than predicted by canonical models of the hemodynamic response. Several studies have established nonlinear properties of the hemodynamic response that have significant implications for fast fMRI. Read More

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September 2021

Blood copper and risk of cardiometabolic diseases-A Mendelian randomization study.

Hum Mol Genet 2021 Sep 15. Epub 2021 Sep 15.

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.

Observational evidence links higher blood levels of copper with higher risk of cardiovascular diseases. However, whether those associations reflect causal links or can be attributed to confounding is still not fully clear. We investigated causal effects of copper on the risk of cardiometabolic endpoints (stroke, coronary artery disease and type 2 diabetes) and cardiometabolic risk factors in two-sample Mendelian randomization studies. Read More

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September 2021